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AN INTEGRAL & COMPREHENSIVE APPROACH
ON BIOHACKING IMMUNITY
28th of May 2020 // Integral European Conference // IEC Online 2020 // Dr. Olli Sovijärvi, M.D.
Dr. Olli Sovijärvi
Licentiate of Medicine, University of Helsinki [2000–2006]
Integral Theory Online Certificate @ JFK [2010-11]
Private practitioner @ Helsinki Antioxidant Clinic [2012-18]
CEO of Biohacker Center [2015- ]
Head author of Biohacker’s Handbook [2019]
Future book projects:
Biohacker’s Brain Nutrition Book [estimated 2020]
Resilient Human Being [estimated 2021]
Ken Wilber meet-up in Denver 2011.
2010-2011
UPGRADE
YOURSELF
WORK
MIND SLEEP
NUTRITION
EXERCISE
Higher
performance
More
productivity
Life
extension
Better
health
Less stress
BIOHACKER'S HANDBOOK
www.biohackingbook.com
BIOHACKING
IS BETTER LIVING THROUGH
SCIENCE, TECHNOLOGY & NATURE
BIOHACKER’S FLU GUIDE
https://biohack.to/fludownload
• Transmission of viral and bacterial diseases
• Immune system and its function
• Behavioral strategies for strengthening the
immune system
• Nutrients, foods, supplements, and herbs
relevant to the immune system
• Foods and substances that can weaken the
immune response
• Common supplements and drugs that show no
promise in infection prevention
• Technological and practical interventions to
prevent infections
• Air purification
• Disinfection
• Detecting an infection with laboratory testing
and self-quantification
• Air travel and suggestions for a travel kit
• Food recipes for supporting the immune system
(1925–2008) an American molecular biologist
known for his work in microbial genetics, artificial
intelligence, and the United States space program
40 MFLIGHTS PER YEAR
(STATISTA 2020)
4.7 BILLION TRAVELERS PER YEAR
Lähde: Statista (2020)
AIR TRAVEL WILL DOUBLE IN 15 YEARS
1.4 BILLION INCOMING TOURISTS
"CHUNYUN": 3 BILLION TRIPS
OF WHICH 79 MILLION BY AIRPLANES
389 000 DIES
15.2M CARDIOVASCULAR DISEASE
3.0M COPD
3.0M PULMONARY DISEASES
1.6M DIABETES
1.5M ALZHEIMER’S
1.4M GASTROENTERITIS
1.4M CAR ACCIDENT
Lähde:
Paget, J. et al. (2019). Global mortality associated with seasonal
influenza epidemics: New burden estimates and predictors from
the GLaMOR Project. Journal of Global Health, 9(2).
– WHO (2018)
TO SEASONAL INZLUENZA YEARLY
Source: Karesh, W. et al. (2012). Ecology of zoonoses: natural and unnatural histories. Lancet Ecology of
zoonoses: natural and unnatural histories. The Lancet 380 (9857): 1936–1945. Review.
TRANSMISSION OF A DISEASE FROM ANIMAL TO HUMAN (ZOONOSIS)
THE WORLD HAS BECOME
A MASSIVE PETRI DISH
FOR INFECTIOUS DISEASES
QUADRANT-MODEL FOR STRESS
WHAT COVID-19 HAS INITIATED GLOBALLY?
Individual fear-mongering
Negative self-talk
Chronic emotional distress
PTSD (in worst-case), psychosis, anxiety,
depression
Interest in immune system & overall
health
Awakening of a new level of
consciousness
Collective MASSIVE fear
Peer pressure from the government,
WHO, work places, families
More family distress, arguing etc.
due to ”lock-down”
Violence & suicide rates?
Couples finding each-other again
More time for family & kids etc.
Physical chronic stress symptoms, sleep
disturbance, nervous system problems
etc.
Disease itself (COVID-19), but also
normal flu’s interpreted as being
COVID-19
Downregulation of the immune system
More exercise, better nutrition, self-care
Reduction in air pollution
Purification of global air quality
Wild animal life flourishing
Ozone layer repairing
Technological innovations
More aggressive build-up of 5G
(?)
Fall of millions of businesses
BIOHACKER'S APPROACH TO COVID-19
1. PRECAUTION
Prepare internal
environment (body &
immune system)
2. PREVENTION
Prepare external
environment
(surroundings, air,
water, supplies)
3. AVOIDANCE
Active avoidance,
social distancing,
reducing exposure
4. MITIGATION
Slow down replication,
support immune
system, avoid infecting
others
TEST FOR ANTIBODIES
LEARN MECHANISMS OF ACTION, THEN:
5. SUPPORT
FORTIFY YOUR IMMUNE SYSTEM1. PRECAUTION
Prepare internal
environment (body &
immune system)
Source: Biohacker’s Invincible Immunity (2017)
Source: Biohacker’s Invincible Immunity (2017)
Source: Biohacker’s Invincible Immunity (2017)
Source: Biohacker’s Invincible Immunity (2017)
• Chronic sleep deprivation
• Lack of exercise
• Poor diet
• Chronic stress
• Smoking and alcohol consumption
• City life
• Emotional turmoil
• Negative thinking patterns
Impairing factors Fortifying factors
• A regular night's sleep
• Regular exercise
• Optimal dietary intake of nutrients
• Rest, meditation and relaxation
• Reduction of alcohol and tobacco use
• Nature connection
• Positive mindset & outlook on life
IMMUNITY-BALANING FACTORS
Source: Biohacker’s Invincible Immunity (2017)
QUIT SMOKING.
2019-nCov and SARS-nCov share the same receptor, ACE2. There is a
significantly higher ACE2 gene expression in people who smoke cigarettes
than in those who do not smoke. This indicates that smokers may be more
susceptible to 2019-nCov.
China is the “leading” country in the world: total prevalence was 27.7 %
(51.2 % among men and 2.7 % among women).
