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www.gavi.org
CEO BOARD REPORT
Seth Berkley MD
10 December 2014, Geneva
Reach every child
KEY EVENTS AND
UPDATES1
Gavi/2013/EvelynHockstein
Gavi Board meeting
9-10 December 2014
Ebola: a human security challenge
Source: Ebola response roadmap situation report, 3 December 2014
>17,000 cases
> 6,000 deaths
Gavi Board meeting
9-10 December 2014
>17,000 cases
> 6,000 deaths
Why is Ebola different?
Affects the entire region,
continent
Gavi Board meeting
9-10 December 2014
• WB: Ebola could
cost West Africa
US$ 32 billion
by 2015
• IMF: sub-Saharan
Africa growth forecast
down from 5.5% to 5%
(largely Ebola)
• Morbidity and mortality from
other diseases on the rise
Surrounding
and high-risk
countries
United States
of America
MaliSenegal
Nigeria
Spain
Guinea
Sierra
Leone Liberia
Risk of further spread
Why is Ebola different?
Gavi Board meeting
9-10 December 2014
Liberia: HPV demonstration project launch
postponed from Nov 2014 until… April 2015?
Gavi Board meeting
9-10 December 2014
July 2014 global public health milestone:
pentavalent in all 73 Gavi-supported countries
Introduced pentavalent independently of Gavi funding
Gavi Board meeting
9-10 December 2014
September 2014: first introduction of
inactivated polio vaccine (IPV) – Nepal
UNICEF/2014/ChandraShekhar
Gavi Board meeting
9-10 December 2014
Acting on the call: ending preventable child
and maternal deaths
June 2014
Gavi Board meeting
9-10 December 2014
UNGA week:
Gavi and vaccines feature
Gavi Board meeting
9-10 December 2014
Aid Transparency Index, October 2014:
Gavi remains in top “very good” category
Gavi Board meeting
9-10 December 2014
VACCINE
INTRODUCTIONS2
Gavi/2013/EvelynHocksteinGavi/2013/EvelynHockstein
Gavi Board meeting
9-10 December 2014
Vaccine introductions in 2014
Gavi Board meeting
9-10 December 2014
Source: Gavi data as of 30 November 2014.
Pentavalent vaccine Pneumococcal vaccine Rotavirus vaccine
Vaccine introduction targets reached
one year in advance
Cumulative country introductions
Projections (SDF10)
Actual
Target
*
Gavi Board meeting
9-10 December 2014
South Sudan
Pentavalent vaccine
Vietnam
Measles-rubella campaign
Senegal
HPV demonstration project
Senegal
Rotavirus vaccine
Niger
Rotavirus
and pneumococcal vaccines
Tanzania
Measles-rubella campaign
12 additional states in India
Pentavalent vaccine
Nepal
Inactivated polio vaccine
Acceleration of IPV introductions:
Gavi vaccine support, 2011–2015
Source: Gavi data as of 1 December 2014.
Note: Only the first phase of introductions and
campaigns is included.
Gavi Board meeting
9-10 December 2014
IPV implementation showcases
successful fast-track approach
Source: Gavi data as of 2 December 2014.
* Ukraine has introduced IPV independently of
Gavi financing.
All Gavi-supported countries
expected to have introduced IPV –
within 2 years of Board decision.
Gavi Board opens
window of support.
1st IPV introduction in
Nepal – within 1 year
of Board decision.
Gavi Board meeting
9-10 December 2014
IPV: after successful roll-out,
four big issues remain
Wastage
• WHO recommended multi-dose vial policy for IPV
= significantly reduced wastage
Supply
• Delays in scaling up capacity of 10-dose vial, delayed prequalification
of 5-dose vial = short-term constraints in availability
Demand
• GPEI using IPV in campaigns (capped at 8m doses, not financed by
Gavi) in some endemic areas = increasing demand
Flexibility of financing
• Gavi’s usual ability to move funds through time restricted by funding
envelope = reduced flexibility
Gavi Board meeting
9-10 December 2014
India to introduce rotavirus, rubella, polio and
Japanese encephalitis vaccines
“The introduction of four new lifesaving vaccines will
play a key role in reducing childhood and infant mortality
and morbidity in the country.”
Narendra Modi, Prime Minister of India
Gavi Board meeting
9-10 December 2014
Status of pentavalent vaccine
introductions in India
Data as of 1 December 2014.
• Already introduced
in 12 states
• Dec 2014–Jan 2015:
8 additional states
• From April 2015:
remaining 16 states
• 27 million children in
36 states covered by
the end of 2015
BROADER
LANDSCAPE3
Gavi/2013/EvelynHocksteinGavi/2013/EvelynHockstein
Gavi Board meeting
9-10 December 2014
Post-2015: Sustainable Development Goals
Three aspects
to development
of SDGs:
Gavi Board meeting
9-10 December 2014
Gavi calling for:
Good health
central to
prosperity
Concise, easy-to-
communicate
goals
Bold and ambitious
indicators
New financing models
– domestic financing,
ODA and leveraging
markets
A data
revolution
Value of public-
private partnerships
The goals
Financing
the agenda
Monitoring
and indicators
Global Financing Facility for reproductive,
maternal, neonatal, child and adolescent health
Photo:StuartRamsonforUnitedNationsFoundation
Launched September 2014
Gavi Board meeting
9-10 December 2014
SAGE: five out of six Global Vaccine Action
Plan targets off track
Only vaccine introduction target on track for 2015
Strategic Advisory Group of Experts on Immunization. 2014 Assessment Report of the Global Vaccine Action Plan.
October 2014. Available on: www.who.int/immunization/global_vaccine_action_plan/en/
Gavi Board meeting
9-10 December 2014
Reduce child mortality by two-thirds
MDG 4
12.7million
deaths in 1990
million
deaths
17
million
deaths in 2013
6.3
if accounting for
population growth
(based on 1990
mortality rate)
Pneumonia
and diarrhoea
leading causes
of death
Estimated annual rate of reduction in under-five mortality
at the global level in 2000–2013, by cause
Source: The Lancet (DOI:10.1016/S0140-6736(14)61698-6)
Terms and Conditions
Reported measles incidence rate*,
October 2013 – September 2014
*Rate per 1'000'000 population
Data in HQ as of 11 November 2014.
Data source: surveillance DEF file
The boundaries and names shown and the designations used on this map do not
imply the expression of any opinion whatsoever on the part of the World Health
Organization concerning the legal status of any country, territory, city or area or of its
authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines
on maps represent approximate border lines for which there may not yet be full
agreement. ©WHO 2014. All rights reserved.
