2. Agenda
• Working group progress update
• Priorities for future research
o Review potential studies
o Other research ideas
o Setting priorities
• Additional items
4. Progress update
• Published studies
o Manise M, Bakayoko B, Schleich F, Corhay JL, Louis R. 2016. IgE
mediated sensitization to aeroallergens in an asthmatic cohort:
relationship with inflammatory phenotypes and disease severity. The
International Journal of Clinical Practice. 70 (7): 596-605
5. Active study update: Quantify the burden of acute
versus chronic rhinosinusitis in routine clinical practice
(REG_P001)
Objective
• Quantify the burden of rhinitis and
rhinosinusitus and characterize related
management approaches in UK primary care
• assess the incidence of acute and chronic
rhinosinusitis and rhinitis in current clinical
practice
• Assess the number of consultations for rhinitis
and rhinosinusitis and that result in a prescription
of an antibiotic, steroid or antihistamine
Methodology
Design: Retrospective cohort using OPCRD
Population: Consultations coded for rhinitis and
rhinosinusitis symptoms resulting in prescriptions
for antibiotics, oral steroids and/or antihistamines
in the last 5 years.
7. Conclusions
• In the OPCRD, acute rhinosinusitis consultations make up 35% of
all primary care consultations for rhinitis and rhinosinusitis
• Interestingly, almost three-quarters of patients (71%) consulting
for acute rhinosinusitis and 58% of patients with chronic
rhinosinusitis receive an antibiotic prescription
Paper in draft format (Prof. Fokkens)
8. Australian Survey of Allergic Rhinitis Sufferers
(REG-RES1615)
Aim
To build and disseminate a comprehensive picture of the burden and unmet
need of allergic rhinitis patients in Australia.
Methodology
Design: Online survey with discrete choice experiment with patients
recruited through specialist recruitment agency
Inclusion criteria:
• Self-reported diagnosis of allergic rhinitis by a medical professional.
• 18 years of age or older
• Currently resident in Australia
• Able to give informed consent
• Able to complete the protocol requirements
9. Australian Survey of Allergic Rhinitis Sufferers
(REG-RES1615)
• In total 1151 participants completed the survey, of those 621
(54%) were symptomatic on the day of completing the survey.
• Most of the sample (N=1016, 88%) used medication to treat their
AR
• Most participants (80%) use more than one medication
• Two thirds of participants see a doctor or specialist for their AR
• Only 13% of participants had received immunotherapy for their
AR, this was most commonly for grass pollen (66%) or dust mite
(62%) allergies
10. Australian Survey of Allergic Rhinitis Sufferers
(REG-RES1615)
• In discrete choice analysis, participants showed a strong
preference for:
o a treatment that provides complete symptom relief compared to mild
symptom relief (OR:12.069; 95% CIs: 10.674 - 13.646; WTP: $73.63)
o a treatment that provides moderate symptom relief compared to mild
symptom relief (OR:2.584; 95% CIs: 2.431 - 2.747; WTP: $28.07)
o a treatment that is taken once a day compared to three times a day (OR:
0.643; CIs: 0.607 – 0.681: WTP: -$13.06)
o administration attribute (tablets and nasal spray compared to nasal spray
alone) was not a significant predictor of choice
11. Future interests
• Two projects with short proposals
• Four other potential project ideas
12. Working title
Burden of allergic diseases
Objective
1. Improve understanding of the true burden of allergic
disease
2. Gain evidence to inform improved consumer
guidance in the future
Rationale
• A substantial proportion of patients with allergic
disease do not present in primary care; instead
purchase OTC therapies from the pharmacy.
• To understand the true burden of allergic disease there
is a need to evaluate the burden of allergic disease
presenting in the pharmacy setting as well as in
clinical practice.
Evaluate the burden of allergic disease study from the multi-stakeholder
(primary case, secondary care, pharmacy) perspectives (REG_P016)
Proposed by Dermot Ryan; 2016
Proposed methodology
Design: Questionnaire based study within the pharmacy
setting with digital data collection
13. Objective
1. To characterise people with asthma in primary care prescribed at
least one course of oral steroids in the preceding 12 months
based on their medication profile and asthma management
practices.
2. To identify the patient-related factors associated with oral steroid
use.
Proposed methodology
Design: This will be a retrospective, real-world, cross-sectional observational study using
data extracted from the OPCRD
Population: Adult (18-70 years) asthma patients
Exclusion criteria: People with a diagnosis of COPD
Evaluate the prevalence and clinical implications of comorbid nasal
and bronchial hyper responsiveness in patients managed in a range of
settings (primary care, specialist/secondary care, pharmacy)
(REG_P017)
Working title
Characterising the factors associated with oral steroid use by
patients with asthma in primary care.
Proposed by Sinthia Bosnic-Anticevich; 2016
Rationale
• Suboptimal asthma medication use is fundamental in poor
asthma control.
• To date we do not know whether people with asthma make
decisions not only about whether they will take their
medications, but which medications they chose to take when
they experience poor asthma control.
• By identifying the factors associated with oral steroid use, we
may be able to distinguish patients with severe asthma from
those with less severe asthma who have inappropriate
asthma management practices.
14. Potential projects with no proposals
• REG_P018: Real-world effectiveness of allergen immunotherapy
• Link between severe asthma and allergic/nasal symptoms
o REG to look at questions on ISAR dataset, and in OPCRD.
• EUFOREA App:
o Potential validation study through REG allergy working group. Overlap
with Technologies and Asthma working groups.
• REG project to validate EUFOREA clinical project on reasons for
uncontrolled disease.
o Study nearly completed
15. Other research ideas?
• Real-life impact of sinus surgery on the following relevant
parameters
o Asthma
o Oral AB/CS use
o Absenteism
• Exploratory study on the patients’ ideas / feedback on mHealth tools
and what these tools could mean for them
o Rhinosinusitis
o Astma
16. Setting priorities
• Are these projects still:
o Relevant?
o Feasible?
o Valid?
o A priority?
• How do we set priorities in allergy research?
o Close collaboration with patients / organizations
o Brainstorming during ERRF, Nov. 2017
• How to we ensure these priorities are pursued?
o Project leader + post-doctoral researcher + REG responsible per project
• What are the two most important projects to push forwards?
o MySinusitisCoach