Cai, G. (2020). Tobacco-Use Disparity in Gene Expression of ACE2, the Receptor of 2019-nCov. Preprints 2020: 2020020051.
SMOKING INCREASES THE RISK FOR
ALL UPPER RESIPIRATORY INFECTIONS & COVID-19
STOP OR LIMIT ALCOHOL CONSUMPTION.
Excessive consumption of
alcohol impairs the immune
system and increases the
vulnerability to lung
infections.
Zhang. P. & Bagby, G. & Happel, K. & Raasch, C. & Nelson, S. (2008). Alcohol abuse, immunosuppression, and pulmonary infection. Current Drug Abuse Reviews 1 (1): 56–67. Review.
Environmental pollution in the form of
cadmium (Cd) has been shown to disrupt
mitochondrial function and potentiate
pulmonary inflammation in animal studies.
Cadmium elevates inflammatory IL-4 levels
and alters metabolites associated with fatty
acid metabolism, leading to increased
pulmonary inflammation during a viral
infection.
AVOID AIR POLLUTION
Hu, X. et al. (2019). Environmental Cadmium Enhances Lung Injury by Respiratory Syncytial Virus Infection. The American Journal of Pathology 189( 8): 1513–1525.
HORMESIS
ROS
Oxidative damage
Antioxidants
Oxidative damage
Oxidative damage repair
Resistance to Ox stress
Regular exercise
Strenuous exercise
overtraining syndrome
Too high
Ox Stress
Too low
Ox stress
BeneficialeffectNull-negativeeffect
Benefit
lack
Magnitude of Stress/Exercise
ROS
Oxidative damage
Antioxidants
Oxidative damage
Oxidative damage repair
Resistance to Ox stress
FOR EXAMPLE EXERCISE, PHYTOCHEMICALS, SAUNA, ICE SWIMMING, SUNLIGHT
INCREASE HORMETIC (BENEFICIAL) STRESSORS
HORMETIC DOSE RESPONSE
GET ENOUGH SUN
VITAMIN D: POWER SOURCE FOR KILLER T CELLS
Source: Biohacker’s Handbook: Invincible immunity (2017) & Bergman, P. et al. (2013)
Several meta-analyzes support the use
of vitamin D in the prevention of
respiratory diseases.
Source: Holick 2013
Source: Holick 2016
BLUE LIGHT, (INFRA)RED LIGHT & UV LIGHT
PHOTOBIOMODULATION
GET ENOUGH SLEEP & RECOVERY
Besedovsky, L., Lange, T., & Haack, M. (2019). The Sleep-Immune Crosstalk in Health and Disease. Physiological reviews, 99(3), 1325–1380. https://doi.org/10.1152/physrev.00010.2018
DOYOU USE
THE SLEEP HORMONE
MELATONIN?
Supplementing with melatonin may be useful in
the early stages of infection to facilitate proper
immune system response by increasing T-helper
cell production, particularly of CD4+ cells.
Production of IL-2, IL-6, and IL-12 are also
stimulated by melatonin.
Srinivasan, V. et al. (2005). Melatonin, immune function and aging.
Immunity & Ageing 2: 17.
24:00
YÖ
12:00
PÄIVÄ
06:00
AAMU
18:00
ILTA
02:00
04:30
06:45
07:30
08:30
10:00
14:30
15:30
17:00
18:30
19:00
21:00
22:30
Syvin uni
Matalin
ruumiinlämpötila
Nopein nousu
verenpaineessa
Suolen toiminta
aktivoituu
Melatoniinin eritys
loppuu
Korkea vireystila
Paras koordinaatio
Nopein reaktiokyky
Tehokkain verenkierto
ja lihasvoima
tehokkaimmillaan
Korkein verenpaine
Korkein
ruumiinlämpötila
Melatoniinin
eritys alkaa
Suolen toiminta
vaimenee
NIGHT
DAY
MORNINGEVENING
Deepest sleep
Lowest body temperature
Sharpest rise in blood pressure
Melatonin secretion stops
Bowel movement likely
Highest testosterone secretion
High alertness
Best coordination
Fastest reaction time
Greatest cardiovascular
efficiency and muscle strength
Highest blood pressure
Highest body temperature
Melatonin secretion starts
Bowel movements suppressed
Fix your natural
circadian
rhythm
Haspel JA, Anafi R, Brown MK, et al. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. JCI Insight. 2020;5(1):e131487.
CIRCADIAN REGULATION IN MAMMALS
Haspel JA, Anafi R, Brown MK, et al. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. JCI Insight. 2020;5(1):e131487.
Source: Froy, O. (2007). The relationship between nutrition and circadian rhythms in mammals. Frontiers in Neuroendocrinology 28 (2–3): 61–71. Review.
Multilayered circadian control of
leukocyte trafficking.
Schematic depiction of the circadian
regulation of specific leukocyte trafficking
steps (55–57, 68). These include the egress
of leukocytes from the bone marrow;
adhesion of circulating leukocytes to
endothelial cells in the capillary beds of
end organs; and removal of leukocytes
from the parenchyma of organs by
phagocytosis or by migration to area
lymph nodes.
Haspel JA, Anafi R, Brown MK, et al. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. JCI Insight. 2020;5(1):e131487.
FIX YOUR GUT LINING
How to fix:
L-glutamine
Rao, R., & Samak, G. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of Epithelial Biology & Pharmacology 5 (Suppl 1-M7): 47–54.
Roxas, M. & Jurenka, J. (2007). Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Alternative Medicine Reviews 12 (1): 25–48.
Berlutti, F. et al. (2011). Antiviral properties of lactoferrin--a natural immunity molecule. Molecules (Basel, Switzerland) 16 (8): 6992–7018.
LACTOFERRIN
Wu, H.-J. & Wu, E. (2012). The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 3 (1): 4–14.
