This document discusses the benefits of mass vaccination programs for animal diseases that can infect humans (zoonoses). It first presents data showing that mass vaccinating 25 million livestock animals in Mongolia against brucellosis would provide over $30 million in total societal benefits, including public health benefits, private health benefits, reduced household income loss, and agricultural benefits. It then uses a mathematical model to show that mass dog vaccination is less costly than human post-exposure prophylaxis for controlling rabies transmission between dogs and humans. Finally, it references a study that found an approach combining dog and human vaccination for rabies control in N'Djaména to be more cost-effective than human

1. Epidemiology and Public Health
Human and Animal Health Unit
Understanding zoonoses impacts:
The added value from One Health
approaches
Jakob Zinsstag

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„One Health“ requirements
Necessary (but not sufficient)
– Recognition of intextricable
linkage of human and animal
health
Sufficient:
– Added value of health and
wellbeing of humans and animals
and/or financial savings from a
closer cooperation of human
and animal health.

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Courtesy: Dr. Jan Kolar, Prague
Is it profitable to mass vaccinate 25 million sheep, goat and
cattle in Mongolia to prevent human brucellosis?

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5. Synoptic view of benefits and costs of animal brucellosis mass
vaccination in Mongolia
Distribution of Benefits
0
5000000
10000000
15000000
20000000
25000000
30000000
Intervention
cost
Public
health
benefits
Private
health
benefits
Household
income
loss
Total Health
Benefits
Agricultural
Benefits
Total
Societal
Benefits
Sector
US$

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s dog mass vaccination less costly
han human post-exposure prophylaxis
o control human rabies?

7. 7
Simplified deterministic model of rabies transmission
between dogs and humans
S
R L
I
YX Z
βIS
λ δ σ
γ
αIX π κ
b1
b2
μ2
μ1 μ1
ρ
Dogs
Humans
S = susceptible dogs
L= latent infected dogs
I= rabid dogs
R= vaccinated dogs
X= susceptible humans
Y= exposed humans
Z = rabid humans
μ2

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Comparative profitability of rabies control
in N‘Djaména
(Zinsstag et al. PNAS 2009, 106(35) 14996–15001
Human vaccination alone
Dog and human vaccination

9. Infected humans / infected animal in selected zoonoses
5. April 2016 9

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