2. Who Are We?
A fully credentialed manufacturer of high
performance skin care products and
health benefiting supplements
We offer a stock line of low minimum
products (6 units per product)
Our products are labeled and branded
using our clients name
We use medical grade, high potency
ingredients formulated at very high
concentrations
3. What We Do?
We provide innovative high end skin care
products and nutritional supplements to:
Skin Care
Physicians-Plastic Surgeons, Dermatologists
Naturopaths
High-End Spas
Destination and Resort Spas
Medi-Spas
Supplements
Physicians
Naturopaths
Chiropractors
Sports Stores
Gyms
Supplement Stores
4. What We Do?
Provide a science based approach to formulation
using experienced chemists and physicians
We search world wide to source the most powerful
and effective ingredients. France, Switzerland,
Germany, Italy, Australia and many more
We use breakthrough innovative ingredients that
are considered best in their class
We provide the most powerful ingredients
available, and they are formulated in higher than
expected concentrations
We offer a convergence of science, advanced
engineering, and highly responsive ingredients
6. What We Do?
Our products benefit all age groups and skin types but our focus is:
oxidative
stress
and visual
elastin beauty
wrinkle Anti-Aging
reduction
7. What We Do? The Skin Care Company?
We stimulate the skin for rapid and dramatic
improvements in its appearance
Dramatically improve the appearance of:
fine lines and wrinkles
reduce the appearance of age spots
discolorations
improve skin elasticity and collagen
production
improve texture
reduce puffiness
improve skin hydration and tone
8. What We Do?
Our anti-aging products are designed to
produce extraordinary results
Designed to be at the head of the most
impressive class of skin care products
Nothing currently on the market comes close
to matching their effectiveness
that are formulated at very high concentrations
specifically designed to work synergistically
designed to be highly bio-available and
penetrate deeply
9. What We Do?
Scientific team of chemists, physicians, para-
medical aestheticians and other healthcare
professionals
State of the art ingredient technology
High levels of bio-actives
Molecular engineering
Process engineering
10. Credentialed Manufacturing
State of the Art manufacturing facility with an:
In-house analytical & formulation laboratory
Separate enclosed production clean rooms
Ambient clean air system
Water purification and monitoring systems
Vendor certification program
Ingredient authentication
Global sourcing
cGMP Certified
NSF Certified
FDA Audited
11. Owned By Healthcare Professionals
Dr. Angela DeRosa DO, MPH, CPE,(Chief Medical and
Compliance Officer), board certified Internist specialized in
two AZ medical schools, past senior medical director for P&G
Pharmaceuticals.
Mirijana Potocnjak, (Chief Scientist and Operations Officer) is a
biologist/chemist with 13 years of nutraceutical and skin care
product development experience. Extensive background in
herbs, botanicals, and organic ingredients. She is the primary
formulating chemist for our products.
Judy Curran RN, (Chief Executive and Marketing Officer)
educated both as a Registered Nurse and in Business, has over
30 years experience in domestic and international business and
product development within the health and beauty industry.
Clinical experience in Burns, Wound Care, and Skin Care.
12. Stock Product Line
SKIN CARE PRODUCTS SUPPLEMENT PRODUCTS
PEPTIDE ANTI-AGING SERUM -1oz THERMOGENIC APPETITE
STEM CELL SERUM ! oz SUPPRESSANT
TIGHTENING SERUM 1 oz WEIGHT LOSS CARBOHYDRATE
CONTROL
PEPTIDE EYE SERUM - ! oz
WEIGHT LOSS FAT BURNER
EYE LASH LENGTHENER
(LIPOTROPIC)
LIGHTENING SERUM 1 oz
NATURAL HAPPINESS
CELLULITE CREAM 5 oz
LIVER SUPPORT
FACIAL/BODY HAIR INHIBITOR 1 oz
MENOPAUSE SYMPTOM RELIEF
JOINT SUPPORT
MUSCLE CRAMP OIL
Q IMMUNE
14. Why We Use Serums As Our
Product Base?
Cosmetic serums are highly
concentrated skin treatment products
Ingredients in serums are generally
10 times more concentrated and
biologically active than in creams
Serums use powerful targeted
ingredients of small molecular sizes in
order to penetrate deeper and more
quickly than creams
Serums are considered the primary
vehicle to deliver supercharged
ingredients
16. Understanding Serums
Serums do not clog pores
Serums are generally selected to achieve a
very focused result such as wrinkle reductions
They generally offer a single or limited action
verses other products which use more
ingredients at lower concentrations to try to
tackle a large number of actions
Serums are designed to penetrate and not act
as a moisturizing barrier therefore, clients with
dry skin should apply a moisturizing layer after
the serums have absorbed
17. Improvement Using Plant Stem Cells
4',%$'*-./0*53*67'*%,*%6$*8)'"*9'::*;<*
!"#$%&'"'()*+,)'$*-./0*123*
18. Serums
Serums often seem miraculous because
they show some of their beneficial results
almost immediately and the visible
changes can be very dramatic
Serums can be used by any age client
from teen to adult
Serums can be matched to various skin
types and conditions through ingredient
selection
19. Serums vs Moisturizers
Moisturizers use ingredients with larger molecular
lipids topically and create a moisture barrier
Moisturizers leave a fine film on the surface of the
skin whereas serums deliver their ingredients deeper
into the tissue
Serums use more active ingredients which are
targeted to change the characteristics of the skin
Once our serums have been absorbed a moisturizer
can be applied if needed
20. Ingredient Categories
Natural Earth Harvested Ingredients
Natural Lab Constructed Ingredients
Lab Synthesized Synthetic Ingredients
Animal Derived Ingredients
Bases For Creams And Serums
Delivery Systems
Active vs Inactive Ingredients
Preservatives
21. Natural Earth Harvested Ingredients
Natural earth harvested ingredients include:
Standardized botanicals, organics and wild crafted
botanicals
Extracts, Essential Oils, Purees
Herbs
Minerals
Ingredients in their naturally harvested state are often not
well absorbed topically due to large molecular sizes and
may not be concentrated or specific enough to produce
noticeable positive results on the skin
It is difficult to formulate sophisticated 100% organic
products that can achieve our performance goals, but the
use of some organic ingredients can be a marketing
advantage
22. Natural Lab Constructed Ingredients
Natural lab constructed ingredients are copied
in the lab, on a molecular level, to mirror nature
Organic chemists build identical molecular
replicas of earth-natural ingredients except that
they screened and designed to focus on a
particular function which will yield the targeted
results we are seeking
This includes many peptides, other amino
acids, vitamins, some anti-oxidants etc.
