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Lifecycle Nutrition: Pregnancy
         and Lactation
        TA: Helen Corless
Nutrition before Pregnancy

             • Maintain a healthy
               weight
             • Nutrient status
               –   Folate
               –   Iron
               –   Vitamin B12
               –   Vitamin A
             • Chronic conditions
             • Substance use
Nutrition & Male Fertility

• Weight
• Zinc
• Antioxidants
• Alcohol
Fetal Development
Physiology of Pregnancy
• Fetal growth:
  – Zygote: fertilized ovum
  – Blastocyst: first 2 weeks
     • Cells differentiate into fetus & placenta
  – Embryo: weeks 2-8
     • Development of organ systems
  – Fetus: week 9-delivery
     • Growth
  – Newborn
Physiology of Pregnancy
• Placental Development
  – Placenta: metabolically active organ
    • Interwoven fetal and maternal blood vessels
    • Exchange of oxygen, nutrients, and waste
      products
  – Amniotic sac
  – Umbilical cord
Placental Development
Stages of Development
Day 23
   • 2mm long (=)
   • Beginning
     development of
     major organs
   • Critical stage for
     neural tube
     development
Day 28
   • 6mm long (===)
   • At this point, the
     heart is beating,
   • Lim buds will form
     the arms and legs
Week 9
   • 44mm long
   • Embryo has become a
     fetus
   • Complete CNS,
     beating heart,
     digestive system, well-
     defined fingers and
     toes, beginnings of
     facial features
Week 12
    • 82mm long, weighs
      about 1oz
    • Arms, hands,
      fingers, legs, feet
      and toes formed
    • Organs grow and
      mature
    • Less affected by
      nutritional
      deficiencies
Week 26
    • 250mm long,
      weighs 2-3 lbs
    • 3rd trimester
    • Rapid growth
    • Able to survive if
      born prematurely
      – Lungs
      – Nutrient stores
      – Feeding
Week 40
    • Baby ready to be
      born
    • Less amniotic fluid,
      baby almost fills
      uterus
    • Plump arms and
      legs
• Full term fetus usually weighs between 7
  and 9 lbs at birth
• Full term: 38-42 weeks
Definition of a
        Successful Pregnancy
• Gestation at least 37 weeks
  – Lung development
• Birth weight >5.5 lb
• Otherwise
  – Low birth weight (LBW)
  – Small for gestational age (SGA)
  – Preterm vs. SGA
     • Potential for catch-up growth
     • Malnutrition
If a baby is born at 38 weeks and
weighs 4lbs, he/she would be
considered:

a)   Low birth weight (LBW)
b)   Small for gestational age (SGA)
c)   Preterm
d)   Both a and b
e)   All of the above
If a baby is born at 38 weeks and
weighs 4lbs, he/she would be
considered:

a)   Low birth weight (LBW)
b)   Small for gestational age (SGA)
c)   Preterm
d)   Both a and b
e)   All of the above
Critical Periods
• Times of intense development and
  rapid cell division
  – Cellular activities can occur only during
    these times
• Organ and tissue development
  most vulnerable to adverse
  influences
• First trimester
Neural Tube Development
• Critical period is 17-30 days gestation
• Most women unaware they are
  pregnant during this time
• Vulnerable to
  – Nutrient deficiencies
  – Nutrient excesses
  – Toxins
Neural Tube Defects
       • Anencephaly
         – Brain either missing
           or fails to develop
       • Spina bifida
         – Incomplete closure of
           spinal cord and its
           bony encasement
       • Affects 30/100,000
         newborns in US
Neural Tube Development
Spina Bifida
Neural Tube Defects
• Cause unknown
• Risk factors
  – Family history
  – Maternal diabetes
  – Maternal obesity
  – Anti-seizure medications
  – Mutations in enzymes
Which of the following has been
shown to prevent neural tube
defects?

a)   Vitamin B12
b)   Vitamin D
c)   Calcium
d)   Folate
Which of the following has been
shown to prevent neural tube
defects?

a)   Vitamin B12
b)   Vitamin D
c)   Calcium
d)   Folate
Folate Supplementation
• Prevents & reduces severity of neural
  tube defects
• Folate status important prior to
  pregnancy and during 1st trimester
• RDA: 600 micrograms
• Fortification of grains
  – 50% of pregnancies are unplanned
Fetal Programming
• Adverse influences at critical stages
  in utero may set the stage for chronic
  disease development later in life
• Maternal nutrition status may change
  gene expression in fetus
• Examples:
  – beta cell growth and diabetes
  – blood vessel growth, lipid metabolism
    and CVD
Maternal Factors
Physiology of Pregnancy
       • Organ & tissue enlargement
           – Breasts
           – Uterus
           – Adipose tissue
       •   BMR increases
       •   Circulatory system changes
       •   Joint flexibility
       •   Fluid retention
           – Estrogen
How much weight should a healthy-
weight woman carrying a single
fetus gain during pregnancy?

a) 5-15 pounds
b) 15-25 pounds
c) 25-35 pounds
d) 35-45 pounds
How much weight should a healthy-
weight woman carrying a single
fetus gain during pregnancy?

a) 5-15 pounds
b) 15-25 pounds
c) 25-35 pounds
d) 35-45 pounds
Maternal Weight
• Birth weight is most reliable indicator
  of infant health
• Maternal weight prior to conception
  influences fetal growth
  – Underweight
    • Risk of LBW, preterm, infant death
  – Overweight and obesity
    • Medical complications for mother
    • Risks for infant
Maternal Weight
• Weight gain during pregnancy
  – Correlates closely to infant birth
    weight
  – Recommendations (single birth)
     • Healthy weight: 25-35lbs
     • Underweight: 28-40lbs
     • Overweight: 15-25lbs
  – Most women gain more than
    recommended!
Maternal Weight Gain




