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Intracranial anurysm
1. College Of Nursing
Madras Medical College
Chennai-03
INTRACRANIAL ANEURYSM
PRESENTED BY
EDWIN JOSE.L
MSc(nursing) I YEAR
College of nursing
Madras medical college
Chennai-03
2. INTRODUCTION
Intracranial aneurysm represents an abnormal dilatation on the
arterial wall of the cerebral vessel.
Usually develops in a vessel segments ,most often near a
bifurcation point with an underlying structural abnormalities.
Approximately 85% of aneurysm are located in the anterior
circulation of the circle of Willis.
It represents a significant health concern predominantly because
of significant morbidity and mortality associated with rupture and
subarachnoid hemorrhage
7. Circle of willis
The circle of Willis begins to form when the right and left internal carotid artery (ICA)
enters the cranial cavity and each one divides into two main branches: the anterior
cerebral artery (ACA) and middle cerebral artery (MCA).
The anterior cerebral arteries are then united and blood can cross flow by the anterior
communicating (ACOM) artery.
The ACAs supply most midline portions of the frontal lobes and superior medial parietal
lobes.
The MCAs supply most of the lateral surface of the hemisphere, except the superior
portion of the parietal lobe (via ACA) and the inferior portion of the temporal lobe and
occipital lobe.
The ACAs, ACOM, and MCAs form the anterior half, better known as the anterior cerebral
circulation.
Posteriorly, the basilar artery (BA), formed by the left and right vertebral arteries,
branches into a left and right posterior cerebral artery (PCA), forming the posterior
circulation.
The PCAs mostly supply blood to the occipital lobe and inferior portion of the temporal
lobe.
9. Definition – intracranial aneurysm
Intracranial or cerebral aneurysm is an abnormal focal dilation of
an artery in the brain that results from a weakening of the inner
muscular layer (the intima) of a blood vessel wall.
The vessel develops a "blister-like" dilation that can become thin
and rupture without warning.
The resultant bleeding into the space around the brain is called a
subarachnoid (SAH).
This kind of hemorrhage can lead to a stroke, coma and/or death.
11. INCIDENCE
Aneurysm are most prevalent between the ages of 35-60years
The female to male ratio is 3:2 , but before 40 male and female s
are equally affected
About 10-30%of patients can have multiple aneurysms
About 3-5% of new strokes are due to aneurysm rupture related
to subarachnoid hemorrhage
12. RISK FACTORS
Alcohol abuse
Cigarette smoking
Female sex
Genetic condition
Hormonal therapy-estrogen therapy
Older age
Positive family history
Uncontrolled hypertension
13. GENETIC AND OTHEr MEDICAL CONDITIONS ASSOCIATED WITH
Aortic aneurysm
Bicuspid aortic valve defects
Coartcation of aorta
Ehrler's-Danlos syndrome
Fibromuscular dysplasia
Hereditary hemorrhagic telangiectasis
Intracranial arteriovenous malformation
Klinefelter syndrome
17. SACCULAR ANEURYSMS……
90% of intracranial aneurysm are saccular or “berry shaped” and
develop as a thin walled sac protruding from the arteries of the
circle of willis or its main branch
It consists of an out pouching of deficient collagenized tunica
muscularis that protrudes through a localized defect in the internal
elastic lamina
Tunica muscularis and the elastic lamina terminate at the
aneurysm neck and the aneurysm wall is very thin ,consisting of
only intima and adventitia.
85% of saccular aneurysm are found at the polygon of Willis.
18. Cont…..
Anterior communicating artery – 30-35%
Internal carotid artery – 30% (posterior communicating artery, carotid
bifurcation, ophthalmic artery)
Middle cerebral artery – 22%
Posterior circulation -8-10%
According to size it is grouped into
Small < 10mm
Large 10-25mm
Gaint >25mm
According to the neck width
Small neck < 4mm
Large neck > 4mm
20. FUISIFORM ANEURYSMS……
Fusiform aneurysms are exaggerated arterial ectasia caused by
atherosclerosis
It occurs mostly in older patients
It involves longer vessel segments
They can lead to mass effect or ischemia, whereas rupture is
uncommon.
