social pharmacy d-pharm 1st year by Pragati K. Mahajan
Rasa Shastra in Ayurveda
1. INTRODUCTION OF RASSASTRA Dr. M. Srinivas Naik Dept. of. Rassastra Dr. N.R.S. Govt. Ayurvedic college Vijayawada-2 msnaik108@gmail.com
2. Rasa Shastra in Ayurveda The term ‘Rassastra’ is composed of two words ‘Rasa’ and ‘Shastra’ where Rasa means absorbable form of drugs and Shastra means science of knowledge. Rasa Shastra or "Vedic Chemistry“ Nagarjuna, considered to be the father of Rasa Shastra
3.
4. Rassastra is Ayurvedic pharmaceutics, which deals with the drugs of mineral origin, their varieties, characteristics, processing techniques, properties and their therapeutic uses.
5. This science is often referred to as "alchemy" and the resultant medications are called rasas, which mainly comprise of metallic ashes called Bhasma. Rasa Shastra in Ayurveda
6.
7. This means they are able to carry the herbs mixed with them faster to the desired site and start the action immediately.
8. They acts as catalysts and increase the bioavailability of the herbs to the cell.
9.
10. To inculcate the therapeutic properties in the minerals for which many specific types of yantras (instruments) are designed.
78. SHODANA PROCESS: Objects: To remove physical impurities (Sand, mud, stone e.g..Shilajatu) To remove chemical impurities (Naga, Vanga in parada) Neutralizing toxicity. (Sulphur- by milk) Enriching therapeutic value (Sodhana of Abraka – Triphala) Suitable for marana (sukshma by grinding) Incorporating organic qualities (metal, mineral – inorganic, herbal, animal Products – organic)
83. UTTANIA (Moving): A grain of rice, barley, etc. will float over the preparation like a swan on a lake. NIRUJA: When prepared, Bhasma heated with a silver plate will stick to it. The form will remain unchanged. NISWADU (Taste): The Bhasma should be completely tasteless. Sour, bitter, or sweet tones indicate incomplete preparation. 7. NISCHANDRA (Sparking): There should be no shining or sparkly particles in the Bhasma; they show unchanged substance, particularly for gold, silver, and mica. Bhasma Preparation Tests
84. 8) AWAMI (Biological): When a tiny bit of the Bhasma has been put on the tip of the tongue, there should be no effect. Impure Bhasma will cause nausea or vomiting. 9) AMLA (Sour): When Bhasma is put with citrus juice, especially lemon, it should retain its color and original form. 10) NIRDHUM (Smokeless): Finished Bhasma will not emit any smoke when put over fire, while the impure form emits smoke. Bhasma Preparation Tests
92. Hence we have dasha puta (10 cycles), satha puta (100 cycles), Shahasra puta (1000 cycles), etc.
93. To ensure that the Bhasma is properly prepared, a set of tests are also specified.
94.
95. OBJECTIVE PARAMETERS Determination of Loss of drying Total ash Water soluble ash Acid insoluble ash Solubility test Namburi Phased Spot Test (NPST) Estimation of sulphur and arsenic (Chemical Assay and Thermo Gravy matry)
96. 4. Powder X ray defraction (XRD) study It is the most useful technique in the characterization crystalline materials such as 6. Minerals, metals, inter metallic and ceramics Scanning electron microscopy (SEM) 8. Energy dispersive X ray analysis : This technique is used in conjunction with SEM and is not a surface science technique Atomic absorption spectrometry (AAS) 10. Inductive coupled Plasma Atomic Emission Spectrometry) ICP AES 11. Analysis of wash out solution by ICP OES 12. Particle size analysis
97. CHARACTERIZATION WITH MODERN INSTRUMENTS X-ray Photoelectron Spectroscopy --------(XPS) X-ray Diffraction ----------------------------(XRD) X-ray Fluorescence --------------------------(XRF) Scanning Electron Microscopy ------------(SEM) Energy Dispersive X-ray Analysis---------(EDX) Thermogravimetry ---------------------------(TG) Infrared Spectroscopy -----------------------(IR) Inductive Coupled Plasma Atomic Emission Spectrometry -----------------------------(ICP-AES) Inductive Coupled Plasma with Optical Emission Spectroscopy -------------------------------(ICP-OES) Particle Size Analysis.----------------------(PSA)
98. METAL ANALISERS Portable and mobile on-site metal analyzers - for fast and reliable identification (PMI), sorting and analysis of metals. Stationary metal analyzers - for all kinds of metals in the process control. ICP spectrometers - for the rapid analysis of chemical elements in a variety of matrices including aqueous, semi-conductor, petrochemical, soil, metallurgical and slurries. ICP-MS spectrometers – for the fully simultaneous measurement of the complete, inorganically relevant, mass range.
