2. Definition of COPD
“A disease state characterized by
airflow limitation that is not
fully reversible..”
2
3. New Definition
• Chronic obstructive pulmonary disease (COPD) is
a preventable and treatable disease state
characterized by airflow limitation that is not fully
reversible.
• The airflow limitation is usually progressive and is
associated with an abnormal inflammatory
response of the lungs to noxious particles or
gases, primarily caused by cigarette smoking.
• COPD produces significant systemic
consequences.
3
6. Pathophysiology of COPD
• Increased mucus production and reduced
mucociliary clearance - cough and sputum production
• Loss of elastic recoil - airway collapse
• Increase smooth muscle tone
• Pulmonary hyperinflation
• Gas exchange abnormalities - hypoxemia
and/or hypercapnia
6
8. Key Indicators for COPD Diagnosis
A.Chronic cough Present intermittently or every day
B.Chronic sputum production Present for many yea
C.Dyspnoea that is Progressive
D.Acute bronchitis Repeated episodes
E.History of exposure to risks
8
10. Spirometry in COPD
Normal FEV1 > 80% of predicted value
Predicted value varies with age, height and sex
Normal FEV1% > 70%
Consider spirometry in past and present smokers
over age 45, and patients with chronic
cough, dyspnea or wheezing
10
11. Classification of COPD
• Stage 0 = At Risk(Sx i.e cough…)
• Stage I= Mild COPD(FEV1>80%)
• Stage II= Moderate COPD(FEV1 50-80%)
• Stage III= Severe COPD(FEV1 30-50%)
• Stage IV =Very Severe COPD(FEV1<30%)
11
12. MX
Objectives of COPD Management
• Prevent Progression
• Relieve symptoms
• Improve exercise tolerance and general health
status
• Prevent and treat exacerbations and
complications
• Minimize treatment side effects
12
14. • Reducing exposure to tobacco smoke, occupational
dusts, and chemicals, and indoor and outdoor air
pollutants
• Smoking cessation is the single most
effective
14
15. • None of the existing medications for COPD affects
long-term decline in lung function that is the hallmark
of this disease
15
16. • The long-term O2 with chronic respiratory failure
increases survival
• Improves exercise tolerance
16
17. • All COPD patients benefit from exercise
training program
• Improves both exercise tolerance and
symptoms of dyspnea and fatigue
17
18. What is the difference between asthma&COPD ?
18
19. COPD
• Onset in mid-life
• Symptoms slowly progressive
• Long smoking history
• Dyspnea during exercise
• Largely irreversible airflow limitation
19
20. Asthma
• Onset early in life (often childhood)
• Symptoms vary from day to day
• Symptoms at night/early morning
• Allergy, rhinitis, and/or eczema also present
• Family history of asthma
• Largely reversible airflow limitation
20
22. Introduction
• ILDs represent a large and heterogeneous
group of lower respiratory tract disorders.
• >180 diseases are know to primarily involve the
interstitium.
• An acute phase may occur but onset is usually
insidious, leading to chronic progressive
disease.
22
23. The characteristic of clinical signs
including:
• Dyspnea after exercising
• chest X-ray shows diffuse abnormality of pulmonary
parenchymal, including nodules, linear(reticular)
infiltrates
• pulmonary function tests shows restrictive
hypoventilation reduced diffusing capacity
• tissue biopsy shows a variety pulmonary fibrosis
and
aveolar inflammation
23
28. Physical examinations
• Bilateral basilar, crepitant velcro-like rale are found
in most patients
• wheezing, rhonchi
• tachypnea and tachycardia
• clubbing
• At last, pulmonary hypertention and cor-pulmonale
may be exist
28
29. Chest radiography
It is important method to diagnose the ILDs.
The majority of ILDs cause infiltrates in the
lower lung zones.
29
30. Pulmonary Function
• Pulmonary function tests of ILDs shows restrictive
hypoventilation.
•Spirometry reveals a restrictive pattern. FVC is
reduced, but FEV1/FVC supernormal.
• All lung volumes – TLC, FRC, RV – are reduced.
30
31. 1.IDIOPATHIC PULMONARY FIBROSIS
• It is the prototype ILD
• IPF is an unknown chronic interstitial lung disease.
• clinically : non-productive cough and progressive
dyspnea on effort
• Radiology: reticulonodular/reticular veiling of lower
lung zones on XR chest
• Physiology: restrictive lung function
31
32. 2.SARCOIDOSIS
Definition
Sarcoidosis is a disease of unknown cause and is
characterized by the presence of non-caseating
granulomas in one or more organ, system. It is
considered a systemic disease
Usually lungs and the lymph nodes in the
mediastinum and hilar regions are the most site of
involvement
The clinical course is quite variable asymptomatic
32
33. The cause of sarcoidosis is unknown.
But many researchers have suggested that
immune mechanisms are important in
disease pathogenesis.Genetic factor may
also play an important role.
33
34. The basic pathogenesis includes three
main stages:
Pulmonary alveolus inflammation
formation of non-caseating granulomas
the stage of interstitial fibrosis
34
35. Clinical manifestations
The clinical course is variable
the respiratory system is the most commonly
affected(90% of patients)
sometime with or without extrathoracic disease
35
36. Clinical manifestations
Mainly no symptoms at the time of presentation
sometimes the disease is identified because of
abnormalities on a chest radiograph
some patients present with respiratory symptoms
such as dyspnea and cough
36
37. Specific signs and symptoms depend on the
particular organ system(s) involved
Respiratory system disease
Intrathoracic nodal involvement and parenchymal lung
disease are the most common ways in which sarcoidosis
affeccts the respiratory system
The pulmonary parenchyma demonstrates well
defined,non-caseating granulomas with the pulmonary
interstitium
Usually upper lobes of the lung tend to be more involved
37
39. Experimental examinations and some specific
examinations
1.elevations in the level of angiotensinconverting
enzyme(ACE) The measurement of serum ACE might
be a useful diagnostic and prognostic test in
sarcoidosis
2.hypercalcemia:important complication of
sarcoidosis
3.BALF
39
41. Lung Cancer: Defined
Uncontrolled growth of malignant cells in
one or both lungs and tracheo-bronchial
tree
A result of repeated carcinogenic irritation
causing increased rates of cell replication
Proliferation of abnormal cells leads to
hyperplasia, dysplasia or carcinoma in situ
41
42. Where Does it Come From?
Radiation Exposure
Smoking
Environmental/ Occupational
Exposure
Asbestos
Radon
Passive smoke
42
43. Smoking Facts
Tobacco use is the leading cause of lung cancer 87%
of lung cancers are related to smoking
Risk related to:
age of smoking onset
amount smoked (pack yrs)
gender
product smoked
depth of inhalation
43
44. Lung cancer is the most preventable form of cancer
Quitting tobacco use significantly reduces risk
of all cancers.
44