UPREGULATE YOUR MICROBIAL DIVERSITY IN THE GUT
PROBIOTICS
◦ Especially older adults can benefit from a long-term use of an oral
blend of probiotics including Lactobacillus plantarum,
Lactobacillus rhamnosus and Bifidobacterium lactis which enhance
secretory immunity and increase IgA antibodies.
◦ In another study, a probiotic strain Bacillus subtilis, was shown to
stimulate IgA in the elderly to reduce the frequency of respiratory
infections by 45 %. Lactobacillus plantarum has been shown to
enhance human mucosal and systemic immunity and also prevent
NSAID-induced (such as ibuprofen) reduction in T regulatory cells.
Pregliasco, F. et al. (2008). A new chance of preventing winter diseases by the administration of synbiotic formulations. Journal of Clinical Gastroenterology 42 (Suppl 3 Pt 2): S224–S33.
Lefevre, M. et al. (2015). Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a
randomized, double-blind placebo-controlled study. Immunity and Ageing 12 (1): 24.
de Vos, P. et al. (2017). Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal
Anti-inflammatory Drug Induced Reduction in T Regulatory Cells. Frontiers in immunology 8: 1000.
AUTOPHAGY ACTIVATION: CLEARANCE OF DAMAGED CELLS
Fed Starved
Nobel
Price 2016
• Upregulates glutathione
production
• Upregulates autophagy
• Increases ketone production
INTERMITTENT FASTING &
Time-restricted feeding
Anton, S. et al. (2018). Flipping the Metabolic Switch: Understanding
and Applying the Health Benefits of Fasting. Obesity (Silver Spring,
Md.) 26 (2): 254–268.
MITOCHONDRIAL SUPPORT
NAD & ATP
Aman et al (2018) ‘Therapeutic potential of boosting NAD+ in aging and age-related diseases’, KeAi, Volume 2, Pages 30-37
Ketosis and ketones increase mitochondrial
biogenesis and mitochondrial volume & mass
Lower blood glucose = better immune
system function & lower risk for COVID-19
KETONES + GLUCOSE FROM BLOOD
NRF2 (nuclear factor erythroid-2-related factor 2)
is a transcription factor that activates over 500
genes via molecules called sirtuins. NRF2
activation can be achieved through exercise,
calorie restriction (including fasting) and ingestion
of natural nutrients that are NRF2 activators.
2. PREVENTION
Prepare external
environment
(surroundings, air,
water, supplies)
Ref: NASA
AIR
PURIFYING PLANTS
HUMIDITY PARTICLES
Song C, Ikei H, Miyazaki Y. Physiological Effects of Nature Therapy: A Review of the Research in Japan. Tchounwou PB, ed. International Journal of Environmental Research and Public Health. 2016;13(8):781.
10 mins in the forest:
blood pressure drops
pulse rate drops
20 mins in the forest:
mood begins to rise
60 mins in the forest:
better attention & cognition
120 mins in the forest:
immune system begins to recuperate
NEXT GENERATION
AIR FILTERATION
PHOTOCATALYSIS
KILLS VIRUSES & BACTERIA
NANOTECHNOLOGY
FILTERS INDOOR AIR’S
PATHOGENS
3. AVOIDANCE
Active avoidance,
social distancing,
reducing exposure
SOCIAL DISTANCING & HYSTERIA GONE WRONG
USE CONTACTLESS
PAYMENT
WASH WITH SOAP AVOID DRYERS
REASONABLE EVERYWHERE
WHEN TRAVELING (is again possible…)
AVOID STRESS
AND QUEUES
•Avoid Friday afternoons
•Get Frequent Flyer status
•Avoid Check-in bags
•Pack just what you need
•Choose airport / airline
WASH YOUR HANDS
IMMEDIATELY
AFTER SECURITY
THE MOST
UNHYGIENIC
TRAY IN THE
WHOLE AIRPORT
Dehydration accelerates:
Humidity in airplanes is
around 10-20% (standard
30-50%).
Moisture in the nasal hair
helps filter out pathogens.
DRINK 250ml H2O PER HOUR
HumidiFlyer
SKIP AIRPLANE FOOD
AVOID AISLE SEATS
• The biggest amount of possible
microbes lie in the aisle seats
onto which other passengers
touch.
• You will also be most exposed to
other passengers and aircraft
personnel.
AVOID GOING TO THE TOILET
• Go to the toilet before the flight
• 38 % passengers use toilet once, 9 % twice & 3 % more often
• If you have to use toilet, avoid touching any surfaces and wash your hands
Hertzberg, V. S. & al. (2018). Behaviors, movements, and transmission of droplet-mediated respiratory diseases
during transcontinental airline flights. Proceedings of the National Academy of Sciences, 115(14), 3623–3627.
DISINFECT SEAT BEALT
AND OTHER SURFACES
DIRECT AIR CONDITIONING
TOWARDS YOURSELF
• Airplane air is filtered via HEPA multiple times per minute
• It creates an air bubble that protects from possible pathogens
IN REALITY: MASK IS FUTILE…
• If your are not sitting in front of
or next to a sick person
• Give the mask rather to the sick
person
• Many viruses go through N95
mask
4. MITIGATION
Slow down replication,
support immune
system, avoid infecting
others
• Essential to the functioning of
immune system cells
• Reduces oxidative stress and
inflammatory markers
Source:
Prasad, A. S. (2008). Zinc in Human Health: Effect of Zinc on Immune Cells. Molecular Medicine, 14(5-6), 353–357.
Science, M. et al. (2012). Zinc for the treatment of the common cold: a systematic review and meta-analysis of
randomized controlled trials. CMAJ : Canadian Medical Association Journal, 184(10), E551–E561.
Before going
in public:
Zinc acetate
lozenge or spray
FORTHCOMING RESEARCH ON VITAMIN C & COVID-19
BOOST GLUTATHIONE PRODUCTION
SELENIUM – PROTECT FROM OXIDATIVE STRESS
2–4 Brazil nuts contain
selenium for daily need
Source: Guillin, O. M. et al. (2019). Selenium, Selenoproteins and Viral Infection. Nutrients, 11(9), 2101.