Most of our ingredients fit this category
23. Peptide Synthesis Methodology
Generally a biomedical researcher will
explore the possibility of increasing the
native potency or performance
characteristics of a given substance,
such as a peptide.
Small amounts of the peptide are used.
The amino acid chain is manipulated to
achieve the desired characteristics,
activity, potency.
A larger scale of the synthesis is then
created in order to initiate studies.
Upon successful validation, a larger
scale production synthesis is completed
24. Lab Synthesized Synthetic Ingredients
These are substances that are
formulated or manufactured by a
chemical process or by a process that
chemically changes a substance
extracted from naturally occurring plant,
animal, or mineral sources, except that
this does not apply to substances
created by naturally occurring biological
processes
These ingredients are specifically
designed to perform a targeted function
25. Animal Derived Ingredients
Animal derived ingredients are
chosen by most cosmetic
manufacturers to produce certain
results
Examples of this would be:
albumen, whey, marine oils
Our products are never tested on
animals
26. Bases For Creams And Serums
Base ingredients such as fatty
alcohols, waxes, acids, fixatives,
humectants, coloring, scents,
binding, stabilizing and gelling
agents help the formulator achieve
certain characteristics in creams
and to a lesser extent serums.
Bases contribute to viscosity,
moisturization, texture, feel, and
help to bind certain ingredients to
make a smooth emulsion.
27. Delivery Systems
to a carrier such as a liposome
If your high-tech ingredient does not reach the intended target
in the body it will not respond as intended
Our products rely on increasingly sophisticated delivery
systems to put active materials exactly where they are needed
most
Enhanced skin delivery enables our formulators to achieve
targeted and timed release of actives and enhance the
efficacy and delivery of the effective concentration at the
required site of action
Enhancing penetration, makes the right delivery system
critical in formulating hard-to-use ingredients
peptides, hyaluronic acid, vitamin C and other vitamins,
collagen and essential fatty acids as well as many other
ingredients
28. Active vs Inactive Ingredients
An active ingredient, is biologically active , it makes changes in the tissue or acts
a catalyst for the body to act in a pre-determined way. It is responsible for
producing a desired effect. It gives the product its main characteristics
Materials that work physiologically within the skin or aid in protecting the skin
from insult are also called active ingredients. Although a cosmetic, by legal
definition, can only serve to beautify and protect the surface of the skin, many
cosmetic products can be shown to penetrate the dermal layers of the skin to
exact a physiological change. One must be careful to market only beautifying
aspect of a product
Peptides are an example of an active material They have the ability to penetrate
the skin, where they can increase the production of collagen, elastin, and
intracellular substances thus improving the appearance of the skin
Thousands of cosmetic actives are used to affect the skin in a variety of ways.
Some are used to lighten, tighten, and firm the skin
Inactive ingredients are considered biologically inert and may serve as:
the bases forming the products solution, waxes, emollients, coloring
agents, fillers, diluents, preservatives, solvents, lubricants, etc.
Most skin care products contain primarily in-active ingredients and add only a
few select active ingredients at low concentrations. Our products contain 95%-
99% active ingredients, these are the highest concentrations in the market.
29. Emulsions
The majority of creams and lotions are emulsions
liquid is dispersed as fine droplets in the other making it
homogeneous
Homogenized milk is an example of a typical oil-in-
water (o/w) emulsion. Using an emulsifier called
sodium caseinate
The majority of emollients used in personal care and
beauty items are fats and oils, also called lipids.
Some of the key characteristics required in good
emollients are good spreading properties, low toxicity/skin
irritation and good oxidative stability.
30. Surfactants
Most emulsifiers can be considered surfactants or surface-active agents.
These materials are able to reduce the surface tension of water.
Example: Washing a greasy pan (fat) is easy with soap, because the
soap (surfactant), binds to the oil, and emulsifies with the water, it pulls
the grease off of the pan.
Fatty acids that are reacted with an emulsifier can form soaps. The
process of soap formation is called saponification. The negatively
charged stearic acid group is the main emulsifying unit of the soap, giving
it the anionic classification. Positively charged emulsifiers are called
cationic.
Nonionic emulsifiers are often used in skin-care emulsion for their safety
and low reactivity. Glycerin, commonly added to cosmetic emulsions for
its humectant properties, is the backbone of a class of emulsifiers called
Glyceryl esters .
Stearic acid is a major component of many of the fats and oils used in
beauty treatments, stearate-based emulsifiers are particularly useful.
Fatty acids are key components of many cosmetic emulsifiers due their
miscibility in a variety of natural and synthetic oils.
Esters polyethylene glycol or ethylene glycol are called PEG esters. A
PEG ester's solubility is determined by the number of PEG molecules
reacted per molecule of acid. In a formulation, are typically used
for slip and feel.
31. Moisturizers
The main distinction between moisturizers and emollients is their
solubility in water. Healthy skin requires moisture. Moisturizers are
generally polar materials that are hygroscopic in nature; they hold
onto water
Glycerin is a very cost-effective ingredient used to help reduce
transdermal water loss
Sorbitol, sucrose, glucose, and other sugars are also commonly
used to hydrate the skin
Aloe, which contains a mixture of polysaccharides, carbohydrates,
and minerals, is also an excellent moisturizer
Moisturizers lay on the surface of the skin and act as a protective
barrier. But as a barrier they may block the penetration of other
useful (ie. peptides) ingredients that need to reach deeper tissue
levels to work
32. Waxes/Thickeners
Waxes
Waxes are composed primarily of long-chain esters that are solid at room
temperature. Common waxes used in cosmetics are beeswax, candelilla,
carnauba, polyethylene, emulsifying, and paraffin.
Waxes function as structuring agents, adding rigidity and barrier
properties. By combining waxes with different properties you can add
shine, flexibility, and brittleness
Waxes are particularly useful in hand creams and mascara emulsions for
their thickening and waterproofing properties.
