GRF 2nd One Health Summit 2013: Presentation by Claude Favrot, ECVD Vetsuisse Faculty, Zurich

1. Zürich Universität- Vetsuisse Fakultät
Klinik für Kleintiermedizin
Dermatologie Abteilung
Human & canine atopic dermatitis:
Similarities and differences
Prof. Dr Claude Favrot, MsSc, Dip.ECVD
Vetsuisse Faculty, Zurich

2. Human versus canine AD
• Many similarities and some (minor)
differences

3. CAD: Definition (Halliwell for ICADA, 2008)
• A genetic predisposed, inflammatory and
pruritic dermatitis, that often develops in
association with environmental allergenspecific IgE

8. CAD: Localization
32%
58%
32%
42%
62%
75%
80%
66%

9. CAD: A familial disease

10. Genetic make-up
Food
Food
UV
Stress
Microbes
Stress
Impaired epidermal
barrier
+
Impaired imm.syst.
Th2 responders
High IgE responders
Climate
Irritant contact d.
Allergic contact d.
+
Allergenes:
Environmental,
food, microbes,
autoallergens
Microbes
Contactants
Atopic dermatitis,
Atopic-like dermatitis
Favrot, 2011

11. Diagnosis of CAD
•
•
•
Exclusion of resembling diseases
Criteria
Allergy tests:
–
–
–
IgE serology
Intradermal testing
Elimination diet

13. Major allergens
• House dust mites and storage mites. 90%
–
–
–
–
Dermatophagoides Farinae
DP, AC, Tyrophagus
Numerous cross reactions
Derf15 >Derf1, Derf2
• Pollens. 30%
– Cedar, Ragweed, Birch, Dandelion...
• Molds: 50%
• Epithelia: 5%

14. Role of food
• Food hypersensitivity
–
–
Atopic dermatitis
Urticaria, Angioedema, GI
• Elimination diet and provocation
– IgE driven?

15. CAD treatment
•
•
•
Glucocorticoids and Calcineurin inhibitors
Systemically rather than topically
Allergen-specific immunotherapy
– 70% success rate
• New trends:
–
–
Jak inhibitors: Oclacitinib
C kit inhibitors: Masitinib

17. Allergy march in atopic dogs?
• Food allergy in younger dogs?
• Pollen allergy before mites allergy?

18. Conclusion
• Human atopic dermatitis is a good model
for canine atopic dermatitis 

19. Any
question?