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Welcome!
Colorectal Cancer
Newly Diagnosed: Where to go from here…
Part of Fight Colorectal Cancer’s Monthly Patient Webinar Series

Our webinar will begin shortly

www.FightColorectalCancer.org
877-427-2111
Fight Colorectal Cancer
1. Tonight’s speaker: Dr. Edward Crane, MD

2. Archived webinars: Link.FightCRC.org/Webinars
3. Follow up survey to come via email. Get a free Blue Star of
Hope pin when you tell us how we did tonight.
4. Ask a question in the panel on the right side of your screen and
look for hyperlinks during throughout the presentation.
5. Or call the Fight Colorectal Cancer Answer Line at 877-427-2111
www.FightColorectalCancer.org
877-427-2111
Fight Colorectal Cancer
Disclaimer
The information and services provided by Fight Colorectal
Cancer are for general informational purposes only.
The information and services are not intended to be substitutes
for professional medical advice, diagnosis, or treatment.
If you are ill, or suspect that you are ill, see a doctor
immediately. In an emergency, call 911 or go to the nearest
emergency room.
Fight Colorectal Cancer never recommends or endorses any
specific physicians, products or treatments for any condition.
www.FightColorectalCancer.org
877-427-2111
Fight Colorectal Cancer
Up coming webinars
Research and Treatment News:
Highlights from the 2014 Gastrointestinal Symposium
Wednesday, February 19th 2014
4:00pm – 5:00pm EDT
Take the Wheel:
Healthy lifestyle changes that may reduce your risk of a
CRC recurrence
Wednesday, March 26th 2014
3:00pm - 4:00pm EDT
Fight Colorectal Cancer

Dr. Edward Crane, MD
“Good listening is the key to taking excellent care of patients. I
always tell my patients that he or she is the captain of the ship
and my job is to help with navigation”…
www.FightColorectalCancer.org
877-427-2111
January 22, 2014
The Presenter: Dr. Ed Crane
 Board certified in medical







hematology, medical oncology,
internal medicine and palliative
care
OHC physician
www.OHCare.com
Trained in oncology and
hematology at Moffitt Cancer
Center in Tampa, FL
Chair of the cancer program at
West Chester and Mercy
Fairfield Hospitals
Enjoys exercising and spending
time with family in spare time
What is the colon?
 Last part of the digestive

system
 Extracts water, sodium and
some fat soluble vitamins
 Approximately 5 feet in
length
How does a cancer form in the
colon?
 Most colon cancers begin as a

polyp
 The whole process may take
5-10 years
 As the polyps grow, they can
develop cancerous cells that
then multiply to become a
tumor
 Some cancers in a genetic
cancer syndrome can bypass
the polyp phase
How is colon cancer staged?
 Stage I very superficial with

minimal invasion
 Stage II through most if not all
of the layers of the colon but no
lymph node involvement
 Stage III lymph node
involvement but has not
travelled away from the colon
 Stage IV travelled away from the
colon
Colon Cancer Incidence
 Over 100,000/year diagnosed with colon cancer in the

United States
 Over 40,000/year diagnosed with rectal cancer
 Average age is in the 60’s but I have treated patients
from 28-90
Risk Factors
 Colon polyps
 Family history
 Inflammatory bowel diseases (Ulcerative Colitis or

Crohn’s Disease)
 Type II diabetes
 Red meats and processed meats
 Smoking
Hereditary Cancer Syndromes
 HNPCC- Hereditary Non-Polyposis Colorectal Cancer
 Accounts for 3% of all colon cancer
 Age less than 50 or strong family history
 Tends to be right sided colon cancer but not always
 Skips the polyp step in cancer formation
 Those with the gene have an 80% chance of developing colon
cancer
 Risk of uterine cancer
 Familial Adenomatous Polyposis
 Hundreds of polyps throughout colon and rectum
 100% chance of one becoming cancer before age 40 if not
removed
What is the most important aspect of care when
a patient is diagnosed with colon cancer?

The
Patient!
Positive Quote
Sedona, AZ
 “You yourself, as much as

anybody in the entire
universe, deserve your love
and affection.” – Buddha
What do you need as a patient?
 A team of doctors that communicate
 What does it mean to have multidisciplinary clinics?
 Gastroenterologist
 Medical Oncologist
 Who helps the physicians?
 Treatment nurses/treatment suite
 Proximity of office
 Personality/Professionalism/Bedside manner
 Availability of clinical trials
 Surgeon: Importance of colorectal fellowship?
 Laparascopic trained?
 Complication rates/average length of stay in the hospital
 Radiation oncologist
Other Support Services