<1 (81 countries or 42%)
≥1 - <5 (29 countries or 15%)
≥5 - <10 (14 countries or 7%)
≥10 - <50 (37 countries or 19%)
≥50 (19 countries or 10%)
No data reported
to WHO HQ
(14 countries or 7%)
Not applicable
USA:
> 600 cases
from 1 January
to 31 October-
highest since
2000
Japan:
> 3-fold
increase in
cases in
Jan-Feb 2014
compared with
2013
UK:
1,200 cases
so far in 2014
– the most
since 1994
Australia:
> 300 cases
so far in 2014
– twice as
many as in
2013
Country outbreaks: www.cdc.gov/measles/cases-outbreaks.html,
http://pediatrics.about.com/od/measles/a/measles-outbreak.htm
(updated 15 November), http://www.nih.go.jp/niid/en/all-
surveillance/2292-idwr/idwr-article-en/4440-idwrc-1408-en.html
Wild Poliovirus Cases1
, last 6 Months2
Country with WPV case in previous 6 months
1Excludes cases caused by vaccine-derived polioviruses and viruses detected from environmental surveillance.
Endemic country
Poliovirus type 1
2Onset of paralyses 19 May – 18 November 2014
IMB Report, October, 2014 – Pakistan:
• “Pakistan’s polio programme is a disaster”
• Home to 80% of world’s polio cases in 2014
• Pakistan polio virus paralysed 38 children in
Syria and Iraq in last year
IMB Report, October, 2014 – Nigeria:
• Hope to stop transmission by early 2015
• In last decade, Nigeria virus has infected 26
other countries
• In 2013, Nigeria polio virus caused large
outbreaks in Horn of Africa and Central Africa
Gavi Board meeting
9-10 December 2014
Wild poliovirus cases, 2009‒2014
Source: Data in WHO HQ as of 18 November 2014
Gavi Board meeting
9-10 December 2014
Polio and routine immunisation
Gavi collaborates with GPEI
on immunisation system
strengthening in polio
focus countries:
• AFR: Nigeria, South Sudan,
DR Congo, Chad, Ethiopia,
Angola
• EMR: Pakistan, Afghanistan, Somalia
• SEAR: India
Progress and way forward:
• 8 /10 countries developed annual integrated EPI plans
• Accountability frameworks to help strengthen routine
immunisation (RI)
• Improved RI an essential component to polio eradication
Gavi Board meeting
9-10 December 2014
Source: Roadmap team
0
5
10
15
20
25
30
35
2012 2013 2014 2014
Vaccinator time spent on special campaigns, Punjab provinces
Less time on polio campaigns = + 20,000
vaccinator days for routine immunisation/month
Percentageofvaccinatortimespent
onspecialcampaigns(%)
(Jan‒May) (Jun‒Oct)
8%
11%
30%
8%
Gavi Board meeting
9-10 December 2014
Carriage prevalence of streptococcus
pneumoniae bacteria, pre- and post-vaccine
Source: Hammitt L, Akech DO, Morpeth SC et al. Population effect of 10-valent pneumococcal conjugate vaccine on
nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya:
findings from cross-sectional carriage studies. Lancet Global Health, July 2014.
0
5
10
15
20
25
30
35
40
Pre-vaccine Post-vaccine
Children aged <5 Individuals aged 5 years or older
Carriageprevalence
(2009‒2010) (2011‒2012)
34%
8%
13%
4%
Gavi Board meeting
9-10 December 2014
Substantial reduction in pneumococcal
disease in South Africa thanks to vaccines
Invasive pneumococcal disease cases by age group
Source: Effects of Vaccination on Invasive Pneumococcal Disease in
South Africa. New England Journal of Medicine, November 13, 2014.
Gavi Board meeting
9-10 December 2014
Rotavirus vaccination prevents 6 out of 10
diarrhoea hospitalisations in South Africa
Source: Effectiveness of monovalent human rotavirus vaccine against admission to hospital for acute rotavirus diarrhea in
South African children: a case-control study. The Lancet Infectious Diseases, October 8, 2014.
Gavi Board meeting
9-10 December 2014
New vaccines approaching licensure
Malaria vaccine:
• RTS,S tested in large-scale clinical trial in Africa, including
> 15,000 children and infants
• Vaccine efficacy: 46% in young children, 27% in infants
• Efficacy data from 32 months follow-up including booster
expected early 2015
• Anticipate WHO recommendation in October 2015
Dengue vaccine:
• Phase three clinical trial included 20,000 Latin American
children aged 9-16
• Shown to reduce risk of infection by 60%
• SAGE will soon advise WHO on any recommended
use of dengue vaccines.
Gavi Board meeting
9-10 December 2014
Sources:
www.plosmedicine.org/article/info%3Adoi%2F10.
1371%2Fjournal.pmed.1001685
www.nejm.org/doi/full/10.1056/NEJMoa1411037
RESOURCE
MOBILISATION4
Gavi/2013/EvelynHocksteinGavi/2013/AdrianBrooks
Gavi Board meeting
9-10 December 2014
Sovereign donors:
• Australia: A$ 50 million for 2015 (US$ 44 million)
• Japan: US$ 8.7 million for 2014
Private sector donors:
• Lions Clubs International Foundation: US$ 3 million in-kind for
2014–2017, matched by the Bill & Melinda Gates Foundation and DFID
• “La Caixa” Foundation: €1 million for 2014 (US$ 1.4 million)
Closing the gap for 2016–2020 – building momentum:
• European Commission: €175 million*
• Norway: at least US$ 1.1 billion
• United Kingdom: £1 billion
• Canada: C$ 500 million
• Germany: indication to pledge €500 million**
• Netherlands: €250 million requested by Dutch Parliament
New pledges since the June Board meeting
Gavi Board meeting
9-10 December 2014
* For 2014-2020.
** For 2015-2020.
Exchange rates as of 1 December 2014.
‫رفعت‬500‫أمريكي‬ ‫دوالر‬ ‫مليون‬ IFFIm ‫أو‬‫ل‬‫صكوك‬
• Sukuk = financial certificate that complies with Islamic law
• Largest ever Sukuk issuance in the public market
• Over-subscribed
• Diverse investor base:
• 68% Middle East and Africa
• 21% Asia
• 11% Europe
• Expanding engagement with Islamic world
Gavi Board meeting
9-10 December 2014
First IFFIm Sukuk bonds raise US$ 500 million
Co-financing update
32
52
57
62
67 68
8
5
7
4
9 13
1
US$
21m
US$
31M
US$
32m
US$
36m
US$
64m
US$
79m
0
10
20
30
40
50
60
70
80
90
0
10
20
30
40
50
60
70
2008 2009 2010 2011 2012 2013
AmountinUS$(millions)▬
Numberofcountriesco-financingGavivaccines
Partial payment
Late payment
Fulfilled requirement
By 2013, co-financing will have more than tripled in comparison to 2008
Gavi Board meeting
9-10 December 2014
Zimbabwe
Afghanistan*
Angola*
Cameroon
Congo Republic*
Djibouti
Ghana
Guinea*
Kenya
Kiribati
Kyrgyzstan
Pakistan*
Sierra Leone
Solomon Islands
* Defaulted both in 2012 and 2013.
