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Drug Delivery Markets: Oral Delivery

July 1, 2009


Since our last edition of this report in 2007, the oral drug delivery market is the largest
segment of the drug delivery market, and there’s no sign that it is slowing down. With
pharmaceutical companies increasingly turning to drug delivery to extend the revenue-
earning lifetime of their biggest products, and seeking to tap into the growing elderly
population that requires products with a level of ease-of-use and cost benefit, it’s no
surprise that the oral drug delivery market is a $35 billion industry and expected to grow
as much as ten percent per year.

Kalorama’s Drug Delivery Markets: Oral Delivery provides the definitive break down of
the market for oral delivery drug markets. The report covers both the major technologies
in oral delivery (controlled-release, delayed release, pulsatile-release, taste-masked and
microemulsion formulations) and the products that use these delivery technologies.

In the reporting of market size and growth through 2013, Kalorama’s unique analysis
breaks out separates the value of the technology portion of the market from the
active ingriedient portion of the market, allowing for a deeper understanding of the value
of the market attributable to the delivery technologies themselves.

This focused report provides information on the revenues for relevant companies and
provides information critical to assessing the opportunities available in this market,
including:

         Legacy Companies in Oral Delivery as well as Recent Entrants
         Current World Wide Revenue Across Product Categories and Future Forecasts
         Revenues by Combonent and by Component ( Pharmaceutical vs. Technology
         portion of Revenue) Type of Delivery (Timed Release vs. Other)
         Challenges Faced by Oral-Delivery Technology Companies
         Success Stories and Pitfalls
         The Trends That are Expected to Lead to Global Growth

Kalorama’s trusted information-gathering process provides most accurate study of the
oral delivery drug market available today. Information and analysis presented in this
report is based on extensive interviews with senior management of top companies in
the industry. While major research literature and government information is culled,
information is corroborated and key market insights originate from interviews with
industry leaders.

Product managers, marketing managers, business development executives, advertising
agency or investment firm executives, and information and research center librarians
are among the individuals who will find this report on the oral delivery drug market
essential.



Additional Information

New York, July 14, 2009 — The worldwide market for oral drugs using drug delivery
technologies has experienced tremendous growth over the last few years according to
Drug Delivery Markets: Oral Delivery, a new report from Kalorama Information, a
leading publisher in the life sciences research market, a trajectory that is projected to
gain momentum through 2013 as other pharmaceutical product areas are challenged.

In 2008, the oral drug delivery market reached revenues at the manufacturer’s level of
$43 billion for both major technologies in oral delivery and the products that use these
delivery technologies. Kalorama forecasts the market will reach $71 billion by 2013, with
a compound annual growth rate (CAGR) of almost 11% for the five-year period
beginning in 2009.

Over the next few years, Kalorama projects consolidation will increasingly impact the
market as funding from big companies leads to better products and more research and
development. Large pharmaceutical companies are expected to continue acquiring drug
delivery companies to expand their presence, deepen product lines, and create
potential extensions for existing products; while larger drug delivery companies will
continue to acquire smaller start-up companies to broaden their drug delivery platforms.

“Those products with enhanced delivery technologies have a better chance of meeting
economic and patent challenges near-term,” says Bruce Carlson, publisher of Kalorama
Information. “That’s why we will see drug delivery companies become more involved
earlier in the research and development process. Higher-quality products with
exceptional drug delivery methods will encourage patient compliance and innovative
discoveries.”

Additional market drivers include growth in the elderly population, patent issues among
large pharmaceutical companies, differentiation of existing and future products by drug
delivery mechanism, population growth, and new developments in drug delivery that are
both fueling growth in the pharmaceutical market and providing opportunities to extend
product lifecycles.
Drug Delivery Markets: Oral Delivery provides the definitive breakdown of the global
oral drug delivery market. The report covers both the major technologies in oral delivery
(controlled-release, delayed release, pulsatile-release, taste-masked and microemulsion
formulations) and the products that use these delivery technologies. Included are
market size and growth through 2013, in addition to information critical to assessing the
opportunities available in the market.

