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Preventing Oxygen
    Toxicity: a whole system
            approach
           Prof Tony Davison
       Co-Respiratory Lead East of
                 England
       Co-Chair and Co-author BTS
      Emergency Oxygen Guideline



Oxygen is the most commonly used
               drug
     in emergency medicine
• 34% of emergency ambulance
  patients receive oxygen

• Oxygen is used in about 2 million
  ambulance journeys in the UK
  each year




                                      1
Oxygen in Hospital

• 17.5% of UK hospital
  patients are receiving
  oxygen at any given
  time
•   About 18,000 people every day
•   More than 2 million per year




    Oxygen saves lives but too much may
               cause death
    • Essential in severely ill patients with low blood
      oxygen levels
    • Too much oxygen may cause 2,000-4,000
      avoidable deaths per year in chronic
      obstructive pulmonary disease flare ups
    • Too much oxygen is linked to increased risk of
      death in strokes, ICU patients and survivors of
      cardiac arrest




                                                          2
Chaos reigned until 2008
  • Most patients were given too much oxygen
    And there was disagreement about how much oxygen to give


  • Oxygen was rarely prescribed                                         68% of UK
    hospital patients who were using oxygen in 2008 had no prescription and most
    prescriptions were incomplete


  • Doctors and nurses had very little knowledge
    about safe use of oxygen




        Solution – Novel Guideline
• Guideline development group undertook
evidence review 2003-04

• Universal participation - 21 other societies and
colleges




                                                                                     3
UK Emergency Oxygen Guideline
       published 2008




                                4
Key Principles
• Oxygen is a treatment for low oxygen (Hypoxemia)
  (Giving oxygen does not relieve breathlessness or increase the oxygen supply
  to vital organs if the patient’s oxygen level is normal to start with)


• Aim for a normal oxygen saturation level for most
  patients (94-98%)
• Aim at a lower level for (88-92%) for those at risk from
  higher doses of oxygen

• Doctors prescribe a “target range” and nurses adjust
  equipment and flow rates to achieve the desired target
  range




                         Oxygen Alert Card

  Safeguards COPD patients who are most at risk from
                   oxygen poisoning




                                                                                 5
“They gave me a card
because I’m intolerant
of too much oxygen.
They used to whack up
the oxygen in the
ambulance on the way
to hospital.”




                         6
“I think it is a good
“Last time I was               thing, it stops them
admitted they didn’t           poisoning me with
turn the oxygen up             too much oxygen
too high”                      because I mustn’t
                               have too much.”




     Implementation and Dissemination
         from Guideline to patient
• No point in having guideline
  recommendations if they are not
  implemented for patient safety


• Included as integral part of guideline
  – this is unique




                                                       7
Implementation from Guideline to Patient

                       Doctors must prescribe




                             Monitoring
Need Local                                                         Need
Oxygen                                                            Training
Policy
               Nurses must be able to change oxygen being given




                All patients receive correct and safe oxygen




        Online appendix of Guideline includes
              implementation materials
 • Summary of recommendations
 • Sample local oxygen policy
 • Patient information sheet (developed with patients)
 • Example of new prescription chart




                                                                             8
Oxygen prescription
Model for oxygen section in hospital prescription charts
      DRUG                      OXYGEN
                       (Refer To Trust Oxygen Policy)
      Circle target oxygen saturation                           STOP DATE
      88-92%          94-98%            Other___

      Starting device/flow rate________
      PRN / Continuous

         Tick if saturation not indicated                       PHARM



      (Saturation is indicated in almost all cases except for
          palliative terminal care)
      SIGNATURE / PRINT NAME                                    DATE
                                                                ddmmyy




      Online appendix of Guideline includes
            implementation materials
• Summary of recommendations
• Sample local oxygen policy
• Patient information sheet (developed with patients).
• Example of new prescription chart
• Example of new monitoring chart
• Lecture for Doctors
• Education materials for nurses
 – unique drop-in training




