1. Ibogaine in the treatment of chronic hepatitis C Howard S. Lotsof. President Dora Weiner Foundation Staten Island, NY http://www.doraweiner.org 6th National Conference on Harm Reduction Oakland, California, November 2006

3. Tabernanthe iboga shrub

4. Roots contain ibogaine

5. Total Alkaloid Extract Large piece 2cm x 2cm, approx 4 grams Estimate 15% ibogaine Courtesy Sara Glatt

6. Ibogaine HCl 99.4% purity

7. Hepatitis C (HCV) timeline 1973: Non A, Non B hepatitis is described 1989: HCV RNA virus identified 1990: Anti HCV effects of ibogaine reported 2005: Patent application for ibogaine to treat chronic HCV

8. HCV infection Most common viral infection in the United States New infections per year 1990 - 242,000 New infections per year 2001 - 25,000 New infections per year 2004 - 25,000 Greater than 75% of IVDUs test positive

12. Opioids

13. Cocaine

14. Alcohol

15. Nicotine

17. HCV patent application

18. Example 1 Report A thirty-three year old male diagnosed with HCV and using 1/4 gram of heroin a day was administered 25 mg/kg ibogaine HCl. Following administration of ibogaine heroin use ceased along with swelling of the liver and pain in the area of the liver.

19. Example 2 Liver enzyme values reduced by 14 mg/kg ibogaine Enzyme Pre Post ALT 410 50 AST 201 25 GGT 155 33

20. Example 3

21. Example. 4 A forty-two year old female testing positive for HCV RNA type 3. RNA IU/ml was 12,600,000. Subject was administered a total of 27 mg/kg ibogaine HCl in the following regimen: 6 x 2 mg/kg 1 x 12 mg/kg 1 x 3 mg/kg HCV RNA IU/ml was reduced to 50,100. Prior to ibogaine treatment patient’s urine was dark and stool light. Post treatment color of urine and stool returned to normal.