Source: Gavi data as of 5 December 2014.
1st wave 2nd wave
Under-5 mortality
rate1 41 63
GNI per capita at
entering graduation5 $2,400 $1,800
2013 total fertility
Rate2 3.0 3.6
Vaccines introduced3 2.1 4.6
Average length of
graduation period
(years)4
6 5
Graduating countries: 1st wave entered
graduation in 2011, 2nd wave in 2012–2020
 Successfully introduced
most/all Gavi vaccines
 High impact due to high
burden of vaccine-
preventable diseases
× Higher fiscal burden
following graduation
× Faster pace of financial
scale-up required
 Successful transition to
self-financing
 Projected vaccine costs
affordable (at Gavi price)
 Low risk to sustainability
of vaccine programmes
× Missed opportunities for
vaccine introductions
1. Source: World Bank World Development Indicators, accessed September 2014.
2. Total Fertility Rate; Source: UN World Population Prospects, accessed October 2014
3. Modeled using GAVI’s Adjusted Demand Forecast
4. 1st wave obtained from GAVI Secretariat, 2nd wave modeled
5. World Bank GNI per capita 2013 and earlier, modeled starting in 2014
Gavi Board meeting
9-10 December 2014
• Health financing assessments in graduating countries – findings
to support dialogue on sustainable financing
• Graduation missions to support assessments and plans, building
on health financing dialogue and working with Ministers of
Finance
• Discussion paper on role of health insurance mechanisms in
financing immunisation service delivery
World Bank Group supporting country
graduation efforts in 2015
Will help shape World Bank involvement
in 2016–2020 strategy
Gavi Board meeting
9-10 December 2014
Further reduction in vaccine prices
* Future targets are not publicised to avoid setting a minimum price.
Source: UNICEF Supply Division, 2014.
Cost to fully immunise a child with pentavalent,
pneumococcal and rotavirus vaccines reached a new low
in mid 2014 – but more needs to be done
Gavi Board meeting
9-10 December 2014
Further reduction in vaccine prices
Cost to fully immunise a child with pentavalent,
pneumococcal and rotavirus vaccines reached a new low
in mid 2014 – but more needs to be done
Future targets are not publicised to avoid setting a minimum price.
Source: UNICEF Supply Division, 2014.
Gavi Board meeting
9-10 December 2014
Development
7 completed
HPV, pentavalent, yellow fever,
rotavirus, measles-rubella, IPV,
Japanese encephalitis,
pneumococcal (2014)
1 update
Pentavalent (2014)
3 in development
Cholera, HPV update, meningitis
2 on hold
Typhoid, malaria
Implementation
Gavi Secretariat coordinates
interventions in close
cooperation with partners
Stakeholders include
Secretariat, UNICEF Supply
Division, Bill & Melinda
Gates Foundation, WHO
Vaccine roadmaps
Gavi Board meeting
9-10 December 2014
Japanese encephalitis vaccine
• First tender concluded July 2014
• Gavi’s first Chinese vaccine supplier
• GAVI-supported campaigns forecast
to require > 75 million doses 2015–2020
• Secured sufficient supply to meet
increasing demand through 2016
• First introduction expected
in Lao PDR 2015
Gavi Board meeting
9-10 December 2014
Vaccine delivery innovation:
Uniject for pentavalent vaccine
Gavi Board meeting
9-10 December 2014
• Prequalified in November 2014
• New delivery model:
• Simplifies vaccine administration
• Reduces missed opportunities by ensuring syringe and vial
always available together
• Facilitates outreach
• Will explore making available to Gavi-supported countries
COVERAGE
AND EQUITY5
Gavi/2013/EvelynHockstein
Gavi Board meeting
9-10 December 2014
Immunisation coverage increasing:
reaching more children than ever before
Coverage of third dose of DTP-containing vaccines
increased to 76% in Gavi-supported countries
Source: WHO/UNICEF Estimates of National Immunization Coverage, July 2014.
Gavi Board meeting
9-10 December 2014
 Projections (SDF10)
Actual
Target
Progress towards vaccine coverage goals,
but still behind target
Pentavalent vaccine Pneumococcal vaccine Rotavirus vaccine
Coverage in Gavi-supported countries (%)
Gavi Board meeting
9-10 December 2014
Investment for 36 HSS grants recommended
for approval, January 2011 – October 2014
Procurement & supply
chain management:
US$ 214 m (26%)
Service delivery:
US$ 177 m (21%)
Health workforce
and human resources:
US$ 161 m (20%)
Health
information systems:
US$ 109 m (13%)
Programme management:
US$ 76 m (9%)
Empower community
and other local actors:
US$ 69 m (8%)
Other:
US$ 25 m (3%)
Gavi Board meeting
9-10 December 2014
2013 intermediate results: Burundi
All but grant utilisation was stable or improved
% of community
health workers trained
Availability of community
health workers
% of facilities with functioning
cold chains
Timeliness of district
reporting
% of districts reporting
negative drop-out rates
% of districts report a verification factor
equal to or greater than
the DTP3 coverage
Gavi grant execution rate
Baseline (2012 unless otherwise specified)
2013 result
2013 target
(2013 baseline)
(2011 baseline)
Gavi Board meeting
9-10 December 2014
28
20
8
21 30 46
16 15
11
0
10
20
30
40
50
60
70
2013 projections based on
country requests
2014 APR with 2013
adjustments
Latest end-of-year projections
with 2014 adjustments
Understocked Appropriately stocked Overstocked
Pentavalent vaccine - projected number of countries with “appropriate” stock
levels (central warehouse + 1 level), by the end of 2014
Definitions: Understocked = less than 4 months of stock,
overstocked = more than 8 months of stock
Improvement of stocks –
further improvement expected
Gavi Board meeting
9-10 December 2014
Full country evaluation: preliminary district
level summary, Zambia
