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New dimensions on
 neuroprosthetics
      Simon Schultz
  Imperial College London

     A long term view
Reading out neuronal activity
•   e.g. ratiometric calcium sensor YC3.60




                                             Lutcke et al Frontiers in Neural Circuits 2010
Of Cre mice and men


           Cre driver lines




                  From O’Connor Nature 2009
Writing brain signals

         Channelrhodopsin-2 (ChR2)
         Deisseroth, Boyden
Erasing brain signals




AAV-CAG-ArchT-GFP, NeuroTrace
Where to next?

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