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RAINBOW HOSPITAL OSCE
QUESTION 1
QUESTION 1
• What is your diagnosis?
• Name 4 conditions in which it is seen.
• What is the underlying mechanism?
ANSWER 1
• Cherry Red spot

• Tay sachs disease, Sandhoff disease, Niemann pick
  disease, central retinal artery occlusion.

• Due to loss of transparency of the retinal ganglion
  cell layer secondary to lipid accumulation/edema.
  Because ganglion cells are not present in the fovea,
  the fovea transmits the underlying choroidal colour.
QUESTION 2
• Surface marking of right lung.
ANSWER
• 2.5cm above the medial end of clavicle.
• Sternoclavicular joint.
• 4th costal cartilage.
• Midclavicular line at 6th rib.
• Midaxillary line at 8th rib.
• Lateral border of erector spinae at 10th rib.
• Oblique fissure – line joining spine of T3 vertebra to 6 th
  rib in midclavicular line.
• Horizontal fissure – horizontal line extending from 4th
  costal cartilage continued to meet oblique fissure in
  midaxillary line.
QUESTION 3
QUESTION 3
• What is your diagnosis.
• Mention a few potential reversible causes of
  this condition.
• Name 2 drugs used in treatment.
ANSWER 3
• Wide complex tachycardia – ventricular
  tachycardia.
• Hypoxia, hypothermia, hypo/hyperkalemia,
  hypoglycemia, Toxins, tamponade, tension
  pneumothorax, trauma.
• Amiodarone, procainamide.
QUESTION 4
• You have done therapeutic aspiration of
  pleural fluid from a child with empyema.
  Mention how will you dispose the following
  after the procedure.
• Gloves.
• 18 gauge needle.
• Disposable syringe.
• Cotton and gauze.
ANSWER 4
•   Gloves – yellow bin.
•   needle – puncture proof container.
•   Disposable syringe – red bin.
•   Cotton and gauze - yellow bin.
QUESTION 5
  This is the MRI of an infant evaluated for
recurrent seizures with developmental delay
QUESTION 5
• What is your diagnosis?
• Mention 2 ocular abnormalities associated
  with this condition.
• Name the syndrome associated with this
  condition.
ANSWER 5
• Lissencephaly (absence of cerebral
  convolution and poorly formed sylvian fissure)
• Hypoplasia of the optic nerve and
  microphthalmia.
• Miller-Dieker syndrome.
QUESTION 6
QUESTION 6
• Identify the organism.
• Mention 4 commonly used stains for
  identification of the organism.
• Mention 2 drugs used in treatment.
ANSWER 6
• Pneumocystis jirovecii
• Grocott/gomori silver, toluidine blue, giemsa,
  fluorescein-labeled monoclonal antibody
  stains.
• Trimethoprim-sulfamethoxazole, pentamidine
  isethionate, atovaquone, trimethoprim plus
  dapsone, clindamycin plus primaquine.
QUESTION 7
• Demonstration of cerebellar signs.
ANSWER 7
•   Nystagmus – gaze evoked nystagmus.
•   Gait – unsteady and irregular with a wide base.
•   Intention tremor.
•   Dysdiadokokinesia.
•   Past pointing.
•   Coordination – finger nose and heel shin test.
•   Reflexes – pendular knee jerk.
•   Dysarthria – scanning and robotic with syllable
    pronounced individually and slowly.
QUESTION 8
• Counsel a mother whose child has been
  diagnosed to have Acute lymphoblastic
  leukemia.
ANSWER 8
• Introduces self.
• Says that child has been diagnosed to have
  leukemia which is a blood cancer of WBC’s.
• Shows sympathy and reassures that the
  overall prognosis is excellent.
• Says that the etiology is not known.
• Says that treatment involves drugs (chemo)
  and occasionally radiotherapy.
• Says that the duration of treatment will be 2 ½ to 3yrs.
• Says regarding side effects of chemo like hairfall,
  infections, bleeding tendencies etc.
• Also mentions about long term complications like
  decreased growth, repeat cancer.
• Stresses the need for neutropenic care – avoid giving
  outside food, avoid overcrowded places, avoid
  frequent visitors.
• Mention the risk of relapse – CNS, testicular, blood and
  hence the need for regular followup after completion
  of treatment.
• Mention about vaccination – to consult doctor before
  giving regular vaccines.
QUESTION 9
• A 3 yr old child is brought with history of
  sudden onset of difficulty in breathing. The
  child was playing with toys and was found
  drowsy by the mother.
• On arrival in the ER, the child is unresponsive,
  tachypneic, cyanosed with good peripheral
  pulses.
• Mention the steps in management of this
  child.
ANSWER 9
• Open the victim’s airway using a tongue-jaw
  lift and look for an object in the mouth and
  pharynx. If an object is visible, remove it. Do
  not perform blind finger sweeps.
• Open the airway with a head tilt-chin lift and
  attempt to provide rescue breaths. If breaths
  are not effective, reposition the head and
  reattempt ventilation.
• If the breaths are still not effective, prepare
  to perform abdominal thrusts (Heimlich’s
  maneuver).
• Repeat the steps until the object is dislodged
  and the airway is patent or until attempts
  have lasted approximately 1 minute. If the
  infant remains unresponsive after 1minute,
  activate the EMS system.
QUESTION 10
• Elicit Moro’s reflex, rooting and sucking reflex,
  palmar and plantar grasp in this neonate.
QUESTION 11
• This is the electrolyte report of a 1yr old infant
  who was evaluated for failure to thrive,
  recurrent vomiting and polyuria.
• Na – 134mEq/dl, K – 2.6mEq/dl, Cl 100mEq/dl,
  HCO3 – 28mEq/dl.
QUESTION 11
•   What is your diagnosis.
•   Mode of inheritance?.
•   What is the underlying defect.
•   Treatment.
ANSWER 11
• Barrter syndrome.
• Autosomal recessive inheritance.
• Defect in sodium and chloride resorption in
  the loop of henle.
• Oral potassium supplement, potassium
  sparing diuretic, Indomethacin.
QUESTION 12
• While drawing blood sample from a patient,
  whose HIV status is unknown, your hospital
  nurse has an accidental needle stick injury
  (non intact skin, small volume exposure).
• Mention the setps which should be taken in
  such a situation with regards to the following.
QUESTION 12
•   Care of the exposed site.
•   Counselling of the health care personnel.
•   Counselling of the source.
•   Tests to be done and timing of the test.
•   Drug therapy – duration and dose.
•   Administrative action.
ANSWER 12
• Wash the exposed site thoroughly with running water.
  Wash skin with soap.
• Reassure and inform about PEP.
• Counsel the source and obtain consent for testing –
  determination of HIV,HBV,HCV status of the source.
• HIV,HBV,HCV testing of the health care personnel. HIV
  testing at zero hour, 6wks, 12wks, 6months.
• Zidovudine 300mg BD & Lamivudine 150mg BD for 4
  weeks.
• Recording and reporting of the even.t
QUESTION 13
• A 1-1/2 year old with VSD on antifailure drugs
  develops illness suggestive of influenza.
• What Category does this child belong to as
  per govt of India guidelines.
• Mention 2 appropriate steps recommended
  for this category
• What is the correct dosage and duration of
  oseltamivir in children?
ANSWER 13