                                                                            9
Online appendix of Guideline includes
            implementation materials
• Summary of recommendations
• Sample local oxygen policy
• Patient information sheet (developed with patients).
• Example of new prescription chart
• Example of new monitoring chart
• Lecture for Doctors
• Education materials for nurses
 – unique drop-in training
All of these were piloted at Southend and/or Salford




       Implementation and Dissemination
             Oxygen Champions

 • Pilot sites illustrated importance of local champions


 BTS asked for volunteer medical and
 nursing/physiotherapy oxygen champions in every
 trust responsible for:
 • Introducing local oxygen policy
 • Organising training for nurses and doctors
 • Conducting audit




                                                           10
Implementation and Dissemination
Advantage of Partnership
    Incorporation of Emergency Oxygen Guidelines in
                      other Guidelines
 • JRCALC (Joint Royal Colleges Ambulance Liaison Committee)
 Oxygen Guideline April 2009
 • BTS Pneumonia Guideline 2009
 • NICE Guideline for Chest Pain of Recent Onset –
 March 2010
 • Resuscitation Council (UK) Guideline 2010
 • European Resuscitation Guideline 2010
 • BTS-SIGN Asthma Guideline 2011




         National Patient Safety Agency
    Rapid Response Report – September 2009


   281 reports of serious incidents involving
          poor oxygen management:

        • Caused 9 deaths

        • May have contributed to 35 further
          deaths




                                                               11
National Patient Safety Agency
        Rapid Response Report – September 2009

                           Immediate Actions

              • Oxygen must be prescribed in all situations in
                accordance with BTS guideline
              • Pulse oximetry should be available in all
                locations where oxygen is used




    •
     BTS Emergency Oxygen Audits
    Audit 1    July-
               July-Sept 2008 Before Guideline launch in October 2008
    Audit 2    November 2009
    Audit 3    Oct-
               Oct-November 2010
    Audit 4    Aug-
               Aug-November 2011


    Audit 5 Aug-November
            Aug-
    2012

•    Oxygen champions conducted audits

•    Methodology- BTS online Audit tool




                                                                        12
Overview of results 2008-2012
                      2008-
Year             2008              2009             2010              2011               2012
Hospitals           99                47                90               156              145


 Wards             712               300             1,026              1919             1733


Patients         14,830             7,113            22,017           41,009             38,094

Percent
  on             17.5%             18.4%             15.5%             13.7%             14.0%
Oxygen

           *Definition of “on oxygen” in 2008-09 included patients with a prescription
            who were not on oxygen at the time of audit




  Oxygen prescribing 2008-2011
                     2008-

  Year              2008             2009              2010              2011             2012


   Target             10%              40%               41%              43%              46%
   Range

 No Written           68%              31%               44%              52%              48%
   Order




                                                                                                  13
Drug rounds & Observation Rounds

  Year           2008             2009       2010      2011            2012
  Percent
   of drug
  rounds on           5%          27 %        16 %      20 %           20%
which oxygen
was signed for
 on the drug
    chart


 Percent of
observed over
   expected       94 %            93 %        99 %      100 %          100%
 observation
 rounds with
  oximetry




                   Implementation Audits

                           2009 2009         2010    2011       2012
         Year               Feb
                           n=72
                                  Nov n=61    n=51   N=127      N=95

      Oxygen Policy
      Implemented           6%      21%      37%     89%        83%

         Printed
         Oxygen             9%      28%      51%     72%        80%
       Prescription
         O2 on
       Monitoring           7%      34%      33%     58%        69%
         Chart
      Nurse Training
      Implemented           7%      13%      18%     31%        42%
      Doctor training
       implemented          4%      10%      11%     31%        42%




                                                                              14
Electronic Prescribing in 2012
• 11 of 94 responding hospitals (12%) have
  fully Electronic Prescribing in 2012  (8% in 2011)



• Partial Electronic Prescribing (8%) (7% in 2011)

• Paper Prescribing (80%)