21.
22. DISSECTING ANEURYSMS….
Dissecting aneurysm are rare and in patients who with
SAH have a poor natural history due to high rebleeding
rate
It usually seen on small perforated vessel due to chronic
hypertension
23.
24. MYCOTIC ANEURYSM
It is very rare and develop from infection in the arterial wall often
deriving from bacterial endocarditis
Only distal branches of the cerebral arteries are commonly
involved and the aneurysm are fusiform and eccentric without the
neck that characterize saccular aneurysm.
25. Signs and symptoms
Unruptured aneurysm:
Most cerebral aneurysms do not show symptoms until they either become
very large or rupture. Small unchanging aneurysms generally will not
produce symptoms.
A larger aneurysm that is steadily growing may press on tissues and nerves
causing:
pain above and behind the eye
numbness
weakness
paralysis on one side of the face
a dilated pupil in the eye
vision changes or double vision.
26. Cont…
Ruptured aneurysm:
When an aneurysm ruptures (bursts), one always experiences a sudden and
extremely severe headache (e.g., the worst headache of one’s life) and may
also develop:
double vision
nausea
vomiting
Nuchal rigidity
Photosensitivity- sensitivity to light
Seizures
loss of consciousness (this may happen briefly or may be prolonged)
cardiac arrest.
27. Specific signs and symptoms
Anterior communicating artery:
This is the most common site of aneurysmal SAH (34%).
Usually, ACoA aneurysms are silent until they rupture.
Suprachiasmatic pressure may cause visual field deficits, abulia or akinetic
mutism, amnestic syndromes, or hypothalamic dysfunction.
Neurological deficits in aneurysmal rupture may reflect intraventricular
haemorrhage (79%), intraparenchymal haemorrhage (63%), acute
hydrocephalus (25%), or frontal lobe strokes (20%).
28. Anterior cerebral artery:
Aneurysms of this vessel, excluding ACoA, account for about 5% of
all cerebral aneurysms.
Most are asymptomatic until they rupture, although frontal lobe
syndromes, anosmia, or motor deficits may be noted.
Middle cerebral artery:
Aneurysms of the middle cerebral artery,account for about 20% of
aneurysms, typically at first or second division in the sylvian
fissure.
Aphasia, hemiparesis, hemisensory loss, anosognosia, or visual
field defects may be noted.
29. Internal carotid artery:
Besides PCoA aneurysms, aneurysms of the ICA, account for about 4% of all
cerebral aneurysms.
Supraglenoid aneurysms may cause ophthalmoplegia due to compression of
cranial nerve (CN) III or variable visual defects and optic atrophy due to
compression of the optic nerve.
Chiasmal compression may produce bilateral temporal hemianopsia.
Hypopituitarism or anosmia may be seen with giant aneurysms.
Cavernous-carotid aneurysms exert mass effects within the cavernous sinus,
producing ophthalmoplegia and facial sensory loss.
Rupture of these aneurysms typically produces a carotid-cavernous fistula,
SAH, or epistaxis.
30. Posterior communicating artery:
Aneurysms present at the junction of the termination of the ICA and PCoA
account for 23% of cerebral aneurysms they are directed laterally,
posteriorly, and inferiorly.
Pupillary dilatation, ophthalmoplegia, ptosis, mydriasis, and hemiparesis may
result.
Basilar artery:
Basilar tip aneurysms,are the most common in the posterior circulation,
accounting for 5% of all aneurysms.
Clinical findings usually are those associated with SAH, although bitemporal
hemianopsia or an oculomotor palsy may occur.
Dolichoectatic aneurysms may cause bulbar dysfunction, respiratory
difficulties, or neurogenic pulmonary edema.
31. Leaking aneurysm
Sometimes an aneurysm may leak a small amount of blood into
the brain (called a sentinel bleed).