Virus infection increases oxidative stress (ROS) &
increases the severity of the disease.
Garlic is a natural antibiotic and antimicrobial agent that kills viruses directly and
strengthens immunity in multiple studies.
Iciek, M. & Kwiecień, I. & Włodek, L. (2009). Biological properties of garlic and garlic-derived organosulfur compounds. Environmental and Molecular Mutagenesis 50 (3): 247–265.
Guo, N. et al. (1993). Demonstration of the anti-viral activity of garlic extract against human cytomegalovirus in vitro. Chinese Medicine Journal (Engl) 106 (2): 93–96.
Harris, J. & Cottrell, S. & Plummer, S. & Lloyd, D. (2001). Antimicrobial properties of Allium sativum (garlic). Applied Microbiology and Biotechnology 57 (3): 282–286.
GARLIC & BLACK GARLIC.
MEDICINAL MUSHROOMS
• Shiitake (Lentinula edodes)
• Reishi (Ganoderma lucidum)
• Turkey tail (Trametes versicolor)
• Cordyceps (Cordyceps sinensis)
• Maitake (Grifola frondosa)
• Agaricus blazei
• Matsutake (Tricholoma matsutake)
• Lion’s mane (Hericium erinaceus)
• Chaga (Inonotus obliquus)
Numerous important drugs such as
penicillin, griseofulvin, erythromycin
and cyclosporin have been isolated
from medicinal fungi.
The medicinal properties of fungi are
often polysaccharides or triterpenes.
BETA-GLUCANS.
Source: Biohacker’s Handbook: Invincible immunity (2017)
OREGANO OIL.
Rodriguez-Garcia, I. et al. (2016). Oregano Essential Oil as an Antimicrobial and Antioxidant Additive in Food Products. Critical Reviews in Food Science and Nutrition 56 (10): 1717–1727.
Oregano and especially oregano essential oil is an effective antifungal and antibacterial substance.
RAW HONEY.
Source: Maddocks, S. & Jenkins, R. (2013). Honey: a sweet solution to the growing problem of antimicrobial resistance? Future Microbiology 8 (11): 1419–1429. Review.
Honey has antimicrobial peptides (including bee
defensin-1, defensin-2, hemenopectin and
apidaecin) and medicinal properties (such as
flavonoids, polyphenols, vitamins and minerals) that
strengthen the immune system.
Isoliquiritigenin (ILG) present in licorice has been recognized as a potent inhibitor of influenza virus replication in
human bronchial epithelial cells and an inhibitor of inflammatory cytokines. Administration of ILG reduces the
morbidity of mice infected with the H1N1 virus. Glycyrrhizin, an active compound of licorice root, has also been used
to inhibit the replication of SARS-associated coronavirus.
LICORICE ROOT.
Cinatl, J. et al. (2003). Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet 361 (9374): 2045–2046.
Traboulsi, H. et al. (2015). The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrobial Agents and Chemotherapy 59 (10): 6317–6327.
Kang, S. & Min, H. (2012). Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System. Journal of Ginseng Research 36 (4): 354–368.
American as well as Asian ginseng, regulate immune cells such as macrophages, T-cells and
natural killer cells. It also has antimicrobial properties. 
GINSENG-ROOT.
ELDERBERRY AND OTHER DARK BERRIES.
Taking 15 ml of elderberry extract 4 times per day 48 hours
after the onset of influenza virus A and B, can relieve the
symptoms on average 4 days earlier than without taking it.
Zakay-Rones, Z. & Thom, E. & Wollan, T. & Wadstein, J. (2004). Randomized Study of the Efficacy
and Safety of Oral Elderberry Extract in the Treatment of Influenza A and B Virus Infections. Journal of
International Medical Research 32 (2): 132–140.
Eucalyptus, cinnamon, clove, pimento, thyme and rosemary oils have been shown to have antibacterial
and antiviral properties on airborne pathogens.
ESSENTIAL OILS
Swamy, M. & Akhtar, M. & Sinniah, U. (2016). Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An
Updated Review. Evidence-based Complementary and Alternative Medicine 2016: 3012462.
NITRIC OXIDE (NO) PRODUCTION
Supplementation with NO boosters (for example L-arginine and L-citrulline as well as foods rich in nitrates
such as beets and leafy greens) may inhibit viral replication cycles for example in SARS coronavirus.
Åkerström, S. et al. (2005). Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Journal of Virology 79 (3): 1966-1969.
WHAT DOES NOT WORK BASED ON STUDIES
Multi-Vitamins
Echinacea
Cough medications
Antihistamines
Analgesics such as paracetamol
Anti-inflammatory drugs
Acetaminophen or paracetamol has actually been
shown to increase the duration of colds as it
reduces the natural antibody response.
Prymula, R. et al. (2009). Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody
responses in children: two open-label, randomised controlled trials. The Lancet 374 (9698): 1339–1350.
In the cases of pneumonia, NSAIDs are actually
harmful to the patient and impair neutrophil
intrinsic functions, their recruitment to the
inflammatory site, and the resolution of
inflammatory processes after acute pulmonary
bacterial challenge. This means slower recovery
from the disease itself.
Voiriot, G. et al. (2019). Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients. Journal of Clinical Medicine 8 (6): 786.
TEST FOR ANTIBODIES > IF POSITIVE > GET TO WORK HELPING OTHERS
MEASURE THE CONDITION OF YOUR IMMUNE SYSTEM
5. SUPPORT
CAN WE TRUST TESTING?