•Normal: 3.5lbs in 1st tri, then 1lb/week after that
•Underweight: 5lbs in 1st tri, then just over 1lb/week
•Overweight: 2lbs in 1st tri, then 2/3lb per week
What makes up the weight?
• Weight gain supports growth and
  development of…
  – Placenta
  – Uterus
  – Blood supply
  – Fluid volume
  – Breasts
  – Infant
• Fat stores (small amount)
Weight
                                                                     gain (lb)
                                                Increase in               2
                                                breast size
                                                Increase                  4
                                                mother's
                                                fluid volume
                                                Placenta                  1 1/2
                                                Increase in               4
                                                blood supply
                                                to the placenta
                                                Amniotic fluid            2
                                                Infant at birth           7 1/2
                                                Increase in size          2
                                                of uterus and
                                                supporting
                                                muscles
                                                Mother's                   7
                                                necessary
1st trimester   2nd trimester   3rd trimester                             30
                                                fat stores
                                                                    Stepped Art
                                                                   Fig. 15-8, p. 502
Which of the following is true about
exercise and pregnancy?
a) Pregnant women should exercise
   very little and rest as much as
   possible
b) Pregnant women should get as much
   exercise as possible, even if they did
   not exercise prior to getting pregnant
c) Pregnant women can continue an
   exercise regimen that they had prior
   to getting pregnant with some
   adjustments
Which of the following is true about
exercise and pregnancy?
a) Pregnant women should exercise
   very little and rest as much as
   possible
b) Pregnant women should get as much
   exercise as possible, even if they did
   not exercise prior to getting pregnant
c) Pregnant women can continue an
   exercise regimen that they had prior
   to getting pregnant with some
   adjustments
Exercise during Pregnancy
• Benefits of physical activity
  –   improve fitness
  –   manage or prevent gestational diabetes
  –   facilitate labor
  –   reduce stress
  –   fewer discomforts
  –   strength to carry weight
• Inactive women should not begin an
  intense exercise program during
  pregnancy
Exercise during Pregnancy
           Recommendations
           • Regular, mild to
             moderate
           • Low-impact
           • Avoid sports with risk
             of falling or being hit
           • Protect abdomen
           • Maintain adequate
             diet
           • Heat and hydration
Nutrition during Pregnancy
Energy & Nutrient Needs
• Needs tend to be higher than any
  other time in life
• To meet needs
  – Make careful selections
  – Body maximizes absorption
  – Body minimizes losses
Key Nutrients During Pregnancy

 • Calories
   • First trimester: No or little extra
   • Second trimester: +340 kcals/day
   • Third trimester: +450 kcals/day
 • Protein
   • +25 g/day (or 1.1 g/kg body weight)
 • Carbohydrate
   • 175 g/day
Key Nutrients During Pregnancy

 • Folate
 • B12
 • Iron
 • Zinc

 These nutrients are needed for the
  synthesis of DNA and new cells
Key Nutrients During Pregnancy

 • Folate
   – Non-pregnant women: 400 µg/day
   – Pregnant women: 600 µg/day

 • B12
   – Non-pregnant women: 2.4 µg/day
   – Pregnant women: 2.6 µg/day
Key Nutrients During Pregnancy
 • Iron
    – Premenopausal women: 18 mg/day
    – Pregnant women: 27 mg/day

 • Zinc
   – Non-pregnant women: 8 mg/day
   – Pregnant women: 11 mg/day
Key Nutrients During Pregnancy
 • Vitamin D
   – AI does not increase during pregnancy
   – Critical for bone and teeth development

 • Calcium
   – AI does not increase during pregnancy
   – Absorption and retention increases
   – Deficiency common; needed to conserve
     maternal stores
Nutrition during Pregnancy
• Vegetarians
  – Able to meet most nutrient needs
    through diet alone
  – Exception: iron
• Vegans
  – May require supplementation for B12,
    calcium, vitamin D
  – B12 deficiency: spinal chord damage,
    psychomotor retardation
Common Concerns
• Nausea & vomiting
  – “Morning sickness”
  – Hormonal changes
• Constipation and hemorrhoids
• Heartburn
• Food cravings and aversions
  – Hormone changes
  – Pica
Malnutrition and Pregnancy

• Fertility
  – Amenorrhea
  – Sperm
  – Loss of sexual interest
• Placental development
  – Poor development
  – Risk of LBW, physical and cognitive
    abnormalities
Malnutrition and Pregnancy

• Fetal development
  – Fetal growth retardation
  – Birth defects
  – Miscarriage and stillbirth
  – Premature birth
  – LBW
Risks During Pregnancy
• Gestational diabetes
  – Affects 1/25 women
  – Increased risk of type 2 diabetes and
    hypertension later in life
  – Complications during labor & delivery
  – Effects on infant
    • High birth weight
    • Birth defects
  – Avoid excessive weight gain
Risks During Pregnancy
• Preexisting hypertension
  – Risk of LBW infant
  – Risk of placental separation; stillbirth


• Gestational hypertension
  – 50% mild, no adverse effect
  – 50% early sign of preeclampsia
Risks During Pregnancy
• Preeclampsia (pregnancy-induced)
  – Gestational hypertension + protein in
    urine
  – Affects nearly all maternal organs; may
    retard fetal growth
  – Risk of placental separation
  – Cause unknown
  – Genetic predisposition?
• Eclampsia: seizures & coma
Risks During Pregnancy
         Fetal Alcohol Syndrome
         • Irreversible mental and
           physical retardation
         • Recall CNS critical
           period
         • Entirely preventable
Risks during Pregnancy
          Smoking
          • Restricts blood
            supply to fetus
          • Lung development
          • Increased risk for:
            –   Complications
            –   LBW infant
            –   Lung problems
            –   SIDS
          • Preventable!
Risks during Pregnancy
           Mercury
           • Omega-3 fatty
             acids
           • Fish contain high
             amounts of
             mercury
           • Mercury can impair
             fetal growth and
             CNS development
Lactation
Were you breastfed as an
infant?