  Oxygen prescribing and documentation
             on drug rounds

                                         2008          2009        2010*          2011          2012


  Was        UK
  oxygen     mean                          5%          27%           16%          20%           20%
  signed for
  on drug
  Rounds?
             Salford                      0%            8%          63%           84%           80%


 *Electronic prescribing with “Admissions Order Set” was introduced at SRFT over the course of 2010




                                                                                                       15
Making it happen every time



• Use Admission Orders Bundles




                             Admission Orders

                             Choose from
                             Medicine,
                             Surgery or
                             Critical Care




                                                16
Recent clinical evidence
• Mortality in acute COPD was 9% when high
  concentration oxygen was given compared with
  4% mortality with controlled oxygen (target range
  88-92%)1

• Mortality in acute COPD was 11% when >35%
  oxygen was given but 7% when lower doses of
  oxygen were used2
• Need for ventilatory support; 22% v 9%2
 1. Austin MA, et al. BMJ. 2010 Oct 18;341:c5462. doi: 10.1136/bmj.c5462
 2. Roberts CM et al. Thorax 2011: 66: 43




                                                 Summary

        • Things are getting better—but slowly

        • There are institutional barriers to modernisation of clinical
          practice

        • Training of health care professionals is the greatest
          challenge

           BTS Oxygen Audits are supported by NAGCAE (National
            Advisory Group on Clinical Audit and Enquiries) and
            included in Trust Quality Accounts




                                                                           17
Moving Forward
• BTS e-learning programme
• Oxygen spend down 10% - Target Chief
  Executives – QIPP Programme
• BTS audit gives results for individual
  wards/doctors
• Review guidelines; new Paediatric section




            Moving Forward
  Overview of Emergency Oxygen produced by
           NHS Improvement in 2012




                                              18
What else can be done
• Emergency oxygen will be taken under the
  umbrella of Patient Safety in the Outcomes
  Strategy( Domain 5 )
• Oxygen Toxicity should be a never event
• BTS audit results should be published for each
  Trust. Data can drive change.
• Pharmacists should be more involved in
  monitoring oxygen prescription and drug chart
  completion




          What else can be done
• Failure to prescribe and complete the drug
  chart should be recorded as a critical incident
• All staff should have a competency certificate
  for emergency oxygen
• Emergency oxygen should be included in
  induction training for all nursing and medical
  staff




                                                    19
What else can be done
• Emergency oxygen should be included in the
  mandatory resuscitation training
• Improvement in emergency oxygen could be
  start up project for the Respiratory Alliance




              Moving Forward
• Need substantial yearly improvements in use of emergency
  oxygen across UK
           Safer and better care for
              all patients receiving
                Emergency Oxygen

                   Saving Lives



                                                             20

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Preventing Oxygen Toxicity: A Whole System Approach