• Category B

• Home isolation and oseltamivir therapy

• For weight 15kg 30mg BD for 5 days
QUESTION 14
• 16 year old girl presents with h/o passing red
  coloured urine for the last few hours. There
  was no h/o fever. There was h/o drug intake
  for diarrheal illness 3 days ago.
  O/E she had gross pallor and a tinge of scleral
  icterus
• What is the provisional diagnosis?
• Describe the peripheral smear picture in this
  girl.
• Immediate steps in management.
ANSWER 14
• Acute intravascular hemolysis

• Fragmented RBC,Bite cells,nucleated
  RBCs,severe thrombocytopenia

• Packed cell transfusion
QUESTION 15
• Mention the duration and temperature at
  which the following blood products can be
  stored?
• 1.Red Blood Cells
• 2.Fresh Frozen Plasma
• 3.Platelet Concentrate
• 4.Cryoprecipitate
ANSWER 15
• Packed RBC – 42 days in the refrigerator or 10
  years in the freezer.
• FFP - 1 year in the freezer
• Platelet Concentrate – 5 days at room
  temperature
• Cryoprecipitate – 1 year in the freezer
QUESTION 16
QUESTION 16
• This is the karyotype obtained from the
  bonemarrow of a 6 year old girl with a
  hematological malignancy.
• Comment on the abnormality
• Mention 1 favourable and 1 unfavourable
  translocation in ALL
ANSWER 16