• C-reactive protein (CRP)
• Complete blood count
• White blood cell count (WBC count), in particular
consider also taking WBC differential
• Polymorphonuclear leukocyte counts (to distinguish
between bacterial and viral infections)
• Procalcitonin (PCT)
• Interleukin-6 (IL-6)
BASIC LAB TESTS FOR EVALUATING POSSIBLE INFECTION
Source: Biohacker’s Invincible Immunity (2017)
MEASURING THE CONDITION OF THE IMMUNE SYSTEM
BIOHACKER’S FLU GUIDE
https://biohack.to/fludownload
Biomechanics
Sleep
Time & Energy
Management
Body Maintenance
Diet &
Metabolism
Stress & Health
Management
Epigenetics
Cognitive &
Physical Ergonomics
Focus, Concentration &
Brain Health
Productivity, Flow &
Task Management
Biomarkers
Physique
OPTIMIZED
HEALTH &
PERFORMANCE
Recovery
M.D., AUTHOR & BIOHACKER
OLLI SOVIJÄRVI
THANK YOU.
Follow @biohackingbook – www.biohackingbook.com

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An integral and comprehensive approach on biohacking immunity // Integral European Conference 2020

  • 1. AN INTEGRAL & COMPREHENSIVE APPROACH ON BIOHACKING IMMUNITY 28th of May 2020 // Integral European Conference // IEC Online 2020 // Dr. Olli Sovijärvi, M.D.
  • 2. Dr. Olli Sovijärvi Licentiate of Medicine, University of Helsinki [2000–2006] Integral Theory Online Certificate @ JFK [2010-11] Private practitioner @ Helsinki Antioxidant Clinic [2012-18] CEO of Biohacker Center [2015- ] Head author of Biohacker’s Handbook [2019] Future book projects: Biohacker’s Brain Nutrition Book [estimated 2020] Resilient Human Being [estimated 2021] Ken Wilber meet-up in Denver 2011.
  • 5. BIOHACKING IS BETTER LIVING THROUGH SCIENCE, TECHNOLOGY & NATURE
  • 6. BIOHACKER’S FLU GUIDE https://biohack.to/fludownload • Transmission of viral and bacterial diseases • Immune system and its function • Behavioral strategies for strengthening the immune system • Nutrients, foods, supplements, and herbs relevant to the immune system • Foods and substances that can weaken the immune response • Common supplements and drugs that show no promise in infection prevention • Technological and practical interventions to prevent infections • Air purification • Disinfection • Detecting an infection with laboratory testing and self-quantification • Air travel and suggestions for a travel kit • Food recipes for supporting the immune system
  • 7.
  • 8. (1925–2008) an American molecular biologist known for his work in microbial genetics, artificial intelligence, and the United States space program
  • 9. 40 MFLIGHTS PER YEAR (STATISTA 2020)
  • 10. 4.7 BILLION TRAVELERS PER YEAR Lähde: Statista (2020) AIR TRAVEL WILL DOUBLE IN 15 YEARS
  • 12. "CHUNYUN": 3 BILLION TRIPS OF WHICH 79 MILLION BY AIRPLANES
  • 13. 389 000 DIES 15.2M CARDIOVASCULAR DISEASE 3.0M COPD 3.0M PULMONARY DISEASES 1.6M DIABETES 1.5M ALZHEIMER’S 1.4M GASTROENTERITIS 1.4M CAR ACCIDENT Lähde: Paget, J. et al. (2019). Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the GLaMOR Project. Journal of Global Health, 9(2). – WHO (2018) TO SEASONAL INZLUENZA YEARLY
  • 14.
  • 15.
  • 16. Source: Karesh, W. et al. (2012). Ecology of zoonoses: natural and unnatural histories. Lancet Ecology of zoonoses: natural and unnatural histories. The Lancet 380 (9857): 1936–1945. Review. TRANSMISSION OF A DISEASE FROM ANIMAL TO HUMAN (ZOONOSIS)
  • 17. THE WORLD HAS BECOME A MASSIVE PETRI DISH FOR INFECTIOUS DISEASES
  • 18.
  • 20. WHAT COVID-19 HAS INITIATED GLOBALLY? Individual fear-mongering Negative self-talk Chronic emotional distress PTSD (in worst-case), psychosis, anxiety, depression Interest in immune system & overall health Awakening of a new level of consciousness Collective MASSIVE fear Peer pressure from the government, WHO, work places, families More family distress, arguing etc. due to ”lock-down” Violence & suicide rates? Couples finding each-other again More time for family & kids etc. Physical chronic stress symptoms, sleep disturbance, nervous system problems etc. Disease itself (COVID-19), but also normal flu’s interpreted as being COVID-19 Downregulation of the immune system More exercise, better nutrition, self-care Reduction in air pollution Purification of global air quality Wild animal life flourishing Ozone layer repairing Technological innovations More aggressive build-up of 5G (?) Fall of millions of businesses
  • 21.
  • 22. BIOHACKER'S APPROACH TO COVID-19 1. PRECAUTION Prepare internal environment (body & immune system) 2. PREVENTION Prepare external environment (surroundings, air, water, supplies) 3. AVOIDANCE Active avoidance, social distancing, reducing exposure 4. MITIGATION Slow down replication, support immune system, avoid infecting others TEST FOR ANTIBODIES LEARN MECHANISMS OF ACTION, THEN: 5. SUPPORT
  • 23. FORTIFY YOUR IMMUNE SYSTEM1. PRECAUTION Prepare internal environment (body & immune system)
  • 28. • Chronic sleep deprivation • Lack of exercise • Poor diet • Chronic stress • Smoking and alcohol consumption • City life • Emotional turmoil • Negative thinking patterns Impairing factors Fortifying factors • A regular night's sleep • Regular exercise • Optimal dietary intake of nutrients • Rest, meditation and relaxation • Reduction of alcohol and tobacco use • Nature connection • Positive mindset & outlook on life IMMUNITY-BALANING FACTORS Source: Biohacker’s Invincible Immunity (2017)
  • 29. QUIT SMOKING. 2019-nCov and SARS-nCov share the same receptor, ACE2. There is a significantly higher ACE2 gene expression in people who smoke cigarettes than in those who do not smoke. This indicates that smokers may be more susceptible to 2019-nCov. China is the “leading” country in the world: total prevalence was 27.7 % (51.2 % among men and 2.7 % among women). Cai, G. (2020). Tobacco-Use Disparity in Gene Expression of ACE2, the Receptor of 2019-nCov. Preprints 2020: 2020020051.