a) Yes
b) No
c) Unsure
Which of the following is
true for you (females)?
a) I plan to breastfeed
b) I plan to formula feed
c) I plan to do a combination of both
d) I have never thought about how I
   am going to feed my offspring
e) I do not plan on having children
Which of the following is
true for you (males)?
a) I want my future wife to breastfeed
b) I do not care whether my children
   are breastfed or not
c) I have never thought about how I
   want my offspring to be fed
d) I do not plan on having children
Recommendations
•   American Academy of Pediatrics
•   American Academy of Family Physicians
•   American College of Obstetricians and Gynecologists
•   American College of Nurse-Midwives
•   American Dietetic Association,
•   American Public Health Association


     – Officially recommend that most infants
       breastfeed for at least 12 months.
     – Also recommend that for about the first six
       months infants be exclusively breastfed,
       meaning that they not be given any foods or
       liquids other than breast milk.
Healthy People 2020
•   Breastfeeding ever – 81.9%
•   Breastfeeding at 6 months – 60.5%
•   Breastfeeding at 1 year – 34.1%
•   Exclusively through 3 months – 44.3%
•   Exclusively through 6 months – 23.7%
•   Reduce the proportion of breastfed newborns who
    receive formula supplementation within the first 2
    days of life – to 15.6% (from 25.6%)
How far is the US from these goals?

                   U.S. Rates   Healthy People
                                2020 Goals

   Breastfeeding        75%         81.9%
   Ever

   Breastfeeding        43%         60.5%
   at 6 months

   Breastfeeding       22.4%        34.1%
   at 12 months
Benefits for infant
• Optimal nutrition
    – Nutritionally superior to formula
    – Sterile and always fresh
    – More easily digestible
•   Immune protection
•   Fewer allergies and intolerances
•   Fewer respiratory, GI, and ear infections
•   Cognitive benefits
•   Infant-led feeding
•   May protect against some chronic diseases
    later in life
Benefits to Mother
• Increased rate of uterine contraction after
  childbirth and consequent reduced risk of
  postpartum blood loss
• Possible reduced risk of pre-menopausal
  breast and ovarian cancers
• Amenorrhea and decreased fertility
• Promotes mother-infant bond
• Weight loss
• Convenience
• Economic benefits
Anatomy of the Breast
Hormonal Control of
    Lactation
          • Hormonal controls
            – Prolactin
            – Oxytocin: MER
          • Sucking stimulus
            signals release of
            prolactin
          • Supply follows
            demand
Composition of Breast Milk
• Colostrum
  – First fluid, thick, yellowish
  – Rich in immune factors and protein
  – About 20 kcal/oz
   – Bifidus flora
• In first 24hrs, total intake: 10-108ml
• Transitional milk: 6-13 days postpartum
Composition of Breast Milk
• 20 calories per ounce
• Whey:Casein (70:30)
  – More easily digested
• Foremilk vs. hindmilk: fat content
  – Don’t limit time at breast
  – No clear distinction
• Contains small amount of Fe
  – Sufficient for first 6 months
  – Absorption is facilitated by high vitamin C
    concentration
A newborn baby needs to be given
small amounts of water in addition
to breastmilk to meet his/her needs


a) True
b) False
Nutrient Requirements for
        Lactation
• Energy requirement
   – Extra 500 kcals/day
   – Higher needs than pregnancy
• Increased need for carbohydrate
• Fluid intake
• Inadequacies reduce quantity and not
  quality of milk
Contraindications to
        Breastfeeding
• Maternal HIV
• Inborn errors of metabolism of child
  (galactosemia)
• Alcohol
• Certain medications
• Smoking
• Illicit drugs
• Caffeine
Common Problems
•   Sore nipples
•   Engorgement
•   Plugged duct
•   Mastitis

Breastfeeding is a LEARNED SKILL!
Improper Latch!
That’s Better!
Formula Feeding
• Safety and adequacy
• Preparation
• Can interfere with breastfeeding
  – Supply & demand
  – Nipple confusion/preference
• More likely to be overfed
  – Increased risk of obesity?
Nipple Confusion
Nipple Confusion
Baby Friendly Hospital
            Initiative
1.    A written bf policy routinely communicated to staff
2.    Train staff in skills to implement policy
3.    Inform pregnant women about benefits and management
      of breast feeding
4.    Help mothers initiate bf within 30 minutes of delivery
5.    Show mothers how to initiate and maintain bf
6.    Give newborns no food or drink other than breast milk
      unless medically indicated
7.    Practice rooming in: allow mothers and infants to stay
      together
8.    Encourage breast feeding on demand
9.    Give no pacifiers
10.   Foster establishment of support groups and refer mothers
      to them
Ban the Bags Campaign
Questions?

