Zambia has a significant HIV epidemic, with an adult prevalence of 14.3% nationally. Prevalence is higher in urban areas and among women. The key drivers of the epidemic include multiple and concurrent sexual partnerships, low condom use, low male circumcision rates, mobility and labor migration, and vulnerabilities of groups like sex workers and men who have sex with men. The response has included programs to increase counseling and testing, condom use, and male circumcision, but challenges remain in changing cultural practices, empowering women, and ensuring program sustainability.