GRF One Health Summit 2012, Davos: Presentation by Prof. Charlotte Braun-Fahrländer - Professor - Swiss Tropical and Public Health Institute (Swiss TPH)

1. Protective factors for the development of childhood asthma and allergies in rural environments Prof. Dr. med Charlotte Braun-Fahrländer Swiss Tropical and Public Health Institute, Basel, Switzerland GRF One Health Summit 2012, Davos Plenary III: Priorities for Health regarding Chronic Respiratory Diseases

4. Braun-Fahrländer et. al. 1999 The persons who are most subjected to the action of pollen belong to a class which furnishes the fewest cases of hay fever, namely, the farming class‘. Charles Blackley 1873 Reported in more than 30 studies in various countries v. Mutius, Nature Rev Immunol 2010 School children living on a traditional farm suffer less from asthma and allergies than their peers living in the same village

5. Farm Exposure in the 1. year of life and asthma/ allergy at school age (ALEX study) % Riedler et al. Lancet 2001; 358:1129-1133

6. Microbial exposures Bacteria, Fungi Allergens Grass pollen, cow epithelia, mites Plant derived material polysaccarides (arabinogalactans) Typical exposures And many others….

7. Diversity of environmental microbial exposure of indoor dust sample is inversely related to asthma Ege et al. NEJM 2011 Farm child Bacteria (PARSIFAL study) Farm child Fungi (GABRIELA study) Farm child Asthma Asthma

8. Unprocessed farm milk consumption independently related to asthma and allergies Waser CEA 2007

9. p<0.0001 p<0.0001 p = 0.0342 Ege, Bieli JACI 2006 TLR2 TLR4 CD14 Genexpression of innate immunity receptors of farm and non-farm children (PARSIFAL)

10. Working model of Immunobiology of farm exposure (Vercelli D, von Mutius E, Nature Reviews Immunology 2010)