2. Kiara Cuesta Martínez
Medicine Student
Molecular Biology
Teacher: Lina Martínez
Nestor Caprov. (January 7, 2016).
Profesional.com look. Retrieved
on January 24, 2015, to look
Profesional.com:
http://www.miradaprofesional.com
/ampliarpagina.php?npag=10&id=
1105#.VqXTQprhDIV
Cooper and Hausman, 2005, "The
Cell" (5th ed.), Marban Editorial,
Madrid.
Sync. (January 18, 2016).
Retrieved on January 24, 2016,
Sync, science is
life:http://www.agenciasinc.es/Noti
cias/Estudian-la-distrofia-
miotonica-con-Drosophila-como-
modelo-biomedico
Mouli Chakraborty, Wake Selma-
Soriano, Emile Magny, Juan
Pablo Couso, Manuel Perez-
Alonso, Nicolas Charlet-
Berguerand, Ruben Artero, and
Beatriz Llamusi: Pentamidine
rescues rhythmicity and
contractility in a Drosophila model
of myotonic dystrophy heart
dysfunction. Disease Models &
Mechanisms (2015) 8, 1569-
1578. Doi: 10.1242 / dmm.021428
In both the first news, in studying
the molecular causes of heart
dysfunction in muscular dystrophy,
it has been proposed as a
compound pentamidine the fix,
because it preserves cardiac
phenotypes.
In the case of the second word, it
allows a better understanding of
the regeneration of nerve tissue,
and thus a therapeutic impact to
the exclusive neurons undergoing
division (except in the
hippocampus), that is, enable
addressing of neurogenesis.
3. Because during evolution have
been preserved fundamental
properties of cells, know its
principles and mechanisms of
development has served as a
model for other more complex
organisms.
Furthermore, the handling of
organisms in the laboratory
can use simpler terms of
applicability, scaled down and
study of molecular, genetic,
embryological of different
species.
Argentine scientists working Dante
Border Peace and revealed the key
role of this protein in the production
of neurons from stem cells in the
olfactory system, since the
processes of neurogenesis
observed in specific parts of the
nervous system.
They studied the behavior of brain-
derived neurotrophic factor (BDNF)
in the olfactory epithelium of the
African clawed frog Xenopus laevis,
observing expression in stem cells
and not on it mature.
"Understanding the mechanisms by
which these stem cells are
reactivated to divide and
differentiate into neurons is key to
decrypt and direct the process of
neurogenesis, and thus achieve
progress both basic science as
applied to medicine" he said Paz.
Researchers at the Translational
Genomics group of the University of
Valencia and INCLIVA, led by Rubén
Artero and Beatriz Llamusi have
published a pioneering study to
determine the molecular causes of
cardiac disorders in myotonic
dystrophy (DM).
Melanoganster reproduced in
Drosophila or "fruit fly" typical
symptoms of the disease and
arrhythmias, defects in contractility
and systolic and diastolic
dysfunction, the first two improved
use of pentamidine.
The study analyzed parameters such
as contractility and rhythmicity that
are altered in the DM and proposed
as a possible therapeutic
pentamidine, it reduces the
arrhythmia in insects and preserves
cardiac phenotypes.
4. Thus, there are models such as:
E. coli bacterial species best
studied mechanisms such as gene
expression, protein synthesis, etc.
Arbacia punctulata: gender body
urchins used for studies of
embryology.
Gallus domesticus: Membrana yolk
used for microbiology studies in
yeast.
Among others.
Because during evolution have
been preserved fundamental
properties of cells, know its
principles and mechanisms of
development has served as a
model for other more complex
organisms.
Furthermore, the handling of
organisms in the laboratory
can use simpler terms of
applicability, scaled down and
study of molecular, genetic,
embryological of different
species.
5. Drosophila melanogaster:
Experimental model easily
reproduced in the laboratory, short
breeding cycle (2 weeks)
Study-related genes chromosomes.
Molecular mechanisms governing
animal development.
Cardiac dysfunction of muscular
dystrophy in an animal biomedical
model, Drosophila melanogaster
was studied.
Argentine scientists working Dante
Border Peace and revealed the key
role of this protein in the production
of neurons from stem cells in the
olfactory system, since the
processes of neurogenesis
observed in specific parts of the
nervous system.
They studied the behavior of brain-
derived neurotrophic factor (BDNF)
in the olfactory epithelium of the
African clawed frog Xenopus laevis,
observing expression in stem cells
and not on it mature.