Thickeners
By incorporating enough wax into a thin lotion, a thick cream can be
formed. Many thickeners are polymers. Cellulose, swells in hot water
creating a gel network. Carbopol, a polyacrylic acid, swells when
neutralized. Carrageenan, pectin, and locust bean gum are also all
examples of cosmetic thickeners
33. Preservatives
Most cosmetic products require the addition of preservative to prevent
microbial contamination and rancidity
Parabens and ester of parabenzoic acid are by far the most commonly used
because of their effectiveness against gram-positive bacteria. We do not use
this group of preservatives.
Phenoxyethanol is used to protect against gram negative strains.
The cosmetic chemist will generally employ a mixture of preservatives to
protect against different bacterial strains as well as yeasts and molds
Antioxidants such as tocopherol (vitamin E) and BHT are also often added to
prevent oxidation of sensitive ingredients as well as protect the skin from free-
radical damage
Shelf life and product preservation is important to consider when the dynamics
of ordering , stocking and distribution are being determined
Efficacy, safety , environmental acceptance and international compliance are
all considered when we select a preservative
34. INCI Names
Ingredients are required to be listed on labels in INCI
compliant format
Ingredients are listed in quantity based descending
order; listing the ingredient with highest concentration in
the product first
INCI stands for the International Nomenclature Of
Cosmetic Ingredients
an ingredient acceptable in both US and international
markets
INCI names are a combination of scientific Latin names
and the English counterpart. An example of Raspberry
Extract would be Rubus Idaeus (Rasberry) Fruit Extract
37. Our Peptides
1. Tripeptide-1 -restores collagen levels substantially. In vitro tests showed
collagen 1 and collagen IV synthesis of 128% (collagen I) and 81% (collagen
IV) respectively after 15 days. Collagen III tripled, this form of collagen is the
most abundant type found in young skin. Tripeptide-1 is a technically
advanced ingredient which renews the appearance of critical collagen fibers
thus helping the body to rebuild the dermal structure. Study showed a 29%
wrinkle depth reduction in 30 days.
2. Palmitoyl Oligo Pentapeptide- It stimulates the production of collagen and
fibronectin . Studies have shown collagen synthesis improved 117%,
Collagen IV synthesis was improved by 327% and hylauronic acid synthesis
increased by 267%. Wrinkle reduction 68%-90%.
3. Dipeptide Diaminobutyroyl Benzylamide Diacetate (Synake) -Mimics a
peptide found in the venom of the Temple Viper. It was designed as
neuromuscular blocking compound acting at the post-synaptic membrane as
a reversible block that prevents acetylcholine from binding to the receptor.
One study demonstrated a 52% reduction in forehead wrinkles.
4. Acetyl Hexapeptide-8 (Argireline) -Mimics the N-terminal end of Snap-25
which competes for a position in the SNARE complex. When the SNARE
complex is interrupted the vesicle release the neurotransmitters that
cause the muscle contractions which form a wrinkle. Studies showed wrinkle
depth reduction of 17% in 15 days and 32% in 28 days.
5. Pentapeptide-18 -Inhibits the release of acetylcholine across the neuro
synapse. It keeps the neuron in a resting state which may interfere with the
muscle contractions that form expression lines and wrinkles. In combination
with Argireline studies show it reduces wrinkle depth of 25% to 47% within 28
days.
38. Our Peptides
6. Acetyl Octapeptide-3 (SNAP-8) -Similar to Argireline but 30% more active.
Decreases neuronal excitability by destabilizing the SNARE complex.
Studies have shown wrinkle depth reduction by 63% in 30 days.
7. Palmitoyl Tripeptide-5 (SynCol) -
collagen.
Also provides skin firming and moisturizing. In vitro tests in human
fibroblasts showed a 119% increase of collagen synthesis compared to the
positive standard.
8. Pentapeptide-3 (Vialox) - It acts at the post-synaptic membrane blocking
sodium ions. The result is that the muscles that form wrinkles stay relaxed.
It inhibits muscle contractions by acting as an competitive antagonist at the
AChR receptor.
9. Acetyl Tetrapeptide-5 Won the technology award in cosmetics in 2005.
Enhances elasticity of the skin, and improves skin smoothness. It prevents
collagen cross links from glycation elasticity loss and the formation of eye
bags. It also helps to prevent liquid from accumulating and inhibits vascular
permeability. In vivo tests of subjects ages 18-65 resulted in elasticity being
improved by 30% in 30 days, puffiness was significantly reduced in 14 days
and eye bags were reduced by 70% in 28 days. Dark circles under the eyes
were also reduced.
10. Palmitoyl Dipeptide-5 Diaminohydroxybutyrate (syn-taks)- neuromuscular
blocking compound acting at the post-synaptic membrane as a reversible
block that prevents acetylcholine from binding to the receptor, resulting in no
uptake of sodium ions. The effect is that it relaxes facial muscles, smoothes
skin, and reduces the appearance of wrinkles. One study demonstrated a
52% reduction in forehead wrinkles.
39. Our Peptides
11. Tripeptide-10 Citrulline Restores collagen levels substantially. In
vitro tests showed collagen 1 and collagen IV synthesis of 128%
(collagen I) and 81% (collagen IV) respectively after 15 days.
Collagen III tripled, this form of collagen is the most abundant type
found in young skin. Studies showed a 29% wrinkle depth reduction
in 30 days. This peptide maintains a long-lasting collagen function
that will help to ensure the appearance of healthy youthful skin.
12. Hexapeptide-10 A peptide that promotes cell adhesion, growth and
migration, regenerating the basal lamina. A study showed cell
growth increased by 74.6%. In addition to promoting cell adhesion
and migration it also helps with the formation of blood vessels, and
improves microcirculation. Cell proliferation results in compacted
epidermis which provides firmness.