  • 30. SMOKING INCREASES THE RISK FOR ALL UPPER RESIPIRATORY INFECTIONS & COVID-19
  • 31. STOP OR LIMIT ALCOHOL CONSUMPTION. Excessive consumption of alcohol impairs the immune system and increases the vulnerability to lung infections. Zhang. P. & Bagby, G. & Happel, K. & Raasch, C. & Nelson, S. (2008). Alcohol abuse, immunosuppression, and pulmonary infection. Current Drug Abuse Reviews 1 (1): 56–67. Review.
  • 32. Environmental pollution in the form of cadmium (Cd) has been shown to disrupt mitochondrial function and potentiate pulmonary inflammation in animal studies. Cadmium elevates inflammatory IL-4 levels and alters metabolites associated with fatty acid metabolism, leading to increased pulmonary inflammation during a viral infection. AVOID AIR POLLUTION Hu, X. et al. (2019). Environmental Cadmium Enhances Lung Injury by Respiratory Syncytial Virus Infection. The American Journal of Pathology 189( 8): 1513–1525.
  • 33. HORMESIS ROS Oxidative damage Antioxidants Oxidative damage Oxidative damage repair Resistance to Ox stress Regular exercise Strenuous exercise overtraining syndrome Too high Ox Stress Too low Ox stress BeneficialeffectNull-negativeeffect Benefit lack Magnitude of Stress/Exercise ROS Oxidative damage Antioxidants Oxidative damage Oxidative damage repair Resistance to Ox stress FOR EXAMPLE EXERCISE, PHYTOCHEMICALS, SAUNA, ICE SWIMMING, SUNLIGHT INCREASE HORMETIC (BENEFICIAL) STRESSORS
  • 35. GET ENOUGH SUN VITAMIN D: POWER SOURCE FOR KILLER T CELLS Source: Biohacker’s Handbook: Invincible immunity (2017) & Bergman, P. et al. (2013) Several meta-analyzes support the use of vitamin D in the prevention of respiratory diseases.
  • 38. BLUE LIGHT, (INFRA)RED LIGHT & UV LIGHT
  • 40. GET ENOUGH SLEEP & RECOVERY Besedovsky, L., Lange, T., & Haack, M. (2019). The Sleep-Immune Crosstalk in Health and Disease. Physiological reviews, 99(3), 1325–1380. https://doi.org/10.1152/physrev.00010.2018
  • 41. DOYOU USE THE SLEEP HORMONE MELATONIN? Supplementing with melatonin may be useful in the early stages of infection to facilitate proper immune system response by increasing T-helper cell production, particularly of CD4+ cells. Production of IL-2, IL-6, and IL-12 are also stimulated by melatonin. Srinivasan, V. et al. (2005). Melatonin, immune function and aging. Immunity & Ageing 2: 17.
  • 42. 24:00 YÖ 12:00 PÄIVÄ 06:00 AAMU 18:00 ILTA 02:00 04:30 06:45 07:30 08:30 10:00 14:30 15:30 17:00 18:30 19:00 21:00 22:30 Syvin uni Matalin ruumiinlämpötila Nopein nousu verenpaineessa Suolen toiminta aktivoituu Melatoniinin eritys loppuu Korkea vireystila Paras koordinaatio Nopein reaktiokyky Tehokkain verenkierto ja lihasvoima tehokkaimmillaan Korkein verenpaine Korkein ruumiinlämpötila Melatoniinin eritys alkaa Suolen toiminta vaimenee NIGHT DAY MORNINGEVENING Deepest sleep Lowest body temperature Sharpest rise in blood pressure Melatonin secretion stops Bowel movement likely Highest testosterone secretion High alertness Best coordination Fastest reaction time Greatest cardiovascular efficiency and muscle strength Highest blood pressure Highest body temperature Melatonin secretion starts Bowel movements suppressed Fix your natural circadian rhythm Haspel JA, Anafi R, Brown MK, et al. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. JCI Insight. 2020;5(1):e131487.
  • 43. CIRCADIAN REGULATION IN MAMMALS Haspel JA, Anafi R, Brown MK, et al. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. JCI Insight. 2020;5(1):e131487.
  • 44. Source: Froy, O. (2007). The relationship between nutrition and circadian rhythms in mammals. Frontiers in Neuroendocrinology 28 (2–3): 61–71. Review.
  • 45. Multilayered circadian control of leukocyte trafficking. Schematic depiction of the circadian regulation of specific leukocyte trafficking steps (55–57, 68). These include the egress of leukocytes from the bone marrow; adhesion of circulating leukocytes to endothelial cells in the capillary beds of end organs; and removal of leukocytes from the parenchyma of organs by phagocytosis or by migration to area lymph nodes. Haspel JA, Anafi R, Brown MK, et al. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. JCI Insight. 2020;5(1):e131487.
  • 46. FIX YOUR GUT LINING How to fix: L-glutamine Rao, R., & Samak, G. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of Epithelial Biology & Pharmacology 5 (Suppl 1-M7): 47–54.