About Kalorama Information
Kalorama Information supplies the latest in independent market research in the life
sciences, as well as a full range of custom research services.



TABLE OF CONTENTS

Chapter One: Executive Summary

      Market Drivers
      Market Size and Growth
        o Total Oral Drug Delivery Market
        o Oral Drug Delivery Technology Only Market




      Competitive and Market Analysis

Chapter Two: Introduction and Overview

      Scope of the Report
      Methodology
      History of Oral Drug Delivery
      Phases of Drug Action
      Barriers to Oral Drug Delivery
      Controlled-Release/Sustained-Release
      Delayed Release and Modified Release
      Fast Dissolving
      Taste-Masked
      Pulsatile Release
      Microemulsion and Others

Chapter Three: Key Trends and Demographics

      The Elderly
      Regulatory Environment
      Patent Protection and Extension
      Earlier Involvement
Consolidation
      Proprietary Product Development
      Implications for Generic and Over-the-Counter Products
      Pharmaceutical Formulation

Chapter Four: New Developments

      Macromolecule Delivery
      Delivery of Hydrophobic Drugs
      Other Delivery Solutions

Chapter Five: Market Size and Growth

      The Total Oral Drug Delivery Market
      Oral Delivery Technology Only Market

Chapter Six: Competitive Analysis

  Competitive Landscape

Chapter Seven: Company Profiles

      ALZA Corporation
      Biovail Corporation
      Elan Corporation, plc
      Emisphere Technologies, Inc.
      Ethypharm
      KV Pharmaceutical
      Labopharm, Inc.
      Penwest Pharmaceutical Company
      Purdue/MundiPharma/Napp Group
      SkyePharma PLC
      Watson Pharmaceuticals, Inc.

Chapte Eight: Companies in Brief
 Alkermes, Inc.
 Astellas Pharma US
 CIMA Labs, Inc. Division of Cephalon
 DepoMed, Inc.
 Eurand, Inc.
 Galenix
 Intelgenx Technologies Corp
 Kos Pharmaceuticals, Inc.
 Lifecycle Pharma
 MicroDose Therapeutics, Inc.
 Scolr Pharma
Xcelience

Appendix: Company Directory

List of Exhibits

Chapter One: Executive Summary

  Chapter Two: Introduction and Overview

      Table 2-1: Selected Types of Oral Solid Preparations
      Table 2-2: Sequence of Drug Action

Chapter Three: Key Trends and Demographics

      Table 3-1: World Population by Age Group 2006-2013
      Figure 3-1: World Population by Age Group 2006-2013
      Table 3-2: Recent Consolidations in the Drug Delivery Market

Chapter Four: New Developments
Chapter Five: Market Size and Growth

      Table 5-1: The Worldwide Market for Oral Drug Delivery Technology and
      Pharmaceuticals Revenues and Growth Rate 2006-2013
      Figure 5-1: Trending in the Worldwide Market for Oral Drug Delivery Technology
      and Pharmaceuticals 2006-2013
      Table 5-2: The Worldwide Market for Pharmaceuticals Utilizing Oral Drug
      Delivery Technologies by Type (Timed Release, Other) 2006-2013
      Figure 5-2: Trending in the Worldwide Market for Pharmaceuticals Utilizing Oral
      Drug Delivery Technologies by Type (Timed Release, Other) 2006-2013
      Table 5-3: The Worldwide Market for Pharmaceuticals Utilizing Oral Drug Market
      Share by Type 2006-2013
      Table 5-4: The Worldwide Market for Oral Drug Delivery Systems by
      Pharmaceutical vs Drug Delivery Components 2006-2013
      Table 5-5: The Worldwide Market for Oral Drug Delivery Systems Distribution of
      Revenue by Pharmaceutical vs Delivery Technology Components 2006-2013
      Figure 5-3: The Worldwide Market for Oral Drug Delivery Systems Share of
      Revenue by Pharmaceutical vs. Delivery Technology Component 2006, 2010

Chapter Six: Competitive Analysis

      Table 6-1: Leading Suppliers of Oral Drug Delivery Technology (Company,
      Proprietary Technology, Approved Products)
Available immediately for Online Download at
http://www.marketresearch.com/product/display.asp?productid=2290102