40. High Performance Skin Care
4ce Of Nature provides a revolutionary approach to
skincare using a collection of powerful serums to
promote youthful skin
The line includes 4 highly transformative, anti-wrinkle,
peptide enriched medical grade serums that when
layered form the treatment component of daily skin
care regimen. Other serums in the line target a
variety of skin problems
experienced producing results far beyond
expectations
The studies in this slide series helps to demonstrate
empirically the efficacy of our products
41. We Built Products With Real Substance
95%-99% of our ingredients in each product
are active ingredients
Our most powerful ingredients are
formulated in concentrations far above the
levels found in competitive high-end
products
Our ingredients are class leading with award
winning process technology
All ingredients are sourced globally for their
intensive performing characteristics
42. Transforming Innovative Ingredients Into
Marketable Products The Advantage Is Yours
We broke away from conventional
thinking to build our products with real
substance and stunning results
Our highly responsive products can be
private labeled to position your
organization for growth
Our skincare system is powerful enough
to build your business by bringing
customers back to you monthly, with
their friends in tow as referrals wanting
to try these products
43. Why We Are Unique?
A Clinical Approach To Skincare
We took a clinical approach to the design of our products. Our lead
formulating chemist is also a biologist
She along with our team of physicians approach the formulation process
by analyzing the physiologic processes of the body that are
compromised
She looks at the cellular processes and selects ingredients that act to
own repair mechanisms
The skin care industry is notorious for selling low concentration, high
profile ingredients that are minimally effective and highly profitable
We took a different approach. We first consider the problem to be
solved and the bodies physiology before ingredients are matched to
solve the issue
Our ingredients are selected for their targeted functions, as well as the
magnitude of their force and ability to correct the issue we identified
44. Secret Formulation Techniques
We use closely held secret formulation techniques
They took several decades to develop
These techniques improve bioavailability, absorption, intensify
action, improve penetration, assist to transfer material to the
targeted cells, increase the results and shorten time of
response
These processes are what make us unique and give our
products a dramatic performance edge
Process engineering and unique ingredient sources makes our
products impossible to duplicate without our formula, giving you
one of a kind products
45. Bio-Vectored Formulas
We use bio-vectors to:
Identify the depth of delivery
Minimize the molecular size and use bonding to
enhance penetration
Achieve a high magnitude of impact and results
Improve the immediacy of the solution
Target the functional component in the transfer of
supercharged ingredients to targeted areas
46. Our Highly Skilled Development Team
Responsive scientific team with expertise in:
Analytical Chemistry
Medicine (2 Physicians and a Nurse with Burn and
Skin Care Expertise)
Biology
Microbiology
Pharmacology
Nutritional Supplementation
Cosmeceuticals
Process Engineering
Aesthetics (Para-medical Aestheticians)
47. ANTI- WRINKLE PEPTIDE SERUM -1oz
The Most Targeted Peptide Enriched Product Available
Re-awakens the cellular regeneration process
Unique blend of eight powerful peptide ingredients
Peptides are the most powerful ingredients in the
anti-aging wrinkle reducing arsenal
Reduces wrinkle volume, depth and density
Encourages the body to rebuild collagen and
elastin for visibly younger skin
Process engineering and unique ingredient
sources makes this product almost impossible to
duplicate without our formula, giving you a one of
a kind product
48. PEPTIDE SERUM INGREDIENTS
Tripeptide-1- patented active peptide that helps the body substantially restore
collagen levels.
Subjects studied from ages 35 to 55 showed a 29% wrinkle depth
reduction in 30 days
Palmitoyl Oligo Pentapeptide - only a limited number of labs have access to this
peptide due to patent restrictions. Stimulates the production of collagen and
fibronectin promoting extracellular matrix renewal and cell proliferation.
An in vivo (human based) study resulted in:
the surface area of the deep wrinkles decreases by 68%, and in some cases
was reduced by as much as 90%
" the density of the main furrows: decreased by 47%
" the area of the moderate wrinkles: decreased by 51%
" the mean area of the main wrinkle: decreased by 22%
Stimulated the synthesis of the extra-cellular Matrix in vitro and ex vivo to very
different extents:
Collagen I : +117%
Collagen IV : +327%
It also stimulates the production of glycosaminoglycans: +267%.
49. Palmitoyl Oligo Pentapeptide Peptide #2
Peptide #2, (one of twelve peptides used in our products) is a fragment
of the C-terminal portion of collagen I
synthesis of collagen I, collagen III and fibronectin
It has a more marked impact on low-density cultures of fibroblasts than
on higher density, confluent cultures
This is relevant because it is closer to aging skin, which has a reduced
population of fibroblasts
50. Deep Wrinkles Reduced By 68%-90%
The surface area occupied by deep wrinkles was reduced by a
mean of 68% over 6 months and in some cases was reduced
by as much as 90%
The density of the main furrows: decreased by 47%
The area of the moderate wrinkles: decreased by 51%
The mean area of the main wrinkle: decreased by 22%
The concentration of this peptide in our products ranges
between 8-16 times greater than the concentration used in this
study
52. Focus Ingredients
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Synake) a neurotrasmitter blocker,
relaxes facial muscles, smoothes skin, and reduces the appearance of wrinkles.
One study demonstrated a 52% reduction in forehead wrinkles.
Acetyl Hexapeptide-8 (Argireline) - reduces the appearance of the depth of wrinkles caused
by facial expressions.
Studies showed wrinkle depth reduction of 17% in 15 days and 32% in 28 days.
Pentapeptide-18 - interferes with the formation of expression wrinkles.
In combination with Argireline studies show it reduces wrinkle depth of 25% to 47% with in
28 days.
Acetyl Octapeptide-3 (SNAP-8) - reduces wrinkle depth from the expression areas of the face
.
Studies have shown wrinkle depth reduction by 63% in 30 days.
Palmitoyl Tripeptide-5 (SynCol) -
product collagen.
Pentapeptide-3 (Vialox) - peptide that offers intensive wrinkle care. It reduces expression line
wrinkles and relaxes muscles.
53. Acetyl Hexapeptide-8 (Argireline) Peptide #4
Peptide #4 was designed to reduce wrinkle depth caused by facial expressions
(forehead and eyes)
It is a neuro-transmitter blocking peptide
It mimics the N-terminal end of Snap-25 which competes for a position in the
SNARE complex
neurotransmitters that cause the muscle contractions which form a wrinkle.
Studies showed wrinkle depth reduction from use of this peptide, of 17% in 15
days and 32% in 28 days.
