The objective was to design curcumin analogues using 3D-QSAR and molecular docking. The highest scoring analogue would be synthesized and confirmed through FT-IR, NMR and TLC. Its anticancer activity against colon and ovarian cancer cell lines would then be established. Curcumin was extracted from turmeric and various analogues were constructed, prepared and their ADMET profiles analyzed to select the best candidate for synthesis and evaluation of antic