  • 47. Roxas, M. & Jurenka, J. (2007). Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Alternative Medicine Reviews 12 (1): 25–48. Berlutti, F. et al. (2011). Antiviral properties of lactoferrin--a natural immunity molecule. Molecules (Basel, Switzerland) 16 (8): 6992–7018. LACTOFERRIN
  • 48. Wu, H.-J. & Wu, E. (2012). The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 3 (1): 4–14. UPREGULATE YOUR MICROBIAL DIVERSITY IN THE GUT
  • 49. PROBIOTICS ◦ Especially older adults can benefit from a long-term use of an oral blend of probiotics including Lactobacillus plantarum, Lactobacillus rhamnosus and Bifidobacterium lactis which enhance secretory immunity and increase IgA antibodies. ◦ In another study, a probiotic strain Bacillus subtilis, was shown to stimulate IgA in the elderly to reduce the frequency of respiratory infections by 45 %. Lactobacillus plantarum has been shown to enhance human mucosal and systemic immunity and also prevent NSAID-induced (such as ibuprofen) reduction in T regulatory cells. Pregliasco, F. et al. (2008). A new chance of preventing winter diseases by the administration of synbiotic formulations. Journal of Clinical Gastroenterology 42 (Suppl 3 Pt 2): S224–S33. Lefevre, M. et al. (2015). Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immunity and Ageing 12 (1): 24. de Vos, P. et al. (2017). Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells. Frontiers in immunology 8: 1000.
  • 50. AUTOPHAGY ACTIVATION: CLEARANCE OF DAMAGED CELLS Fed Starved Nobel Price 2016
  • 51. • Upregulates glutathione production • Upregulates autophagy • Increases ketone production INTERMITTENT FASTING & Time-restricted feeding Anton, S. et al. (2018). Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring, Md.) 26 (2): 254–268.
  • 52.
  • 54. Aman et al (2018) ‘Therapeutic potential of boosting NAD+ in aging and age-related diseases’, KeAi, Volume 2, Pages 30-37
  • 55. Ketosis and ketones increase mitochondrial biogenesis and mitochondrial volume & mass
  • 56. Lower blood glucose = better immune system function & lower risk for COVID-19
  • 57. KETONES + GLUCOSE FROM BLOOD
  • 58. NRF2 (nuclear factor erythroid-2-related factor 2) is a transcription factor that activates over 500 genes via molecules called sirtuins. NRF2 activation can be achieved through exercise, calorie restriction (including fasting) and ingestion of natural nutrients that are NRF2 activators.
  • 59.
  • 60.
  • 63. Song C, Ikei H, Miyazaki Y. Physiological Effects of Nature Therapy: A Review of the Research in Japan. Tchounwou PB, ed. International Journal of Environmental Research and Public Health. 2016;13(8):781.
  • 64. 10 mins in the forest: blood pressure drops pulse rate drops 20 mins in the forest: mood begins to rise 60 mins in the forest: better attention & cognition 120 mins in the forest: immune system begins to recuperate
  • 65. NEXT GENERATION AIR FILTERATION PHOTOCATALYSIS KILLS VIRUSES & BACTERIA NANOTECHNOLOGY FILTERS INDOOR AIR’S PATHOGENS
  • 66. 3. AVOIDANCE Active avoidance, social distancing, reducing exposure SOCIAL DISTANCING & HYSTERIA GONE WRONG
  • 67. USE CONTACTLESS PAYMENT WASH WITH SOAP AVOID DRYERS REASONABLE EVERYWHERE
  • 68. WHEN TRAVELING (is again possible…) AVOID STRESS AND QUEUES •Avoid Friday afternoons •Get Frequent Flyer status •Avoid Check-in bags •Pack just what you need •Choose airport / airline
  • 69. WASH YOUR HANDS IMMEDIATELY AFTER SECURITY THE MOST UNHYGIENIC TRAY IN THE WHOLE AIRPORT
  • 70. Dehydration accelerates: Humidity in airplanes is around 10-20% (standard 30-50%). Moisture in the nasal hair helps filter out pathogens. DRINK 250ml H2O PER HOUR HumidiFlyer
  • 72. AVOID AISLE SEATS • The biggest amount of possible microbes lie in the aisle seats onto which other passengers touch. • You will also be most exposed to other passengers and aircraft personnel.
  • 73. AVOID GOING TO THE TOILET • Go to the toilet before the flight • 38 % passengers use toilet once, 9 % twice & 3 % more often • If you have to use toilet, avoid touching any surfaces and wash your hands Hertzberg, V. S. & al. (2018). Behaviors, movements, and transmission of droplet-mediated respiratory diseases during transcontinental airline flights. Proceedings of the National Academy of Sciences, 115(14), 3623–3627.
  • 74. DISINFECT SEAT BEALT AND OTHER SURFACES
  • 75. DIRECT AIR CONDITIONING TOWARDS YOURSELF • Airplane air is filtered via HEPA multiple times per minute • It creates an air bubble that protects from possible pathogens
  • 76. IN REALITY: MASK IS FUTILE… • If your are not sitting in front of or next to a sick person • Give the mask rather to the sick person • Many viruses go through N95 mask
  • 77. 4. MITIGATION Slow down replication, support immune system, avoid infecting others
  • 78.
  • 79. • Essential to the functioning of immune system cells • Reduces oxidative stress and inflammatory markers Source: Prasad, A. S. (2008). Zinc in Human Health: Effect of Zinc on Immune Cells. Molecular Medicine, 14(5-6), 353–357. Science, M. et al. (2012). Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ : Canadian Medical Association Journal, 184(10), E551–E561. Before going in public: Zinc acetate lozenge or spray
  • 80.
  • 81.
  • 82. FORTHCOMING RESEARCH ON VITAMIN C & COVID-19
  • 84. SELENIUM – PROTECT FROM OXIDATIVE STRESS 2–4 Brazil nuts contain selenium for daily need Source: Guillin, O. M. et al. (2019). Selenium, Selenoproteins and Viral Infection. Nutrients, 11(9), 2101. Virus infection increases oxidative stress (ROS) & increases the severity of the disease.
  • 85. Garlic is a natural antibiotic and antimicrobial agent that kills viruses directly and strengthens immunity in multiple studies. Iciek, M. & Kwiecień, I. & Włodek, L. (2009). Biological properties of garlic and garlic-derived organosulfur compounds. Environmental and Molecular Mutagenesis 50 (3): 247–265. Guo, N. et al. (1993). Demonstration of the anti-viral activity of garlic extract against human cytomegalovirus in vitro. Chinese Medicine Journal (Engl) 106 (2): 93–96. Harris, J. & Cottrell, S. & Plummer, S. & Lloyd, D. (2001). Antimicrobial properties of Allium sativum (garlic). Applied Microbiology and Biotechnology 57 (3): 282–286. GARLIC & BLACK GARLIC.