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Neonatal nutrition By Mili
 

Lifecycle nutrition: Pregnancy and Lactation

  • 1. Lifecycle Nutrition: Pregnancy and Lactation TA: Helen Corless
  • 2. Nutrition before Pregnancy • Maintain a healthy weight • Nutrient status – Folate – Iron – Vitamin B12 – Vitamin A • Chronic conditions • Substance use
  • 3. Nutrition & Male Fertility • Weight • Zinc • Antioxidants • Alcohol
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  • 7. Physiology of Pregnancy • Fetal growth: – Zygote: fertilized ovum – Blastocyst: first 2 weeks • Cells differentiate into fetus & placenta – Embryo: weeks 2-8 • Development of organ systems – Fetus: week 9-delivery • Growth – Newborn
  • 8. Physiology of Pregnancy • Placental Development – Placenta: metabolically active organ • Interwoven fetal and maternal blood vessels • Exchange of oxygen, nutrients, and waste products – Amniotic sac – Umbilical cord
  • 11. Day 23 • 2mm long (=) • Beginning development of major organs • Critical stage for neural tube development
  • 12. Day 28 • 6mm long (===) • At this point, the heart is beating, • Lim buds will form the arms and legs
  • 13. Week 9 • 44mm long • Embryo has become a fetus • Complete CNS, beating heart, digestive system, well- defined fingers and toes, beginnings of facial features
  • 14. Week 12 • 82mm long, weighs about 1oz • Arms, hands, fingers, legs, feet and toes formed • Organs grow and mature • Less affected by nutritional deficiencies
  • 15. Week 26 • 250mm long, weighs 2-3 lbs • 3rd trimester • Rapid growth • Able to survive if born prematurely – Lungs – Nutrient stores – Feeding
  • 16. Week 40 • Baby ready to be born • Less amniotic fluid, baby almost fills uterus • Plump arms and legs
  • 17. • Full term fetus usually weighs between 7 and 9 lbs at birth • Full term: 38-42 weeks
  • 18. Definition of a Successful Pregnancy • Gestation at least 37 weeks – Lung development • Birth weight >5.5 lb • Otherwise – Low birth weight (LBW) – Small for gestational age (SGA) – Preterm vs. SGA • Potential for catch-up growth • Malnutrition
  • 19. If a baby is born at 38 weeks and weighs 4lbs, he/she would be considered: a) Low birth weight (LBW) b) Small for gestational age (SGA) c) Preterm d) Both a and b e) All of the above
  • 20. If a baby is born at 38 weeks and weighs 4lbs, he/she would be considered: a) Low birth weight (LBW) b) Small for gestational age (SGA) c) Preterm d) Both a and b e) All of the above
  • 21. Critical Periods • Times of intense development and rapid cell division – Cellular activities can occur only during these times • Organ and tissue development most vulnerable to adverse influences • First trimester
  • 22.
  • 23. Neural Tube Development • Critical period is 17-30 days gestation • Most women unaware they are pregnant during this time • Vulnerable to – Nutrient deficiencies – Nutrient excesses – Toxins
  • 24. Neural Tube Defects • Anencephaly – Brain either missing or fails to develop • Spina bifida – Incomplete closure of spinal cord and its bony encasement • Affects 30/100,000 newborns in US
  • 27. Neural Tube Defects • Cause unknown • Risk factors – Family history – Maternal diabetes – Maternal obesity – Anti-seizure medications – Mutations in enzymes
  • 28. Which of the following has been shown to prevent neural tube defects? a) Vitamin B12 b) Vitamin D c) Calcium d) Folate
  • 29. Which of the following has been shown to prevent neural tube defects? a) Vitamin B12 b) Vitamin D c) Calcium d) Folate
  • 30. Folate Supplementation • Prevents & reduces severity of neural tube defects • Folate status important prior to pregnancy and during 1st trimester • RDA: 600 micrograms • Fortification of grains – 50% of pregnancies are unplanned
  • 31. Fetal Programming • Adverse influences at critical stages in utero may set the stage for chronic disease development later in life • Maternal nutrition status may change gene expression in fetus • Examples: – beta cell growth and diabetes – blood vessel growth, lipid metabolism and CVD
  • 33. Physiology of Pregnancy • Organ & tissue enlargement – Breasts – Uterus – Adipose tissue • BMR increases • Circulatory system changes • Joint flexibility • Fluid retention – Estrogen
  • 34. How much weight should a healthy- weight woman carrying a single fetus gain during pregnancy? a) 5-15 pounds b) 15-25 pounds c) 25-35 pounds d) 35-45 pounds
  • 35. How much weight should a healthy- weight woman carrying a single fetus gain during pregnancy? a) 5-15 pounds b) 15-25 pounds c) 25-35 pounds d) 35-45 pounds
  • 36. Maternal Weight • Birth weight is most reliable indicator of infant health • Maternal weight prior to conception influences fetal growth – Underweight • Risk of LBW, preterm, infant death – Overweight and obesity • Medical complications for mother • Risks for infant
  • 37. Maternal Weight • Weight gain during pregnancy – Correlates closely to infant birth weight – Recommendations (single birth) • Healthy weight: 25-35lbs • Underweight: 28-40lbs • Overweight: 15-25lbs – Most women gain more than recommended!
  • 38. Maternal Weight Gain •Normal: 3.5lbs in 1st tri, then 1lb/week after that •Underweight: 5lbs in 1st tri, then just over 1lb/week •Overweight: 2lbs in 1st tri, then 2/3lb per week
  • 39. What makes up the weight? • Weight gain supports growth and development of… – Placenta – Uterus – Blood supply – Fluid volume – Breasts – Infant • Fat stores (small amount)
  • 40. Weight gain (lb) Increase in 2 breast size Increase 4 mother's fluid volume Placenta 1 1/2 Increase in 4 blood supply to the placenta Amniotic fluid 2 Infant at birth 7 1/2 Increase in size 2 of uterus and supporting muscles Mother's 7 necessary 1st trimester 2nd trimester 3rd trimester 30 fat stores Stepped Art Fig. 15-8, p. 502
  • 41. Which of the following is true about exercise and pregnancy? a) Pregnant women should exercise very little and rest as much as possible b) Pregnant women should get as much exercise as possible, even if they did not exercise prior to getting pregnant c) Pregnant women can continue an exercise regimen that they had prior to getting pregnant with some adjustments
  • 42. Which of the following is true about exercise and pregnancy? a) Pregnant women should exercise very little and rest as much as possible b) Pregnant women should get as much exercise as possible, even if they did not exercise prior to getting pregnant c) Pregnant women can continue an exercise regimen that they had prior to getting pregnant with some adjustments
  • 43. Exercise during Pregnancy • Benefits of physical activity – improve fitness – manage or prevent gestational diabetes – facilitate labor – reduce stress – fewer discomforts – strength to carry weight • Inactive women should not begin an intense exercise program during pregnancy
  • 44. Exercise during Pregnancy Recommendations • Regular, mild to moderate • Low-impact • Avoid sports with risk of falling or being hit • Protect abdomen • Maintain adequate diet • Heat and hydration
  • 46. Energy & Nutrient Needs • Needs tend to be higher than any other time in life • To meet needs – Make careful selections – Body maximizes absorption – Body minimizes losses
  • 47. Key Nutrients During Pregnancy • Calories • First trimester: No or little extra • Second trimester: +340 kcals/day • Third trimester: +450 kcals/day • Protein • +25 g/day (or 1.1 g/kg body weight) • Carbohydrate • 175 g/day
