Computational Model for Deposition, Clearance and Dosimetry of Inhaled Aerosols and Radionuclides in the Human Lung

Hussain Majid Supervisor: Prof. Dr. Werner Hofmann Computational Model for Deposition, Clearance and Dosimetry of Inhaled Aerosols and Radionuclides in the Human Lung

This presentation will cover ,[object Object],[object Object],[object Object]

Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dust Smoke Fume Mist Clouds Pesticides NO HC CO 2 CO SO 2

Lung deposition calculations-Importance ,[object Object],[object Object],[object Object]

Human Lung Head airway (HA) Air is inspired through nose or mouth down to larynx and rest of the lung. Tracheaobronchial (TB) Bronchial tree is the first part of the lung. This part directs air in to the lung Each branch in the tree splits into 2 parts Alveolar or Pulmonary (Al) Alveoli are located at the end of the bronchial tree and is region where gas exchange occurs. Parent Branch Major daughter Minor daughter Bifurcation

Lung deposition mechanisms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Naso-pharyngeal: impaction, sedimentation, electrostatic (particles > 1 μm) Tracheo-bronchial: impaction, sedimentation, diffusion (particles < 1 μm) Pulmonary: sedimentation, diffusion (particles < 0.1 μm)

Factors that effect deposition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Numbering scheme of asymmetric lung model of Raabe et al. (1974). Particle properties

Particle Clearance mechanisms ,[object Object],[object Object],Particle Clearance mechanisms : The Naso-pharyngeal Compartment: • mucociliary clearance (transport back to nasopharynx ) • mechanical clearance (sneezing, coughing, swallowing) • absorption into circulation (soluble particles). The Tracheo-bronchial Compartment: • mucociliary clearance (transport to oropharynx) • endocytosis into peribronchial region (insoluble particles) • absorption into circulation (soluble particles) The Pulmonary Compartment: • alveolar macrophage mediated clearance • endocytosis by lung epithelial cells into interstitum • absorption into circulation (soluble particles)

Stochastic Lung Dosimetry Model- IDEAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Intersubject variability of particles deposition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Intersubject variability of particles deposition

Intersubject variability of bronchial doses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Intersubject variability of bronchial doses Effect intersubject variations of breathing conditions on particle deposition on left side figure and the corresponding probability distribution of weighted epithelial doses (right figure). distributions of target cellsa cross epithelial tissue.

Dosimetry for inhaled radionuclides ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Particle residence times according to the updated model are calculated stochastically in the acinar region to find total disintegrations in alveolar compartments.

Dosimetry for inhaled radionuclides ,[object Object],[object Object],[object Object]

Comparison of stochastic particle lung deposition with experimental data ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dosimetry for inhaled particles ,[object Object],[object Object],[object Object],[object Object]

Aerosol size distribution, mass concentration measurement and lung deposition calculations for Pakistani cities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],Aerosol size distribution, mass concentration measurement and lung deposition calculations for Pakistani cities

Aerosol size distribution, mass concentration measurements and lung deposition calculations for Pakistan cities ,[object Object],[object Object],[object Object],[object Object]

Conclusion ,[object Object],[object Object],[object Object]

Computational Model for Deposition, Clearance and Dosimetry of Inhaled Aerosols and Radionuclides in the Human Lung

Empfohlen

Empfohlen

Weitere ähnliche Inhalte

Was ist angesagt?

Was ist angesagt? (20)

Andere mochten auch

Andere mochten auch (20)

Ähnlich wie Computational Model for Deposition, Clearance and Dosimetry of Inhaled Aerosols and Radionuclides in the Human Lung

Ähnlich wie Computational Model for Deposition, Clearance and Dosimetry of Inhaled Aerosols and Radionuclides in the Human Lung (20)

Kürzlich hochgeladen

Kürzlich hochgeladen (20)

Computational Model for Deposition, Clearance and Dosimetry of Inhaled Aerosols and Radionuclides in the Human Lung