Post-Transcriptional Modification

Post-Transcriptional Modification The mRNA transcript synthesized by RNA polymerase II is modified in eukaryotes.

Steps of mRNA Processing ,[object Object],[object Object],[object Object]

Nascent RNA transcripts from protein-coding genes are called pre-mRNA . They are associated with proteins until they are exported into the cytosol. These proteins and the mRNA are collectively called heterogenous ribonucleoprotein particles (hnRNP).

Functions of hnRNP ,[object Object],[object Object],[object Object]

5’ CAPPING ,[object Object],[object Object],[object Object]

3’POLYADENYLATION ,[object Object],[object Object],[object Object],[object Object]

RNA SPLICING ,[object Object],[object Object],[object Object],[object Object]

Splicing Mechanism – PART 1 ,[object Object],[object Object],[object Object]

SPLICING MECHANISM – PART 2 ,[object Object],[object Object],[object Object]

SPLICING MECHANISM – PART 3 ,[object Object],[object Object],[object Object],[object Object],[object Object]

Trans-Splicing ,[object Object],[object Object],[object Object]

Ribozymes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Alternative Splicing ,[object Object],[object Object],[object Object]

RNA Editing ,[object Object],[object Object]

Transport Across the Nuclear Membrane ,[object Object],[object Object],[object Object]

Molecular trafficking between the nucleus and the cytoplasm occurs via nuclear pore complexes (NPCs). The NPCs allow passive diffusion of ions and small molecules. Nuclear proteins, RNAs, and ribonucleoprotein (RNP) particles larger than ~9 nm are selectively and actively transported through NPCs by a signal-mediated and energy-dependent mechanism.

Import into the Nucleus ,[object Object],[object Object],[object Object]

MRNA Export through the NPC ,[object Object]

Post-Transcriptional Modification

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