  • 48. Key Nutrients During Pregnancy • Folate • B12 • Iron • Zinc These nutrients are needed for the synthesis of DNA and new cells
  • 49. Key Nutrients During Pregnancy • Folate – Non-pregnant women: 400 µg/day – Pregnant women: 600 µg/day • B12 – Non-pregnant women: 2.4 µg/day – Pregnant women: 2.6 µg/day
  • 50. Key Nutrients During Pregnancy • Iron – Premenopausal women: 18 mg/day – Pregnant women: 27 mg/day • Zinc – Non-pregnant women: 8 mg/day – Pregnant women: 11 mg/day
  • 51. Key Nutrients During Pregnancy • Vitamin D – AI does not increase during pregnancy – Critical for bone and teeth development • Calcium – AI does not increase during pregnancy – Absorption and retention increases – Deficiency common; needed to conserve maternal stores
  • 52.
  • 53. Nutrition during Pregnancy • Vegetarians – Able to meet most nutrient needs through diet alone – Exception: iron • Vegans – May require supplementation for B12, calcium, vitamin D – B12 deficiency: spinal chord damage, psychomotor retardation
  • 54. Common Concerns • Nausea & vomiting – “Morning sickness” – Hormonal changes • Constipation and hemorrhoids • Heartburn • Food cravings and aversions – Hormone changes – Pica
  • 55. Malnutrition and Pregnancy • Fertility – Amenorrhea – Sperm – Loss of sexual interest • Placental development – Poor development – Risk of LBW, physical and cognitive abnormalities
  • 56. Malnutrition and Pregnancy • Fetal development – Fetal growth retardation – Birth defects – Miscarriage and stillbirth – Premature birth – LBW
  • 57. Risks During Pregnancy • Gestational diabetes – Affects 1/25 women – Increased risk of type 2 diabetes and hypertension later in life – Complications during labor & delivery – Effects on infant • High birth weight • Birth defects – Avoid excessive weight gain
  • 58. Risks During Pregnancy • Preexisting hypertension – Risk of LBW infant – Risk of placental separation; stillbirth • Gestational hypertension – 50% mild, no adverse effect – 50% early sign of preeclampsia
  • 59. Risks During Pregnancy • Preeclampsia (pregnancy-induced) – Gestational hypertension + protein in urine – Affects nearly all maternal organs; may retard fetal growth – Risk of placental separation – Cause unknown – Genetic predisposition? • Eclampsia: seizures & coma
  • 60. Risks During Pregnancy Fetal Alcohol Syndrome • Irreversible mental and physical retardation • Recall CNS critical period • Entirely preventable
  • 61. Risks during Pregnancy Smoking • Restricts blood supply to fetus • Lung development • Increased risk for: – Complications – LBW infant – Lung problems – SIDS • Preventable!
  • 62. Risks during Pregnancy Mercury • Omega-3 fatty acids • Fish contain high amounts of mercury • Mercury can impair fetal growth and CNS development
  • 63.
  • 65. Were you breastfed as an infant? a) Yes b) No c) Unsure
  • 66. Which of the following is true for you (females)? a) I plan to breastfeed b) I plan to formula feed c) I plan to do a combination of both d) I have never thought about how I am going to feed my offspring e) I do not plan on having children
  • 67. Which of the following is true for you (males)? a) I want my future wife to breastfeed b) I do not care whether my children are breastfed or not c) I have never thought about how I want my offspring to be fed d) I do not plan on having children
  • 68. Recommendations • American Academy of Pediatrics • American Academy of Family Physicians • American College of Obstetricians and Gynecologists • American College of Nurse-Midwives • American Dietetic Association, • American Public Health Association – Officially recommend that most infants breastfeed for at least 12 months. – Also recommend that for about the first six months infants be exclusively breastfed, meaning that they not be given any foods or liquids other than breast milk.
  • 69. Healthy People 2020 • Breastfeeding ever – 81.9% • Breastfeeding at 6 months – 60.5% • Breastfeeding at 1 year – 34.1% • Exclusively through 3 months – 44.3% • Exclusively through 6 months – 23.7% • Reduce the proportion of breastfed newborns who receive formula supplementation within the first 2 days of life – to 15.6% (from 25.6%)
  • 70.
  • 71. How far is the US from these goals? U.S. Rates Healthy People 2020 Goals Breastfeeding 75% 81.9% Ever Breastfeeding 43% 60.5% at 6 months Breastfeeding 22.4% 34.1% at 12 months
  • 72. Benefits for infant • Optimal nutrition – Nutritionally superior to formula – Sterile and always fresh – More easily digestible • Immune protection • Fewer allergies and intolerances • Fewer respiratory, GI, and ear infections • Cognitive benefits • Infant-led feeding • May protect against some chronic diseases later in life
  • 73. Benefits to Mother • Increased rate of uterine contraction after childbirth and consequent reduced risk of postpartum blood loss • Possible reduced risk of pre-menopausal breast and ovarian cancers • Amenorrhea and decreased fertility • Promotes mother-infant bond • Weight loss • Convenience • Economic benefits
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  • 75.
  • 76. Anatomy of the Breast
  • 77. Hormonal Control of Lactation • Hormonal controls – Prolactin – Oxytocin: MER • Sucking stimulus signals release of prolactin • Supply follows demand
  • 78. Composition of Breast Milk • Colostrum – First fluid, thick, yellowish – Rich in immune factors and protein – About 20 kcal/oz – Bifidus flora • In first 24hrs, total intake: 10-108ml • Transitional milk: 6-13 days postpartum
  • 79. Composition of Breast Milk • 20 calories per ounce • Whey:Casein (70:30) – More easily digested • Foremilk vs. hindmilk: fat content – Don’t limit time at breast – No clear distinction • Contains small amount of Fe – Sufficient for first 6 months – Absorption is facilitated by high vitamin C concentration
  • 80. A newborn baby needs to be given small amounts of water in addition to breastmilk to meet his/her needs a) True b) False
  • 81. Nutrient Requirements for Lactation • Energy requirement – Extra 500 kcals/day – Higher needs than pregnancy • Increased need for carbohydrate • Fluid intake • Inadequacies reduce quantity and not quality of milk
  • 82. Contraindications to Breastfeeding • Maternal HIV • Inborn errors of metabolism of child (galactosemia) • Alcohol • Certain medications • Smoking • Illicit drugs • Caffeine
  • 83. Common Problems • Sore nipples • Engorgement • Plugged duct • Mastitis Breastfeeding is a LEARNED SKILL!
  • 86. Formula Feeding • Safety and adequacy • Preparation • Can interfere with breastfeeding – Supply & demand – Nipple confusion/preference • More likely to be overfed – Increased risk of obesity?
  • 89. Baby Friendly Hospital Initiative 1. A written bf policy routinely communicated to staff 2. Train staff in skills to implement policy 3. Inform pregnant women about benefits and management of breast feeding 4. Help mothers initiate bf within 30 minutes of delivery 5. Show mothers how to initiate and maintain bf 6. Give newborns no food or drink other than breast milk unless medically indicated 7. Practice rooming in: allow mothers and infants to stay together 8. Encourage breast feeding on demand 9. Give no pacifiers 10. Foster establishment of support groups and refer mothers to them
  • 90. Ban the Bags Campaign

