TELOMERES&TELOMERASE UNLOCKING THE SECRET OF ANTI-AGEING

1. TELOMERES&TELOMERASE
UNLOCKING THE SECRET OF
ANTI-AGEING
DR SHARDA JAIN
Consultant Gynaecologist , IVF
& Smart Anti - Ageing

2. • Great Teacher & surgeon ,taught for 2 decades in medical college (PGI Chandigarh , LHMC, Delhi )
• ETHICAL COMMITTEE MEMBER OF MEDICAL COUNCIL OF INDIA
• “TEACHER OF THE TEACHER AWARD” by Delhi Gynaecologist forum 2018
• Life time achievement Award from FOGSI (national organisation of Gynaecologists )
*IMA medical Association
*Lady Harding Medical Collage
*Delhi gynaecologist forum
• *ISAR ( Delhi)
• Founder chairman (for a decade )PushpanjaliCrosslayHospital now Max vaishali
• Founder & director of Lifecare Centre & IVF which is serving east Delhi for last 27 year for GYNAE
care , IVF ,Bariatric surgery , Advanced Lap / Hyst Surgery
• FOUNDER & SECRETARY GENERAL OF DELHI GYNAECOLOGIST FORUM ( 2000 )
• Recognised as Great Medical social worker is behind National movements of Female foeticide ,
Anamia Free India , Adolescent Health , Save uterus, Save girl child etc
NOW HER PASSION 360 * CARE ,DOCTORS TRAINING & SAFETY OF DOCTORS
DR. SHARDA JAIN
M.D. (PGIMER), MNAMS,FICOG,FIMSA,
DHM, QM &AHO
PGDMLS (SYMBIOSIS)

3. OUR BODY IS GOD,s GREATEST
GIFT & NEEDS INVESTMENT & CARE.
• EVERYONE SHOULD CONSIDER HIS /HER BODY AS GREAT PRICELESS
GIFT OF GOD, A MARVELLOUS WORK OF ART…FULL OF MYSTERY
BEYOND HUMAN CONCEPTION.GOOD TO KNOW LITTLE BY LITTLE
• IT IS UPTO US TO TAKE CARE OF IT.
• HEATH,WELLNESS & SMART ANTIAGING IS NOT A MERE PHYSICAL
DIMENTION BUT 360 * CARE—ABOUT METABOLIC PROCESSES
,HARMONAL CHANGES,EMOTIONAL,SOCIAL & SPRITUAL WELL-
BEING.

4. Early adulthood(20-39)
Middle adulthood(40-59)
Late adulthood(60 +)
BUT TO LIVE FOR 100 YEARS & THAT
TOO HEALTHY IS DREAM OF MANY
Lifecare’s Anti-Ageing Centre
ADULTHOOD

5. Ageing has NO mercy

6. Biological clock never stops

7. PRIMARY AGING
• Physiologic changes associated with age.
• Lungs & heart function decreases with age.
Cellular immune system is most affected.
• Liver & kidney functions diminishes as well.
• Decrease in homeostatic reserve & therefore
elderly people cannot tolerate various
diseases stress.

8. CIVILISATION Diseases- Cause
Secondary Aging
• Today there is increased rate of aging which stems
from Life Style diseases & psycho-socio-economic
problems.
• Chronic diseases have mostly replaced acute illness.
• Epidemic of Diabetes, Autoimmune diseases, chronic
CVD .
• Smoking, poor nutrition & lack of exercise is norm.
• To some degree it is Reversible & Controllable so
prevention & early detection is of paramount
importance

9. KNOW DIFFERENT AGEING PROCESSES
1) UNIVERSAL AGEING : age changes that all people face
2) PROBABILISTIC AGEING : age changes that may happen to
some diseases e.g. : onset of type II diabetes,Autoimmune
diseases.
3) CHRONOLOGICAL AGEING : it refers to how old a person is.
4) SOCIAL AGEING : society’s expectations of how people should
act as they grow older.
5) BIOLOGICAL AGEING : an organism’s physical state
as it grows.

10. WHY WE AGE ??

11. WHY WE AGE:MANY THEORIES
• DISPOSABLE SOMA THEORY – We just temporarily house our Genes.
•OXIDATIVE STRESS THEORY – Free radicals cause damage to cells.
•VITAL SUBSTANCE THEORY – A vital substance is limiting.
•GENETIC MUTATION THEORY – Accumulation of mutations cause aging.
•REPRODUCTIVE EXHAUSTION THEORY – After reproduction we die rapidly.
•AGING BY DESIGN THEORY – Aging is programmed. Mitochondrial
•DYSFUNCTION THEORY – Mitochondria become altered.
•THE NEUROENDROCRINE THEORY – Changes in
hormone regulation.

