FOXP2 gene mutated in a speech and language disorder. In humans, mutation of ‘FOXP2’ gene, results in a severe developmental disorder that significantly disrupts speech and language skills.

1. FOXP2 gene-related
speech and language disorders
Dr. A. Harinatha Reddy, M.Sc, Ph.D.
Department of Microbiology,
Sri Krishnadevaraya University
Anantapur, A.P-INDIA.

2. FOXP2 gene mutated in a speech and
language disorder
• In humans, mutation
of ‘FOXP2’ gene,
results in a severe
developmental
disorder that
significantly disrupts
speech and language
skills.

3. FOXP2, is confined to the central nervous
system and greatly impacts on the
development of speech and language
abilities.

4. Classification of speech and language
disorders
Childhood apraxia of speech (CAS),
 Dysarthria (DT),
Developmental language disorder (DLD),
Autism spectrum disorder (ASD)
Speech sound disorders (SSD).

5. • Foxp2(Forkhead Box P2) gene codes for
transcription factor, it has both DNA and Protein
binding domains.

6. • Foxp2 gene regulates expression of several genes
and development of brain, lungs thymus and heart
tissue

7. • Foxp subfamily members contain a zinc finger
domain and a leucine zipper motif.
• In addition to a forehead domain and their DNA
binding capacities and transcriptional activities are
regulated by..
• homo- and heterodimerization via a zinc finger and
a leucine zipper motif.

8. • Three Foxp subfamily members are abundantly
expressed in developing brains and appear to be
involved in the development control of the central
nervous system.

9. • The Foxp subfamily, which consists of four
members, Foxp1, Foxp2, Foxp3 and Foxp4, is
characterized on the basis of its members containing
a C2H2-type zinc finger domain..