• Hyperdiploidy
• BCR ABL – Unfavourable
• TELL AML - Favourable
QUESTION 17
QUESTION 17

• Mention the abnormality in this CXR.
• Mention 3 causes of this appearance.
• What further investigations would you order?
ANSWER 17

•   Mediastinal enlargement
•   Lymphoma
•   Thymoma
•   Teratoma
•   CT chest,CT guided biopsy and HPE
QUESTION 18
QUESTION 18
• What is the abnormality seen on this
  radiograph?

• Name 2 disorders which may give rise to this
  abnormality
ANSWER 18
• Xray skull lateral view showing multiple lytic
  lesions
• Histiocytosis
• Secondaries
• Multiple myeloma
QUESTION 19

• Define Polio eradication and elimination

• Mention core strategies for eradication of
  polio.
• Eradication – No cases of paralytic polio by
  wild polio virus in the last 3 calender years
• Elimination – No cases of paralytic
  poliomyelitis by wild polio virus in 1 calender
  year.
• CORE STRATEGIES:
• Maintaining high routine immunisation
  coverage with 4 doses of OPV
• Mass campaign
• Sensitive Surveillence
• Mop up campaign
QUESTION 20
• HPV VACCINE
• What are the types of vaccine available?
  Mention the serotypes covered by them.
• What is the recommended dose?
• What is the recommended age for
  vaccination?
ANSWER 20
• Quadrivalent vaccine (gardasil) – serotypes 16,
  18, 6, 11.
• Bivalent vaccine (cervarix) – serotypes 16, 18.
• 0.5ml intramuscular at deltoid.
  3 doses - 0, 2, 6months – gardasil.
  3 doses - 0, 1, 6months – cervarix.
• Initiation of vaccine 10-12years of age. Catch
  up vaccination up to 26yrs of age.
QUESTION 21
QUESTION 21
• Identify this graph.
• What do the square and area of each square
  represent?
• What do the horizontal and vertical line
  represent?
• What does the diamond represent?
• What does the centre of diamond represent?
ANSWER 21
• Forest plot (forest plot shows information
  from individual studies that went into meta-
  analysis at a glance. They show the amount of
  variation between the studies and an estimate
  of the overall result.
• Each square symbol represents a study
  contributing to metanalysis and the area of
  square corresponds to the weight of the
  corresponding study to the metaanalysis.
ANSWER 21
• The horizontal line through the square shows
  the confidence interval. The solid vertical line
  represents no effect.
• The diamond represents the overall estimate
  from the meta-analysis.
• The centre of diamond represents the pooled
  point estimate and the horizontal tips
  represent the confidence interval.
QUESTION 22
QUESTION 22

•   Identify this peripheral smear.
•   What is the underlying defect?
•   Confirmatory test for diagnosis?
•   Treatment options?
ANSWER 22
• Hereditary spherocytosis.
• Defect in spectrin or ankyrin - results in
  uncoupling in the vertical interactions of the
  lipid bilayer skeleton and loss of membrane
  microvesicles.
• Osmotic fragility test.
• Folic acid 1mg/day, splenectomy.
QUESTION 23
QUESTION 23
• Identify this peripheral smear.
• Mention a few complications associated with
  this condition.
ANSWER 23
• Plasmodium falciparum malaria.
• Cerebral malaria, blackwater fever, pulmonary
  edema, algid malaria.
QUESTION 24
 1 ½ yr old child with history of chronic diarrhea was
brought with complaints of perioral and perineal rash.
QUESTION 24
•   What is your diagnosis?
•   Mode of inheritance?
•   Investigation used for diagnosis?
•   Treatment of choice?
•   Mention a few differential diagnosis.
ANSWER 24
• Acrodermatitis enteropathica.
• Autosomal recessive – defect in intestinal zinc
  specific transporter gene.
• Low plasma zinc concentration.
• Zinc – 50mg/day for infants, upto 150mg/day
  for children.
• MSUD, organic acidemia, methylmalonic
  acidemia, biotidinase def, severe PEM.
QUESTION 25
QUESTION 25
•   What is your diagnosis?
•   What is the causative organism?
•   Mention a few other manifestations.
•   Mention a few complications.
ANSWER 25
• Erythema infectiosum.
• Parvovirus B19
• Arthropathy, transient aplastic crisis,
  myocarditis.
• Thrombocytopenic purpura, aseptic
  meningitis, infection associated
  hemophagocytic syndrome, persistent
  arthritis.
QUESTION 26
QUESTION 26
• Identify this pedigree chart. What is the mode
  of inheritance.
• Mention a few disorders with this mode of
  inheritance.
ANSWER 26
• X-linked dominant inheritance.
• Hypophosphatemic rickets, incontinentia
  pigmenti.
QUESTION 27
Stool microscopy of a child showed the
              following
QUESTION 27
• What is your diagnosis?
• Mention a few clinical manifestations.
• Drugs used in treatment.
ANSWER 27
• Hookworm egg.
• Iron deficiency anemia, dermatitis, cutaneous
  larva migrans, cough due to
  laryngotracheobronchitis.
• Albendazole 400mg stat, Mebendazole 100mg
  BD for 3 days, pyrantel palmoate 11mg/kg OD
  for 3 days.
QUESTION 28