Silicone imprints were made for this study and measured by confocal
profilometry
54. How It Works
Muscles are contracted when they receive neurotransmitters released from a nerve cell in a
process known as neuronal exocytosis
The neurotransmitter involved is acetylcholine and it is released from a vesicle into the
synapse
The process involves several proteins, channels and vesicles
The SNARE protein complex is essential for neurotransmitter release at the synapsis and
mediates the final steps of exocytosis
It is a complex formed by three proteins: VAMP, Syntaxin and SNAP-25
This complex is like a cellular hook that captures vesicles (a process called docking) and
brings them close to the membrane to enable their fusion
55. How It Works
Neuro-transmitter acetylcholine
and it is released from a vesicle
into the synapse
The SNARE protein complex is
formed by 3 proteins, VAMP,
Syntaxin, and SNAP-25 and it is
essential for neuro-transmitter
release at the synapse and
mediates the final steps of
exocytosis
Acting as cellular hook it
captures vesicles and brings
them close to the membrane to
enable fusion
57. Botlinum Toxin A
Botulinum Toxin A paralyses the muscle by
selectively blocking acetylcholine release
at the neuromuscular junction
BoNT-A cleaves the protein SNAP-25
irreversibly, and therefore the SNARE
complex cannot assemble
The nerve signal cannot be relayed, the
muscle cannot contract and it is paralyzed.
58. Destabilized SNARE Complex,
Peptide #4
If the SNARE complex is slightly
destabilized, the vesicle cannot release
neurotransmitters. As a consequence,
muscle contraction is attenuated and the
muscle is relaxed
Peptide #4 is a mimic of the N-terminal
end of SNAP-25 and it competes with
the natural protein for a position in the
SNARE complex, so it destabilizes its
formation, without breaking any of its
components
59. In Vitro Efficacy
Inhibition of glutamate release
at mM concentrations is a
clear indicator of the potent
anti-expression wrinkle activity
of the peptide.
Inhibition of glutamate release
by depolarized neuron is a
validated cell assay for
measuring the potential
activity of compounds on the
inhibition of neuronal
exocytosis.
Untreated neuron cultures
were used as a negative
control and cultures treated
with Botulinum Toxin A (BoNT-
A) were used as a positive
control
60. Two In-Vitro Tests Related To The
Formation Of Wrinkles
Reduction in the depth of
wrinkles up to 17% after 15 days
with 10% Peptide # 4 solution
The depth of the furrow
decreased a maximum
value of 32% in 28 days
with a cream containing
5% Peptide #4 solution.
The concentration in our
formula is much higher
61. Another Study
This peptide reduces the severity
of wrinkles around the eyes, up to
17% after 15 days of treatment
and up to 27% after 30 days of
treatment
Objective:
To determine the effectiveness of
the peptide #4 cream in reducing
the severity of wrinkles
67. Dipeptide Diaminobutyroyl Benzylamide
Diacetate (Synake)
A neuro-transmitter blocking Peptide
A small peptide that mimics the activity of a
polypeptide found in the venom of a Viper
Capable of reducing mimic wrinkles by
inhibiting contractions
Reduced forehead wrinkles by 52%
68. Ra: average roughness
Rt: maximum difference between the highest peak
and the deepest furrows
Rz: mean value of these different maxima Study On Smoothing
A decrease of the Ra expresses a smoothed relief
A decrease of the Rt and Rz expresses a decrease of
And Anti-Wrinkle
wrinkle depth Effect Of Peptide # 3
69. Wrinkles Decrease 52% On The Forehead
Measurements on Volunteer #29 showed that Peptide #3 was able to
reduce forehead wrinkles by up to 52%
In vitro measurements showed that Peptide #3 (at a concentration of
0.5mM) was able to reduce the frequency of contractions of
innervated muscle cells by 82% (p<0.05) after 2 hours of treatment
and anti-wrinkle effect on this area
70. Wrinkle Height Profile
Using the PRIMOS® technique, parallel stripe patterns are
projected on the sample with successive phase shift.
The analysis of fringe deformations provided a qualitative
and quantitative evaluation of each height profile
71. Acetyl Octapeptide-3 (SNAP-8) Peptide #6
A wrinkle reducing peptide that is similar to
Argireline but 30% more active.
It reduces wrinkle depth from the expression
areas of the face such as the forehead and
eyes.
It decreases neuronal excitability by
destabilizing the SNARE complex.
Studies have shown wrinkle depth reduction
by 63% in 30 days.
72. Inhibition Of Snare Complex Formation
Demonstrates the blocking of SNARE complex formation. The lower the
SNARE complex in vitro, the higher the efficacy of the anti-wrinkle cream.
Evaluated the antagonistic competitive efficacy of the peptide patterned after
SNAP-25 N-Terminal domain compared to native SNAP-25(positive control).
Peptide #6 has the capacity to assemble with syntaxin and synaptobrevin
forming the SNARE complex, which was measured.
Heat and consequent thermal decomposition was the negative control
73. Modulation Of Glutamate Release In A Neuron Cell Culture
Peptide #6 Peptide #6
Glutamate is the most excitatory abundant neurotransmiter in the nervous system.
The release of glutamate in a primary cell culture of neurons was measured to
compare the in vitro activitiy of Peptide 6 and Botulinum Toxin A (positive control)
Peptide #6 inhibits glutamate release in a dose-dependent manner
74. 63% Reduction Value Of Wrinkle Depth With Peptide #6
Skin topography analyses were performed to measure the effectiveness of
a cream containing 10% Peptide #6
Silicon imprints were obtained from around the eyes of 17 women
volunteers pre-test and after the 28 day treatment.
Analyses of imprints were performed by confocal profilometry
76. Stem Cell Serum
Using state of art technology to culture plant stem cells
Based on high-tech bioreactor plant cell culture technology, that was awarded the
Innovation Award in 2008
First stem cell ingredient is from a rare apple, known for its longevity
A study with our first ingredient with subjects between the ages of 37-64,
showed a significant and visible decrease in wrinkle depth for 100% of the
subjects by the 28 days.
Study results showed that the CFE (colony-forming efficiency) was stimulated
by 92% in the presence of 0.04% of the stem cell extract. This clearly showed
an improved maintenance of the stem cell characteristics of epidermal stem
cells.
Second plant stem cell ingredient is from a rare Gamay grape ,which has extremely
high anthocyanins, this ingredient fights photo-aging and delays cell death
Study results showed this stem cell extract to strongly increase CFE: the CFE
was stimulated by almost 80% Clearly showing that it helps the epidermal stem
cells maintain their stem cell characteristics.
77. Why Use Plant Stem Cells
Epidermal stem cells rejuvenate and promote the balance of
cells in the skin and help to regenerate damaged tissue.
Aging reduces the number of stem cells in the skin and
diminishes their ability to repair the skin.
Plant stem cells contain specific epigenetic factors that help to
maintain the regeneration capacity of stem cells in the skin.
The result is a remarkable improvement in the appearance of
the skin as well as a reduction in wrinkles, and protection
against oxidative stress.