  • 86. MEDICINAL MUSHROOMS • Shiitake (Lentinula edodes) • Reishi (Ganoderma lucidum) • Turkey tail (Trametes versicolor) • Cordyceps (Cordyceps sinensis) • Maitake (Grifola frondosa) • Agaricus blazei • Matsutake (Tricholoma matsutake) • Lion’s mane (Hericium erinaceus) • Chaga (Inonotus obliquus) Numerous important drugs such as penicillin, griseofulvin, erythromycin and cyclosporin have been isolated from medicinal fungi. The medicinal properties of fungi are often polysaccharides or triterpenes.
  • 87. BETA-GLUCANS. Source: Biohacker’s Handbook: Invincible immunity (2017)
  • 88. OREGANO OIL. Rodriguez-Garcia, I. et al. (2016). Oregano Essential Oil as an Antimicrobial and Antioxidant Additive in Food Products. Critical Reviews in Food Science and Nutrition 56 (10): 1717–1727. Oregano and especially oregano essential oil is an effective antifungal and antibacterial substance.
  • 89. RAW HONEY. Source: Maddocks, S. & Jenkins, R. (2013). Honey: a sweet solution to the growing problem of antimicrobial resistance? Future Microbiology 8 (11): 1419–1429. Review. Honey has antimicrobial peptides (including bee defensin-1, defensin-2, hemenopectin and apidaecin) and medicinal properties (such as flavonoids, polyphenols, vitamins and minerals) that strengthen the immune system.
  • 90. Isoliquiritigenin (ILG) present in licorice has been recognized as a potent inhibitor of influenza virus replication in human bronchial epithelial cells and an inhibitor of inflammatory cytokines. Administration of ILG reduces the morbidity of mice infected with the H1N1 virus. Glycyrrhizin, an active compound of licorice root, has also been used to inhibit the replication of SARS-associated coronavirus. LICORICE ROOT. Cinatl, J. et al. (2003). Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet 361 (9374): 2045–2046. Traboulsi, H. et al. (2015). The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrobial Agents and Chemotherapy 59 (10): 6317–6327.
  • 91. Kang, S. & Min, H. (2012). Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System. Journal of Ginseng Research 36 (4): 354–368. American as well as Asian ginseng, regulate immune cells such as macrophages, T-cells and natural killer cells. It also has antimicrobial properties.  GINSENG-ROOT.
  • 92. ELDERBERRY AND OTHER DARK BERRIES. Taking 15 ml of elderberry extract 4 times per day 48 hours after the onset of influenza virus A and B, can relieve the symptoms on average 4 days earlier than without taking it. Zakay-Rones, Z. & Thom, E. & Wollan, T. & Wadstein, J. (2004). Randomized Study of the Efficacy and Safety of Oral Elderberry Extract in the Treatment of Influenza A and B Virus Infections. Journal of International Medical Research 32 (2): 132–140.
  • 93. Eucalyptus, cinnamon, clove, pimento, thyme and rosemary oils have been shown to have antibacterial and antiviral properties on airborne pathogens. ESSENTIAL OILS Swamy, M. & Akhtar, M. & Sinniah, U. (2016). Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review. Evidence-based Complementary and Alternative Medicine 2016: 3012462.
  • 94. NITRIC OXIDE (NO) PRODUCTION Supplementation with NO boosters (for example L-arginine and L-citrulline as well as foods rich in nitrates such as beets and leafy greens) may inhibit viral replication cycles for example in SARS coronavirus. Åkerström, S. et al. (2005). Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Journal of Virology 79 (3): 1966-1969.
  • 95.
  • 96. WHAT DOES NOT WORK BASED ON STUDIES Multi-Vitamins Echinacea Cough medications Antihistamines Analgesics such as paracetamol Anti-inflammatory drugs Acetaminophen or paracetamol has actually been shown to increase the duration of colds as it reduces the natural antibody response. Prymula, R. et al. (2009). Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. The Lancet 374 (9698): 1339–1350. In the cases of pneumonia, NSAIDs are actually harmful to the patient and impair neutrophil intrinsic functions, their recruitment to the inflammatory site, and the resolution of inflammatory processes after acute pulmonary bacterial challenge. This means slower recovery from the disease itself. Voiriot, G. et al. (2019). Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients. Journal of Clinical Medicine 8 (6): 786.
  • 97. TEST FOR ANTIBODIES > IF POSITIVE > GET TO WORK HELPING OTHERS MEASURE THE CONDITION OF YOUR IMMUNE SYSTEM 5. SUPPORT
  • 98. CAN WE TRUST TESTING?
  • 99. • C-reactive protein (CRP) • Complete blood count • White blood cell count (WBC count), in particular consider also taking WBC differential • Polymorphonuclear leukocyte counts (to distinguish between bacterial and viral infections) • Procalcitonin (PCT) • Interleukin-6 (IL-6) BASIC LAB TESTS FOR EVALUATING POSSIBLE INFECTION
  • 100. Source: Biohacker’s Invincible Immunity (2017) MEASURING THE CONDITION OF THE IMMUNE SYSTEM
  • 102. Biomechanics Sleep Time & Energy Management Body Maintenance Diet & Metabolism Stress & Health Management Epigenetics Cognitive & Physical Ergonomics Focus, Concentration & Brain Health Productivity, Flow & Task Management Biomarkers Physique OPTIMIZED HEALTH & PERFORMANCE Recovery
  • 103. M.D., AUTHOR & BIOHACKER OLLI SOVIJÄRVI THANK YOU. Follow @biohackingbook – www.biohackingbook.com