Gavi Board meeting
9-10 December 2014
Full country evaluation: preliminary trends in
sub-national coverage and equity, Bangladesh
DTP3-containing vaccination coverage by district, 1995-2013
Gavi Board meeting
9-10 December 2014
Full country evaluation: biomarkers for rubella antibody
positivity in pre and post MR campaign, Bangladesh
55 54
59
54
95 96
86
93
0
10
20
30
40
50
60
70
80
90
100
Rural Urban Rural Urban
Rajshahi Sylhet
Percentage
Pre-MRC Post-MRC
Gavi Board meeting
9-10 December 2014
Source: MDG survey, 2013; CI refers to 95% confidence interval; OR = Odds ratio
Inequities in Immunization take many forms
Immunization inequities by population characteristics, Madagascar, 2011
100
90
80
70
60
50
40
30
20
10
Madagascar
(63%)
Boys
(63.1)
Girls (62.6)
Urban (87)
Rural (59)
Secondary
education
or more
(80)
No formal
instruction
(47)
Birth Order 2nd
(68)
Birth Order 6+ (50)
Mother’s
education
Wealthiest
quintile
(74%)
Poorest
quintile
(49%)
% DTP3 Itasy
Region (89)
Menabe
region (26)
Gavi Board meeting
9-10 December 2014
New programme review model:
first year experience
• High-level panel: Gavi Secretariat, WHO, UNICEF and
Independent Review Committee members
• 70 countries reviewed in 2014
• More in-depth look at programmes, strengthens links
to business plan and HSS
• Workload for partners and Secretariat higher than
expected – increased engagement and accountability
• Partner joint appraisals welcomed:
• strengthens partnerships
• grounds discussions in country context
Gavi Board meeting
9-10 December 2014
Supply chain fund:
Example – Mali support
• Gavi funded 110 solar fridges,
24 electrical fridges + temperature
recorders for 1,000 fridges to help
prepare for rotavirus vaccine roll-out
• Because of catalytic aspect of Gavi supply
chain fund, Mali government self-
financed 11 additional refrigerators
• Supply chain fund is financed by
the ELMA foundation to help quickly
address gaps
Gavi Board meeting
9-10 December 2014
New Gavi-funded solar fridge and freezer
in Maiduguri, Nigeria
The only functioning fridge at Yarwa PHC
Gavi Board meeting
9-10 December 2014
Source: Lydon P, Zipursky S, Tevi-Benissan C et al. Economic benefits of keeping vaccines at ambient temperature during
mass vaccination: the case of meningitis A vaccine in Chad. Bull World Health Organ 2014;92:86–92 .
Gavi Board meeting
9-10 December 2014
Note: data shown are actual costs recorded in the
mass vaccination campaign run in three regions
of Chad in Dedember 2011 and the costs
estimated in a modelled scenario in which a CTC
was implemented.
Controlled temperature chain (CTC)
for meningitis A vaccines
Modelled impact on cold chain costs in three regions in Chad, 2011
(cost in US$ per person vaccinated)
RISK
MANAGEMENT6
Gavi/2012/SalaLewis
Gavi Board meeting
9-10 December 2014
First articulation of comprehensive risk
management approach
Gavi Board meeting
9-10 December 2014
 Operationalisation: initial focus on strengthening fiduciary risk
management in Gavi Secretariat
 Other elements to be developed as part of risk management
implementation plan in 2015
Misuse of funds 2000–2014
100% of countries have agreed
to reimburse misused funds
Gavi Board meeting
9-10 December 2014
Repayments since
the June Board meeting:
REIMBURSED
TO DATE:
US$ 6.2 m
New cases:
Gavi-Nigeria joint letter of understanding
Systemic weaknesses in financial controls…
may have led to the inappropriate use of funds.
The GoN agrees… to reimburse Gavi for any
amounts identified as inappropriately used
The way forward… underlines our common
commitment to saving children’s lives
through an effective immunisation program.
Gavi Board meeting
9-10 December 2014
GOING FORWARD7
Gavi/2011/DounePorter
Gavi Board meeting
9-10 December 2014
Ebola: 4 recommended areas for Gavi action
Gavi Board meeting
9-10 December 2014
Recovery of health and
immunisation systems
# cases
(illustrative)
TimeProduction &
Procurement
funding
Future outbreak
preparedness
1
4
Funding vaccine roll-out
2
Funding vaccine roll-out
2
3
Current
outbreak
Potential
future
outbreak
(magnitude
unknown)
Future
outbreak with
stockpile
present
Business plan 2015: a bridging plan
Gavi Board meeting
9-10 December 2014
Four main areas in implementation
of 2016–2020 strategy
Country
engagement model/
coverage & equity
Global strategies,
policies &
programmes
Business plan
redesign
 Plans for improving coverage & equity
 Gavi programme/support to improve coverage & equity
 Alliance model at country level
Started:
a) Supply chain
b) Eligibility, graduation,
co-financing
c) Private sector
d) ATAP
e) Innovation/market shaping
f) Data strategy
 New processes and funding
 Coordination & engagement mechanisms
 Organisational review
1
2
3
Indicators & targets
4  Develop indicators, baseline &
targets
In pipeline:
g) HSS formula
h) Leadership, management
& coordination
i) Non-financial instruments
for sustainability
j) Demand generation
Gavi Board meeting
9-10 December 2014
79 Gavi Board meeting
9-10 December 2014
Building global momentum
Germany
Leadership in action
“Together, we can support Gavi, the
Vaccine Alliance in its endeavour to
vaccinate 300 million children between
2016 and 2020, thus helping to save
lives. Together, we can succeed in
reaching all children in our world and
giving them the chance to live a
healthy life”
Dr Angela Merkel
German Federal Chancellor
Gavi Board meeting
9-10 December 2014
Reach every child: Gavi pledging conference
Berlin, 27 January 2015
“Health is a key area… a main focus of our G7 presidency.
Our start in the year 2015 will be the replenishment conference of Gavi.”
