HBV infection-sensitive human cells for HBV research - Cell Well Ltd.

1. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! CELL WELL LTD. COMPANY PROFILE WE OFFER: Human Hepatocyte-like cells for HBV research. A new tool for antiviral drug and vaccine screening and studying the unknown steps of HBV life cycle.

2. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! Cell Well Ltd. is a privately-owned supplier of cell-based products for pre-clinical screening, Hepatitis research, scientific investigation, cell research, drug design and discovery. KEY FACTS: Latvian Biomedical Research and Study Center (BMC) – our collaboration Partner with over 40 years of experience in Hepatitis research; Product is manufactured in accordance with EU standards and ISO 9001:2008, on BioSpherix stem cell workstation; Production and Storage facilities located in BMC. Scientific personnel withpractical expertise in Hepatitisresearch and Stem cell application for therapy and laboratory research. Our CSO, Uldis Berzins, working on Biospherix Stem Cell Workstation. Photo: Valdis Ilzens. ABOUT US.

3. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! We believe that, by combining our scientific background and practical knowledge in Hepatitis and Stem Cells research we are able to deliver the most effective research and screening tools to meet the urgent needs of investigators’ community to keep their RESEARCH MOVING FORWARD! Front view of Latvian Biomedical Research and Study Center building. Photo: BMC.

4. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! COMPANY PRODUCTS Cell-based products– represent a state of art tools developed by application of Stem Cell technologies involving modification of adipose derived stem cells (ADSC). Hepatitis related products – arecurrently represented with a next generation Hepatitis B virus research (HBV) model, 4bHHl – Human Hepatocyte-like cells susceptible to HBV infection. Research pipeline - We have more Products in Research pipeline including the development of human cell-based model for HCV research. We guarantee theQUALITYandSPECIFICATIONof our products described in Products’ specification and instruction manual. We can assure that the products you use in your experiments perform THE SAME every time. Additionally, we are ready to customize our products to meet your specific needs.

5. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! A NOVEL MODEL FOR HBV RESEARCH. 4bHHl IN BRIEF: 4bHHl cell culture was developed by modification of ADSCs isolated from subcutaneous adipose tissue of healthy donor; HBV infection of 4bHHl cells was proved by detection of newly synthesized HBV transcripts upon infection of cells with HBV; BENEFITS IN BRIEF: 4bHHl represents a new generation sustainable model with following benefits: susceptible to HBV infection; proved HBV replication; HBV infection maintainability; lower costs of cultivation; 4bHHl cells homogeneity. Cell Well Ltd. GUARANTEES the susceptibility of 4bHHl to HBV infection, at conditions described in 4bHHl Specification and Instruction. Conventionally used cell cultures ARE NOT ABLE to provide advantages inherent to 4bHHl cells.

6. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! APPLICATION OF 4bHHl. 4bHHl cell culture provides a unique tool for investigation of unresolved issues of HBV biology, development of new therapy, and infection neutralization testing. Cell biology. Studying the host cell response to infection, viral interference with cell signaling pathways, oncogenesis etc. HBV biology. Studying the viral-host interactions and viral entry and uncoating –the unknown steps of HBV life cycle. Clinical testing. Antiviral drug and vaccine prototype screening. New therapy. Discovery and evolution of new antiviral drug and vaccine candidates. COMMITMENT. As a result of scientific collaboration with BMC, an independent research institution with more than 40 years of front-line experience in Hepatitis research, HBV infection of 4bHHl cells was proved by detection of newly synthesized HBV transcripts upon infection of cells with HBV. 4bHHl cells can be infected with HBV by standard procedure described by Gripon et al.

7. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! WE OFFER For Investigators: Benefit from using a next generation HBV research model, 4bHHl – Human Hepatocyte-like cells susceptible to HBV infection – a new tool for antiviral drug and vaccine screening and studying the unknown steps of HBV life cycle. For Distributors: Become a qualified Cell Well Ltd. distributor today and benefit from providing a state of art tool for accelerating and improving pre-clinical and medical research of your customers.

8. CELL WELL LTD.– HELPING TO MOVE YOUR RESEARCH FORWARD! Contacts Maxim Vlasenko CEO Tel.: +371 27820000 E-Mail: maxim@cell-well.eu Web url: www.cell-well.eu