1.Mark the parts of the ETCO2 graph and explain each part.
2.Mention 2 conditions which cause this type of ETCO2
recording
ANSWER 28




 2.Intravenous bicarbonate injection
Release of a tourniquet from a surgical
limb
QUESTION 29
QUESTION 29
• Identify this condition.
• Mention 3 treatment options
• Mention 2 complications
ANSWER 29
• Dense bones suggestive of osteopetrosis
• Steroids,Interferon,Bone marrow
  Transplantation
• Infections,Bleeds,Loss of vision
Question 30
A 1 month old child
was brought with pink
staining of the diapers
since birth. He also had
history of blisters on
sun exposed areas.
On examination the
color of the urine is as
shown.
1.   What is your diagnosis?
2.   Name the deficient enzyme.
3.   What are the other clinical manifestations?
4.   Mention the diagnostic lab finding.
Answer:
1. Congenital Erythropoietic Porphyria (Gunther disease)
2. Uroporphyrinogen III synthase (UROS)
3. Bullous cutaneous photosensitivity– hydroa aestivale,
   hypertrichosis,
   erythrodontia,
   hemolytic anemia,
    bone abnormalities
4. Markedly elevated levels of uroporphyrin I and
   coproporphyrin I in urine,stool and RBC’s.
http://groups.yahoo.com/group/PediatricsDNB/