78. Focus Ingredients
Malus Domestica Fruit Cell Culture - Awarded the Innovation
Award in 2008. It uses a liposomal delivery system and is
based on plant stem cells from an endangered fruit(apple) that
is known for its longevity. Studies have demonstrated its
remarkable age delaying and anti-wrinkle effects in humans.
Palmitoyl Oligo Pentapeptide - Promotes collagen helps to
improve the visible signs of aging.
Vitis Vinifera (Grape) Fruit Cell Extract - Plant stem cells contain
specific components, called epigenetic factors. They regulate
the activity and the function of the cell. These plant stem cells
improve the vitality of skin stem cells, and protect them against
negative environmental influences
79. Improvement Using Apple Stem Cell
Before (day 0) of use of our
Apple Stem Cell
After (day 28)
80. TIGHTENING SERUM- 1 oz
Reduce The Appearance Of Loose Skin And Enlarged Pores
Contains peptides designed to help you look younger
by increasing the elastin and collagen in your skin
Reduces the appearance of loose skin and improves
the skins resilience
Improves cell proliferation resulting in a more
compacted epidermis which provides firmness
Provides a noticeable tightening effect, strengthens
connective tissue, and provides protection against
oxidative stress.
81. Focus Ingredients
Tripeptide-10 Citrulline - A peptide that substantially restores collagen levels.
Showed a 29% wrinkle depth reduction in 30 days. This peptide maintains a long-lasting
collagen function.
Pullulan - An anti-oxidant that also helps to retain moisture.
Hexapeptide-10 - A peptide that promotes cell adhesion, growth and migration, regenerating
the basal lamina. Tests have been carried out to quantify the increase in cellular adhesion
of keratinocytes and fibroblasts.
A study showed cell growth increased by 74.6%.
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine (syn-taks) - It helps to restore
the structural integrity of the skin, reducing wrinkles, and improving tone.
Palmitoyl Dipeptide-5 Diaminohydroxybutyrate (syn-taks) - It helps to restore the structural
integrity of the skin, reducing wrinkles, and improving tone.
Enteromorpha Compressa Extract - An edible form of green algae that produces a large
array of bioactive compounds found useful in the treatment of inflammation, allergies and
bacterial and viral infections.
Theobroma Cacao(Cocoa) Extract Provides anti-oxidant and anti-stress effects for skin
preparations. Acts as a skin balancer and energizer reducing cell degeneration and
protecting the skin from cell damage.
82. PEPTIDE EYE SERUM-! oz
Award Winning Ingredients Used In This Powerful Peptide Serum
Exciting powerful eye serum
using award winning ingredients.
This product provides dramatic
reductions in baggy eyes, dark
circles, fine lines and wrinkles.
Returning the skin to a much
more youthful state.
83. Focus Ingredients
Acetyl Tetrapeptide-5 - Won the technology award in cosmetics in
2005.
In vivo tests of subjects ages 18-65 resulted in elasticity being
improved by 30% in 30 days,
puffiness was significantly reduced in 14 days and
eye bags were reduced by 70% in 28 days.
Dark circles under the eyes were also reduced.
Acetyl Octapeptide-3 (SNAP-8) It reduces wrinkle depth from the
expression areas of the face such as the forehead and eyes. It
decreases neuronal excitability by destabilizing the SNARE
complex.
Studies have shown wrinkle depth reduction by 63% in 30 days
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Synake) - A
wrinkle reducing active peptide that mimics a peptide found in the
venom of the Temple Viper. It was designed as neuromuscular
blocking compound acting at the post-synaptic membrane
One study demonstrated a 52% reduction in forehead wrinkles.
84. EYE LASH LENGTHENER 10ml
We Broke From Conventional Thinking When This Product Was Designed
Unparalleled combination of class
leading formulation processes and
performance based ingredients
Uses Keratinocyte Growth Factor
partnered with a variety of powerful
ingredients that benefit the follicles
ability to add new hair.
We set the stage by improving the
environment for growth and then
added the trigger that makes it
happen.
85. Focus Ingredients
L-Acetyl Carnitine - Reactivates the hair follicles. Transfers fatty acids to the
mitochondria to be used as energy and to enhance active metabolism needed
for cellular repair.
Niacinamide - An anti-inflammatory and vasodilator. It stimulates collagen and acts
as an anti-oxidant. It reduces inflammation.
Soy Isoflavones - Helps preserve elasticity limiting the breakage of hair.
Saw Palmetto Extract - Thought to block cell receptor sites required to absorb
DHT. May improve hair growth, maintains healthy hair and helps to reverse
hair loss.
Keratin - Primary constituent of hair it wraps the hair follicle with a keratin bond that
protects and strengthens the hair shaft.
Nettle Extract - Partially blocks 2 enzymes, 5a-reductase, which makes
dihydrotestosterone (DHT) and aromatase enzyme. These enzymes are
thought to block hair growth.
Hexanoyl Dipeptide-3 Norleucine Acetate: - A peptide that activates follicle
regeneration.
86. Focus Ingredients
Lecithin- A natural emulsifier and lubricant. It also protects cell follicles from
oxidation and breakdown.
L-Arginine - An amino acid that may bring oxygen to the tissue. It may act on
the follicle by promoting the formation of L-proline, an amino acid that is
essential to the synthesis of collagen. It is thought to play a role in cell
division.
L-Glutamine - An amino acid that helps with cell rejuvenation. Acts as an eye
tissue nutrient.
Zinc - Benefits cellular growth and appears to limit DHT production. It helps
with absorption of vitamins and proteins that are necessary for hair growth
and maintenance.
Keratinocyte Growth Factor (KGF) - A growth factor that promotes hair
growth, it is synthesized by fibroblasts. A complex growth factor it contains
an 160 amino acid chain that stimulates cell replication. This is made
specifically for our product.
Superoxide Dismutase - An enzyme that prevents oxidative stress and
enhances antioxidant balance. SOD is found in the dermis and epidermis
and is important in the production building new cells.
87. LIGHTENING SERUM 1 oz
Revolutionary Serum Significantly Lightens And Reduces The Appearance Of Skin
Discoloration
An aesthetic treatment that significantly
reduces the appearance of skin discoloration
and lighten and brightens the appearance of
the skin.
Each individual responds differently to
ingredients, we approached this issue by using
ten distinctly different skin lightening
ingredients.
