Market Research Reports, Inc. has announced the addition of “Cell Line Development Services Global Market - Forecast to 2025” research report to their offering. See more at - http://mrr.cm/Ubk

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Category : Healthcare
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Introduction to Report
 Launch Date: August 16, 2017
 Number of Pages: 238
 Geography Coverage: Global
 Available Format: PDF
Price For Single User License: USD 3,600
Price For Site User License: USD 5,400
Price For Global User License: USD 7,200
Delivery Time: Within 24 Hours (During Working
Days)

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About the Report
The cell line development service market is
expected to grow at double digit CAGR to reach
$1,214.7 million by 2025.
Increasing demand for biologics and biosimilars,
growing incidence rate of oncology and
immunological disorder and growth in research
activities related to the diseases are driving the
market. Technological improvements in
development, manufacturing, screening
technologies and assays are giving immense
growth opportunity for the market.

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Key Highlights:
Cell lines are one the major tools used in research for
studying the normal physiology and biochemistry of
cells, the effects of drugs and toxic compounds on the
cells, drug screening and development and large scale
manufacturing of biological compounds.
Cell culture is the process by which cells are grown
under controlled conditions derived from microbial or
animal cells.
Cell lines are subculture of primary culture also known
as sub-clone.
Cell lines derived from primary cultures have a limited
life span, after subsequent cultures, cells with the
highest growth capacity dominate which are selected
for further cell development.
Primary cells are cells that are cultured directly from a
subject and have a limited lifespan.

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Key Highlights: Continues..
An immortalized cell line can proliferate indefinitely
either through random mutation or deliberate
modification which are useful especially for production
of therapeutics.
Cell lines are essential for a wide range of applications
including gene function studies, drug discovery assays,
the production of biotherapeutics and diagnostics.
The application for cell lines includes research,
bioproduction and diagnostics.
Among research, cell lines are used for studying
disease, screening, cell-based assays are used during
discovery phase and preclinical development.
Cell lines are used to produce a wide range of
biotherapeutics including vaccine, recombinant
proteins that include peptides, cytokines, hormones and
clotting factors, enzymes and monoclonal antibodies.

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Key Highlights: Continues..
Among cell line type, CHO cell line is the most
frequently used mammalian system, which is used in
the manufacture of more than 57% of currently
approved biologics.
CHO cells have been the industry’s cell line workhorse
for production of biopharmaceuticals.
These cell line has several major advantages being
versatile, relatively easy to work with, having well-
understood glycosylation patterns.
Approximately 26 monoclonal antibodies and 31
recombinant proteins are produced using CHO cell
lines.
The increasing demand for biologics and biosimilars
has increased the demand for production cell lines.
The expiration of blockbuster biologics has also driven
the emergence of biosimilars.

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Key Highlights: Continues..
Companies are working to produce efficient and less
time consuming expression systems and also using
automation and robotics in screening of cell lines to
speed up the process.
The SURE technology platform by Selexis S.A
(Switzerland) has been able to generate stable and high
performing cell lines in three months with productivity
levels of 1-7 g/L for monoclonal antibodies and about 76
drugs in clinical phase and 3 marketed drugs have been
developed.
Biotherapeutics including monoclonal antibodies,
peptides, recombinant proteins, vaccines, blood related
products are produced in a wide variety of platforms,
including non-mammalian expression systems
(bacterial, yeast, plant and insect) and mammalian
expression systems (including human cell lines).

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Report Coverage:
1. Executive Summary
2. Market Dynamics
3. Cell Line Development Services Market, By
Expression System
4. Cell Line Development Services, By Cell Type
5. Cell Line Development Services, By
Application
6. Cell Line Development Technological
Advancements
7. Key Developments
8. Market Share Analysis
9. Company Profiles
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Company Coverage: (Partial List)
1. Abzena Plc
2. Boehringer Ingelheim
3. Catalent Inc.
4. Charles River Laboratories
5. Cook Pharmica
6. Crown Biosciences
7. Fujifilm Diosynth Biotechnologies
8. Genscript Biosciences Corporation
9. Horizon Discovery Group, Plc
10. Jhl Biotech Inc.
11. Lonza Group
12. Merck Kgaa
13. Patheon N.V.
For more details regarding Report coverage see the last slide
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