Hinweis der Redaktion

  1. Maternal nutrition status prior to pregnancy can have a significant impact on fetal growth and development, as well as a woman ’s ability to conceive in the first place! Weight: both underweight and overweight are associated with infertility and increased risk of complications; excess body fat can disrupt menstruation and hormone production. Achieve a healthy weight prior to pregnancy as dieting while pregnant is never a good idea! Importance of a balanced diet: Malnutrition reduces fertility and impairs early development of the fetus. Problems with nutrients can occur very early in pregnancy before woman recognizes she is pregnant. Folate, Iron, and B12 are especially important for fetal development; increased needs during pregnancy Vitamin A supplementation should be avoided as this may adversely affect the pregnancy Conditions such as diabetes, HIV/AIDS, PKU, and STDs can adversely affect a pregnancy and should be managed prior to pregnancy to ensure a healthy outcome Harmful substances, such as cigarettes, alcohol, drugs or environmental contaminants, can can cause miscarriage, birth defects, and can impair fertility -> eliminate use prior to pregnancy
  2. Although the woman ’s nutrition has the most direct influence on the developing fetus, the man’s nutrition status is also important, since malnutrition can affect male fertility Overweight and obese men have low sperm counts and hormonal changes that reduce fertility Zinc is a cofactor for enzymes involved in testosterone production, DNA replication, protein synthesis, and cell division. Zinc helps protect sperm from bacteria and chromosomal damage and also plays a role in sexual organ development. A deficiency of zinc can impair male fertility but this can be reversed over time with supplementation. Antioxidants can help protect sperm from oxidative damage (free radicals). Men with diets rich in antioxidant nutrients have higher sperm counts and motility Heavy alcohol use can lower sperm production, but light to moderate intake does not appear to have an effect. Remember, the dietary guideline for alcohol use is no more than 2 drinks per day for males
  3. Ovum (egg) + sperm = zygote Once the ovum is fertilized, it becomes a zygote. About 30 hours after fertilization, the zygote reproduces itself by dividing in half. Although the zygote begins as a single cell, it rapidly divides to become a blastocyst
  4. Zygote travels down fallopian tube and continues to rapidly divide (to become blastocyst). Blastocyst arrives in uterus about 4-5 th day after conception. Implants into lining of uterus, usually within two weeks of fertilization. When the blastocyst has implanted, at around two weeks after conception the developing infant becomes an embryo .
  5. Placenta is embedded in the uterine wall that develops in the early days of pregnancy. Placenta performs the respiratory, absorptive, and excretory functions that the fetus ’ lungs, digestive system, and kidneys will provide after birth. Placenta also produces an array of hormones involved in pregnancy and lactation. Amniotic sac: a fluid-filled balloonlike structure that houses the developing fetus; provides protection to developing fetus Umbilical cord: a ropelike structure containing fetal blood vessels that extends through the fetus ’s belly button-to-be to the placenta These three structures are expelled from the uterus during childbirth
  6. As you can see from this diagram there is no actual mingling of fetal and maternal blood (placental villi are fingerlike projections, much like intestinal villi) Maternal arteries bring fresh blood with oxygen and nutrients to the fetus, while maternal veins carry fetal wastes away
  7. During zygotic stage, cells rapidly divide; differentiate into fetus and placenta During embryonic stage, you see the beginning development of major organs; by the end of 8 weeks, the embryo (1.25in) has a complete central nervous system, a beating heart, a digestive system, well-defined fingers and toes and the beginnings of facial features During the fetal stage is when the major growth occurs: this infant grew 20 times longer and 50 times heavier during the fetal stage
  8. Embryonic stage
  9. Embryonic stage
  10. By the end of the first trimester, the fetus weighs about 1 oz. Arms, hands, fingers, legs, feet and toes are fully formed. Organs begin to grow and mature. Still affected by nutritional deficiencies and other insults, but not as severe and a full recovery is possible (if not entirely likely).
  11. Beginning of third trimester fetus weighs 2-3 lbs. Another time of rapid growth, and fetus will double in length and will multiply its weight by 5 times. An infant that is born at about 26 weeks has a good chance of surviving a premature delivery, with care in neonatal ICU. Lungs are not well developed. Baby will not have enough calcium and iron stored in its body, and also will not have much fat. Preterm infants also have less ability to suck and swallow, so feeding is challenging.
  12. LBW infants < 5.5lbs; LBW infants more likely to have complications, birth defects, early death VLBW infants (<3.5lbs) struggle both in immediate survival and long-term development Preterm infants may be small, but if their size and weight are appropriate for their age, they can catch up in growth given adequate nutritional support; SGA infants have suffered growth failure in the uterus and do not catch up as well Infants, whether full or preterm, who weight less than they should for a fetus at their stage of gestation are called small for gestational age. For example, a baby born at 30 weeks, who is less than 5.5 lbs, may still be the appropriate weight for 30 weeks gestation – so it is LBW but not SGA. But baby born at 37 weeks but who weights less than 5.5 lbs is SGA but not preterm.
  13. Nutritional deficiencies, some medications, high intakes of vitamin A, or radiation can change or stop development. The effects are often irreversible. Most spontaneous abortions, or miscarriages, happen during this time. (This is why most people wait until the second trimester to announce they are pregnant)