Angela Merkel
Federal Chancellor, Germany
Gavi Board meeting
9-10 December 2014
15 years of saving lives:
what we have achieved together
> 280 vaccine intros &
campaigns supported
 > 280 intros & campaigns
Gavi’s portfolio grown
from 3 to 11 vaccines
 > 280 intros & campaigns
 From 3 to 11 vaccines
Pentavalent vaccine
in 73/73 Gavi countries
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
Improved
injection safety
in 68 countries
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
Health system
strengthening
support to 65 countries
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
Pneumococcal vaccine
in 45 countries
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
24 countries approved
for HPV vaccine support
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
US$ 9bn committed
to countries
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
US$ 5 billion raised
via vaccine bonds
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
Countries have
co-financed more
than US$ 250m
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
 US$ 250m in co-financing
Average pentavalent
vaccine price down
by 40%
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
 US$ 250m in co-financing
 Pentavalent price down 40%
Suppliers of Gavi
vaccines increased
from 5 to 16
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
 US$ 250m in co-financing
 Pentavalent price down 40%
 From 5 to 16 vaccine suppliers
Vaccine coverage up
from 60% to 76%
in Gavi countries
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
 US$ 250m in co-financing
 Pentavalent price down 40%
 From 5 to 16 vaccine suppliers
 Vaccine coverage up to 76%
500 million children
immunised
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
 US$ 250m in co-financing
 Pentavalent price down 40%
 From 5 to 16 vaccine suppliers
 Vaccine coverage up to 76%
 500m children immunised
More than 6 million
future deaths prevented
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
 US$ 250m in co-financing
 Pentavalent price down 40%
 From 5 to 16 vaccine suppliers
 Vaccine coverage up to 76%
 500m children immunised
 > 6m future deaths prevented
15 years of saving lives:
what we have achieved together
 > 280 intros & campaigns
 From 3 to 11 vaccines
 Pentavalent in 73/73 countries
 Injection safety in 68 countries
 HSS support to 65 countries
 Pneumo vaccine in 45 countries
 HPV support to 24 countries
 US$ 9bn committed
 US$ 5bn via vaccine bonds
 US$ 250m in co-financing
 Pentavalent price down 40%
 From 5 to 16 vaccine suppliers
 Vaccine coverage up to 76%
 500m children immunised
 > 6m future deaths prevented
YEARS
OF SAVING
LIVES
TOGETHER
www.gavi.org
THANK YOU

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Gavi - CEO Board Report 10 Dec 2014

  • 1. www.gavi.org CEO BOARD REPORT Seth Berkley MD 10 December 2014, Geneva Reach every child
  • 3. Ebola: a human security challenge Source: Ebola response roadmap situation report, 3 December 2014 >17,000 cases > 6,000 deaths Gavi Board meeting 9-10 December 2014
  • 4. >17,000 cases > 6,000 deaths Why is Ebola different? Affects the entire region, continent Gavi Board meeting 9-10 December 2014 • WB: Ebola could cost West Africa US$ 32 billion by 2015 • IMF: sub-Saharan Africa growth forecast down from 5.5% to 5% (largely Ebola) • Morbidity and mortality from other diseases on the rise Surrounding and high-risk countries
  • 5. United States of America MaliSenegal Nigeria Spain Guinea Sierra Leone Liberia Risk of further spread Why is Ebola different? Gavi Board meeting 9-10 December 2014
  • 6. Liberia: HPV demonstration project launch postponed from Nov 2014 until… April 2015? Gavi Board meeting 9-10 December 2014
  • 7. July 2014 global public health milestone: pentavalent in all 73 Gavi-supported countries Introduced pentavalent independently of Gavi funding Gavi Board meeting 9-10 December 2014
  • 8. September 2014: first introduction of inactivated polio vaccine (IPV) – Nepal UNICEF/2014/ChandraShekhar Gavi Board meeting 9-10 December 2014
  • 9. Acting on the call: ending preventable child and maternal deaths June 2014 Gavi Board meeting 9-10 December 2014
  • 10. UNGA week: Gavi and vaccines feature Gavi Board meeting 9-10 December 2014
  • 11.
  • 12. Aid Transparency Index, October 2014: Gavi remains in top “very good” category Gavi Board meeting 9-10 December 2014
  • 14. Vaccine introductions in 2014 Gavi Board meeting 9-10 December 2014
  • 15. Source: Gavi data as of 30 November 2014. Pentavalent vaccine Pneumococcal vaccine Rotavirus vaccine Vaccine introduction targets reached one year in advance Cumulative country introductions Projections (SDF10) Actual Target * Gavi Board meeting 9-10 December 2014
  • 22. 12 additional states in India Pentavalent vaccine
  • 24. Acceleration of IPV introductions: Gavi vaccine support, 2011–2015 Source: Gavi data as of 1 December 2014. Note: Only the first phase of introductions and campaigns is included. Gavi Board meeting 9-10 December 2014
  • 25. IPV implementation showcases successful fast-track approach Source: Gavi data as of 2 December 2014. * Ukraine has introduced IPV independently of Gavi financing. All Gavi-supported countries expected to have introduced IPV – within 2 years of Board decision. Gavi Board opens window of support. 1st IPV introduction in Nepal – within 1 year of Board decision. Gavi Board meeting 9-10 December 2014
  • 26. IPV: after successful roll-out, four big issues remain Wastage • WHO recommended multi-dose vial policy for IPV = significantly reduced wastage Supply • Delays in scaling up capacity of 10-dose vial, delayed prequalification of 5-dose vial = short-term constraints in availability Demand • GPEI using IPV in campaigns (capped at 8m doses, not financed by Gavi) in some endemic areas = increasing demand Flexibility of financing • Gavi’s usual ability to move funds through time restricted by funding envelope = reduced flexibility Gavi Board meeting 9-10 December 2014
  • 27. India to introduce rotavirus, rubella, polio and Japanese encephalitis vaccines “The introduction of four new lifesaving vaccines will play a key role in reducing childhood and infant mortality and morbidity in the country.” Narendra Modi, Prime Minister of India Gavi Board meeting 9-10 December 2014
  • 28. Status of pentavalent vaccine introductions in India Data as of 1 December 2014. • Already introduced in 12 states • Dec 2014–Jan 2015: 8 additional states • From April 2015: remaining 16 states • 27 million children in 36 states covered by the end of 2015
  • 30. Post-2015: Sustainable Development Goals Three aspects to development of SDGs: Gavi Board meeting 9-10 December 2014 Gavi calling for: Good health central to prosperity Concise, easy-to- communicate goals Bold and ambitious indicators New financing models – domestic financing, ODA and leveraging markets A data revolution Value of public- private partnerships The goals Financing the agenda Monitoring and indicators
  • 31. Global Financing Facility for reproductive, maternal, neonatal, child and adolescent health Photo:StuartRamsonforUnitedNationsFoundation Launched September 2014 Gavi Board meeting 9-10 December 2014