         oscepediatrics.blogspot.in/

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Rainbow Hospital OSCE

  • 3. QUESTION 1 • What is your diagnosis? • Name 4 conditions in which it is seen. • What is the underlying mechanism?
  • 4. ANSWER 1 • Cherry Red spot • Tay sachs disease, Sandhoff disease, Niemann pick disease, central retinal artery occlusion. • Due to loss of transparency of the retinal ganglion cell layer secondary to lipid accumulation/edema. Because ganglion cells are not present in the fovea, the fovea transmits the underlying choroidal colour.
  • 5. QUESTION 2 • Surface marking of right lung.
  • 6. ANSWER • 2.5cm above the medial end of clavicle. • Sternoclavicular joint. • 4th costal cartilage. • Midclavicular line at 6th rib. • Midaxillary line at 8th rib. • Lateral border of erector spinae at 10th rib. • Oblique fissure – line joining spine of T3 vertebra to 6 th rib in midclavicular line. • Horizontal fissure – horizontal line extending from 4th costal cartilage continued to meet oblique fissure in midaxillary line.
  • 8. QUESTION 3 • What is your diagnosis. • Mention a few potential reversible causes of this condition. • Name 2 drugs used in treatment.
  • 9. ANSWER 3 • Wide complex tachycardia – ventricular tachycardia. • Hypoxia, hypothermia, hypo/hyperkalemia, hypoglycemia, Toxins, tamponade, tension pneumothorax, trauma. • Amiodarone, procainamide.
  • 10. QUESTION 4 • You have done therapeutic aspiration of pleural fluid from a child with empyema. Mention how will you dispose the following after the procedure. • Gloves. • 18 gauge needle. • Disposable syringe. • Cotton and gauze.
  • 11. ANSWER 4 • Gloves – yellow bin. • needle – puncture proof container. • Disposable syringe – red bin. • Cotton and gauze - yellow bin.
  • 12. QUESTION 5 This is the MRI of an infant evaluated for recurrent seizures with developmental delay
  • 13. QUESTION 5 • What is your diagnosis? • Mention 2 ocular abnormalities associated with this condition. • Name the syndrome associated with this condition.
  • 14. ANSWER 5 • Lissencephaly (absence of cerebral convolution and poorly formed sylvian fissure) • Hypoplasia of the optic nerve and microphthalmia. • Miller-Dieker syndrome.
  • 16. QUESTION 6 • Identify the organism. • Mention 4 commonly used stains for identification of the organism. • Mention 2 drugs used in treatment.
  • 17. ANSWER 6 • Pneumocystis jirovecii • Grocott/gomori silver, toluidine blue, giemsa, fluorescein-labeled monoclonal antibody stains. • Trimethoprim-sulfamethoxazole, pentamidine isethionate, atovaquone, trimethoprim plus dapsone, clindamycin plus primaquine.
  • 18. QUESTION 7 • Demonstration of cerebellar signs.
  • 19. ANSWER 7 • Nystagmus – gaze evoked nystagmus. • Gait – unsteady and irregular with a wide base. • Intention tremor. • Dysdiadokokinesia. • Past pointing. • Coordination – finger nose and heel shin test. • Reflexes – pendular knee jerk. • Dysarthria – scanning and robotic with syllable pronounced individually and slowly.
  • 20. QUESTION 8 • Counsel a mother whose child has been diagnosed to have Acute lymphoblastic leukemia.
  • 21. ANSWER 8 • Introduces self. • Says that child has been diagnosed to have leukemia which is a blood cancer of WBC’s. • Shows sympathy and reassures that the overall prognosis is excellent. • Says that the etiology is not known. • Says that treatment involves drugs (chemo) and occasionally radiotherapy.
  • 22. • Says that the duration of treatment will be 2 ½ to 3yrs. • Says regarding side effects of chemo like hairfall, infections, bleeding tendencies etc. • Also mentions about long term complications like decreased growth, repeat cancer. • Stresses the need for neutropenic care – avoid giving outside food, avoid overcrowded places, avoid frequent visitors. • Mention the risk of relapse – CNS, testicular, blood and hence the need for regular followup after completion of treatment. • Mention about vaccination – to consult doctor before giving regular vaccines.
  • 23. QUESTION 9 • A 3 yr old child is brought with history of sudden onset of difficulty in breathing. The child was playing with toys and was found drowsy by the mother. • On arrival in the ER, the child is unresponsive, tachypneic, cyanosed with good peripheral pulses. • Mention the steps in management of this child.
  • 24. ANSWER 9 • Open the victim’s airway using a tongue-jaw lift and look for an object in the mouth and pharynx. If an object is visible, remove it. Do not perform blind finger sweeps. • Open the airway with a head tilt-chin lift and attempt to provide rescue breaths. If breaths are not effective, reposition the head and reattempt ventilation.