Each ingredient operates in a slightly different
way to ensure that the outcome will be what
you expect.
88. Focus Ingredients
Diaminopropionoyl Tripeptide-33 - A peptide that reduces the appearance of
photo-aging. It promotes the DNA repair systems capacity, and provides the
skin protection from aging.
Arbutin - Arbutin has a depigmenting effect on the skin. Increases cutaneous
luminosity, cutaneous smoothness, with a significant reduction of cutaneous
tint, and cutaneous dyschromia.
Inhibits the tyrosinase enzyme and has been documented by in vitro
studies to have an enzymatic inhibition level of 56%.
Kojic Acid - An effective skin lightener, inhibits melanin production, helps to
balance skin tones, fading dark spots and freckles caused by sun exposure,
aging, and cutaneaous hyper-pigmentation.
Licorice Root - A skin whitener, anti-inflammatory, anti-microbial and anti-oxidant.
Magnesium Ascorbyl Phosphate - It significantly affects the appearance of skin
lightening acting to inhibit tyrosinase to reduce the formation of melanin. It also
promotes collagen synthesis.
89. Focus Ingredients
Bellis Perennis (Daisy) Flower Extract - Highly efficient natural skin lightener by
influencing melanin formation.
An in vitro study done in the Philippines showed a reduction of tyrosinase and
tyrosinase activity resulting in a significant lightening effect.
Diacetyl-Boldine - A skin lightener, was shown to be 30 times more effective than kojic
acid.
In vitro tests showed it inhibited the activity of tyrosinase by 56%.
A study of Asian subjects showed skin lightening improved by 71%, hyper-pigmented areas
decreased by 54%, complexion was viewed as 65% move even, and 74% more radiant.
A study of Caucasian subjects showed a 23% reduction in age spots. It provides the skin
with an even, luminous and mat complexion.
1-aminoethylphosphinic acid - Used as a skin lightener to reduce age spots. Acts
different from tyrosinase inhibitors, it slows down melanogenesis providing a whitening
effect by decreasing melanin systhesis at the DOPA-Chrome level
Dimethylmethoxy Chromanyl Palmitate - Provides considerable skin lightening.
A study of Asian women ages 18-46 showed a 37% inhibition of tyrosinase activity, it
stopped endogenous tyrosinase activity by 43% and was found to have a better di-
pigmenting effect than Kojic acid.
90. CELLULITE CREAM 5 oz
Finally A Solution That Actually Works
This intensely effective approach to lustrous,
youthful, smooth skin, reduces the appearance
of cellulite.
A Brazilian study of 99 women showed more
than
88% experienced a decreased circumference their thighs and arms
68% saw an additional reduction of their hip size when the caffeine
ingredient was analyzed.
Pseudoalteromonas Ferment Extract study
showed
128% increase in collagen 1 within 15 days
81% increase in type IV collagen
91. Focus Ingredients
Lecithin - May reduce the accumulation of fluids, reduce inflammation and improve
circulation. Helps the body improve the support structures under skin to keep cellulite from
showing through.
Caffeine - Vasoconstrictor, reduces fluid retention and may improve fat metabolism.
Butcherbroom (Ruscus Aculatus) Root Extract - Decreases excess fluids, anti-
inflammatory.
Tea-Hydroiodide - Is a skin conditioning agent.
Ivy (Hedera Helix) Extract - Tones, tightens and helps reduce build up of waste products
in tissue.
Carnitine - A naturally occurring amino acid supports the transport long chair fatty acids to
the mitochondria where it is used for energy. Thought to improve appearance of dimpled
skin.
Tripeptide-1 - A patented peptide that acts as a skin conditioning agent.
Panthenol - Provitamin B5 has the effect of filling in areas and stretching the skin.
92. Focus Ingredients
Marrubium Vulgare Extract - An anti-inflammatory that assists in absorption.
Pseudoalteromonas Ferment Extract - A glycoprotein found at the bottom of a glacier in Antartica, it is
thought to increase elastin and collagen.
One study showed a 128% increase in collagen 1 within 15 days and a 81% increase in type IV collagen.
Acetyl Tetrapeptide-5 - A peptide that reduces edema in tissue.
Pentapeptide-18 - A neuropeptide that helps to relax muscles and tighten the skin.
Rucus Aculeatus Root Extract - Improves microcirculation in the skin, and capillary permeability.
Citrus Medica Limonum Peel Extract - Benefits circulation and helps improve blood flow.
Solidago Virgaurea Extract - Improves circulation, contracts tissue, reduces fluids.
Astragalus Membranaceus Root Extract - Benefits micro-circulation, firms and smoothes the skin and
helps to reduce the appearance of imperfections.
Ilex Paraguariensis Leaf Extract(Yerba Mate) - Has a relaxing effect on muscle tissue, burns fat.
Cameilia Oleifera Extract(Green Tea) - Rich in anti-oxidants and anti-inflammatory properties.
Cola Acuminata Seed Extract - Provides the stimulating and fluid draining effects of caffeine. Improves
texture on uneven dimpled skin.
Japanese Pepper Extract: - A pepper that results in a hot or tingling sensation to the skin. It is an anti-
oxidant that also benefits microcirculation. Anti-inflammatory.
93. FACIAL/BODY HAIR INHIBITOR 1 oz
Dramatically Reduce The Appearance Of Unsightly Hair
Hair growth cycles can take 3-4 months with 80% of
your hair in a growth cycle at any one time.
Most cultures dictate the aesthetic level of hair for
both men and women and social acceptance is
affected for those who violate those norms.
It effectively helps to dramatically reduce the
appearance of unsightly hair
A study on one of our key ingredients showed a decrease
of 30% in hair length and a 16% reduction in density within
60 days.
94. Focus Ingredients
Larrea Diviaricata Extract - A hair growth inhibitor that also has anti-oxidant and
anti-microbal properties.
Lauryl Isoquinolinium Bromide - A major hair growth inhibiting ingredient. It
decreases the length and density of hair, reduces the need for shaving or
depilation. It targets the hair follicle cells and decreases new hair formation.
One study showed a decrease of 30% in hair length and a 16% reduction in
density within 60 days.
Pseudoalteromanoas Ferment Extract - It maintains natural bio-protective
properties and promotes keratinocyte growth and fibroblast adhesion for a skin
regenerating effect.