12. Theories on Why We Age:
•WEAR AND TEAR THEORY – Self explanatory
•THE RATE OF LIVING THEORY – Similar to the Vital Substance Theory
•THE WASTE PRODUCT ACCUMULATION THEORY – Self explanatory
•THE CROSS-LINKING THEORY – Proteins such as collagen crosslink.
•THE IMMUNE SYSTEM THEORY – Decreased immune function.
•ERRORS AND REPAIRS THEORY – Inaccurate repair of damage.
•THE ORDER TO DISORDER THEORY – Decreased maintenance of order.
•TELOMERE THEORY OF AGING – Telomere length controls aging.

13. UNDERSTANDING BIOLOGY OF THE
TELOMERES / TELOMERASE
IS THE MOST IMPORTANT EVENT
IN THE HISTORY OF
“ANTI-AGING MEDICINE”

14. “Hayflick’s Contribution
From “HAYFLICK’S LIMIT,” we know that human cell lines
have a “BUILT-IN MORTALITY.”
That means there’s an “INTERNAL AUTHORITY” that sets
the limit on cell division and shuts down the cell line
causing death when the limit is reached.
He did not talk on TELOMERE
Today we know that Mechanism is the telomere
in anti- ageing.

15. Telomeres are seen as
the bright red signals
on the
chromosome end

16. What do Telomeres do?
Telomeres are PROTECTIVE pieces of DNA
material at the ends of chromosomes. Like the
PLASTIC TIPS ON SHOELACES, telomeres
prevent chromosome ends from fraying and
sticking to each other, which would damage
genetic information to cause CANCER, other
diseases or PREMATURE AGEING.

17. Telomere function
Replication Capping
(RED)
SUMMARY OF WHAT TELOMERES DO?

18. Blackburn, Carol Greider and Jack Szostak were
awarded
The 2009 Nobel prize in physiology and
medicine
for the discovery of telomere and telomerase.

19. Telomeres Tell Cells How Old They Are
Gene expression may explain the relationship between
telomere length and aging.
Cells with LONGER TELOMERES behave
like YOUNGER CELLS.
Cells with SHORTER TELOMERES behave
like Older cells.

20. People who are older have
chromosomes that have
replicated more times.

21. Young Cells Have Long Telomeres...
Old Cells Have Short Telomeres
Two Studies Published in the Journal
“Nature”
in 1990 Provided Strong Evidence:
Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of
human fibroblasts. Nature 345:458–460
Vaziri H, Schachter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Harley CB
(1993) Loss of telomeric DNA during aging of normal and trisomy 21 human
lymphocytes. Am J Hum Genet 52:661–667

22. Since then hundreds of published,
peer-reviewed studies show the
relationship between telomere length
and markers of disease, life span and
quality of life.

23. ELIZABETH BLACKBURN
THE NOBEL PRIZE WINNER 2009
THE SCIENTIST GAVE IMPORTANT MESSAGE THAT
LENGTHENING OF THESE TELOMERES WILL
KEEP PEOPLE HEALTHIER FOR LONGER TIME &
SHELVE OFF SOME IMORTANT DISEASES OF AGING

24. Artificial Shortening the Long Telomeres
of Young Cells ACCELERATES Aging

25. WHAT NEXT Breaktrough?
• Dr. Jerry Shay and his colleagues (The
University of Texas Southwestern
Medical Center at Dallas ) found that
CELLULAR AGING CAN BE BY PASSED OR
PUT ON HOLD BY THE INTRODUCTION
OF THE CATALYTIC COMPONENT OF
TELOMERASE.

26. HOW DOES TELOMERASE WORKS?
• Telomerase works by adding back t
Telomeric DNA to the ends of
chromosomes, thus compensating for the
loss of telomeres that normally occurs as
cells divide.
• Most normal cells do not have this
enzyme and thus they lose telomeres with
each division.

28. Telomeres & Telomerase
Activator
Currently in modern medicine the only way to
lengthen telomeres is through the activation of
an enzyme called telomerase. Ta 65
TA-65
TELOMERASE ACTIVATOR
Is it a key to unlocking
the longevity puzzle?
AVAIBLE IN WESTERWORLD
..

29. DID YOU KNOW ?
• Shortened telomeres are found in
many LIFESTYLE Diseases:
– Atherosclerosis
– Heart disease
– Hepatitis
– Cirrhosis
The Abnormal Stress of Modern Life
have been shown to greatly hasten
the reduction of Telomeres.