  • 32. SAGE: five out of six Global Vaccine Action Plan targets off track Only vaccine introduction target on track for 2015 Strategic Advisory Group of Experts on Immunization. 2014 Assessment Report of the Global Vaccine Action Plan. October 2014. Available on: www.who.int/immunization/global_vaccine_action_plan/en/ Gavi Board meeting 9-10 December 2014
  • 33. Reduce child mortality by two-thirds MDG 4 12.7million deaths in 1990 million deaths 17 million deaths in 2013 6.3 if accounting for population growth (based on 1990 mortality rate) Pneumonia and diarrhoea leading causes of death
  • 34. Estimated annual rate of reduction in under-five mortality at the global level in 2000–2013, by cause Source: The Lancet (DOI:10.1016/S0140-6736(14)61698-6) Terms and Conditions
  • 35. Reported measles incidence rate*, October 2013 – September 2014 *Rate per 1'000'000 population Data in HQ as of 11 November 2014. Data source: surveillance DEF file The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. ©WHO 2014. All rights reserved. <1 (81 countries or 42%) ≥1 - <5 (29 countries or 15%) ≥5 - <10 (14 countries or 7%) ≥10 - <50 (37 countries or 19%) ≥50 (19 countries or 10%) No data reported to WHO HQ (14 countries or 7%) Not applicable USA: > 600 cases from 1 January to 31 October- highest since 2000 Japan: > 3-fold increase in cases in Jan-Feb 2014 compared with 2013 UK: 1,200 cases so far in 2014 – the most since 1994 Australia: > 300 cases so far in 2014 – twice as many as in 2013 Country outbreaks: www.cdc.gov/measles/cases-outbreaks.html, http://pediatrics.about.com/od/measles/a/measles-outbreak.htm (updated 15 November), http://www.nih.go.jp/niid/en/all- surveillance/2292-idwr/idwr-article-en/4440-idwrc-1408-en.html
  • 36. Wild Poliovirus Cases1 , last 6 Months2 Country with WPV case in previous 6 months 1Excludes cases caused by vaccine-derived polioviruses and viruses detected from environmental surveillance. Endemic country Poliovirus type 1 2Onset of paralyses 19 May – 18 November 2014 IMB Report, October, 2014 – Pakistan: • “Pakistan’s polio programme is a disaster” • Home to 80% of world’s polio cases in 2014 • Pakistan polio virus paralysed 38 children in Syria and Iraq in last year IMB Report, October, 2014 – Nigeria: • Hope to stop transmission by early 2015 • In last decade, Nigeria virus has infected 26 other countries • In 2013, Nigeria polio virus caused large outbreaks in Horn of Africa and Central Africa Gavi Board meeting 9-10 December 2014
  • 37. Wild poliovirus cases, 2009‒2014 Source: Data in WHO HQ as of 18 November 2014 Gavi Board meeting 9-10 December 2014
  • 38. Polio and routine immunisation Gavi collaborates with GPEI on immunisation system strengthening in polio focus countries: • AFR: Nigeria, South Sudan, DR Congo, Chad, Ethiopia, Angola • EMR: Pakistan, Afghanistan, Somalia • SEAR: India Progress and way forward: • 8 /10 countries developed annual integrated EPI plans • Accountability frameworks to help strengthen routine immunisation (RI) • Improved RI an essential component to polio eradication Gavi Board meeting 9-10 December 2014
  • 39. Source: Roadmap team 0 5 10 15 20 25 30 35 2012 2013 2014 2014 Vaccinator time spent on special campaigns, Punjab provinces Less time on polio campaigns = + 20,000 vaccinator days for routine immunisation/month Percentageofvaccinatortimespent onspecialcampaigns(%) (Jan‒May) (Jun‒Oct) 8% 11% 30% 8% Gavi Board meeting 9-10 December 2014
  • 40. Carriage prevalence of streptococcus pneumoniae bacteria, pre- and post-vaccine Source: Hammitt L, Akech DO, Morpeth SC et al. Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya: findings from cross-sectional carriage studies. Lancet Global Health, July 2014. 0 5 10 15 20 25 30 35 40 Pre-vaccine Post-vaccine Children aged <5 Individuals aged 5 years or older Carriageprevalence (2009‒2010) (2011‒2012) 34% 8% 13% 4% Gavi Board meeting 9-10 December 2014
  • 41. Substantial reduction in pneumococcal disease in South Africa thanks to vaccines Invasive pneumococcal disease cases by age group Source: Effects of Vaccination on Invasive Pneumococcal Disease in South Africa. New England Journal of Medicine, November 13, 2014. Gavi Board meeting 9-10 December 2014
  • 42. Rotavirus vaccination prevents 6 out of 10 diarrhoea hospitalisations in South Africa Source: Effectiveness of monovalent human rotavirus vaccine against admission to hospital for acute rotavirus diarrhea in South African children: a case-control study. The Lancet Infectious Diseases, October 8, 2014. Gavi Board meeting 9-10 December 2014
  • 43. New vaccines approaching licensure Malaria vaccine: • RTS,S tested in large-scale clinical trial in Africa, including > 15,000 children and infants • Vaccine efficacy: 46% in young children, 27% in infants • Efficacy data from 32 months follow-up including booster expected early 2015 • Anticipate WHO recommendation in October 2015 Dengue vaccine: • Phase three clinical trial included 20,000 Latin American children aged 9-16 • Shown to reduce risk of infection by 60% • SAGE will soon advise WHO on any recommended use of dengue vaccines. Gavi Board meeting 9-10 December 2014 Sources: www.plosmedicine.org/article/info%3Adoi%2F10. 1371%2Fjournal.pmed.1001685 www.nejm.org/doi/full/10.1056/NEJMoa1411037
  • 45. Sovereign donors: • Australia: A$ 50 million for 2015 (US$ 44 million) • Japan: US$ 8.7 million for 2014 Private sector donors: • Lions Clubs International Foundation: US$ 3 million in-kind for 2014–2017, matched by the Bill & Melinda Gates Foundation and DFID • “La Caixa” Foundation: €1 million for 2014 (US$ 1.4 million) Closing the gap for 2016–2020 – building momentum: • European Commission: €175 million* • Norway: at least US$ 1.1 billion • United Kingdom: £1 billion • Canada: C$ 500 million • Germany: indication to pledge €500 million** • Netherlands: €250 million requested by Dutch Parliament New pledges since the June Board meeting Gavi Board meeting 9-10 December 2014 * For 2014-2020. ** For 2015-2020. Exchange rates as of 1 December 2014.
  • 46. ‫رفعت‬500‫أمريكي‬ ‫دوالر‬ ‫مليون‬ IFFIm ‫أو‬‫ل‬‫صكوك‬ • Sukuk = financial certificate that complies with Islamic law • Largest ever Sukuk issuance in the public market • Over-subscribed • Diverse investor base: • 68% Middle East and Africa • 21% Asia • 11% Europe • Expanding engagement with Islamic world Gavi Board meeting 9-10 December 2014 First IFFIm Sukuk bonds raise US$ 500 million
  • 47. Co-financing update 32 52 57 62 67 68 8 5 7 4 9 13 1 US$ 21m US$ 31M US$ 32m US$ 36m US$ 64m US$ 79m 0 10 20 30 40 50 60 70 80 90 0 10 20 30 40 50 60 70 2008 2009 2010 2011 2012 2013 AmountinUS$(millions)▬ Numberofcountriesco-financingGavivaccines Partial payment Late payment Fulfilled requirement By 2013, co-financing will have more than tripled in comparison to 2008 Gavi Board meeting 9-10 December 2014 Zimbabwe Afghanistan* Angola* Cameroon Congo Republic* Djibouti Ghana Guinea* Kenya Kiribati Kyrgyzstan Pakistan* Sierra Leone Solomon Islands * Defaulted both in 2012 and 2013. Source: Gavi data as of 5 December 2014.