  • 1. Preventing Oxygen Toxicity: a whole system approach Prof Tony Davison Co-Respiratory Lead East of England Co-Chair and Co-author BTS Emergency Oxygen Guideline Oxygen is the most commonly used drug in emergency medicine • 34% of emergency ambulance patients receive oxygen • Oxygen is used in about 2 million ambulance journeys in the UK each year 1
  • 2. Oxygen in Hospital • 17.5% of UK hospital patients are receiving oxygen at any given time • About 18,000 people every day • More than 2 million per year Oxygen saves lives but too much may cause death • Essential in severely ill patients with low blood oxygen levels • Too much oxygen may cause 2,000-4,000 avoidable deaths per year in chronic obstructive pulmonary disease flare ups • Too much oxygen is linked to increased risk of death in strokes, ICU patients and survivors of cardiac arrest 2
  • 3. Chaos reigned until 2008 • Most patients were given too much oxygen And there was disagreement about how much oxygen to give • Oxygen was rarely prescribed 68% of UK hospital patients who were using oxygen in 2008 had no prescription and most prescriptions were incomplete • Doctors and nurses had very little knowledge about safe use of oxygen Solution – Novel Guideline • Guideline development group undertook evidence review 2003-04 • Universal participation - 21 other societies and colleges 3
  • 4. UK Emergency Oxygen Guideline published 2008 4
  • 5. Key Principles • Oxygen is a treatment for low oxygen (Hypoxemia) (Giving oxygen does not relieve breathlessness or increase the oxygen supply to vital organs if the patient’s oxygen level is normal to start with) • Aim for a normal oxygen saturation level for most patients (94-98%) • Aim at a lower level for (88-92%) for those at risk from higher doses of oxygen • Doctors prescribe a “target range” and nurses adjust equipment and flow rates to achieve the desired target range Oxygen Alert Card Safeguards COPD patients who are most at risk from oxygen poisoning 5
  • 6. “They gave me a card because I’m intolerant of too much oxygen. They used to whack up the oxygen in the ambulance on the way to hospital.” 6
  • 7. “I think it is a good “Last time I was thing, it stops them admitted they didn’t poisoning me with turn the oxygen up too much oxygen too high” because I mustn’t have too much.” Implementation and Dissemination from Guideline to patient • No point in having guideline recommendations if they are not implemented for patient safety • Included as integral part of guideline – this is unique 7
  • 8. Implementation from Guideline to Patient Doctors must prescribe Monitoring Need Local Need Oxygen Training Policy Nurses must be able to change oxygen being given All patients receive correct and safe oxygen Online appendix of Guideline includes implementation materials • Summary of recommendations • Sample local oxygen policy • Patient information sheet (developed with patients) • Example of new prescription chart 8
  • 9. Oxygen prescription Model for oxygen section in hospital prescription charts DRUG OXYGEN (Refer To Trust Oxygen Policy) Circle target oxygen saturation STOP DATE 88-92% 94-98% Other___ Starting device/flow rate________ PRN / Continuous Tick if saturation not indicated PHARM (Saturation is indicated in almost all cases except for palliative terminal care) SIGNATURE / PRINT NAME DATE ddmmyy Online appendix of Guideline includes implementation materials • Summary of recommendations • Sample local oxygen policy • Patient information sheet (developed with patients). • Example of new prescription chart • Example of new monitoring chart • Lecture for Doctors • Education materials for nurses – unique drop-in training 9
  • 10. Online appendix of Guideline includes implementation materials • Summary of recommendations • Sample local oxygen policy • Patient information sheet (developed with patients). • Example of new prescription chart • Example of new monitoring chart • Lecture for Doctors • Education materials for nurses – unique drop-in training All of these were piloted at Southend and/or Salford Implementation and Dissemination Oxygen Champions • Pilot sites illustrated importance of local champions BTS asked for volunteer medical and nursing/physiotherapy oxygen champions in every trust responsible for: • Introducing local oxygen policy • Organising training for nurses and doctors • Conducting audit 10
