2. IMPLANT – is defined as insertion of any object
or a material , which is alloplastic in nature either
partially or completely into the body for therapeutic ,
experimental , diagnostic or prosthetic purpose .
3. FATHER OF IMPLANT DENTISTRY:
Per Ingvar Branemark
4. Advantage of Implant
To overcome the drawbacks of removable
prostheses
Bone maintenance of height and width
Ideally esthetic tooth positioning
Improved psychological health
Increased stability in chewing
Increased retention
Eliminates need to involve adjacent teeth
5. Materials used in the fabrication of the implant can be
generally classified into two different ways :
1. Chemical point – metals and ceramics
2. Biological point – biodynamic materials :
biotolerant , bioinhert , bioactive.
6. Materials regardless of use fall into four different
categories :
1. Metal and metal alloys : metals that are used in
implants are titanium , tantalum , and alloys Ti-Al-
Va , Co-Cr-Mb , Fe-Co-Ni
2. Ceramics
3. Synthetic polymers
4. Natural materials
7. Bioinhert materials allow close approximation of
bones in their surface leading to contact
osteogenesis.
These materials allow formation of new bone in their
surface and ion exchange with the tissue leads to the
formation of chemical bonding along the interface
bonding osteogenesis.
8. Biotolerant are those that are not necessarily rejected
when implanted into the living tissiue.
They are human bone morphogenetic protein-2( rh
BMP-2 ) which includes bone formation de nevo.
Biomemtic are tissue interegated engineered materials
design to mimic specific biologic processes and help
optimize the healing/regenerative response of the
host microenviroment.
9. Bioinhert and bioactive materials are also called
osteoconductive meaning that they can act as
scaffolds allowing bone growth on their surfaces.
10. Factors affecting implant biomaterials
1. Mechanical
2. Chemical
3. Electrical and
4. Surface specific properties
11. Chemical factors:
Corrosion : loss of metallic ions from the surface of the
metal to the surrounding enviroment.
General : occurs when the metal is immersed into an
electrolyte solution.
Pitting : occurs in an implant with a small surface pit
placed in a solution.
Crevice : occurs in the bone-implant interface or an
implant device where an overlay or composite type
surface exist on metallic substrate in a tissue/fluid
environment with minimal surface , little or no oxygen
may be present in the crevice.
12. Surface – specific factors
Event at the bone-implant interface:
The performance of the implant can be classified in
terms of :
1. The response of the host to the implant
2. The behaviour of the material in the host
13. Material response: The event that occurs
immediately upon implantation of metals i.e. Results
in release of proteins to the blood from the wound
surface and cellular activity in the interfacial region.
Host response: Involves series of cellular and matrix
events ideally culminating in tissue healing leading
to intimate apposition of the bone to the
biomaterials i.e. Osseo integration.
14. Electrical factors
Physiochemical method:
1. Surface energy
2. Surface charge
3. Surface composition are the three factors that aim
to improve the bone implant interface.
15. Morphologic method :
Alteration in biomaterials surface morphology and
roughness have been used to influence the cells and
tissue response to the implant.
Biochemical method:
The goal is to immobilize protein, enzyme or peptide
on biomaterials for the purpose of inducing specific
cell and tissue response.
16. Mechanical properties
Properties considered are:
1. Modulus of elasticity
2. Tensile strength
3. Compressive strength
4. Elongation and
5. Metallurgy
17. Classification of implant
1. Based on implant design
2. Based on attachment mechanism
3. Based on macroscopic body design
4. Based on the surface of the implant
5. Based on the type of the material
18. Classification based on implant design:
1. Endosteal
1. Ramus frame
2. Root form
3. Blade form
2. Sub-periosteal
3. Transosteal
4. Intramucosal
19. Endosteal implant:
A device which is placed into the alveolar bone
and/or basal bone of the mandible or maxilla
Transect only one cortical plate
20. Blade form implant:
It consist of thin plates in the form of blade embedded
into the bone
21. Ramus frame implant:
Horse shoe shaped stainless steel device
Inserted into the mandible from one retromolar pad
to the other
It passes through the anterior symphysis area
22. Root form implant:
Designed to mimic the shape of the tooth
For directional load distribution
27. Osseo integration:
Direct contact between the bone and the surface of
the loaded implant
Described by BRANEMARK
Bio active material that stimulate the formation of
bone can also be used
28. Biological considerations for
osseointegration
Bone implant interface
Bone remodeling
Foreign body reaction
29. Bone to implant interface
Mechanism of osseointegration
Ultrastructure in osseointegration
Destruction of osseointegration
Soft tissue implant interface
Peri-implant membrane
Disease activity in peri-implant tissue
Neuromuscular system as it relates to the
implant
30. Osseointegration is defined as a direct bone
anchorage to an implant body which can
provide a foundation to support a prosthesis.
“Direct structural and functional connection between ordered, living bone and
surface of a load carrying implant”.
31. American Academy of Implant Dentistry defined it as “contact
established without interposition of non bone tissue between
normal remodeled bone and on implant entailing a sustained
transfer and distribution of load from the implant to and within
bone tissue”.
32. Biological Considerations for
Osseointegration
Bone implant interface
When compared to compact bone spongy bone has
less density and hardness is not a stable base for
primary fixture fixation.
In the mandible the spongy bone is more dense than
maxilla.
With primary fixation in compact bone,
osseointegration in the maxilla require a longer
healing period.
33. Bone remodelling
Osseointegration requires new bone
formation around the fixture. A process
resulting from remodeling within bone
tissue.
Osteoblastic and osteoclastic activity helps
maintain blood calcium without change in
quantity of bone
34. To maintain a constant level of bone
remodeling there should be proper local
stimulation, crucial levels of thyroid
hormone, calcitonin and vitamin D.