A study showed increased collagen I synthesis by 81% after 7 days and 128%
after 15 days and increased collagen IV synthesis 36% after 7 days and 81%
after 15 days.
Subtilisin - A keratinolytic protease that invades the hair structure and causes
proteolytic cleavage which reduces intercellular adhesion and reduces hair
growth. It also diminishes the size of hair follicles and hair shafts.
Palmatine - Slows mitosis and therefore reduces hair growth.
95. New Products
Roll Off Wrinkles A strong peptide formula that comes in bottle with a roller ball. It can
be carried in your pocket or purse and used throughout the day. It is particularly designed
to eliminate the more difficult wrinkles
Anti-Oxidant Serum A serum loaded with anti-oxidants that will protect the skin from free
radical scavengers, nourish and revitalize it
Telomer Protect Serum - The discovery of telomeres won the 2009 Nobel Prize in
youthful cell function. Every time your cells divide, your telomeres shorten. When your
telomeres become too short, cell division stops and your cells can no long divide to build
new cells. This product helps maintain telomeres and extend the lifespan of your skin cells.
up your sagging skin
Inside Out Beauty Supplement Designed using three proprietary blends of the
ingredients. The first is a powerful blend of amino acids which encourages the body to
produce Human Growth Hormone. This hormone declines with aging and that loss results
in a loss of energy, stamina, strength, muscle tone and skin tone, thickness and wrinkle
formation. This blend can dramatically assist the body to achieve the vigor and
characteristics of a more youthful state. The other two blends focus on adding anti-
oxidants to the body to improve both health and beauty.
97. Why We Are Unique
We use the highest quality ingredients
We formulate using high concentrations of the most potent ingredients
We use semi-manual encapsulation processes to eliminate the need for excipents
We perform vendor audits, and all ingredients are tested for purity, potency, authentication
We participate in an extensive audit by an outside auditing company
We use the most cutting edge advancements to aging in recent history
An unparalleled approach to beauty and wellness
95%-99% of our ingredients in each product are active ingredients
Our formulation team includes physicians
Our formulations use clinical strengths of medical grade ingredients
All products are manufactured in house in our fully accredited manufacturing plant
98. Appetite Suppressant/Thermogenic
This appetite suppressant works by
Diminishing appetite
Increases the sensation of fullness
Improves mood
Helps to develop a perceived sense of happiness
Unlike other supplements this product approaches appetite suppression from
many angles, and gives the body several opportunities to feel satiety.
It acts as a thermogenic
burning of fat.
It is caffeine, and ephedra free.
It controls appetite during times of boredom or emotional distress.
99. WEIGHT LOSS CARBOHYDRATE CONTROL - 180 caps
The Help You Need To Control Carbs
Helps to break the vicious weight gain cycle
and control carbohydrate cravings.
Helps reduce the absorption of starch
Breaks down carbs into absorbable sugars
Helps the body better regulate glucose and insulin
Improves pancreatic function by mediating insulin
release
Helps the body better use calories and metabolize
glucose
Reduces carbohydrate cravings
Stimulates the brain to feel satisfied and full
100. WEIGHT LOSS FAT BURNER (LIPOTROPIC) - 60 caps
Power Up Your Ability To Burn Away Fat
This supplement helps to:
Control appetite and improve mood
Breakdowns fat and converts it to energy
Removes and metabolizes excess fat from the
liver
its effect on fat storage
formation on arterial walls
101. NATURAL HAPPINESS 60 caps
Renew Your Sense Of Joy, Re-energize Your Life
A non sedating formula that helps
maintain and elevate mood levels
Combats fatigue
Increases energy levels and
improves malaise
Helps minimize depression and
relieve tension, irritability, stress
and anxiety
Improves memory
102. LIVER SUPPORT 180 caps
Is Your Liver Working Overtime? What Are You Doing To Protect It?
Aids in liver detoxification
Improves digestion
Enhances bile production and flow
Assists in neutralizing and
eliminating toxins, provides anti-
oxidant benefits
Helps protect the liver from damage
and supports its optimal functioning
103. MENOPAUSE SYMPTOM RELIEF 60 caps
Live Comfortably As Menopause Approaches
Improves menopause symptoms
Helps regulate mood swings
Helps regulate hormonal swings
Reduces hot flashes and night sweats
Minimizes weight gain
Improves bladder incontinence and
overactive bladder
104. JOINT SUPPORT 480 grams
Reduce Pain, Swelling, Tenderness And Stiffness
Helps build synovial fluid and cartilage
Improves mobility and reduces discomfort
Improves health and function of cartilage
Reduces pain, swelling, tenderness and
stiffness
Improves athletic recovery
105. MUSCLE CRAMP OIL 4oz
Stop Painful Sudden Forceful Muscle Cramps
Helps restore magnesium levels in the body
Helpful to athletic recovery
Helps relieve aches, pain, muscle cramps,
and stiffness
Helps maintain muscle function
Calms nerves
Supports restful sleep
Highly absorbable without GI side effects
common with oral version and acts quickly
106. Q IMMUNE 120 caps
An Unprecedented Approach To Immune Support
The discovery of the biologic importance of our key ingredient
Germanium has been touted as a landmark development in the field of
nutritional and metabolic medicine
Dramatically improves the efficiency of oxygen utilization at a cellular
level
Each atom of germanium is bonded to three atoms of oxygen, making it
an efficient carrier of oxygen, it is believed oxygen cannot be properly
metabolized by cancer cells
Powerful regulator of the immune system, activating an under-active
system and suppressing over-activity when necessary
Our unique proprietary engineered blending process transforms this
combination of ingredients and dramatically enhances their
effectiveness
bioavailability
provides a compounding effect with the supporting
ingredients
107. 4ce Of Nature
and one of a kind.
technology, and process engineering as we
transform our secret processes and a set of
incredibly responsive ingredients, into highly
responsive products.
ever experienced
Producing rapid and stunning changes to the
skin
Transforming tired, aged, wrinkled skin into
vibrant youthful restored skin
Protecting younger skin from the ravages of
aging
108. 4ce Of Nature
Using highly concentrated peptide enriched formulas our products
produce astounding results.
Nothing currently on the market comes close to our products
performance
Process engineering offers our products a unique edge and protects
against competitors attempts at duplication
Small molecular sizes allow deep penetration
Unique delivery systems maximize absorption
Careful PH balancing help our products to penetrate deeper and
respond faster