  • 25. • If the breaths are still not effective, prepare to perform abdominal thrusts (Heimlich’s maneuver). • Repeat the steps until the object is dislodged and the airway is patent or until attempts have lasted approximately 1 minute. If the infant remains unresponsive after 1minute, activate the EMS system.
  • 26. QUESTION 10 • Elicit Moro’s reflex, rooting and sucking reflex, palmar and plantar grasp in this neonate.
  • 27. QUESTION 11 • This is the electrolyte report of a 1yr old infant who was evaluated for failure to thrive, recurrent vomiting and polyuria. • Na – 134mEq/dl, K – 2.6mEq/dl, Cl 100mEq/dl, HCO3 – 28mEq/dl.
  • 28. QUESTION 11 • What is your diagnosis. • Mode of inheritance?. • What is the underlying defect. • Treatment.
  • 29. ANSWER 11 • Barrter syndrome. • Autosomal recessive inheritance. • Defect in sodium and chloride resorption in the loop of henle. • Oral potassium supplement, potassium sparing diuretic, Indomethacin.
  • 30. QUESTION 12 • While drawing blood sample from a patient, whose HIV status is unknown, your hospital nurse has an accidental needle stick injury (non intact skin, small volume exposure). • Mention the setps which should be taken in such a situation with regards to the following.
  • 31. QUESTION 12 • Care of the exposed site. • Counselling of the health care personnel. • Counselling of the source. • Tests to be done and timing of the test. • Drug therapy – duration and dose. • Administrative action.
  • 32. ANSWER 12 • Wash the exposed site thoroughly with running water. Wash skin with soap. • Reassure and inform about PEP. • Counsel the source and obtain consent for testing – determination of HIV,HBV,HCV status of the source. • HIV,HBV,HCV testing of the health care personnel. HIV testing at zero hour, 6wks, 12wks, 6months. • Zidovudine 300mg BD & Lamivudine 150mg BD for 4 weeks. • Recording and reporting of the even.t
  • 33. QUESTION 13 • A 1-1/2 year old with VSD on antifailure drugs develops illness suggestive of influenza. • What Category does this child belong to as per govt of India guidelines. • Mention 2 appropriate steps recommended for this category • What is the correct dosage and duration of oseltamivir in children?
  • 34. ANSWER 13 • Category B • Home isolation and oseltamivir therapy • For weight 15kg 30mg BD for 5 days
  • 35. QUESTION 14 • 16 year old girl presents with h/o passing red coloured urine for the last few hours. There was no h/o fever. There was h/o drug intake for diarrheal illness 3 days ago. O/E she had gross pallor and a tinge of scleral icterus • What is the provisional diagnosis? • Describe the peripheral smear picture in this girl. • Immediate steps in management.
  • 36. ANSWER 14 • Acute intravascular hemolysis • Fragmented RBC,Bite cells,nucleated RBCs,severe thrombocytopenia • Packed cell transfusion
  • 37. QUESTION 15 • Mention the duration and temperature at which the following blood products can be stored? • 1.Red Blood Cells • 2.Fresh Frozen Plasma • 3.Platelet Concentrate • 4.Cryoprecipitate
  • 38. ANSWER 15 • Packed RBC – 42 days in the refrigerator or 10 years in the freezer. • FFP - 1 year in the freezer • Platelet Concentrate – 5 days at room temperature • Cryoprecipitate – 1 year in the freezer
  • 40. QUESTION 16 • This is the karyotype obtained from the bonemarrow of a 6 year old girl with a hematological malignancy. • Comment on the abnormality • Mention 1 favourable and 1 unfavourable translocation in ALL
  • 41. ANSWER 16 • Hyperdiploidy • BCR ABL – Unfavourable • TELL AML - Favourable
  • 43. QUESTION 17 • Mention the abnormality in this CXR. • Mention 3 causes of this appearance. • What further investigations would you order?
  • 44. ANSWER 17 • Mediastinal enlargement • Lymphoma • Thymoma • Teratoma • CT chest,CT guided biopsy and HPE
  • 46. QUESTION 18 • What is the abnormality seen on this radiograph? • Name 2 disorders which may give rise to this abnormality
  • 47. ANSWER 18 • Xray skull lateral view showing multiple lytic lesions • Histiocytosis • Secondaries • Multiple myeloma
  • 48. QUESTION 19 • Define Polio eradication and elimination • Mention core strategies for eradication of polio.
  • 49. • Eradication – No cases of paralytic polio by wild polio virus in the last 3 calender years • Elimination – No cases of paralytic poliomyelitis by wild polio virus in 1 calender year. • CORE STRATEGIES: • Maintaining high routine immunisation coverage with 4 doses of OPV • Mass campaign • Sensitive Surveillence • Mop up campaign
  • 50. QUESTION 20 • HPV VACCINE • What are the types of vaccine available? Mention the serotypes covered by them. • What is the recommended dose? • What is the recommended age for vaccination?
