Ready-to-use Pre-Made Oncolytic Virus Product.pdf
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Creative Biolabs has built a state-of-the-art oncolytic virus engineering platform which provides a series of purified pre-made oncolytic virus for reporter-encoding, cytokine-expressing, immune checkpoint antibody-arming, capsid-modifing and miRNA-expression. https://www.creative-biolabs.com/oncolytic-virus/pre-made-oncolytic-virus.htm
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Ready-to-use Pre-Made Oncolytic Virus Product.pdf
- 2. Contents Definition of Oncolytic Virus Immunotherapy History of Oncolytic Virus Immunotherapy Properties of Oncolytic Viruses Mechanism of Action of Oncolytic Viruses Clinical Trials of Oncolytic Virus Immunotherapy Approved Oncolytic Virus Immunotherapy Oncolytic Virus Combination Therapy
- 3. Oncolytic virus immunotherapy is a therapeutic approach to cancer treatment that utilizes native or genetically modified viruses that selectively replicate within tumor cells. Definition of Oncolytic Virus Immunotherapy
- 4. History of Oncolytic Virus Immunotherapy
- 5. Properties of Oncolytic Viruses ss/ds DNA or RNA genome ability to infect host cells and replicate directly infect and lyse tumor cells in situ do not require tumor-associated antigens in the vector
- 8. Mechanism of Action of Oncolytic Viruses entry into cancer cells exploit cancer immune evasion pathway directly lytic effect on tumor cells induce systemic anti-tumor immunity target oncogenic pathways
- 9. Oncolytic viruses entry into cancer cells
- 10. Oncolytic viruses exploit cancer immune evasion pathways
- 11. Oncolytic viruses induce local and systemic anti-tumor immunity
- 12. Oncolytic viruses can target oncogenic pathways
- 13. Clinical Trials of Oncolytic Virus Immunotherapy
- 14. Key oncolytic viruses in clinical trials
- 15. Approved Oncolytic Virus Immunotherapy Virus Trade name Developer Indication Approval Ad5 H101 安柯瑞Oncorine® ECHO-7 2014 2015 2016 2005 HSV-1 2015 2015 Nasopharyngeal carcinoma Melanoma Metastatic melanoma
- 16. Oncolytic Virus Combination Therapy Combination with Adoptive T Cell Therapy Combination with Immune Checkpoint Inhibitors Combination with Cytokines Combination with Cancer Vaccines Combination with Chemoradiotherapy
- 17. Combination with adoptive T cell therapy
- 18. Combination with immune checkpoint inhibitors
- 20. Immunostimulatory transgenes encoded by oncolytic viruses Combination with cytokines
- 21. Combination with cancer vaccines
- 22. Thanks!