VACCINE DELIVERY SYSTEM

1. 1
Vaccine Delivery
System
Presented by:-
Maneesh Banyal
( Assistant Professor)

2. Contents…..
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 About vaccines
 Uptake of antigen
 Single shot vaccines
 Mucosal and transdermal delivery of vaccines
 References

3. Vaccination….
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 It is the administration of antigenic material to
stimulate immune system.
 It is the most effective method of preventing
infectious diseases.
 It is largely responsible for the elimination of
diseases such as polio, small pox, measles
and tetanus from much of the world.

4. History …
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 The term vaccine and vaccination are derived
from variolae vaccine ( small pox of the cow),
the term devised by Edward Jenner to denote
cow pox in 1976.
 The second generation of vaccines was
introduced in 1880s by Louis Pasteur who
developed vaccines for chicken cholera and
anthrax.

5. Uptake of antigens …..
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 Antigens generated by endogenous and exogenous
antigen processing activate different effector functions.
 EXOGENOUS PATHOGENS:-
Eliminated by:
antibodies and phagocyte activation by T helper cells
that use antigens generated by exogenous processing.
 ENDOGENOUS PATHOGENS:-
Eliminated by:
killing of infected cells by CTL that use antigens
generated by endogenous processing

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7. Immune system
Myeloid cells Lymphoid cells
How do vaccines work …..
Granulocytic monocytic T cells B cells
Natural killer
cells
Neutrophils
Basophils
Eosinophils
Macrophages
Kupffer cells
Dendritic cells
Helper cells
suppressor cells
Cytotoxic cells
Plasma
cells
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9. Single shot vaccines….
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 The single shot vaccines is a combination
product of a prime component – Antigen with
an appropriate adjuvant – and a microsphere
component that encapsulates antigen and
provides the booster immunizations by
delayed release of antigen.
 The single shot vaccines are prepared by “
NanoMix” technology.

10. Mucosal and transdermal
delivery
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 Iontophoresis
 Sonophoresis
 Elecroporation
 Transdermal nanoemulsion
 Polymer used on transdermal vaccine delivery

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16. References…
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 Aggarwal , G, Dhawan ,S.(2009). Development,
fabrication and evaluation of transdermal drug
delivery system,parmaceuticals scientific
Innovation and research,561(3),5-12
 Hansen, K.J. (2010). Transdermal delivery of
vaccines and therapeutic proteins, fundamentals
vaccine delivery in infectious disease
 Makidon ,P. E. (2009). Oil in water nanoemulsion
as mucosal vaccine adjuvants, development of
nanoemulsion based vaccine. University of
Michigan,(pp. 1-191).

17. Thank you
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