Common machinery of tablet manufacturing & Small scale & large scale manufacturing

2. Presentation Over
Common machinery of tablet
manufacturing
Small scale & large scale manufacturing

3. CONTENTS
 Introduction
 Properties of tablets
 Advantages & disadvantages
 Formulation
 Machineries in tablet processing
 Large scale manufacturing
 Characteristics & motives of large scale manufacturing
 Problems associated with large scale manufacturing
 Remedy of large scale manufacturing problems
 Small scale manufacturing
 Reasons behind selection of small scale manufacturing
 Concept of pilot plant
 Comparism between large scale manufacturing and small scale manufacturing
 Conclusion
1

4. Introduction:
Solid dosage form is most frequently taking drugs. It may
be administered orally as powders, pills, capsules and
tablets. Tablets is most widely use in medicine form.
Tablets are-
 Solid dosage form
 Administered orally
 Contain unit dosage form
 Prepared by molding or compression

5. Properties of Tablet
 Elegant product identity with no defects
 Sufficient strength to withstand mechanical shock
 Should have chemical & mechanical Stable
 Release active ingredients in predicted ways
 Should have elegance to customer

6. Advantages of tablets:
 Ease of accurate dosing.
 Good physical & chemical stability.
 Lighter & compact.
 Lower cost.
 Provides greatest dose precision.
 Highly convenient

7. Disadvantage
 Difficult to swallow
 Difficult to formulate a drug with poor wettability & slow dissolution into a tablet .
 Slow onset of action .
 2. Some drugs resist compression into dense compacts, owing to amorphous nature,
low density character.
 3. Drugs with poor wetting, slow dissolution properties, optimum absorption high
in GIT may be difficult to formulate or manufacture as a tablet that will still
provide adequate or full drug bioavailability.
 4. Bitter testing drugs, drugs with an objectionable odor or drugs that are sensitive
to oxygen may require encapsulation or coating. In such cases, capsule may offer
the best and lowest cost.

8. Formulation of tablets
1. Active ingredients.
2. Excipients.
- Diluent: Mannitol, Glucose
- Binder:Gelatin, Cellulose
- Disintegrants: cellulose
- Glidant: Silica , Talc
- Lubricant: PEG , Mangnesium stearate
- Anti adherent: Starch
- Sorbent: Microcrystalline cellulose
- Coloring agent:

9. Machineries in tablet processing
Fig: Tablet Press

10. Machineries in tablet processing
Fig: Mass mixer
Fig: Oscillating granulator Fig: Rapid Mixer Granulator
Fig: Multi Mill Machine Fig: Double cone blender Fig: Drum mixer

11. Machineries in tablet processing
Fig: Fluid bed dryer Fig: Vacuum Tray Dryer
Fig: Compression machine Fig: Film coating
Fig: Automated
mechanical shifter
Fig: Strip machine

12. Machineries in tablet processing
Fig: Blister Machine Fig: Single press Fig: Rotary Press

13. What is packing
Packing is a process by which wrappe the finished product.
It stands to get following feature:-
 Prevent drug degradation
 Prevent environmental changes
 unit-dose form
 Proper labeling
 barcode labeling
 prevention of microbial contamination
 Proper marketing

14. Packing Equipment
A. Blister packers
B. Bottling and filling lines
C. Cappers
D. Cartoners
E. Counters
F. Induction Sealers
G. Labelling equipment
H. Tube fillers

15. Packing Equipment
Fig: Capping Machine Fig: Counter Machine Fig: Labeling Machine
Fig: Cartoner Fig: SealerFig: Bottling Machine

16. Small scale production
Small scale manufacturing refers to the production of a commodity with a
small plant size firm. The investment in machinery is lower when compared to
large scale units.
Small scale appropriate if :-
 The business produces non-standardized
 The market size is limited
 Products have to be customized

17. Pilot plants
Pilot plants are small-scale production systems used to
 practically test and validate a production technology
before commercialization.
 Generally, the primary motivation behind building and
operating pilot plants is to understand and explore a
new technology.
 Lessons learned can help establish valuable
experience and data that results in a safer, more
efficient and commercially viable larger or full-scale
production facility.

18. Large Scale Manufacturing
The term “Large scale manufacturing” refers to the production of a
commodity on a large scale with a large sized firm. It requires huge
investments in plant and machinery.
Large scale firms characterized by
 Large scale production
 Market size is large
 Mechanization
 High labor
 Products in good quality.

19. Motive of large scale production
 Desire for increase sales
 Desire for large customer base
 Desire for economy
 Desire for global company
 Desire to overcome competition
 Desire to achieve monopoly status
 Desire to long term profitability
 Desire to increase demand

20. Problem associate in large scale production
 Less supervision
 Individual tastes ignored
 Absence of personal element
 Possibility of depression
 Dependence of foreign markets
 Cut-throat competition
 International complications
 Less adaptability

21. Problems can be avoided by small scale manufacturing
 Close supervision
 Economical management
 Personal attention
 Personal touch with employees
 Grater adaptability
 Independence
 Nature of demand
 Nature of industry

23. Have Any Question