  14. Each organ/tissue grows to maturity according to its own schedule, with greater intensity at some times more than others Each organ and tissue is most vulnerable to nutrient deficiencies or toxins during its own critical period. If the adversity occurs during the purple timeframe, the damage is likely to be severe and unlikely to be reversible. If it happens in the green timeframe, it is probably going to be less severe and possible reversible. Notice that CNS development begins after only two weeks of gestation; many women may not realize that they are pregnant at this time.
  15. Anencephaly often results in miscarriage; infants born with anencephaly die shortly after birth
  16. If the upper end of the neural tube fails to close, the brain will not develop, resulting in anencephaly. If it fails to close in the lower parts, spina bifida results.
  17. Spina bifida is characterized by incomplete closure of the spinal cord and its bony encasement. The meninges membranes covering the spinal cord often protrude as a sac, which can rupture and lead to meningitis. Spina bifida is accompanied by varying degrees of paralysis depending on damage to spinal cord. Mild cases may not even be noticed, while severe cases can lead to death
  18. High dose folate supplements require a prescription due to the fact that folate can mask vitamin B12 deficiency (pernicious anemia) Neural tube defects occur early in development before most women realize they are pregnant. Grain products are therefore fortified to ensure adequate intake in women of childbearing age. Fortification has been successful in improving folate status in women and reducing occurrence of neural tube defects
  19. There ’s some evidence that certain adverse influences may set the stage for chronic disease later in life. For example, poor maternal nutrition may affect the baby’s blood vessel growth in the uterus, and may set the stage for lipid metabolism and lean body mass development in a way that will put the baby at risk for CVD later in life. Pancreatic (beta) cells are responsible for producing insulin. Malnutrition during the critical period of pancreatic cell growth may develop fewer beta cells, which may be insufficient in times of overnutrition during adulthood when body needs more insulin
  20. Organ & tissue enlargement: heart, thyroid, liver, kidneys, uterus, breasts, adipose tissue Uterus and its supporting muscles increase in size and strength BMR increases dramatically; energy needs of prengant woman are greater Blood volume doubles to carry additional nutrients and other materials Joints become more flexible to prepare for pregnancy Estrogen promotes water retention, which can cause swelling Breasts enlarge in preparation for lactation
  21. Mom: Obese women have high risk of medical complications, such as hypertension, gestational diabetes, and postpartum infections; have more complications with labor and delivery Infants of obese women: more likely to be post term & larger (>9lbs) -> this increases likelihood for difficult labor/delivery, birth trauma and cesarean section Poor development -> higher risk of heart defects and other abnormalities, likely due to poor glycemic control and undiagnosed diabetes Maternal obesity may double the risk for neural tube defects
  22. Health care professionals monitor weight gain using prenatal weigh-gain grids like these A larger weight gain in a short time indicates excessive fluid retention and may be the first sign of preeclampsia
  23. Only about 7 lbs of the 30 lbs is fat. That fat serves a necessary purpose, too: to provide energy for labor and lactation. Lose most, but not all of the weight fairly immediately after delivery. Most women do not return to their pre-pregnancy weight.
  24. Inactive women may start moderate exercise program (e.g. walking) upon physicians approval Women with high-risk pregnancies will likely have to restrict physical activity
  25. Many of exercise guidelines aimed at preventing excessively high internal body temperature and hydration, both of which can harm fetal development
  26. Nutrient needs during pregnancy and lactation are higher than at any other time.
  27. Pregnant woman have higher energy needs than non-pregnant women, due to increased BMR (2nd and 3rd trimester) Increase in nutrient needs is often greater than extra energy needs (15-20%), so nutrient-dense foods should be chosen to supply the extra calories Ample carbohydrate is necessary to fuel fetal brain; protein-sparing action Protein needs are higher; avoid high-protein supplements
  28. It is best to obtain sufficient folate from a combination of supplements, fortified foods, and a diet that includes fruits, juices, green vegetables, and whole grains Slightly greater need for B12, which activates the folate enzyme. Need for B12 can easily be met by a diet that includes even modest amounts of meat, fish, eggs, or milk products together with body stores Vegans need to take daily supplements of B12 or B12-fortified foods to prevent neurological complications of a deficiency
  29. Pregnant women need iron to support their enlarged blood volume and to provide for placental and fetal needs Body makes several adaptations to help meet exceptional needs for iron: menstruation stops & iron absorption improves Most women of childbearing age have inadequate iron stores and may need to take a supplement Zinc is required for DNA and RNA synthesis and thus for protein synthesis and cell development Zinc absorption increases when intakes are low; routine zinc supplementation is not advised
  30. Vitamin D plays a role in calcium absorption and utilization; consequently, severe maternal vitamin D deficiency interferes with normal calcium metabolism, resulting in rickets in the infant and osteomalacia Although AI does not incease for either vitamin D or calcium, it is important that women get sufficient amounts of these nutrients in their diets
  31. Pregnant women who make wise food choices can meet most of their nutrient needs, with the possible exception of iron Supplements are routinely prescribed by for pregnant women by most physicians. Some are over-the-counter, others by prescription because of their high folate content (1000 ug), which could be problematic for certain non-pregnant people, such as the elderly, since it would mask a vitamin B12 deficiency.
