Hyperpituitarism is the overproduction of pituitary hormones, usually caused by a pituitary adenoma. The three hormones most commonly overproduced are prolactin, adrenocorticotropic hormone, and growth hormone. This can lead to disorders like Cushing's disease, prolactinoma, acromegaly, and gigantism. Hyperpituitarism is diagnosed through physical exams, labs, and imaging tests and treated through medications, surgery, or radiation to shrink tumors and reduce hormone levels.

3. HYPERPITUTARISM
 Hyperpituitarism is the primary hypersecretion of
pituitary hormones.
 It typically results from a pituitary adenoma.
 There are usually three hormones that are over secreted due
to pituitary adenoma are prolactin, adrenocorticotropic
hormone (ACTH) and growth hormone (GH).

4. Contd…
 Some of the common disorders as a result of
hypersecretion of piutitary glands are as
follows:
 Excess prolactin: Prolactinoma.
 Excess ACTH: Cushing’s disease.
 Excess GH: Gigantism and Acromegaly.

5. ETIOLOGY
 Pituitary tumor
 Inherited condition known as multiple
endocrine neoplasia type 1

6. CLINICAL FEATURES
 Headache
 Visual field loss
or Double vision
 Excessive sweating
 Hoarseness
 Milk secretion
from breast
 Sleep apnea
 Joint pain and limitation
of motion
 Muscle weakness

7. Difference between Gigantism & Acromegaly
7
Gigantism
 Start in infancy and growth is
continuous.
 Onset before puberty.
 Excessive growth 8-
9feet,enlargement of organs
heart, liver, spleen.
Acromegaly
 Starts at age 20-50yrs and
growth is slow.
 Onset after puberty.
 Increase in size of hands, feet,
lower jaw, skin becomes thick
and coarse.

8. DIAGNOSIS
 Physical examination
 Laboratory investigations
 Radiological imaging studies

9. TREATMENT
Medication:
Drugs may be used to shrink large tumors before
surgery or in cases where surgery is not an option.
Medication to reduce prolactin levels is usually the
preferred treatment for patients with a prolactinoma.

10. Cond…
Bromocriptine and Cabergoline are
dopamine agonists (drugs that behave like
dopamine) and can shrink prolactinomas and return
secretions of prolactin to normal levels.
Acromegaly may be treated with Somastatin analogs
(octreotide) to lower growth hormone levels and
shrink tumors.