Support Groups
Cancer Support Community
Cancer Family Care
American Cancer Society
Physical Therapy/Dietary at local hospital
Exercise groups at local Y
Personal Trainer
Friends and Family
www.clinicaltrials.gov
www.nccn.org for patients tab
www.OHCare.com
www.FightColorectalCancer.org
http://www.nccn.org/patients/guidelines/colon/index.html#1
Important Issues to Keep in Mind
 A patient is not a diagnosis
 A patient is not a statistic
 There is a certain social undertone to having been

diagnosed with cancer
 There is nothing wrong with you as a person

 You do not have to let it dominate your life or

conversation unless you need it to be that way
Half Dome viewed from Glacier
Point, Yosemite National Park

 Surround yourself with

people who are going to lift
you higher
Treatment for Colon Cancer
 It depends upon the stage
 A standard treatment after surgery for stage III and some

stage II colon cancers is FOLFOX
 Given every 2 weeks and requires a home infusion pump






Diarrhea and mouth sores
Numbness and tingling
Cold sensitivity
Fatigue and increased risk of infection
Chemobrain

 Xeloda, a pill, can be used as treatment, too.
 Utilized when side effects of FOLFOX might be too harsh for
the patient
Treatment for Colon Cancer
 For stage IV cancers, Avastin is usually added to the

chemotherapy
 Multiple treatment option including FOLFIRI, Xeloda,
Cetuximab, Panitumumab, Regorafenib
 May have surgery or radiation, as well
 A few stage IV cancer still have the opportunity for
cure, determined by the number and size of tumors in
the liver, if they are localized to only one lobe, and if
they reduce significantly in size with chemotherapy
Treatment for Rectal Cancers
 Combined chemotherapy (infusion Mon-Fri) or

Xeloda with radiation
 Surgery
 Further chemotherapy either FOLFOX or Xeloda
On the Horizon
Somewhere in the Caribbean
 Personalized Medicine
 Determining aspects of the

tumor that create sensitivity
or resistance to certain
treatments
 Oncotype DX testing to
determine who might benefit
from adjuvant chemotherapy
 Prevention through improved
screening
Questions?
Mariposa Grove, Yosemite
National Park
 No question is too big or too

small
 If you have further questions

later after the talk, I can be
e-mailed from our website:
www.OHCare.com
Fight Colorectal Cancer
CONTACT US
Fight Colorectal Cancer
1414 Prince Street, Suite 204
Alexandria, VA 22314
(703) 548-1225
Toll-Free Answer Line: 1-877-427-2111
www.FightColorectalCancer.org

Email us: Info@FightColorectalCancer.org

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Webinar: Colon Cancer Newly Diagnosed