US: 800.298.5699

UK +44.207.256.3920

Int'l: +1.240.747.3093

Fax: 240.747.3004

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Drug Delivery Markets: Oral Delivery

  • 1. Get more info on this report! Drug Delivery Markets: Oral Delivery July 1, 2009 Since our last edition of this report in 2007, the oral drug delivery market is the largest segment of the drug delivery market, and there’s no sign that it is slowing down. With pharmaceutical companies increasingly turning to drug delivery to extend the revenue- earning lifetime of their biggest products, and seeking to tap into the growing elderly population that requires products with a level of ease-of-use and cost benefit, it’s no surprise that the oral drug delivery market is a $35 billion industry and expected to grow as much as ten percent per year. Kalorama’s Drug Delivery Markets: Oral Delivery provides the definitive break down of the market for oral delivery drug markets. The report covers both the major technologies in oral delivery (controlled-release, delayed release, pulsatile-release, taste-masked and microemulsion formulations) and the products that use these delivery technologies. In the reporting of market size and growth through 2013, Kalorama’s unique analysis breaks out separates the value of the technology portion of the market from the active ingriedient portion of the market, allowing for a deeper understanding of the value of the market attributable to the delivery technologies themselves. This focused report provides information on the revenues for relevant companies and provides information critical to assessing the opportunities available in this market, including: Legacy Companies in Oral Delivery as well as Recent Entrants Current World Wide Revenue Across Product Categories and Future Forecasts Revenues by Combonent and by Component ( Pharmaceutical vs. Technology portion of Revenue) Type of Delivery (Timed Release vs. Other) Challenges Faced by Oral-Delivery Technology Companies Success Stories and Pitfalls The Trends That are Expected to Lead to Global Growth Kalorama’s trusted information-gathering process provides most accurate study of the oral delivery drug market available today. Information and analysis presented in this report is based on extensive interviews with senior management of top companies in
  • 2. the industry. While major research literature and government information is culled, information is corroborated and key market insights originate from interviews with industry leaders. Product managers, marketing managers, business development executives, advertising agency or investment firm executives, and information and research center librarians are among the individuals who will find this report on the oral delivery drug market essential. Additional Information New York, July 14, 2009 — The worldwide market for oral drugs using drug delivery technologies has experienced tremendous growth over the last few years according to Drug Delivery Markets: Oral Delivery, a new report from Kalorama Information, a leading publisher in the life sciences research market, a trajectory that is projected to gain momentum through 2013 as other pharmaceutical product areas are challenged. In 2008, the oral drug delivery market reached revenues at the manufacturer’s level of $43 billion for both major technologies in oral delivery and the products that use these delivery technologies. Kalorama forecasts the market will reach $71 billion by 2013, with a compound annual growth rate (CAGR) of almost 11% for the five-year period beginning in 2009. Over the next few years, Kalorama projects consolidation will increasingly impact the market as funding from big companies leads to better products and more research and development. Large pharmaceutical companies are expected to continue acquiring drug delivery companies to expand their presence, deepen product lines, and create potential extensions for existing products; while larger drug delivery companies will continue to acquire smaller start-up companies to broaden their drug delivery platforms. “Those products with enhanced delivery technologies have a better chance of meeting economic and patent challenges near-term,” says Bruce Carlson, publisher of Kalorama Information. “That’s why we will see drug delivery companies become more involved earlier in the research and development process. Higher-quality products with exceptional drug delivery methods will encourage patient compliance and innovative discoveries.” Additional market drivers include growth in the elderly population, patent issues among large pharmaceutical companies, differentiation of existing and future products by drug delivery mechanism, population growth, and new developments in drug delivery that are both fueling growth in the pharmaceutical market and providing opportunities to extend product lifecycles.