  32. Giving infants vitamin B12 supplements corrects the blood and neurological symptoms of deficiency, as well as structural abnormalities, but cognitive and language development delays may persist
  33. NAUSEA & VOMITING About 75% of women experience in early stages. Begins about 3 weeks, ends usually around 3 months. Pregnancy hormones: increases sense of smell; may be related to this. Probably evolved to serve a useful function: to protect pregnant women and embryo from food-borne infections and toxins. To help: avoid spicy or greasy foods, eat smaller, more requent meals; eat slowly and drink liquids between meals. CONSTIPATION & HEMORRHOIDS Pregnancy hormones alter muscle tone. Slowed movement of GI tract, possibly aggravated by high doses of iron. Later, fetus crowds out intestine. Generous amounts of fiber, adequate fluids and regular exercise. Hemorrhoids often accompany: straining. HEARTBURN Relaxed GI muscles: cardiac sphincter. Growing fetus puts increasing pressure on the mother ’s stomach. Avoid lying down right after eating; eat smaller, more frequent meals; eat less fat, so the stomach will empty faster; avoid spicy foods. May need to take an antacid, should consult MD but many are safe for pregnancy. FOOD CRAVINGS & AVERSIONS Most commonly craved items: fruit and juices; sweets; desserts and chocolates. Myth that mothers instinctively know what to eat and cravings are the result of a natural desire to consume needed nutrients. This isn ’t really the case (I.e. cravings do not reflect physiological needs). Cravings more likely to be related to hormonal changes or to family traditions. Some crave strange, non-food items, such as starch, chalk, soap, or dirt: pica . Can be risky, craved substances can be toxic and harmful. Not known why this occurs. Most common aversions are to non-alcoholic caffeinated beverages, meat, fish, poultry, and eggs.
  34. Malnutrition can prevent the placenta from developing fully, so the placenta can ’t deliver optimal nutrients to the fetus.
  35. Without adequate nutrition during pregnancy, fetal growth and infant health are compromised
  36. GESTATIONAL DIABETES Usually develops during the second half of pregnancy, with subsequent return to normal after childbirth Some of the hormones of the placenta antagonize the action of insulin. This can lead to gestational diabetes, which is a high blood glucose concentration that develops during pregnancy and returns to normal after birth. Usually develops in the second half of pregnancy. Screening between 24 and 28 weeks recommended for all woman at “average” risk non fasting oral tolerance test (one hour after 50 g load) If positive, Oral glucose tolerance test: 100 grams glucose with measurements hourly for three hours: at one hour, over 180; at 2 hours over 155 and at 3 hours, over 140. More common in women with a family history of diabetes or who are obese. The fetus grows to be quite large – increased risk of c-section. Birth defects: heart damage, limb deformities, and neural tube defects Diet and exercise are the first two approaches Probably 3 regular meals with small snacks is the cornerstone of the diet. Also important to limit high GI foods. Glucose monitoring becoming increasingly common. If not normalized in two weeks, insulin is added to regimen If it ’s not controlled, there’s an increased risk of type 2 diabetes and hypertension later in life.
  37. Blood flow through the vessels that supply oxygen and nutrients to the placenta diminishes. Preeclampsia is the most serious maternal complication of pregnancy. Symptoms include: upper abdominal pain, severe headaches, swelling, vomiting, blurred vision, sudden weight gain, fetal growth retardation
  38. Head: small in size; forehead narrow and receding Nose short and upturned Jaw underdeveloped, receding chin, receding or flattened upper jaw Eyes: extra skinfolds on eyelids; drooping eyelids; downward slant of eyes; small eyes Ears: uneven in placement and size, poorly formed outer ear Lips: absence of groove in upper lip; flat & thin upper lip Irreversible mental retardation – one of the leading causes of MR.
  39. Limits oxygen and nutrient delivery and waste removal
  40. Provides optimal nutrition to the infant – and it ’s always safe & ready to go, does not require any preparation Less diarrhea, ear infections. Reduces the chances of some allergies Cognitive benefits on IQ are unclear. Thought to be due to ARA and DHA (docosahexanoic acid ). They ’ve started adding these to formula. Obesity. Not sure why. Could be self-regulation of energy intake, or lifestyle of families who breast feed. Overall seems to have a beneficial but small effect on overweight. Arthritis, heart disease, diabetes. Decreased cost of medical care for the infants. Don ’t need to purchase formula, which is still more expensive than the extra food a mother needs to eat to support breastfeeding.
  41. Reduced risk of breast cancer related to lifetime duration of breast feeding. Evidence for ovarian cancer is less clear. Not reliable method of birth control though.
  42. During pregnancy, hormones from the placenta stimulate cells in the breast to form milk-producing lobules.
  43. After birth, the mother produces the hormone prolactin to maintain the changes in the breast and the ability to produce milk. The sucking of the infant stimulates the release of prolactin from the pituitary gland. Milk synthesis occurs as the infant nurses. The more the infant suckles, the more milk is produced – supply follows demand.
  44. Can eat an extra 300 calories or so per day and let the fat stores of pregnancy provide the rest. In this way may help with the return to pre-pregnancy weight. Should not diet – may hinder milk production. Protein and fats about the same, need more carbs because glucose is used to make lactose in breast milk. Fluid demands increase; women should drink to thirst. One recommendation is to drink a glass of water every time the baby nurses.
  45. Mixed messages!