  • 1. Welcome! Colorectal Cancer Newly Diagnosed: Where to go from here… Part of Fight Colorectal Cancer’s Monthly Patient Webinar Series Our webinar will begin shortly www.FightColorectalCancer.org 877-427-2111
  • 2. Fight Colorectal Cancer 1. Tonight’s speaker: Dr. Edward Crane, MD 2. Archived webinars: Link.FightCRC.org/Webinars 3. Follow up survey to come via email. Get a free Blue Star of Hope pin when you tell us how we did tonight. 4. Ask a question in the panel on the right side of your screen and look for hyperlinks during throughout the presentation. 5. Or call the Fight Colorectal Cancer Answer Line at 877-427-2111 www.FightColorectalCancer.org 877-427-2111
  • 3. Fight Colorectal Cancer Disclaimer The information and services provided by Fight Colorectal Cancer are for general informational purposes only. The information and services are not intended to be substitutes for professional medical advice, diagnosis, or treatment. If you are ill, or suspect that you are ill, see a doctor immediately. In an emergency, call 911 or go to the nearest emergency room. Fight Colorectal Cancer never recommends or endorses any specific physicians, products or treatments for any condition. www.FightColorectalCancer.org 877-427-2111
  • 4. Fight Colorectal Cancer Up coming webinars Research and Treatment News: Highlights from the 2014 Gastrointestinal Symposium Wednesday, February 19th 2014 4:00pm – 5:00pm EDT Take the Wheel: Healthy lifestyle changes that may reduce your risk of a CRC recurrence Wednesday, March 26th 2014 3:00pm - 4:00pm EDT
  • 5. Fight Colorectal Cancer Dr. Edward Crane, MD “Good listening is the key to taking excellent care of patients. I always tell my patients that he or she is the captain of the ship and my job is to help with navigation”… www.FightColorectalCancer.org 877-427-2111
  • 7. The Presenter: Dr. Ed Crane  Board certified in medical      hematology, medical oncology, internal medicine and palliative care OHC physician www.OHCare.com Trained in oncology and hematology at Moffitt Cancer Center in Tampa, FL Chair of the cancer program at West Chester and Mercy Fairfield Hospitals Enjoys exercising and spending time with family in spare time
  • 8. What is the colon?  Last part of the digestive system  Extracts water, sodium and some fat soluble vitamins  Approximately 5 feet in length
  • 9. How does a cancer form in the colon?  Most colon cancers begin as a polyp  The whole process may take 5-10 years  As the polyps grow, they can develop cancerous cells that then multiply to become a tumor  Some cancers in a genetic cancer syndrome can bypass the polyp phase
  • 10. How is colon cancer staged?  Stage I very superficial with minimal invasion  Stage II through most if not all of the layers of the colon but no lymph node involvement  Stage III lymph node involvement but has not travelled away from the colon  Stage IV travelled away from the colon
  • 11. Colon Cancer Incidence  Over 100,000/year diagnosed with colon cancer in the United States  Over 40,000/year diagnosed with rectal cancer  Average age is in the 60’s but I have treated patients from 28-90
  • 12. Risk Factors  Colon polyps  Family history  Inflammatory bowel diseases (Ulcerative Colitis or Crohn’s Disease)  Type II diabetes  Red meats and processed meats  Smoking
  • 13. Hereditary Cancer Syndromes  HNPCC- Hereditary Non-Polyposis Colorectal Cancer  Accounts for 3% of all colon cancer  Age less than 50 or strong family history  Tends to be right sided colon cancer but not always  Skips the polyp step in cancer formation  Those with the gene have an 80% chance of developing colon cancer  Risk of uterine cancer  Familial Adenomatous Polyposis  Hundreds of polyps throughout colon and rectum  100% chance of one becoming cancer before age 40 if not removed
  • 14. What is the most important aspect of care when a patient is diagnosed with colon cancer? The Patient!
  • 15. Positive Quote Sedona, AZ  “You yourself, as much as anybody in the entire universe, deserve your love and affection.” – Buddha
  • 16. What do you need as a patient?  A team of doctors that communicate  What does it mean to have multidisciplinary clinics?  Gastroenterologist  Medical Oncologist  Who helps the physicians?  Treatment nurses/treatment suite  Proximity of office  Personality/Professionalism/Bedside manner  Availability of clinical trials  Surgeon: Importance of colorectal fellowship?  Laparascopic trained?  Complication rates/average length of stay in the hospital  Radiation oncologist
  • 17. Other Support Services             Support Groups Cancer Support Community Cancer Family Care American Cancer Society Physical Therapy/Dietary at local hospital Exercise groups at local Y Personal Trainer Friends and Family www.clinicaltrials.gov www.nccn.org for patients tab www.OHCare.com www.FightColorectalCancer.org
  • 19. Important Issues to Keep in Mind  A patient is not a diagnosis  A patient is not a statistic  There is a certain social undertone to having been diagnosed with cancer  There is nothing wrong with you as a person  You do not have to let it dominate your life or conversation unless you need it to be that way
  • 20. Half Dome viewed from Glacier Point, Yosemite National Park  Surround yourself with people who are going to lift you higher
  • 21. Treatment for Colon Cancer  It depends upon the stage  A standard treatment after surgery for stage III and some stage II colon cancers is FOLFOX  Given every 2 weeks and requires a home infusion pump      Diarrhea and mouth sores Numbness and tingling Cold sensitivity Fatigue and increased risk of infection Chemobrain  Xeloda, a pill, can be used as treatment, too.  Utilized when side effects of FOLFOX might be too harsh for the patient
  • 22. Treatment for Colon Cancer  For stage IV cancers, Avastin is usually added to the chemotherapy  Multiple treatment option including FOLFIRI, Xeloda, Cetuximab, Panitumumab, Regorafenib  May have surgery or radiation, as well  A few stage IV cancer still have the opportunity for cure, determined by the number and size of tumors in the liver, if they are localized to only one lobe, and if they reduce significantly in size with chemotherapy
  • 23. Treatment for Rectal Cancers  Combined chemotherapy (infusion Mon-Fri) or Xeloda with radiation  Surgery  Further chemotherapy either FOLFOX or Xeloda
  • 24. On the Horizon Somewhere in the Caribbean  Personalized Medicine  Determining aspects of the tumor that create sensitivity or resistance to certain treatments  Oncotype DX testing to determine who might benefit from adjuvant chemotherapy  Prevention through improved screening
  • 25. Questions? Mariposa Grove, Yosemite National Park  No question is too big or too small  If you have further questions later after the talk, I can be e-mailed from our website: www.OHCare.com
  • 26.
  • 27. Fight Colorectal Cancer CONTACT US Fight Colorectal Cancer 1414 Prince Street, Suite 204 Alexandria, VA 22314 (703) 548-1225 Toll-Free Answer Line: 1-877-427-2111 www.FightColorectalCancer.org Email us: Info@FightColorectalCancer.org