"Understanding the mechanisms by
which these stem cells are
reactivated to divide and
differentiate into neurons is key to
decrypt and direct the process of
neurogenesis, and thus achieve
progress both basic science as
applied to medicine" he said Paz.
6. The DM is the most common type of
muscular dystrophy in adults. It is caused
by a mutation in the DMPK gene, which
causes an increase in the number of
repetitions of the triplet CTG passing of
several hundred copies 5-34, fact that
causes the emergence and disease
development.
7. Pentamidine may interfere with the
incorporation of nucleotides in DNA and
RNA; oxidative phosphorylation and
inhibit biosynthesis of DNA, RNA,
proteins and phospholipids. In addition
to preserving cardiac phenotypes.
9. MY PERSONAL OPINION:
This study seems useful for
understanding the molecular
basis of cardiac disorders, and
therapeutic alternatives, in this
case, pentamidine.
10. Xenopus laevis:
Fundamental study of
embryonic development
of the first vertebrates.
Large and abundant
eggs that develop
outside the mother
(easier to study)
Researchers at the Translational
Genomics group of the University of
Valencia and INCLIVA, led by Rubén
Artero and Beatriz Llamusi have
published a pioneering study to
determine the molecular causes of
cardiac disorders in myotonic
dystrophy (DM).
Melanoganster reproduced in
Drosophila or "fruit fly" typical
symptoms of the disease and
arrhythmias, defects in contractility
and systolic and diastolic
dysfunction, the first two improved
use of pentamidine.
The study analyzed parameters such
as contractility and rhythmicity that
are altered in the DM and proposed
as a possible therapeutic
pentamidine, it reduces the
arrhythmia in insects and preserves
cardiac phenotypes.
11. In African frog Xenopus laevis
response was tested against
damage to the olfactory epithelium
that were performed in the
laboratory. This model has genes in
humans.
.
12. .
The discovery of the
expression of BDNF protein-a
protein that stimulates growth
and differentiation-stem cells
in the olfactory epithelium and
neural cell sustentacular,
would yield information about
neurogenesis takes place.
13. PERSONAL COMMENT:
I think that because of the difficulty that
means no neuronal regeneration
(except in hippocampus and olfactory
epithelium) understand the processes
that lead to neurogenesis in these areas
involves therapeutic possibilities
neurodegenerative diseases.
.
15. Various cells to study
aspects of cellular and
molecular biology are
used; besides the
characteristics and
experimental principles
they are applicable to
other cells.
In both the first news, in studying
the molecular causes of heart
dysfunction in muscular dystrophy,
it has been proposed as a
compound pentamidine the fix,
because it preserves cardiac
phenotypes.
In the case of the second word, it
allows a better understanding of
the regeneration of nerve tissue,
and thus a therapeutic impact to
the exclusive neurons undergoing
division (except in the
hippocampus), that is, enable
addressing of neurogenesis.
16. The study of these cells,
can overcome the difficulty
of understanding such
complex organisms like
humans (200 types of
cells), through experimental
models that share
characteristics.
17. It brings us closer to
understanding the molecular
biology and its application in
therapy .
18. • Néstor Caprov. (07 de 01 de 2016). Mirada Profesional.com. Recuperado el 24
de 01 de 2015, de Mirada Profesional.com:
http://www.miradaprofesional.com/ampliarpagina.php?npag=10&id=1105#.VqXT
QprhDIV
• Cooper y Hausman, 2005, "La Célula" (5ª ed.), Editorial Marbán, Madrid.
• Sinc. (18 de 01 de 2016). Recuperado el 24 de 01 de 2016, de Sinc, la ciencia
es vida: http://www.agenciasinc.es/Noticias/Estudian-la-distrofia-miotonica-con-
Drosophila-como-modelo-biomedico
• MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB.
Fac. de Medicina, 2006. 208 p.
• Mouli Chakraborty, Estela Selma-Soriano, Emile Magny, Juan Pablo Couso,
Manuel Perez-Alonso, Nicolas Charlet-Berguerand, Ruben Artero, and Beatriz
Llamusi: Pentamidine rescues contractility and rhythmicity in a Drosophila model
of myotonic dystrophy heart dysfunction. Disease Models & Mechanisms (2015)
8, 1569-1578. Doi:10.1242/dmm.021428
