2014-0826 Davos
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5th International Disaster and Risk Conference IDRC 2014 Integrative Risk Management - The role of science, technology & practice 24-28 August 2014 in Davos, Switzerland
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2014-0826 Davos
- 1. Preventing chronic diseases by reducing exposures to endocrine disrupting compounds. John Peterson Myers, Ph.D. Environmental Health Sciences and Carnegie Mellon University Environmental Health Sciences
- 2. Hormone-related cancers ADHD Environmental Health Sciences Infertility Asthma Learning disabilities Pre-term birth Diabetes Allergies Degenerative diseases Autism Fibroids Heart disease AutoimmunityEndometriosis Obesity polycystic ovaries
- 3. Endocrine disruption 1. Related to today’s human epidemics. 2. Ubiquitous exposure 3. Powerful effects even at low doses 4. We know enough now to start eliminating exposures and making people healthier Environmental Health Sciences
- 4. 19 Feb 2013: WHO – UNEP report Environmental Health Sciences
- 5. 2013 WHO-UNEP report Many endocrine related disorders are on the rise, far too rapidly to be a change in gene frequency. ~800 chemicals in common use are known to disrupt endocrine function. Human and wildlife exposure is ubiquitous. Numerous laboratory, wildlife and epidemiological studies are consistent with endocrine disruption impacts on human health. Disease risk due to EDCs may be significantly underestimated. Significant opportunities for disease prevention by reducing exposures may be within reach. Environmental Health Sciences
- 6. Glucocorticoid hormone Tumor suppressing protein Cell nucleus Receptor Environmental Health Sciences Kaltreider et al. 2002
- 7. Glucocorticoid hormone Arsenic Cell nucleus Receptor Environmental Health Sciences Kaltreider et al. 2002
- 8. Revolution in science 1. Low doses matter a lot 2. Events in the womb don’t stay in the womb 3. The tools we have used to assess safety are profoundly misguided Environmental Health Sciences
- 9. Same strain of mice Same caloric intake Same activity levels Environmental Health Sciences Newbold et al. 2005, 2007 1 part per billion
- 10. 2.5 parts per billion of atrazine Environmental Health Sciences
- 12. 1,000,000 10,000 100 0.1 Recommended application Run-off Streams Surface water Safe for drinking water Rain Environmental Health Sciences 1 PPB Safe short term Hayes et al. 2002 ATRAZINE This result
- 13. Revolution in science 1. Low doses matter a lot 2. Events in the womb don’t stay in the womb 3. The tools we have used to assess safety are profoundly misguided Environmental Health Sciences
- 14. Kidneys Control Bladder Testes Environmental Health Sciences Kidneys Bell Jones et al. 2007 T&E2 Capsule T&E2 Capsule Bladder Testis BPA
- 15. Revolution in science 1. Low doses matter a lot 2. Events in the womb don’t stay in the womb 3. The tools we have used to assess safety are profoundly misguided Environmental Health Sciences
- 16. 1 part per billion What about 1000 ppb? Same strain of mice Same caloric intake Same activity levels Environmental Health Sciences Newbold et al. 2005, 2007
- 17. Non-monotonicity of tamoxifen Environmental Health Sciences Welshons, in Vandenberg et al. 2012
- 19. Revolution in science Epigenetics and endocrine disruption Environmental Health Sciences
- 20. OLD: Toxic components work by overwhelming the body’s defenses by brute force. Environmental Health Sciences NEW: Some compounds work by hijacking control of gene expression.
- 21. OLD: Toxic components work by overwhelming the body’s defenses by brute force. Environmental Health Sciences NEW: Some compounds work by hijacking control of gene expression. Only high levels matter “Normal” levels which could not even be measured 20 years ago matter
- 22. Hormone-related cancers ADHD Environmental Health Sciences Infertility Asthma Learning disabilities Pre-term birth Diabetes Allergies Degenerative diseases Autism Fibroids Heart disease AutoimmunityEndometriosis Obesity polycystic ovaries
- 23. A new way forward. the 4th R: Redesign Environmental Health Sciences
- 24. Designing against EDC hazard Tiered Endocrine Disruptor Protocol Voluntary… based on current science Not about current replacements Economically efficient Driven by endocrinological principles Designed to evolve with the science Environmental Health Sciences