12. Sacroiliac Joint
âstructural Lesions
X rays and CT only show chronic lesions
FORESTIER CLASSIFICATION
â˘âŻ Stade I - Broaden joint
â˘âŻ Stade II - stamps
â˘âŻ Stade III - cloody
â˘âŻ Stade IV - Fusion
15. Sacroiliac Joint
â Structural Lesions
FORESTIER CLASSIFICATION
â˘âŻ Grade I - Pseudo â ĂŠlargissement
â˘âŻ Grade II - Timbre â poste
â˘âŻ Grade III - Aspect marĂŠcageux
â˘âŻ Grade IV - Fusion
16. SpA Diagnostic
Several diagnostic criteria based on
clinical and radiological signs
AMOR
ESSG
European
Spondylarthropathy
Study Group
New York
modifiĂŠ
Existence of an X-ray, at least, sacroiliitis grade
2 bilaterally or grade 3 unilateral
ASAS
Assessment of
SpondyloArthritis
international
Society
Sacro-iliite IRM
ou radiographique
18. 2009 ASAS Criteria
axial spondyloarthritis
chronic Lombalgia and < 45 year-old
And
MRI or Xray
Sacroiliitis + 1 ĂŠlĂŠment
arthritis
enthesitis
uveitis
dactylitis
or
HLA B27 +
+ 2 ĂŠlĂŠments
Psoriasis
AINS good Reponse
EnthĂŠrocolopathy
High CRP
family history
HLA B27
19. Our patient
axial spondyloarthritis
chronic Lombalgia and < 45 year-old
And
MRI or Xray
Sacroiliitis + 1 ĂŠlĂŠment
arthritis
enthesitis
uveitis
dactylitis
or
HLA B27 +
+ 2 ĂŠlĂŠments
Psoriasis
AINS good Reponse
EnthĂŠrocolopathy
High CRP
family history
HLA B27
20. inflammatory lesions / ASAS criterias
sub chondral Ĺdema on 2 concecutive slices or 2
localisations on the same slice (STIR)
(Rudwaleit M et al. Ann. Rheum.Dis.2008)
24. Diagnostic value of MRI
Sensitivity ?
SI MR+ in 75% SpA patients
Weber
 U
 et
 al
 Eular
 2013
 OP
 273
Â
Specificity ?
inflammatory Signal in 11% of the control patients
Aydin et al. Ann Rheum Dis 2012
Edema and fatty infiltration in 27% of the control patients
U Weber et al; Arthritis & Rheum; octobre 2010
retrospective study : 110
p. (28 SPA)
Abnormality in 21% of the control patients
C Cyteval Skeletal Radiology 2013
25. Questions
â˘âŻ
Will they have an interest in stopping the
NSAID before MRI?
â˘âŻ If the MRI is the first SI â⯠Should we repeat the MRI SI later?
â⯠Should we do an MRI of the spine (or after a
negative MRI SI)?
26. Faut-il arrĂŞter les AINS avant lâIRM?
Evolution of edema with anti TNF
A. Larbi â J Malghem 2010
27. Should we stop NSAIDs before the MRI?
20 patients with SpA treated by NSAIDs (etoricoxib)
â˘âŻ MRI lumbar spine and SI to S0 and S6 (20 patients)
â˘âŻ 15/20 patients (71%) had lesions on MRI S0 (63 lesions in total)
â˘âŻ 12/20 (60%) responders
â˘âŻSI : S0 : 11 MRI + (25 lesions) Ă ď S6 : 9 MRI + (22 lesions)
â˘âŻSpine: A S0 : 11 MRI + (38 lesions) Ă ď S6 : 9 MRI + (36 lesions)
Low impact of etoricoxib on inflammatory
lesions in MRI, even if clinical improvement
Jarre4
 SJ
 et
 al.