  • 48. 1st wave 2nd wave Under-5 mortality rate1 41 63 GNI per capita at entering graduation5 $2,400 $1,800 2013 total fertility Rate2 3.0 3.6 Vaccines introduced3 2.1 4.6 Average length of graduation period (years)4 6 5 Graduating countries: 1st wave entered graduation in 2011, 2nd wave in 2012–2020  Successfully introduced most/all Gavi vaccines  High impact due to high burden of vaccine- preventable diseases × Higher fiscal burden following graduation × Faster pace of financial scale-up required  Successful transition to self-financing  Projected vaccine costs affordable (at Gavi price)  Low risk to sustainability of vaccine programmes × Missed opportunities for vaccine introductions 1. Source: World Bank World Development Indicators, accessed September 2014. 2. Total Fertility Rate; Source: UN World Population Prospects, accessed October 2014 3. Modeled using GAVI’s Adjusted Demand Forecast 4. 1st wave obtained from GAVI Secretariat, 2nd wave modeled 5. World Bank GNI per capita 2013 and earlier, modeled starting in 2014 Gavi Board meeting 9-10 December 2014
  • 49. • Health financing assessments in graduating countries – findings to support dialogue on sustainable financing • Graduation missions to support assessments and plans, building on health financing dialogue and working with Ministers of Finance • Discussion paper on role of health insurance mechanisms in financing immunisation service delivery World Bank Group supporting country graduation efforts in 2015 Will help shape World Bank involvement in 2016–2020 strategy Gavi Board meeting 9-10 December 2014
  • 50. Further reduction in vaccine prices * Future targets are not publicised to avoid setting a minimum price. Source: UNICEF Supply Division, 2014. Cost to fully immunise a child with pentavalent, pneumococcal and rotavirus vaccines reached a new low in mid 2014 – but more needs to be done Gavi Board meeting 9-10 December 2014
  • 51. Further reduction in vaccine prices Cost to fully immunise a child with pentavalent, pneumococcal and rotavirus vaccines reached a new low in mid 2014 – but more needs to be done Future targets are not publicised to avoid setting a minimum price. Source: UNICEF Supply Division, 2014. Gavi Board meeting 9-10 December 2014
  • 52. Development 7 completed HPV, pentavalent, yellow fever, rotavirus, measles-rubella, IPV, Japanese encephalitis, pneumococcal (2014) 1 update Pentavalent (2014) 3 in development Cholera, HPV update, meningitis 2 on hold Typhoid, malaria Implementation Gavi Secretariat coordinates interventions in close cooperation with partners Stakeholders include Secretariat, UNICEF Supply Division, Bill & Melinda Gates Foundation, WHO Vaccine roadmaps Gavi Board meeting 9-10 December 2014
  • 53. Japanese encephalitis vaccine • First tender concluded July 2014 • Gavi’s first Chinese vaccine supplier • GAVI-supported campaigns forecast to require > 75 million doses 2015–2020 • Secured sufficient supply to meet increasing demand through 2016 • First introduction expected in Lao PDR 2015 Gavi Board meeting 9-10 December 2014
  • 54. Vaccine delivery innovation: Uniject for pentavalent vaccine Gavi Board meeting 9-10 December 2014 • Prequalified in November 2014 • New delivery model: • Simplifies vaccine administration • Reduces missed opportunities by ensuring syringe and vial always available together • Facilitates outreach • Will explore making available to Gavi-supported countries
  • 56. Immunisation coverage increasing: reaching more children than ever before Coverage of third dose of DTP-containing vaccines increased to 76% in Gavi-supported countries Source: WHO/UNICEF Estimates of National Immunization Coverage, July 2014. Gavi Board meeting 9-10 December 2014
  • 57.  Projections (SDF10) Actual Target Progress towards vaccine coverage goals, but still behind target Pentavalent vaccine Pneumococcal vaccine Rotavirus vaccine Coverage in Gavi-supported countries (%) Gavi Board meeting 9-10 December 2014
  • 58. Investment for 36 HSS grants recommended for approval, January 2011 – October 2014 Procurement & supply chain management: US$ 214 m (26%) Service delivery: US$ 177 m (21%) Health workforce and human resources: US$ 161 m (20%) Health information systems: US$ 109 m (13%) Programme management: US$ 76 m (9%) Empower community and other local actors: US$ 69 m (8%) Other: US$ 25 m (3%) Gavi Board meeting 9-10 December 2014
  • 59. 2013 intermediate results: Burundi All but grant utilisation was stable or improved % of community health workers trained Availability of community health workers % of facilities with functioning cold chains Timeliness of district reporting % of districts reporting negative drop-out rates % of districts report a verification factor equal to or greater than the DTP3 coverage Gavi grant execution rate Baseline (2012 unless otherwise specified) 2013 result 2013 target (2013 baseline) (2011 baseline) Gavi Board meeting 9-10 December 2014
  • 60. 28 20 8 21 30 46 16 15 11 0 10 20 30 40 50 60 70 2013 projections based on country requests 2014 APR with 2013 adjustments Latest end-of-year projections with 2014 adjustments Understocked Appropriately stocked Overstocked Pentavalent vaccine - projected number of countries with “appropriate” stock levels (central warehouse + 1 level), by the end of 2014 Definitions: Understocked = less than 4 months of stock, overstocked = more than 8 months of stock Improvement of stocks – further improvement expected Gavi Board meeting 9-10 December 2014
  • 61. Full country evaluation: preliminary district level summary, Zambia Gavi Board meeting 9-10 December 2014
  • 62. Full country evaluation: preliminary trends in sub-national coverage and equity, Bangladesh DTP3-containing vaccination coverage by district, 1995-2013 Gavi Board meeting 9-10 December 2014
  • 63. Full country evaluation: biomarkers for rubella antibody positivity in pre and post MR campaign, Bangladesh 55 54 59 54 95 96 86 93 0 10 20 30 40 50 60 70 80 90 100 Rural Urban Rural Urban Rajshahi Sylhet Percentage Pre-MRC Post-MRC Gavi Board meeting 9-10 December 2014
  • 64. Source: MDG survey, 2013; CI refers to 95% confidence interval; OR = Odds ratio Inequities in Immunization take many forms Immunization inequities by population characteristics, Madagascar, 2011 100 90 80 70 60 50 40 30 20 10 Madagascar (63%) Boys (63.1) Girls (62.6) Urban (87) Rural (59) Secondary education or more (80) No formal instruction (47) Birth Order 2nd (68) Birth Order 6+ (50) Mother’s education Wealthiest quintile (74%) Poorest quintile (49%) % DTP3 Itasy Region (89) Menabe region (26) Gavi Board meeting 9-10 December 2014
  • 65. New programme review model: first year experience • High-level panel: Gavi Secretariat, WHO, UNICEF and Independent Review Committee members • 70 countries reviewed in 2014 • More in-depth look at programmes, strengthens links to business plan and HSS • Workload for partners and Secretariat higher than expected – increased engagement and accountability • Partner joint appraisals welcomed: • strengthens partnerships • grounds discussions in country context Gavi Board meeting 9-10 December 2014
