4. INTRODUCTION
Candidiasis is an infection caused by a
yeast
called Candida. Candida normally lives
on the skin and inside the body, in
places such as the mouth, throat, gut,
and vagina, without causing any
problems.
4
Introduction
7. 7
Cutaneous Candidiasis
Intertrigo and cutaneous candidal disease in a
67-year-old female with diabetes mellitus.
Symptoms:
•rashes.
•red or purple patches.
•scaling, or shedding of the skin with flakes.
•erythema, which results in areas of redness.
10. Thrush or acute pseudo-membranous
candidosis , one of the earliest and
the initial manifestations of AIDS.
Chronic hyperplastic candidiasis, Candidal
leukoplakia.
Adherent white patches.
Colonize cheeks, lips, and tongue.
No pian. Does not rub off.
10
Oral Candidiasis
11. - Blastospore form
- Burning, Vulval itch, soreness, Discharges pH= 4-5, Pain or discomfort when
urinating
- Estrogen the lining of vagina to mature and to contain
glycogen, a substrate on which C. albicans thrives
Vulvovaginal
Candidiasis (VVC)
13. 13
1. Candida colonization, higher in pregnancy.
2. Uncomplicated VVC, mild, non-frequent,
and non-persistent. Less than four episodes in a year.
3. Complicated VVC, severe, persistent. Four or
more episodes of thrush in a year
VVC classification;
15. 15
Candida albicans retaining
crystal violet stain from
routine gram stain taken
from SDA.
Candida albicans grows rapidly
in culture, reaching
maturity in 3 days. Colonies
are cream colored, raised,
entire, smooth & butyrous.
Candida albicans
Candida albicans on Sabouraud-Dextrose
Agar at 48 hours at 30C
CAUSATIVE AGENT
16. 16
C albicans is by far the
most common, it
accounts for 80-
90%
C glabrata is the second
most common, it
accounts for 5-
15%
C tropicalis (5%)
Candida species..
There are 150 candida species
17. Pseudohyphae of candida with budding
yeasts are present on this KOH
preparation. Pseudohyphae are
chains of elongated yeast cells
that fail to detach after budding.
(A) Growth of Candida albicans SDA; (B) obverse view of C.
albicans on SDA culture tube; (C) reverse view of C.
albicans on SDA tube; (D) C. albicans produces true
germ tubes with lactophenol cotton blue (LCB) stain;
and (E) chlamydospores of C. albicans with LCB stain.
17
Lab Diagnosis
18. 18
CHROM agar
Why CHROM agar?
- Focus on Candida Species
- High Contrast: intense colony
colouration helping to differentiate
species.
- Candida albicans → green
Candida tropicalis → metallic blue
Candida krusei → pink, fuzzy
Other species → white to mauve
20. ü Amphotericin B
ü Mycostatin
cream
Topical
Systemic
ü Nystatin
ü Ketaconazole
ü Itraconazole
ü Fluconazole
2
0
TREATMENT
21. CONCLUSIONS
C. albicans has been of great interest
because it infects most of
immunocompromised patients worldwide.
The genetics Candida is complex compared
to S. cerevisiae.
Pathogenicity of C. albicans depends upon
two major factors. Immune status of the
host and the virulence factors of this
pathogen.
21
CONCLUSIONS
22. ● Kathleen E. Sullivan, E. Richard Stiehm, Stiehm's Immune Deficiencies, Academic
Press, 2014, Pages 775-802
● Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand. March 2017.
● Edwards JE. Candida species. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell,
Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated
Edition. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 258.
● James WD, Berger TG, Elston DM. Diseases resulting from fungi and yeasts. In:
James WD, Berger TG, Elston DM, eds. Andrews' Diseases of the Skin. 12th ed.
Philadelphia, PA: Elsevier; 2016:chap 15.
● Coronado-Castellote L, Jimenez-Soriano Y. (2013 )Clinical and microbiological
diagnosis of oral candidiasis. J Clin Exp Dent.
● Sahu, Mahesh & Padhy, Rabindra. (2014). Bayesian evaluation of two conventional
diagnostic methods for pathogenic fungal infections. Journal of Acute medicine.
● Barnett JA. A history of research on yeasts 8: taxonomy. Yeast. 2004 Oct
30;21(14):1141-93.
22
REFERENCES
24. This is where you give credit to the ones who are part of this project.
Did you like the resources on this template? Get them for free at our other websites.
◂ Presentation template by Slidesgo
◂ Icons by Flaticon
◂ Infographics by Freepik
◂ Text & Image slide photo created by Freepik.com
2
4
CREDITS