 Ann
 Rheum
 Dis
 2009
Â
28. Should we stop NSAIDs before the MRI?
INFAST Study Design
Part I: Treatment Phase
Screening
/Washout
â˘
â˘
Â
Â
Â
Â
Â
Â
Â
Â
2:1 randomization
IV infusions: weeks 0, 2, 6, 12, 18,
Â
Â
 and 24
 Anti TNF+ AINS
Â
 Placebo + AINS
M0
Â
 MRI
105 p
51 p
M6
Â
 MRI
ET=early termination; IFX=infliximab (anti TNF); IV=intravenous; NPX=Naproxen (AINS); PBO=placebo.
29. Should we stop NSAIDs before the MRI?
Characteristic
Gender,male
Anti TNF+
AINS
Anti TNF+
AINS
a
Placebo+
AINS
Placebo+
AINS
b
(N=105)
M0
M6
69%
(N=51)
M0
M6
78%
Age,years,mean(SD)
31.7(8.51)
30.7(7.34)
Years since symptom
onset,mean(SD)
1.76(0.896)
1.91(1.439)
Spine
SI joint
Spine or SI joint
59%
88%
91%
40%
72.4%
21.9%
Patients with readable MRIs and
active
Lesions ats creening
BASFI=Bath Ankylosing Spondylitis Functional Index; HLA=human leukocyte antigen.
aFor disease characteristics, N=106. bFor disease characteristics, N=52.
59%
90%
94%
54.9%
93.9%
100%
30. Should we stop NSAIDs before the MRI?
Seems that the response is NO
31. Should we repeat the MRI SI later?
â⯠68 patients with recent inflammatory back pain (38% men, age
34.9 Âą 10.3 years)
â⯠MRI SI M0, M24
â⯠44 with negative MRI at baseline
â 15% became +
â⯠24 with positive MRI at baseline
â 30% became-
Van
 den
 Berg
 ACR2012
 (SPACE)
Â
32. Should we repeat the MRI SI later?
157 subjects with chronic back pain <2 years, beginning before age 45
90 with a diagnosis of SpA
MRI M0 and M3
â⯠MRI - : 71/90
â⯠MRI + : 19/90
5/71 MRI + M3
4/19 MRI-M3
diagnosis became + in only 2 patients
Van
 Onna
 et
 al.
 Ann
 Rheum
 Dis
 2011;70:1981-Ââ1985
33. Should we repeat the MRI SI later?
Downloaded from ard.bmj.com on April 15, 2013 - Published by group.bmj.com
Extended report
ccording to the ASAS/OMERACT MRI
tients with early inďŹammatory low back
SpAC
1 Year
2 Years
HLA-B27 positive
+
+
â
+
â
NA
NA
NA
â
â
â
+
+
+
NA
+
NA
+
â
â
+
â
NA
â
+
NA
+
â
NA
NA
8
4
2
0
0
1
0
1
6
0
3
1
0
2
3
s Society; ESpAC, Early Spondyloarthritis Cohort;
7; NA, not available; OMERACT, Outcome
cal Trials.
d either one or two follow-up MRI.
5%), the MRI became positive at 1
HLA-B27-positive patient of these
ed positive at 2 years follow-up, in
nt the MRI became negative again
wo HLA-B27-negative patients the
ars follow-up and in two HLA-B27-
Figure 1 Likelihood of a positive MRI at any time point in patients with
short-standing inďŹammatory back pain assessed at baseline, 1 year and
2 years of follow-up in function of HLA-B27 status and gender. HLA-B27,
human leucocyte antigen B27.
Predictors "positivation" if initially normal MRI: Male,
B27
The likelihood of a positiveVan
 Onna
 et
 al.
