Case Study

1. Multiple Sclerosis Case Study
Katelyn Weimerskirch

2. Consider the Following Patient…
• 28 year old, Monica, presents with fatigue, muscle
pain, weakness, and numbness, and dizziness. After
talking with a doctor who asked her more questions
regarding her health, she admitted to an unstable
mood, occasional bowel and bladder dysfunction, and
balance and coordination issues.

3. Diagnosis
•What would you initially diagnose Monica
with?

4. Multiple Sclerosis

5. Biochemistry
• Autoreactive CD4+ T helper cells activate which increases immune
response.
• The activated CD4+ T cells and proinflammatory cells cross the blood
brain barrier.
• The cells produce proinflammatory cytokines and interferon-gamma.
• They then active microglia and astrocytes which induces myelin
phagocytois.
• Myelin phagocytosis increase the reactivation of CD4+ cells, causing a
feedback loop.

7. Treatment options for Symptoms
• There is no cure for MS
• Physical therapy/Speech therapy/Occupational therapy
• Immunosuppressive drugs to reduce the immune response
• Steroids to reduce inflammation

8. References
• http://pt851.wikidot.com/multiple-sclerosis-cell-bio