  • 11. Implementation and Dissemination Advantage of Partnership Incorporation of Emergency Oxygen Guidelines in other Guidelines • JRCALC (Joint Royal Colleges Ambulance Liaison Committee) Oxygen Guideline April 2009 • BTS Pneumonia Guideline 2009 • NICE Guideline for Chest Pain of Recent Onset – March 2010 • Resuscitation Council (UK) Guideline 2010 • European Resuscitation Guideline 2010 • BTS-SIGN Asthma Guideline 2011 National Patient Safety Agency Rapid Response Report – September 2009 281 reports of serious incidents involving poor oxygen management: • Caused 9 deaths • May have contributed to 35 further deaths 11
  • 12. National Patient Safety Agency Rapid Response Report – September 2009 Immediate Actions • Oxygen must be prescribed in all situations in accordance with BTS guideline • Pulse oximetry should be available in all locations where oxygen is used • BTS Emergency Oxygen Audits Audit 1 July- July-Sept 2008 Before Guideline launch in October 2008 Audit 2 November 2009 Audit 3 Oct- Oct-November 2010 Audit 4 Aug- Aug-November 2011 Audit 5 Aug-November Aug- 2012 • Oxygen champions conducted audits • Methodology- BTS online Audit tool 12
  • 13. Overview of results 2008-2012 2008- Year 2008 2009 2010 2011 2012 Hospitals 99 47 90 156 145 Wards 712 300 1,026 1919 1733 Patients 14,830 7,113 22,017 41,009 38,094 Percent on 17.5% 18.4% 15.5% 13.7% 14.0% Oxygen *Definition of “on oxygen” in 2008-09 included patients with a prescription who were not on oxygen at the time of audit Oxygen prescribing 2008-2011 2008- Year 2008 2009 2010 2011 2012 Target 10% 40% 41% 43% 46% Range No Written 68% 31% 44% 52% 48% Order 13
  • 14. Drug rounds & Observation Rounds Year 2008 2009 2010 2011 2012 Percent of drug rounds on 5% 27 % 16 % 20 % 20% which oxygen was signed for on the drug chart Percent of observed over expected 94 % 93 % 99 % 100 % 100% observation rounds with oximetry Implementation Audits 2009 2009 2010 2011 2012 Year Feb n=72 Nov n=61 n=51 N=127 N=95 Oxygen Policy Implemented 6% 21% 37% 89% 83% Printed Oxygen 9% 28% 51% 72% 80% Prescription O2 on Monitoring 7% 34% 33% 58% 69% Chart Nurse Training Implemented 7% 13% 18% 31% 42% Doctor training implemented 4% 10% 11% 31% 42% 14
  • 15. Electronic Prescribing in 2012 • 11 of 94 responding hospitals (12%) have fully Electronic Prescribing in 2012 (8% in 2011) • Partial Electronic Prescribing (8%) (7% in 2011) • Paper Prescribing (80%) Oxygen prescribing and documentation on drug rounds 2008 2009 2010* 2011 2012 Was UK oxygen mean 5% 27% 16% 20% 20% signed for on drug Rounds? Salford 0% 8% 63% 84% 80% *Electronic prescribing with “Admissions Order Set” was introduced at SRFT over the course of 2010 15
  • 16. Making it happen every time • Use Admission Orders Bundles Admission Orders Choose from Medicine, Surgery or Critical Care 16
  • 17. Recent clinical evidence • Mortality in acute COPD was 9% when high concentration oxygen was given compared with 4% mortality with controlled oxygen (target range 88-92%)1 • Mortality in acute COPD was 11% when >35% oxygen was given but 7% when lower doses of oxygen were used2 • Need for ventilatory support; 22% v 9%2 1. Austin MA, et al. BMJ. 2010 Oct 18;341:c5462. doi: 10.1136/bmj.c5462 2. Roberts CM et al. Thorax 2011: 66: 43 Summary • Things are getting better—but slowly • There are institutional barriers to modernisation of clinical practice • Training of health care professionals is the greatest challenge BTS Oxygen Audits are supported by NAGCAE (National Advisory Group on Clinical Audit and Enquiries) and included in Trust Quality Accounts 17
  • 18. Moving Forward • BTS e-learning programme • Oxygen spend down 10% - Target Chief Executives – QIPP Programme • BTS audit gives results for individual wards/doctors • Review guidelines; new Paediatric section Moving Forward Overview of Emergency Oxygen produced by NHS Improvement in 2012 18
  • 19. What else can be done • Emergency oxygen will be taken under the umbrella of Patient Safety in the Outcomes Strategy( Domain 5 ) • Oxygen Toxicity should be a never event • BTS audit results should be published for each Trust. Data can drive change. • Pharmacists should be more involved in monitoring oxygen prescription and drug chart completion What else can be done • Failure to prescribe and complete the drug chart should be recorded as a critical incident • All staff should have a competency certificate for emergency oxygen • Emergency oxygen should be included in induction training for all nursing and medical staff 19
  • 20. What else can be done • Emergency oxygen should be included in the mandatory resuscitation training • Improvement in emergency oxygen could be start up project for the Respiratory Alliance Moving Forward • Need substantial yearly improvements in use of emergency oxygen across UK Safer and better care for all patients receiving Emergency Oxygen Saving Lives 20