3. Defined as any abnormalities of
cycle length, duration of flow, and
amount of menstrual bleeding.
•It can occur in women of all age
•Common especially in both extreme of
age
ABNORMAL UTERINE
BLEEDING (AUB)
5. INCIDENCE
AUB affects 10-30 % of reproductive-aged women and up to 50 %
of perimenopausal women .
Factors that impact the incidence most greatly are age and
reproductive status.
For example, uterine bleeding is uncommon in prepubertal girls
and menopausal women, whereas rates of abnormal bleeding
increase significantly in adolescent, perimenopausal, &
reproductive-age groups
6. Causes of this bleeding may include
1. neoplastic growth,
2. hormonal dysfunction,
3. reproductive-tract trauma,
4. infection,
5. coagulopathies, and
6. complications of pregnancy.
7. * As a result, abnormal uterine bleeding is a common
gynecologic complaint that may affect females of all ages
7. Classification of AUB
1. Functional uterine bleeding (organic origin)
A. Associated with pregnancy
B. Not Associated with pregnancy
2. Dysfunctional uterine bleeding (non-organic origin)
A. Anovulatory (90% DUB)
B. Ovulatory (10% DUB)
15. Causes of AUB
The cause or DDx of AUB can be classified as
• Pregnancy related
• Infection
• Neoplasm
• Uterine condition
• Systemic illness
• Iatrogenic causes
• DUB
19. Causes of AUB by specific
category of AGE
A. Pre pubertal ( CHILDHOOD)
Vulvo-vaginal & external lesion Eg...trauma
Foreign body in vagina
Precocious puberty
Trauma ..... sexual abuse
23. POST MENOPAUSAL
BLEEDING
– Def :- any vaginal bleeding 6 or more month after menopause
Etiology
– Atrophic endometritis or vaginitis..... common cause
– Exogenous estrogen (HRT)
– Endometrial or cervical polyp
– Endometrial hyperplasia
– Endometrial cancer
– Cervical ca, uterine sarcoma
24. CONT..
– Bleeding after menopause typically originate from benign disease.
– majority of cases resulted from atrophy of the endometrium.
– Benign endometrial polyps may also cause bleeding in this pop/n.
– malignant neoplasms, especially endometrial carcinoma, are
found more frequently in this age group than in others.
25. Excessive weight gain
• Look for signs of PCOS: Hirsutism & acne
• Sign of thyroid disease & evidence of insulin resistance
In suspected bleeding disorder
• Look for petechiae, ecchymosis, skin pallor or swollen joints
• In a suspected case of thrombocytopenic purpura, tourniquet test is performed
Pelvic Examination
• Bimanual examination including speculum examination to assess the size and
contour of the uterus
PHYSICAL EXAMINATION
26. LAB EVALUATION
A complete blood count (CBC) is recommended for women with AUB to
look for anemia
It is recommended to perform a sensitive urine pregnancy test whenever
indicated, or if pregnancy is suspected.
Bleeding time, platelet count, prothrombin time, and partial thromboplastin
time are recommended in all adolescents and in adults with a positive
screen for coagulopathies.
TSH test is done when clinically indicated
27. LAB EVALUATION
Imaging Recommendations on imaging
Ultrasonography is mandatory in AUB to evaluate uterus, adnexa and
endometrial thickness
Doppler ultrasonography: In suspected arteriovenous malformation,
malignancy cases and to differentiate between fibroid and adenomyomas
Hysteroscopy: For diagnosis and characterization of intrauterine
abnormalities
MRI: To differentiate between fibroids and adenomyomas and for mapping
exact location of fibroids while planning conservative surgery and prior to
therapeutic embolization for fibroids
Endometrial Biopsy – to rule out endometrial hyperplasia or endometrial
cancer
Suggested for women > 40 years old who have the risk factors such as
obesity & diabetes.
28. Treatment
1.Medical treatment of AUB
1. Control of heavy bleeding
A. High dose estrogens
B. High dose coc pills
– Hemodynamic instability
Establish ABC
Open iv line
Prepare cross mach blood
30. References
1.American College of Obstetricians
and Gynaecologists (ACOG)
2.Ten Teachers 19th Edition
3.Federation of Obstetric and
Gynaecological Societies of India
(FOGSI)