1. DNA– REPAIRING PROTEIN MAY BE KEY TO
PREVENTING RECURRENCE OF SOME CANCER
-AND-
RETROVIRUS IN THE HUMAN GENOME IS ACTIVE
IN PLURIPOTENT STEM CELL.
Natalia Perilla Hernandez
Medical Student
Third semester

4. INTRDUCTION
In the two news they talk about the
importance to know more about the
genetic.
It is incredible to think that just
knowing a little bit of the composition
of the genetic code we can repair
some of the diseases, and probably
cure the human before birth.

5. DNA– repairing protein may be key to preventing
recurrence of some cancer . Science daily. January.
23, 2013.

6. DNA– repairing
protein may be key to
preventing recurrence
of some cancer
• The KLF8 is a protein that
protect the tumor cell from drugs.
• Jihe Zhao one of the scientific
that discoverd this protein said
that all cell have a DNA repair but
the KLF8 is overexpressed in a
specific cancer such as breast and
ovarian cancer.

7. DNA– repairing
protein may be key to
preventing recurrence
of some cancer
• In the States are between 2.5 million
and 2.7 million women who have
breast cancer. This study is going to
help a lot of people in the future, if
they can find the way to inactivate the
KLF8 protein
• The results showed that KLF8 can
repair the DNA of the carcinogenic cell
when they are attacked with drug that
are used for the treatment of cancer
such as doxorubicin that induce cell
death

8. Student Opinion:
Is important to keep the investigation, because this
let us know more about the tumoral cells and be
more close to finding the cure of cancer.

9. Retrovirus in the human genome is active in pluripotent
stem cell. Science daily . Jan. 28, 2013.

10. Retrovirus in the
human genome is
active in pluripotent
stem cell
• The HERV-H is a retrovirus that
are in human embryonic stem
cell, and is one of the most
abundantly expressed genes in
pluripotent stem cell.
• This retrovirus codify a RNA, and
also have the same sequence that
use to reprogram skin cells into
induced pluripotent stem cells.

11. Retrovirus in the
human genome is
active in pluripotent
stem cell
• The Ips (pluripotent stem cell)
became a new marker of pluripotency.
•The retrovirus infect a cell, when he
goes inside of the genome into the
chromosomal DNA. As a result, the cell
treats the virus as part of his own
genome and begins to make the
proteins that the viral genome needs
to be insert. In rare cases the viral
genome goes inside the germinales
cells and if the resulting embryo
survive the retrovirus can become a
part of a new genetic code.

12. Retrovirus in the
human genome is
active in pluripotent
stem cell
• This chromosomal DNA retrovirus
can potentiality the development of
drugs that protect against the
infections, also can make a better gene
therapy treatments, and use this one
like a marker to find specify anomaly
of the human genome.

13. Student Opinion
it would be nice to continue with the investigation,
because is a way to use the enemies of the human
body in a way to find a cure for a lot of diseases.

15. MEDICAL UTILITY
DNA– repairing protein may be key to preventing
recurrence of some cancer
Discover the protein that allows cancer
cells to reactivate again, gives to the
science an advantage to the cancer
treatment, allowing to make new
techniques and maybe avoid the
treatment that can be worst for the
patient that the disease itself.

16. MEDICAL UTILITY
RETROVIRUS IN THE HUMAN GENOME IS ACTIVE IN
PLURIPOTENT STEM CELL

17. BIBLIOGRAPHY
· Martinez S, Lina Maria. Biología Molecular. 5 ed
Medellín: UPB. Facultad Medicina.
· Dna– repairing protein may be key to preventing
recurrence of some cancer . Science daily. January.
23, 2013.
· Retrovirus in the human genome is active in pluripotent
stem cell. Science daily . Jan. 28, 2013.