1. Bi ophysi cal and bi ochem cal adapt at i ons of
i
m t ochondr i a l eads t o enhanced r espi r at or y cont r ol :
i
Ef f ect s of m at e and i nt ense exer ci se
oder
Dwaynie
Bacon

2. Albert Von Kolliker
1817-

4. The Matrix is the
central cavity of the
mitochondrion. It is
fluid like and houses Inner
The
numerous enzymes and
respiratory complexes. Membrane
The matrix also holds surrounds the matrix and is
mtDNA and is the site most important for the
for oxidative electron transport chain.
phosphorylation. The inner membrane forms
subdivisions called
Cristae. Thesethe
The Outer Membrane encloses
are
protein studded
organelle. It is smooth and compartments that are
contains numerous
proteins called porins. This makesfor cellular
crucial the mitochondrion
permeable to most small molecules.
respiration.

7. Oxidative
Phosphorylation

9. Zoll et al. (2003)
Goal investigate the correlation between
intrinsic mitochondrial
properties and exercise restrictions
Hypothesis Endurance training improves oxida
respiratory control.
Mitochondrial functionality is significan
by durational exercise.

12. Zoll et al.
(2003) mitochondrial
1. 40 % increase in overall
enzyme activity
2. Efficient mitochondrial CK coupling with
oxidative phosphorylation as well as
creatine involved energy transfer
pathways
Mitochondrial function is
dramatically improved after short-

13. Davies et al.
(1980)
Goal investigate the effects of exercise on
overall endurance,
total body O2 consumption and tissue O
consumption
Hypothesis Changes in oxidative cap
morphological alterations of
and or increases in the si
of mitochondria

14. 1. Muscle examinations
2. Determination of O2
consumption
3. Flavoprotein and cytochrome
content

15. 71% NADH
dehydrogenase
109% Succinate
dehydrogenase
168% Choline
dehydrogenase
112% composition of
cytochrome a
116 Composition of
% cytochrome c

16. Davies et al. (1980)
Metabolic fine
tuning
The major determining
factor of respiration is
mitochondria.
The endurance adaptation that
result from physical exercise may
provide protection against
oxidative damage.

17. strengthen respiration
capabilities!
Reverse symptoms of
CHF!
Aid in the treatment
of degenerative

18. Mitochondrial up-
keep
Promote
health
Diminish age-related
complications