Biotech Product- Vaccine

1. Biotech Product-Vaccine
Md. Hamidul Kowsar
Dept. of Pharmacy
State University of Bangladesh
Presented by

2. Biotech products are therapeutic agent
which are manufectured by biotechnological
manufecturing
Biotech products
Application:-
•Insulin
•Vaccine
•Biofuel

3. History
•In 1796, Jenner took pus from the hand of a
milkmaid with cowpox, inoculated an 8-year-
old boy with it, and six weeks
later variolated the boy's arm with smallpox,
afterwards observing that the boy did not
catch smallpox.
• It was banned in 1840 Louis
Pasteur generalized Jenner's idea by
developing what he called a rabies vaccine
• The twentieth century saw the introduction
of several successful vaccines
Edward
Jenner
Louis
Pasteur
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4. Vaccine
Vaccine is a substance that is introduced into the
body to prevent the disease produced by certain
pathogens.
•Hepatitis B
•Tuberculosis
•Anthrax
•Polio
•Typhoid
•Smallpox
Examples

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Many of the common vaccines currently in use consist of
inactivated (killed) or live but attenuated (avirulent) bacterial cells
or viral particles.
Type of vaccines
 Killed/Inactivated.
 Attenuated.
Killed/ Inactivated: Some vaccines contain killed, but previously
virulent, micro-organisms that have been destroyed with chemicals,
heat, radioactivity or antibiotics.
Attenuated: Some vaccines contain live, attenuated
microorganisms. Many of these are live viruses that have been
cultivated under conditions that disable their virulent properties, or
which use closely related but less dangerous organisms to produce
a broad immune response.

6. Examples of vaccines
Disease or pathogen Type of vaccine
Bacterial cells
Plague
Tuberculosis
Typhoid
Inactivated
Live attenuated
Live attenuated
Viral particles
Hepatitis A
Influenza
Polio (Sabin)
Varicella zoster (chickenpox)
Yellow fever
Inactivated
Inactivated
Live attenuated
Inactivated
Live attenuated
Live attenuated

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8. How a vaccine works

9. Production
Vaccines are produced in large scale
as they need to be administered to
large populations of children and adults
to be effective as a public health tool.
This large scale production is often a
challenge.
Stages of vaccine production
Vaccine production has several stages.
Process of vaccine manufacture has
the following steps:
Inactivation – This involves making of
the antigen preparation
Purification – The isolated antigen is
purified
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10. Advantages & Disadvantages