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Masters of the Universe
1. Masters of the Universe
Moderated By: Panel Participants:
2. Masters of the Universe The R&D Conundrum:
Grow via Internal Investment or
External Development?
Jim Mazzo
Chairman & CEO AcuFocus
Executive Chairman, Neurotech
4. Total R&D Spending 2014: Panel
0
5000
10000
15000
20000
25000
R&D ($USD in
millions)
Zeiss
Santen
Allergan
J&J
Novartis
NEARLY
$20
INVESTED IN R&D
BILLION
5. Average R&D Cost per New Medical Device
Venture capital firms invested $2.7 Billion
in U.S. med tech (device) companies in 2014
$50-90
PER PMA
MILLION
$3-5
PER 510k
MILLION
6. Median R&D Cost per New Drug
By # of new drugs the company has brought to market in 10 years
$351 M
$4.2 B
$5.3 B
1 Drug >3 drugs >4 drugs
7. Pharma: % of Pipeline Compounds Originated
Externally
34
40 3838
47
62
Phase I Phase II Phase III
2002
2010
Source: EvaluatePharma database, February 2010 and May 2002; McKinsey analysis.
EXHIBIT 1: OUTSIDE IN
% of reported compounds originated externally
8. R&D Intensity (% of Sales)
Leading Medical Products Companies
Lin J, Horn H, Henry J. In Vivo: The Business & Medicine Report. Elsevier, March 2010.
3
5
8
10
Bottom quartile
3rd quartile
2nd quartile
Top quartile
MEDICAL PRODUCTS
Average: 7.0% 21.3%
Median: 5.8% 20.1%
15
20
22
30
Bottom quartile
3rd quartile
2nd quartile
Top quartile
PHARMA PRODUCTS
10. Accelerating the Innovation Cycle?
or Cutting Off Resources?
Companies
commercializing
medical products
Companies developing new drug
molecules and device innovations
11. R&D Is an Easy Target
“Spending more on R&D won’t
drive results. The most crucial
factors are strategic alignment
and a culture that supports
innovation.”
─ Strategy& (formerly Booz & Co)
The Global Innovation 1000 ─
“The trouble is that it’s hard to measure
strategic alignment & culture, let alone link
them to profitability or market value.”
─ Harvard Business Review ─