Sentinel or warning headaches may result from an aneurysm that
suffers a tiny leak, days or weeks prior to a significant rupture.
However, only a minority of individuals have a sentinel headache
prior to rupture.
33. Cont…..
Most are located on or near the circle of Willis
More than 90% are located are one of the following five
sites
The internal carotid artery at the level of posterior
communicating artery
Junction of the anterior cerebral and anterior communicating
arteries
Proximal bifurcation of the middle cerebral artery
Junction of the posterior cerebral and basilar arteries
Bifurcation of the carotid artery into the anterior cerebral and
middle cerebral arteries.
35. Diagnostic evaluation
History collection
Physical examination
Altered level of consciousness.
Sluggish pupillary reaction.
Motor and sensory dysfunction.
Cranial nerve deficits (extraocular eye movements, facial droop,
presence of ptosis).
Speech difficulties and visual disturbance.
Headache and nuchal rigidity or other neurologic deficits.
36. Cont….
Most cerebral aneurysms go unnoticed until they rupture or are detected
during medical imaging tests for another condition.
Several tests are available to diagnose brain aneurysms and determine the
best treatment. These include:
Computed tomography
Magnetic resonance imaging
Cerebral angiography
Cerebrospinal fluid analysis
Intra arterial digital substration angiography (IADSA)
Magnetic resonance angiogram (MR Angiogram)
37. Computed tomography
Reliable and simple diagnostic test for ruptured aneurysm
Positivity rate is 98-100% of cases for up to 12 hours after onset
and 93% in the first 24 hours
Positive results decreases with time
Findings:
Appears as a well defined round hyperattenuating lesions ,most
apparent on maximum intensity projection images
40. Magnetic resonance imaging
T1 – most of the patent aneurysms appear as flow void or they
may show heterogeneous signal intensity
In thrombosed aneurysms the appearance depends on the age of
clot within the lumen
T2 – typically hypodensed
- laminated thrombus may show a hyper intensed rim
41. MRI brain axial T1 and T2 images showing acute phase haemorrhage
in right temporoparietal region with mass effect and midline shift.
42. CEREBRAL ANGIOGRAPHY
It is widely used modality for imaging and screening intracranial
aneurysm
In this 100ml of contrast medium is injected intravenously at a
flow rate of 4ml/sec
Changes in attenuation values are measured with a region of
interest with the internal carotid arteries and spinal scan is
automatically started
44. Cerebrospinal fluid analysis
Done in patient in whom CT reveals no abnormalities but hav
strong clinical history of SAH
Bloody CSF that fails to clear with continued egress of CSF
suggests SAH
Presence of xanthochromia ,a yellowish discoloration of the
cerebrospinal fluid representing bilirubin from the breakdown of
haemoglobin
Blood from SAH that occurred more than 12 hours before the
spinal tap will results in xanthochromic CSF where fresh blood
occurs with trauma
45. Intra arterial digital substration angiography (IADSA)
Most sensitive tool for the detection of intracranial
aneurysm and should be performed with in 24 hours from
bleeding
Used to demonstrate the aneurysm ,its neck ,size,
location, associated cortical branches, vasospasm, and
additional aneurysm
Performed with selective injection of ICA and vertebral
arteries in order to investigate entire cerebral vasculature
47. MAGNETIC RESONANCE ANGIOGRAM
It is another use full modality ,sensitivity for smaller aneurysm i.e.
<3mm
False negative and false positive aneurysm detected on MRA were
mainly located in skull bone and middle cerebral artery
It shows information about brain tissue and adjacent structure in
relationship to the aneurysm
50. management
Medical management
Unruptured aneurysm:
Studies shows that there is correlation between modifiable risk factors such
as hypertension and smoking and aneurysm rupture
Bed rest
FFP
Vitamin K
Antiseizure drugs
Analgesic agents
Aspirin was successful in reducing aneurysm wall inflammation
51. Surgical management
Patients with a ruptured intracranial aneurysm should be treated
as soon as possible after the haemorrhage to prevent rebleeding
and to provide adequate medical treatment of vasospasm
Surgical clipping
Detachable coils- endovascular coiling
52. Surgical clipping
In 1937 Walter Dandy, an American neurosurgeon introduced
method of “clipping” ,who applied V shaped silver clip to the neck
of an internal carotid artery aneurysm.