  • 66. Supply chain fund: Example – Mali support • Gavi funded 110 solar fridges, 24 electrical fridges + temperature recorders for 1,000 fridges to help prepare for rotavirus vaccine roll-out • Because of catalytic aspect of Gavi supply chain fund, Mali government self- financed 11 additional refrigerators • Supply chain fund is financed by the ELMA foundation to help quickly address gaps Gavi Board meeting 9-10 December 2014
  • 67. New Gavi-funded solar fridge and freezer in Maiduguri, Nigeria The only functioning fridge at Yarwa PHC Gavi Board meeting 9-10 December 2014
  • 68. Source: Lydon P, Zipursky S, Tevi-Benissan C et al. Economic benefits of keeping vaccines at ambient temperature during mass vaccination: the case of meningitis A vaccine in Chad. Bull World Health Organ 2014;92:86–92 . Gavi Board meeting 9-10 December 2014 Note: data shown are actual costs recorded in the mass vaccination campaign run in three regions of Chad in Dedember 2011 and the costs estimated in a modelled scenario in which a CTC was implemented. Controlled temperature chain (CTC) for meningitis A vaccines Modelled impact on cold chain costs in three regions in Chad, 2011 (cost in US$ per person vaccinated)
  • 70. First articulation of comprehensive risk management approach Gavi Board meeting 9-10 December 2014  Operationalisation: initial focus on strengthening fiduciary risk management in Gavi Secretariat  Other elements to be developed as part of risk management implementation plan in 2015
  • 71. Misuse of funds 2000–2014 100% of countries have agreed to reimburse misused funds Gavi Board meeting 9-10 December 2014 Repayments since the June Board meeting: REIMBURSED TO DATE: US$ 6.2 m New cases:
  • 72. Gavi-Nigeria joint letter of understanding Systemic weaknesses in financial controls… may have led to the inappropriate use of funds. The GoN agrees… to reimburse Gavi for any amounts identified as inappropriately used The way forward… underlines our common commitment to saving children’s lives through an effective immunisation program. Gavi Board meeting 9-10 December 2014
  • 74. Ebola: 4 recommended areas for Gavi action Gavi Board meeting 9-10 December 2014 Recovery of health and immunisation systems # cases (illustrative) TimeProduction & Procurement funding Future outbreak preparedness 1 4 Funding vaccine roll-out 2 Funding vaccine roll-out 2 3 Current outbreak Potential future outbreak (magnitude unknown) Future outbreak with stockpile present
  • 75. Business plan 2015: a bridging plan Gavi Board meeting 9-10 December 2014
  • 76. Four main areas in implementation of 2016–2020 strategy Country engagement model/ coverage & equity Global strategies, policies & programmes Business plan redesign  Plans for improving coverage & equity  Gavi programme/support to improve coverage & equity  Alliance model at country level Started: a) Supply chain b) Eligibility, graduation, co-financing c) Private sector d) ATAP e) Innovation/market shaping f) Data strategy  New processes and funding  Coordination & engagement mechanisms  Organisational review 1 2 3 Indicators & targets 4  Develop indicators, baseline & targets In pipeline: g) HSS formula h) Leadership, management & coordination i) Non-financial instruments for sustainability j) Demand generation Gavi Board meeting 9-10 December 2014
  • 77.
  • 78.
  • 79. 79 Gavi Board meeting 9-10 December 2014
  • 80.
  • 81. Building global momentum Germany Leadership in action “Together, we can support Gavi, the Vaccine Alliance in its endeavour to vaccinate 300 million children between 2016 and 2020, thus helping to save lives. Together, we can succeed in reaching all children in our world and giving them the chance to live a healthy life” Dr Angela Merkel German Federal Chancellor Gavi Board meeting 9-10 December 2014
  • 82. Reach every child: Gavi pledging conference Berlin, 27 January 2015 “Health is a key area… a main focus of our G7 presidency. Our start in the year 2015 will be the replenishment conference of Gavi.” Angela Merkel Federal Chancellor, Germany Gavi Board meeting 9-10 December 2014
  • 83. 15 years of saving lives: what we have achieved together > 280 vaccine intros & campaigns supported  > 280 intros & campaigns Gavi’s portfolio grown from 3 to 11 vaccines  > 280 intros & campaigns  From 3 to 11 vaccines Pentavalent vaccine in 73/73 Gavi countries  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries Improved injection safety in 68 countries  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries Health system strengthening support to 65 countries  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries Pneumococcal vaccine in 45 countries  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries 24 countries approved for HPV vaccine support  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries US$ 9bn committed to countries  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed US$ 5 billion raised via vaccine bonds  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds Countries have co-financed more than US$ 250m  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds  US$ 250m in co-financing Average pentavalent vaccine price down by 40%  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds  US$ 250m in co-financing  Pentavalent price down 40% Suppliers of Gavi vaccines increased from 5 to 16  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds  US$ 250m in co-financing  Pentavalent price down 40%  From 5 to 16 vaccine suppliers Vaccine coverage up from 60% to 76% in Gavi countries  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds  US$ 250m in co-financing  Pentavalent price down 40%  From 5 to 16 vaccine suppliers  Vaccine coverage up to 76% 500 million children immunised  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds  US$ 250m in co-financing  Pentavalent price down 40%  From 5 to 16 vaccine suppliers  Vaccine coverage up to 76%  500m children immunised More than 6 million future deaths prevented  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds  US$ 250m in co-financing  Pentavalent price down 40%  From 5 to 16 vaccine suppliers  Vaccine coverage up to 76%  500m children immunised  > 6m future deaths prevented
  • 84. 15 years of saving lives: what we have achieved together  > 280 intros & campaigns  From 3 to 11 vaccines  Pentavalent in 73/73 countries  Injection safety in 68 countries  HSS support to 65 countries  Pneumo vaccine in 45 countries  HPV support to 24 countries  US$ 9bn committed  US$ 5bn via vaccine bonds  US$ 250m in co-financing  Pentavalent price down 40%  From 5 to 16 vaccine suppliers  Vaccine coverage up to 76%  500m children immunised  > 6m future deaths prevented YEARS OF SAVING LIVES TOGETHER