 Ain the case
MRI is negligible (<5%) nn
 Rheum
 Dis
 2011;70:1981-Ââ1985
Â
Â
34. Should we repeat the MRI SI later?
Seems that the response is NO for female
Possible for male
35. Should make sacroiliac and / or spine MRI?
Patients avec atteinte axiale
symptomatique(n=362)
SA axiale nonradiologique (n = 160)
SA axiale radiologique =
SA (n = 202)
43,8 %
63,5 %
36,3 (10,3)
39,1 (11,3)
Duration of the ilness (ans) [DS]
5,7 (6,8)
11,2 (10,0)
BASDAI (0-10) [DS]
4,1 (2,0)
4,3 (2,0)
78,0 %
86,9 %
Males
Ăge (ans) [DS]
HLA B27+
%
Â
90
Â
80
Â
70
Â
60
Â
50
Â
40
Â
30
Â
20
Â
10
Â
0
Â
p
 =
 0,978
Â
77,8
 %
Â
76,7
 %
Â
(112/144)
 (132/172)
Â
No
 X
 Rays
 sign
 of
 sacroilii's
Â
p
 =
 0,004
Â
56,3
 %
Â
(54/96)
Â
28,8
 %
Â
(17/59)
Â
MRI
 ac've
 sacroilii's
Â
Active MRI inflammatory
lesions spinal
Sacroilii's
 seen
 on
 X
 Rays
Â
p
 =
 0,569
Â
6,8
 %
Â
(3/44)
Â
10,0
 %
Â
(6/60)
Â
Active MRI inflammatory lesions
spinal (without sacroiliitis)
Whatever the clinical, sacroiliac MRI seems to be the most profitable review. Only
6.8% of non-radiological axial SA have isolated spinal inflammatory lesions
without sacroiliitis
Rudwaleit-Ââ
 Song
 -ÂâACR
 2010
 -Ââ
 (519)
Â
36. Should make sacroiliac and / or spine MRI?
â˘âŻ Reading MRI of the spine in addition to the SI increases the number of nonradiographic forms that are ultimately recognized positive MRI compared to
reading only SI
Sog IH et al. Arthritis Rheum 2008
â˘âŻ It increases quite significantly the number of false positives (mechanical or
healthy)
â˘âŻ In addition it allows to diagnose other causes of lumbar pain
37. Protocole
â˘âŻ Sacro iliac joint :
â⯠coronal T1- STIR
â⯠Axial STIR
â˘âŻ Spine from T7 to L5:
â⯠Sagittal STIR (or Fat sat T2)
38. â˘âŻ 37 year old woman with inflammatory low back
pain rate
46. Inflam. Rh.
<45 y ears
HyperParaTh
drugs
Sacro-iliac(s)?
Osteoarthritis
Teenager:
>45 years
Pseudo-enlargment
< 20 years
When growth has not finished
Infectious
47. â˘âŻ 67 years old woman with Kidney
insufficiency for 17 years
2rd hyperparathyroidism
57. Inflam. Rh.
<45 years
HyperParaTh
Kidney insufficiency
Sacro-iliac(s)?
Infectious
Osteoarthritis
Teenager:
Pseudo-enlargment
< 20 years
>45 years
Para articular bone
59. Inflam. Rh.
<45 years
HyperParaTh
Kidney insufficiency
Sacro-iliac(s)?
Infectious
Osteoarthritis
Teenager:
Pseudo-enlargment
< 20 years
>45 years
Para articular bone
60. Mr B., 20 years old
Inflammatory Low back pain
67. IsotrĂŠtinoĂŻne and bones
â˘âŻ Sacroiliitis : seldom
*E. Eksioglu et al., Sacroiliitis and polyneuropathy during isotrtinoin treatment 2007
*Elias et al.,Acne fulminans and bilateral seronegative sacroiliitis triggered by isotretinoin 1991
*Bachmeyer et al., Isotretinoin induced bilateral sacroiliitis 2003
68. â˘âŻ Diffuse Idiopathic Skeletal Hyperostosis like
Hyperostosis and calcification of tendons and ligaments
Bone bridges along the anterior longitudinal ligament (6
vertebrae at least)
*J. DiGiovanna et al., Isotretinoin effects on bone