Since then variety of aneurysm clips have been evolved
Aneurysm is clipped through a craniotomy ,a small metal clip
made up of titanium is then applied to neck of the aneurysm
Aneurysm clips comes in all different shapes and sizes and the
choice is based on the size and location of the aneurysm
Clip has a spring mechanism which allows the two jaws of the clip
to close around either side of the aneurysm thus occluding the
aneurysm
54. Endovascular coiling
During 1980’s ,endovascular treatment of aneurysm with balloon was done
which has high rate of rupture
In 1991, Guido Guglielmi ,an American neuroradiologist invented platinum
detachable micro-coil which was approved by FDA in 1995.
Guglielmi detachable coil are soft wire spiral originally made out of
platinum
These coils are deployed into the aneurysms via a microcatheter inserted
through the femoral artery and advanced into the brain
Once the coil are released into the aneurysm the blood flow pattern within
the aneurysm is altered and the slow and sluggish remaining blood flow
leads to thrombosis
56. Flow diversion
Flow diversion bridge the aneurysm neck and divert the blood
flow away from the aneurysm sac ,due to impedance created by
the mesh of the implant
Reduction of the blood flow into the aneurysmal sac causes stasis
of blood flow into the aneurysm which leads to thrombosis and
healing of the aneurysm
58. Nursing management
Nursing assessment:
Altered level of consciousness.
Sluggish pupillary reaction.
Motor and sensory dysfunction.
Cranial nerve deficits (extraocular eye movements, facial droop,
presence of ptosis).
Speech difficulties and visual disturbance.
Headache and nuchal rigidity or other neurologic deficits.
59. Nursing diagnosis
Ineffective tissue perfusion related to bleeding or vasospasm.
Impaired Physical Mobility related to weakness ,paraesthesia
Impaired verbal communication related to impaired cerebral
circulation
Disturbed sensory perception related to altered sensory
reception, transmission, integration
Self care deficit related to neuromuscular impairment
Risk for impaired swallowing related to neuromuscular
impairment
60. Improving cerebral tissue perfusion
Monitor closely for neurologic deterioration, and maintain a neurologic
flow record.
Check blood pressure, pulse, level of consciousness, pupillary responses,
and motor function hourly; monitor respiratory status
Implement aneurysm precautions (immediate and absolute bed rest in a
quiet, nonstressful setting; restrict visitors)
Elevate the head of bed 15 to 30 degrees or as ordered.
Avoid any activity that suddenly increases blood pressure or obstructs
venous return (eg, Valsalva maneuver, straining),
Apply antiembolism stockings or sequential compression devices. Observe
legs for signs and symptoms of deep vein thrombosis tenderness,
redness, swelling, warmth, and edema.
61. Releiving sensory perception
Keep sensory stimulation to a minimum.
Explain restrictions to help reduce patient’s sense of isolation.
Relieving anxiety
Inform patient of plan of care.
Provide support and appropriate reassurance to patient and
family.
62. Monitoring and managing complications
Assess for and immediately report signs of possible vasospasm, and administer
calcium channel blockers or fluid volume expanders as prescribed.
Maintain seizure precautions and maintain airway and prevent injury if
a seizure occurs. Administer antiseizure medications as prescribed, phenytoin is
medication of choice.
Monitor for onset of symptoms of hydrocephalus
Monitor for and report symptoms of aneurysm rebleeding. Rebleeding occurs
most often in the first 2 weeks.
Symptoms include sudden severe headache, nausea, vomiting, decreased level
of consciousness, and neurologic deficit.
Administer medications as ordered.
Hyponatremia: monitor sodium level.
63. Discharge and home care guidelines
Teach patients and family members about disease
condition
Medical treatments
Assistive devices
Follow-up environment