This document summarizes benchmarking of germline small variant calling using Genome in a Bottle (GIAB) reference materials. It highlights best practices for benchmarking, including using benchmarking tools like hap.py and stratified performance metrics. It demonstrates benchmarking an Illumina HiSeq dataset aligned and called against GRCh37 using hap.py and stratifications from the GA4GH benchmarking tool. The results show precision and recall metrics with confidence intervals to evaluate performance across variant classes and difficulty levels. Ongoing work includes developing GIAB resources for GRCh38 and structural variants.