30. How Do We hasten the Loss of the
Telomere ?
• INFLAMMATION
• OXIDATIVE STRESS
• Homocysteine
• DEPRESSION
• EMOTIONAL STRESS
• Physical Trauma

31. MANY STUDIES NOW AVAILABLE ON
TELOMERE
• RESEARCHERS FOUND EVIDENCE THAT HEALTHY
LIFESTYLE MAY RESULT IN LONG TELOMERES
.
• THE INTENTION OF STUDIES WAS TO EXPLORE THE
RELATIONSHIP BETWEEN COMPREHENSIVE
LIFESTYLE CHANGES ANDITS EFFECT ON
TELOMERE LENGTH .

32. A HEALTHY
LIFESTYLE MAY
LENGTHEN
TELOMERES,
REVERSING
CELLULAR AGING !

33. How to Keep
Telomeres Long
▪ RIGHT EXERCISE
▪ ANTI-OXIDANTS
▪ OMEGA 3 Fatty Acid
▪ Vitamin D3
▪ Don’t Smoke
▪ Weight Management
▪ Stress Managment
▪ Reduce Depression
▪ Reduce Pessimism
▪ Be Happy!

34. WAY TO PREVENT/TREAT LIFE STYLE
DISEASES..& be healthy
Vegetarian
diet
Physical
Exercise
Yoga +
Pranayam
Detoxification
Fasting &
Ayurveda
Purification
of Mind
Meditation DE-
ADDICTION
De-stress
Your self
Confidence
Building
Workshop
Recreational
Exercises
Grace Full Anti Ageing
Autologous
Stem Cell
therapy

35. 360* DEGREE CARE
Detoxification
Antioxidants
HRT
Exercise
Dance
Yoga
Aerobics
Zumba
Walk
GROUP ACTIVITY
Is Best
D*iet
MEDITATION
PRANAYAM
Consultation
Anti- Aging
Physician
*LAB TESTS
*Genomic Tests
*Food Allergy
Test
*Advance Metabolic
Analysis
RE GENERATIVE STEM CELL THERAPY
Cosmetic /
Aesthetic
Issues
O2 Cell RT

36. We leaders are perfect example
that HEALTHY LIFESTYLE + CELLULAR
THERAPY DOES MAGIC.
A bright future awaits you…
Take the first step !

37. THE PROGRAM AT
SMART METABOLIC
A N T I A G I N G C E N T R E
(A UNIT OF LIFECARE CENTRE)
IS NOT ABOUT STEM CELL THERAPY ,WEIGHT LOSS OR LOOKING
GOOD..
IT IS HOLISTIC APPROACH ( 360 * CARE )
TO
A N T I A G I N G
THE BEAUTIFUL PART IS THE EASE TO CLIMB MINI MILESTONES EVERY
PASSING DAY
TO BE HEALTHY ,HAPPY WITH MORE POSITIVE &
PROACTIVE ATTITUDE WITH FULL OF G R A T I T U D E .
FIND EASY WAY FOR
ANTI -AGING

38. THE DREAM IMPOSSIBLE
WAS MADE POSSIBLE ..!!
SINCERE THANKS TO
SMART METABOLIC
ANTI AGING CENTRE
( I UNIT OF LIFECARE CENTRE )
“ IT IS WONDERFUL TO FIND A NEW ME
NO MORE XXL CLOTHES
NO MORE INFERORITY COMPLEX
COMPLIMENTS GALORE!
LOOKING GOOD & FEELING GREAT!!
*SWASTI SHREE *

39. SERVICES OFFERED
SMART METABOLIC
ANTI AGING CENTRE
• ANTI AGING
• BARIATRIC SURGERY
• WEIGHT MANAGEMENT & MONITORING
DIET CORRECTION,EXERCISE,MEDITATION,SLEEP
• STEM CELL THERAPY
• HAIR GROWTH AND REJUVENATION
• BIOIDENTICAL HRT ( MENOPAUSE ,
ANDROPAUSE
• PRP

40. VENUE : 11 GAGAN VIHAR , NEAR KARKARI
A unit of Llifecare Centre
Cure morbid obesity / Diabetes/ fatty Liver /
Metabolic & Function Well being / cell
therapies / Diet Correction /
Nutraceuticals / Aesthetics
Monday to Saturday
Contact No : 965058833 ,01122414049
SMART METABOLIC
ANTI – AGEING CENTRE

41. ADDRESS
11 Gagan Vihar, Near
Karkari Morh Flyover,
Delhi - 51
CONTACT US
9650588339
9599044257
011-22414049
WEBSITE :
www.lifecareivf.in
www.lifecarecentre.in
www.lifecareabs.in
…..Caring hearts, healing hands
ISO 9001:2008
Helpline : 9599044257
Web.www.lifecareivf.in
Helpline : 9910081484
29
Year
In
your
service