  • 51. ANSWER 20 • Quadrivalent vaccine (gardasil) – serotypes 16, 18, 6, 11. • Bivalent vaccine (cervarix) – serotypes 16, 18. • 0.5ml intramuscular at deltoid. 3 doses - 0, 2, 6months – gardasil. 3 doses - 0, 1, 6months – cervarix. • Initiation of vaccine 10-12years of age. Catch up vaccination up to 26yrs of age.
  • 53. QUESTION 21 • Identify this graph. • What do the square and area of each square represent? • What do the horizontal and vertical line represent? • What does the diamond represent? • What does the centre of diamond represent?
  • 54. ANSWER 21 • Forest plot (forest plot shows information from individual studies that went into meta- analysis at a glance. They show the amount of variation between the studies and an estimate of the overall result. • Each square symbol represents a study contributing to metanalysis and the area of square corresponds to the weight of the corresponding study to the metaanalysis.
  • 55. ANSWER 21 • The horizontal line through the square shows the confidence interval. The solid vertical line represents no effect. • The diamond represents the overall estimate from the meta-analysis. • The centre of diamond represents the pooled point estimate and the horizontal tips represent the confidence interval.
  • 57. QUESTION 22 • Identify this peripheral smear. • What is the underlying defect? • Confirmatory test for diagnosis? • Treatment options?
  • 58. ANSWER 22 • Hereditary spherocytosis. • Defect in spectrin or ankyrin - results in uncoupling in the vertical interactions of the lipid bilayer skeleton and loss of membrane microvesicles. • Osmotic fragility test. • Folic acid 1mg/day, splenectomy.
  • 60. QUESTION 23 • Identify this peripheral smear. • Mention a few complications associated with this condition.
  • 61. ANSWER 23 • Plasmodium falciparum malaria. • Cerebral malaria, blackwater fever, pulmonary edema, algid malaria.
  • 62. QUESTION 24 1 ½ yr old child with history of chronic diarrhea was brought with complaints of perioral and perineal rash.
  • 63. QUESTION 24 • What is your diagnosis? • Mode of inheritance? • Investigation used for diagnosis? • Treatment of choice? • Mention a few differential diagnosis.
  • 64. ANSWER 24 • Acrodermatitis enteropathica. • Autosomal recessive – defect in intestinal zinc specific transporter gene. • Low plasma zinc concentration. • Zinc – 50mg/day for infants, upto 150mg/day for children. • MSUD, organic acidemia, methylmalonic acidemia, biotidinase def, severe PEM.
  • 66. QUESTION 25 • What is your diagnosis? • What is the causative organism? • Mention a few other manifestations. • Mention a few complications.
  • 67. ANSWER 25 • Erythema infectiosum. • Parvovirus B19 • Arthropathy, transient aplastic crisis, myocarditis. • Thrombocytopenic purpura, aseptic meningitis, infection associated hemophagocytic syndrome, persistent arthritis.
  • 69. QUESTION 26 • Identify this pedigree chart. What is the mode of inheritance. • Mention a few disorders with this mode of inheritance.
  • 70. ANSWER 26 • X-linked dominant inheritance. • Hypophosphatemic rickets, incontinentia pigmenti.
  • 71. QUESTION 27 Stool microscopy of a child showed the following
  • 72. QUESTION 27 • What is your diagnosis? • Mention a few clinical manifestations. • Drugs used in treatment.
  • 73. ANSWER 27 • Hookworm egg. • Iron deficiency anemia, dermatitis, cutaneous larva migrans, cough due to laryngotracheobronchitis. • Albendazole 400mg stat, Mebendazole 100mg BD for 3 days, pyrantel palmoate 11mg/kg OD for 3 days.
  • 74. QUESTION 28 1.Mark the parts of the ETCO2 graph and explain each part. 2.Mention 2 conditions which cause this type of ETCO2 recording
  • 75. ANSWER 28 2.Intravenous bicarbonate injection Release of a tourniquet from a surgical limb
  • 77. QUESTION 29 • Identify this condition. • Mention 3 treatment options • Mention 2 complications
  • 78. ANSWER 29 • Dense bones suggestive of osteopetrosis • Steroids,Interferon,Bone marrow Transplantation • Infections,Bleeds,Loss of vision
  • 79. Question 30 A 1 month old child was brought with pink staining of the diapers since birth. He also had history of blisters on sun exposed areas. On examination the color of the urine is as shown.
  • 80. 1. What is your diagnosis? 2. Name the deficient enzyme. 3. What are the other clinical manifestations? 4. Mention the diagnostic lab finding.
  • 81. Answer: 1. Congenital Erythropoietic Porphyria (Gunther disease) 2. Uroporphyrinogen III synthase (UROS) 3. Bullous cutaneous photosensitivity– hydroa aestivale, hypertrichosis, erythrodontia, hemolytic anemia, bone abnormalities 4. Markedly elevated levels of uroporphyrin I and coproporphyrin I in urine,stool and RBC’s.
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