Kshivets O. Cardioesophageal Cancer Surgery

ARTFICIAL INTELLIGENCE, SYSTEM ANALYSIS AND SIMULATION MODELING IN PREDICTION OF 5-YEAR SURVIVAL OF CARDIOESOPHAGEAL CANCER PATIENTS AFTER COMPLETE LEFT THORACOABDOMINAL ESOPHAGOGASTRECTOMIES Oleg Kshivets, MD, PhD Department of Surgery, Siauliai Public Hospital & Cancer Center, Lithuania The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Abstract ,[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Data ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Radical Procedures ,[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Schemas of Procedures The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

One-Stage Esophagogastroplasty or Esophagoenteroplasty

Schemas of Combined Procedures The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Schemas of D3 Lymphadenectomy The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Survival Rate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

General Cardioesophageal Cancer Patients Survival after Complete Left Thoracoabdominal Esophagogastrectomies (Kaplan-Meier) ( n=150 ) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival ( n=150 )

Results of Univariate Analysis in Prediction of Cardioesophageal Cancer Patients Survival ( n=150 ) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Cox Regression Modeling in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Discriminant Analysis in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Logistic Regression Analysis in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chi2=105.11; df=15; P=0.0000 ; Odds ratio=86.70 The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Correspondence Analysis in Prediction of Cardioesophageal Cancer Patients Survival (n=150) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Multi-Factor Clustering of Clinicopathological Data in Prediction of Cardioesophageal Cancer Patients Survival (n=150) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Neural Networks in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Kohonen Self-Organizing Neural Networks Computing in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150) The 60th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Neural Networks Computing in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) Error=0.0011; Area under ROC Curve=1.00; Correct Classification Rate=100% ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Bootstrap Simulation in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Results of Bootstrap Simulation in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Ratio of Lymphocytes to Cancer Cells & Glucose Level in Prediction of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies (n=150 ) The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Prognostic SEPATH-Model of Cardioesophageal Cancer Patients Survival after Complete Esophagogastrectomies, n=150 The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Holling-Tenner Models of Cardioesophageal Cancer Cell Population and Cytotoxic Cell Population Dynamics

Cardioesophageal Cancer Dynamics

Conclusions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Conclusions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Address: Oleg Kshivets M.D., Ph.D., Consultant Thoracic, Abdominal, General Surgeon & Surgical Oncologist ,[object Object],[object Object],[object Object],[object Object],[object Object],The 60 th Annual Meeting of Society of Surgical Oncology March 15-18, 2007, Washington , DC, the USA

Kshivets O. Cardioesophageal Cancer Surgery

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Kshivets O. Cardioesophageal Cancer Surgery