Udaipur Call Girls 📲 9999965857 Call Girl in Udaipur
Call-on Congress Panel Discussion Part 3 Ho-Chou Tu #ConC2015
1. LIN28 is a Novel Molecular Player
Involved in Colorectal Cancer Development
Ho-Chou Tu, Ph.D
Laboratory of George Q. Daley
Boston Children’s Hospital/Harvard Medical School
Fight Colorectal Cancer Advocacy Workshop
03/16/2015
2. Genetics Changes During CRC Development
Kerr et al., Nature Reviews of Cancer (2003)
Wnt Signaling
3. Our Goals to Improve the Current Field
of CRC Research
1. Generate a late-stage CRC animal model
2. Identify and characterize novel molecular targets
for more specific therapeutic design
12. Acknowledgement
The Daley lab
-George
-Sarah Schwitalla
-Grace LaPier
-Alena Yermalovich
-Sam Ross
-Achia Urbach
-John Powers
-all Daley lab members
-Charlie Fuchs
-Shugi Ogino
-Ziron Qian
DFCI
Rodent Path Core
-Rod Bronson
-Gavin Meredith
-Jeffery Ku
-Shann-Ching Chen
Hinweis der Redaktion
In summary, I have created a novel colorectal cancer mouse model by overexpressing a novel oncoprotein found highly expressed in human CRCs. With this in vivo model in hand, I will set out to further dissect the moledular mechanisms down stream of Lin28, and also it’s interaction withesignaling pathways that’s known to play major roles in CRC development including Wntm Kras and p53….Lastly, we are also developing small molecules that targets Lin28/let-7 interaction, we hope to use this mouse model as a great pre-clinical in vivo platform for drug screen. CRC is the 2nd most cancers world wide, and so far, the best way to target it is still surgery plus conventional chemotherapy…I hope that by generating new animal models, we are able to model human CRC better and help designing more effective drugs