This document provides an overview of social media basics for clinical research. It discusses several popular social media platforms like Twitter, Pinterest, Foursquare, and mobile apps and how they can be used in clinical research. For each platform, it provides examples of their purpose and effective uses in research. It encourages connecting with networks, sharing content, and creating value on social media to advance clinical research. Mobile apps discussed include TrialX for finding clinical trials and Webicina. The Mayo Clinic Center for Social Media is also presented as a model for social media use in healthcare.