Production of Quantum Dots
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This document defines quantum dots as fluorescent semiconductor nanocrystals between 10-100 nm in size that are made up of elements from Groups 12 and 16. It discusses their synthesis using either liquid or organic phase pathways, and their applications in tumor diagnosis, drug delivery, and drug screening by marking target molecules. The advantages of quantum dots include their tunable fluorescent properties and biocompatibility, while challenges include unstable biological coupling and potential biotoxicity from cadmium ion release.
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Production of Quantum Dots
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- 2. CONTENTS • Definition • Synthesis pathway • Application • Advantages • Challenges • Conclusion DEFAULT STYLES 02
- 3. DEFINITION • New biological fluorescence material • Nanoparticle • Size : close to Bohr radius 10 nm • Shape : Spherical • Material : fluorescent semiconductor nanocrystal • Made up : Group 12 and 16 elements DEFAULT STYLES 03
- 6. SYNTHESIS PATHWAY • 2 pathways : liquid phase & organic phase • Restriction in organic phase – High temperature – Complicated step – High cost – Poor stability DEFAULT STYLES 06
- 7. …cont • Liquid phase synthesis (more convenient) – Metal ions – Modified reagents – Tellurium (Te) source – Sulfur (S) or Selenium (Se) source – Auxiliary reagent – Heat DEFAULT STYLES 07
- 8. • Tumor diagnosis – QD-IgG & Cy3-IgG • Drug delivery – Cancer therapy • Drug screening – Mark target molecule 08 APPLICATION Hu M, Yan J, He Y. Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot-based microfluidic protein hip. ACS Nano,2010,4(1):488-494.
- 9. Cancer cell DNA degradation uv Quantum dot Drug molecule Antibody 09
- 10. ADVANTAGES • Good quantum effect – Broad & consecutive excitation spectra – Tunable size-dependant emission – Strong resistance to photo bleaching capacity DEFAULT STYLES 10
- 11. • Biocompatibility – Water solubility – High self producing rate of fluorescent dots – Stability of colloidal particle – Lower nonspecific adsorption • Biological coupling – Unstable coupling after UV irradiation • Biotoxicity – Aqueous environment release Cd ion 11 CHALLENGES
- 12. CONCLUSION • Many advantages – Biochemistry – Target molecule labeling – Fluorescent probe • High prospect to develop DEFAULT STYLES 12