This document discusses identifying potential physiological factors that determine if foot-and-mouth disease virus (FMDV) induces lysis of bovine epithelial cells, including tissue thickness and structure, viral replication dynamics, and receptor distribution. Improved understanding of the role of these factors could help explain lytic or non-lytic responses of epithelial cells to FMDV.

1. Identifying the potential
physiological determinants
of FMDV-induced bovine
epithelial cell lysis
Kyriaki Giorgakoudi Rubina1,2, Simon Gubbins1, John Ward2, Nicholas Juleff1, David Schley1
1The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK,
²Department of Mathematical Sciences, Loughborough University, Leicestershire, LE11 3TU, UK
kyriaki.giorgakoudi@pirbright.ac.uk

2. Keywords
Identifying the potential physiological determinants of FMDV-induced bovine epithelial cell lysis

3. Significance
Improved understanding of the role of
Tissue thickness & structure
Viral replication dynamics
Receptor distribution
in the lytic or non-lytic response of
epithelial cells to FMDV.
Identifying the potential physiological determinants of FMDV-induced bovine epithelial cell lysis