This is a journal reading and analysis on aerosol therapy.

1. DELA PEÑA, K.
JOURNAL READING ON
AEROSOL THERAPY

2. Aerosol delivery aspects within a
highflow therapy system in COPD
patients
JOURNAL TITLE

3. Madney, Laz, Elberry, Rabea, and
Abdelrahim (2020) hypothesized that high-
flow therapy systems can provide the
respiratory support required by critically ill
patients.
On current problems. High-flow therapy is
efficient but requires temporary stopping of
gas flow to the patient.
SUMMARY

4. On methods. Madney et al (2020) investigated
the effects of a high-flow nasal cannula
(HFNC), a high-flow valved facemask (HFM),
and a high-flow mouthpiece (HMP) in terms of
lung deposition and systemic bioavailability of
salbutamol to manage COPD exacerbations.
SUMMARY

5. On result discussion. The use of HFNC was
reported to be the least efficient in terms of
delivering salbutamol to the lungs. Total
delivered salbutamol dose from 30-min and
24-urine samples were significantly lower
compared to HFN and HMP interface results.
However, reports show that the tolerability to
HFNC was higher receiving only 8% of patient
complaints while HFN and HMP received
33.3% and 50% patient complaints
respectively.
SUMMARY

6. In conclusion, amid significant differences in
drug deposition, all interfaces showed similar
lung function improvements. One deciding
factor of using these interfaces then depends
on patient comfort and tolerability.
SUMMARY

7. MY REACTION