This presentation was delivered at a Nesta Hot Topics event – Our Genomic Future – where we discussed what would happen if we all had our genome sequenced. For more on the event visit http://www.nesta.org.uk/event/our-genomic-future
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Hot Topics Our Genomic Future: Dr Ron Zimmern
1.
2.
3. Genetic
Biological Physical
Political Social
Behavioural
Genetic Endowment
Natural Environment
Structural Environment
Individual Behaviour
INDIVIDUALS POPULATIONS
Genetic factors are important determinants of health and disease and it will be as important
to understand these as the external environmental factors with which we are all familiar
6. What Matters –Genes or Environment?
p
p
q q
q
q
Disease
Risk
Disease
RiskE1
E1
E2
E2
7. A better understanding of disease mechanisms
A new
categorisation
of disease
based on
genotype
Novel
therapeutic
interventions
Opportunities
for the
prediction and
prevention of
disease
Greater diagnostic potential through genetic testing
Its implications for clinical care will need to be established
9. Super
Convergence
New Medicine
Old Medicine
Mobile
Connectivity
& Bandwidth
Internet
Social
Networking
Increased
Computing Power
& Data Universe
Wireless
Sensors
Genomics
Imaging
Information
Systems
Adapted from Fig 1: The
transformation of medicine today
to new individualised medicine
enabled by digitising humans.
Eric Topol (2012)
The Creative Destruction of Medicine
Physician driven
Technology as aid
Objective values assessed professionally
Medical profession as trusted intermediaries
Patient defers to physician
Community values predominate
Consumer driven
Technology driven
Subjective values predominate
Decline of trusted intermediaries
Patient as partner
Individualism reigns
Achieving
the right
balance
Information and telecommunication technologies will work with genomic technologies to result in a
new paradigm of care