Probiotics goes beyond digestive and immune health. At the recent Microbiome R&D and Business Collaboration Congress: Asia, DuPont Nutrition & Health shared on how probiotics can influence vaginal microbiota and provide positive health benefits such as weight management for the user.

1. D u P o n t N u t r i t i o n & H e a l t h
MARCH 7, 2019
Vaginal
microbiota
and its
management
Arthur Ouwehand
Global Health & Nutrition Sciences
Kantvik Finland

2. D u P o n t N u t r i t i o n & H e a l t h
Vaginal
microbiota
composition and
function
2

3. D u P o n t N u t r i t i o n & H e a l t h 3
The healthy vaginal microbiota is dominated
by lactobacilli
3

4. D u P o n t N u t r i t i o n & H e a l t h 4
The healthy vaginal microbiota is dominated
by lactobacilli
Matsumoto et al. 2018
Non-pregnant Commercial sex workers Pregnant

5. D u P o n t N u t r i t i o n & H e a l t h 5
The role of vaginal lactobacilli
Amabebe et al. 2018

6. D u P o n t N u t r i t i o n & H e a l t h
Vaginal microbiota
development in
relation to Bacterial
Vaginosis treatment
6

7. D u P o n t N u t r i t i o n & H e a l t h 7
Microbiota development with BV treatment
b-diversity PCA plot; elipses represent 95% CI
Lehtoranta et al. submitted

8. D u P o n t N u t r i t i o n & H e a l t h
Clinical trials
8

9. D u P o n t N u t r i t i o n & H e a l t h 9
Effect of L. rhamnosus HN001 and L. acidophilus
La-14 on vaginosis
Russo et al. 2018 Arch Gynecol Obstetr 9:531
Probiotic
Placebo
0 14 days0 14 days 0 14 days

10. D u P o n t N u t r i t i o n & H e a l t h 10
Effect of L. rhamnosus HN001 and L. acidophilus
La-14 on vaginosis
Russo et al. 2019 Beneficial Microbes 10(1):19-26
Placebo
Probiotic
0 1 2 1 4 6
week weeks month months months
0 1 2 1 4 6
week weeks month months months

11. D u P o n t N u t r i t i o n & H e a l t h 11
Effect of L. rhamnosus HN001 and L. acidophilus
La-14 on vaginosis
Russo et al. 2019 Beneficial Microbes 10(1):19-26

12. D u P o n t N u t r i t i o n & H e a l t h 12
Conclusions
Lactobacilli dominate the healthy vagina:
▪ L. gasseri
▪ L. cripatus
▪ L. jensenii
▪ L. inners, uncertain
Treatment of BV with metronidazole:
▪ Restores microbiota transiently
Oral L. acidophilus La-14 and L. rhamnosus HN001:
▪ Colonise the vagina
▪ May help manage borderline BV
▪ May improve BV treatment outcome
▪ May reduce recurrence after BV treatment

13. Thank You
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