  • 3. Drug Delivery Markets: Oral Delivery provides the definitive breakdown of the global oral drug delivery market. The report covers both the major technologies in oral delivery (controlled-release, delayed release, pulsatile-release, taste-masked and microemulsion formulations) and the products that use these delivery technologies. Included are market size and growth through 2013, in addition to information critical to assessing the opportunities available in the market. About Kalorama Information Kalorama Information supplies the latest in independent market research in the life sciences, as well as a full range of custom research services. TABLE OF CONTENTS Chapter One: Executive Summary Market Drivers Market Size and Growth o Total Oral Drug Delivery Market o Oral Drug Delivery Technology Only Market Competitive and Market Analysis Chapter Two: Introduction and Overview Scope of the Report Methodology History of Oral Drug Delivery Phases of Drug Action Barriers to Oral Drug Delivery Controlled-Release/Sustained-Release Delayed Release and Modified Release Fast Dissolving Taste-Masked Pulsatile Release Microemulsion and Others Chapter Three: Key Trends and Demographics The Elderly Regulatory Environment Patent Protection and Extension Earlier Involvement
  • 4. Consolidation Proprietary Product Development Implications for Generic and Over-the-Counter Products Pharmaceutical Formulation Chapter Four: New Developments Macromolecule Delivery Delivery of Hydrophobic Drugs Other Delivery Solutions Chapter Five: Market Size and Growth The Total Oral Drug Delivery Market Oral Delivery Technology Only Market Chapter Six: Competitive Analysis Competitive Landscape Chapter Seven: Company Profiles ALZA Corporation Biovail Corporation Elan Corporation, plc Emisphere Technologies, Inc. Ethypharm KV Pharmaceutical Labopharm, Inc. Penwest Pharmaceutical Company Purdue/MundiPharma/Napp Group SkyePharma PLC Watson Pharmaceuticals, Inc. Chapte Eight: Companies in Brief Alkermes, Inc. Astellas Pharma US CIMA Labs, Inc. Division of Cephalon DepoMed, Inc. Eurand, Inc. Galenix Intelgenx Technologies Corp Kos Pharmaceuticals, Inc. Lifecycle Pharma MicroDose Therapeutics, Inc. Scolr Pharma
  • 5. Xcelience Appendix: Company Directory List of Exhibits Chapter One: Executive Summary Chapter Two: Introduction and Overview Table 2-1: Selected Types of Oral Solid Preparations Table 2-2: Sequence of Drug Action Chapter Three: Key Trends and Demographics Table 3-1: World Population by Age Group 2006-2013 Figure 3-1: World Population by Age Group 2006-2013 Table 3-2: Recent Consolidations in the Drug Delivery Market Chapter Four: New Developments Chapter Five: Market Size and Growth Table 5-1: The Worldwide Market for Oral Drug Delivery Technology and Pharmaceuticals Revenues and Growth Rate 2006-2013 Figure 5-1: Trending in the Worldwide Market for Oral Drug Delivery Technology and Pharmaceuticals 2006-2013 Table 5-2: The Worldwide Market for Pharmaceuticals Utilizing Oral Drug Delivery Technologies by Type (Timed Release, Other) 2006-2013 Figure 5-2: Trending in the Worldwide Market for Pharmaceuticals Utilizing Oral Drug Delivery Technologies by Type (Timed Release, Other) 2006-2013 Table 5-3: The Worldwide Market for Pharmaceuticals Utilizing Oral Drug Market Share by Type 2006-2013 Table 5-4: The Worldwide Market for Oral Drug Delivery Systems by Pharmaceutical vs Drug Delivery Components 2006-2013 Table 5-5: The Worldwide Market for Oral Drug Delivery Systems Distribution of Revenue by Pharmaceutical vs Delivery Technology Components 2006-2013 Figure 5-3: The Worldwide Market for Oral Drug Delivery Systems Share of Revenue by Pharmaceutical vs. Delivery Technology Component 2006, 2010 Chapter Six: Competitive Analysis Table 6-1: Leading Suppliers of Oral Drug Delivery Technology (Company, Proprietary Technology, Approved Products)
  • 6. Available immediately for Online Download at http://www.marketresearch.com/product/display.asp?productid=2290102 US: 800.298.5699 UK +44.207.256.3920 Int'l: +1.240.747.3093 Fax: 240.747.3004