99. XRF spectrometers - for the analysis of solids, powders and liquids. XRF handheld analyzer - for metal analysis and sorting, compliance screening, environmental testing and mining applications. SPECTRO x SORT - is a compact, ergonomically designed, handheld energy dispersive X-ray fluorescence spectrometer for high throughput elemental testing, screening and analysis of a broad range of materials in widely varying locations, environments and conditions.
105. (the difference is processing, Ayurvedic Sulphur compounds are purified and prepared as per Ayurvedic texts).
106. Inorganic mercury compounds like mercurous chloride and mercuric chloride are white powders and do not generally vaporize at room temperatures like elemental mercury will.
107.
108. (e.g. selenium, vitamin C and E, omega-3 fatty acids) or enhance (e.g. alcohol) mercury’s toxicity for some endpoints.
109. Mercury and other metals become toxic only when they exceed a tolerable safe level.
110. Ayurvedic medicine should standard with our parameters, not with modern parameters our tests should help us ,not for modern people.
149. Oksatmya. Ayurveda has termed it Oksatmya; means which is non-toxic due to practice. We have read the stories of Vishakanyas who were being given Visha. the most important point is, in Ayurveda or Rasashashtra, any metal is never prescribed as raw or virgin metal. For removing free radicals of excess dose of medicine, vitamins A ,B,C And E and panchakarma is advisable.
163. Compounds which act as antibacterial as a result of the presence of mercuric ion are primarily bacteriostatic rather than bactericiedal.
164. The silver salts, such as silver nitrate, although somewhat less active, are still highly efficient germicides.
165. Cu salts are still less active but are highly efficient in the destruction of algae and other chlorophyll containing organisms.
166. The antibacterial activity of heavy metals is most probably due to the formation of poorly dissociable salts of the sulfhydryl groups of proteins e.g., 2 protein – SH + Hg2+ – Protein – S – Hg – S – Protein + 2H+
167. Their effects are reversed by Rx with high conc., of Sulfhydryl compounds.
168. The organic compounds have utility in the Rx of infections of the mucous membranes.Medicinal Use of Heavy Metals
169.
170.
171. NORMAL TESTS REQUIRED Blood Tests : to find heavy metal content or routine tests) LFT : to find the effect on hepatic functioning RFT : to find the effect on kidneys Urine Analysis : to find the effect on excretion Fecal Tests : to find the excretion of heavy metals X-ray chest : recommended for persons with respiratory symptoms X-ray abdomen : to detect ingested metals. Hair & Finger-nail Analysis
172.
173. Heavy metals can block the natural detoxification processes. This can lead to fatigue, nutritional deficiencies, and numerous other health-related issues. Chelation therapy safely and effectively removes heavy metals from the body’s cells and tissues.
174.
175. Once laboratory tests indicate that the heavy metals are undetectable, treatment is considered complete. Often many - if not all - symptoms previously experienced will have resolved, though some may linger, indicating residual damage to organ systems. Therapies can then be targeted to these systems and any specific problems remaining.
176.
177. When ever there is a possibility of toxicity, the rasa oushadhis were mentioned with one or other doshas (viz., parada saptakanchukadoshas, trividhadoshas etc)
178. Where ever advocated, Sodhana (purification) & Marana (calcination) are mandatory to make the metallic / mineral ingredient safe.
179.
180. The ayurvedic mineral or herbo-mineral drugs should be studied for ligand chemistry and chelate chemistry. Ayurvedic bhasmas are expected to be hydrophobic and lyophobic colloidal states / structures therefore, their journey is safe in side the body.