Occlusion or occlusal force stimulus are both
important to optimal bone remodeling
35. Foreign body reaction
Organization or an antigen antibody reaction
occurs when a foreign body is present in the
body.
This reaction occurs in the presence of a protein
but with implant materials devoid of proteins no
antigen antibody reaction
36. When titanium is used no foreign body
reaction are seen.
The implant material is an important factor
for Osseo integration to occur.
37. Biological process of implant
osseointegration
The healing process of implant system is
similar to primary bone healing.
Titanium dental implants show three stages
of healing
38. OSTEOPHYLLIC STAGE
When a implant is placed into the cancellous
marrow space blood is initially present between
implant and bone.
Only a small amount of bone is in contact with
the implant surface; the rest is exposed to
extracellular fluids.
Generalized inflammatory response to the
surgical insult.
39. By the end of first week, inflammatory cells are
responding to foreign antigens.
Vascular ingrowth from the surrounding vital tissues
begins by third day.
A mature vascular network forms by 3 weeks.
Ossification also begins during the first week and the
initial response observed in the migration of
osteoblasts from the trabacular bone which can be
due to the release of BMP’s.
The osteophyllic phase lasts about 1 month.
40. OSTEOCONDUCTIVE PHASE
Once they reach the implant, the bone
cells spread along the metal surface laying
down osteoid.
Initially this is an immature connective
tissue matrix and bone deposited is a thin
layer of woven bone called foot plate
41. Fibro-cartilaginous callus is eventually
remodeled into bone callus.
This process occurs during the next 3
months
Four months after implant placement the
maximum surface area is covered by
bone.
42. OSTEOADAPTIVE PHASE
The final phase begins approximately 4 months
after implant placement.
Once loaded implants do not gain or loose bone
contact but the foot plates thicken in response
and some reorientation of the vascular pattern
may be seen
43. Grafted bone integrates to a higher degree than
the natural host bone to the implant.
To achieve optimal results an osseointegration
period of 4 months is recommended for implants
in graft bone and 4 to 8 months for implant
placed in normal bone.
44. Bioactivity
characteristic of an implant material that allows attachment to
living tissues, whereas a non bioactive material would form a
loosely adherent layer of fibrous tissue at the implant
interface
Bioactive retention is achieved with bioactive
materials such as hydroxyapatite (HA), which
bond directly to bone
45. Factors influencing Osseointegration
Biomaterial for dental implant
Surface composition and structure
Implant design
Heat
Contamination
Primary stability or initial stability
Bone quality
Epithelial down growth
Loading
46. Mechanism of Osseointegration
Blood clot (between fixture & bone)
Clot transformed by phagocytic cell
(1st to 3rd day)
Procallus formation
(containing fibroblasts & phagocytes)
Procallus becomes dense connective tissue
(Differentiation of osteoblasts & fibroblasts)
Callus (Osteoblasts on the fixture)
Fibro cartilagenous callus (between fixture & bone)
Bone callus (Penetrates & matures)
Prosthesis attached to the fixtures stimulating bone remodeling
47. Fibro-integration:
Proposed by Dr.Charles Wiess
Complete encapsulation of the implant with soft
tissues
Soft tissue interface could resemble the highly
vascular periodontal fibers of natural dentition
48. Classification based on implant materials
1. Metallic implant
2. Ceramic and ceramic coated
3. Polymer and
4. Carbon compound
49. Metallic implant:
Most popular material in use today is TITANIUM
Other metallic implants are
stainless steel
cobalt chromium molybdenum alloy
vitallium
50. Metals and alloys in implants
Dental implants are constructed using metals and
alloys. These include titanium , tantalum , and alloys
of aluminium , vanadium , cobalt , chromium ,
molybdenum and nickel.
These materials are generally selected on the basis of
their strength.
The precious metals generally used in restoration such
as gold, platinum and their alloys are less frequently
used as dental implant.
51. Titanium
Discovered in 1789 by Wilhelm Gregor.
Represents only 6% of the earth crust.
Industrial use started 60 years ago with use in
aerospace and defence because of it's light weight,
high strength and high melting point.
Used as biomaterials in dental implants ,orthopaedic
and cardiovascular applications.
Excellent biocompatibility, corrosion resistance, and
desirable physical and mechanical properties.
52. Dr. Wilhelm Kroll is known as the father of titanium
dentistry.
He successfully developed the deoxidation process of
titanium tetrachloride through a reduction process
with magnesium and sodium.
The result was a titanium sponge that could be melted
in an induction casting furnace into a solid alloy and
produced in long cast solid bars
53. General properties of titanium
Melting point is 1680 degree
High tensile strength
Highly ductile
Highly rigidity due to high modulus of elasticity
Low weight
High corrosion resistance
54. American society for testing materials (ASTM)
classified titanium into grades; which vary according
to oxygen(0.18-0.40 wt%) iron (0.20-0.50 wt%) and
other impurities which includes nitrogen , carbon ,
and hydrogen.
Grade I is the purest and softest form , and have
moderately high tensile strength.
As the grade goes up, the stronger the titanium
becomes
Grade V contains aluminum and vanadium along with
titanium, making it stronger than grades I-IV
55. Advantage
Strong
Lightweight
Corrosion Resistant
Cost-efficient
Non-toxic
Biocompatible (non-toxic AND not rejected by the body)
Long-lasting
Non-ferromagnetic
Osseointegrated (the joining of bone with artificial
implant)
Long range availability
Flexibility and elasticity rivals that of human bone
56. Medical grade titanium is used in producing:
Pins
Bone plates
Screws
Bars
Rods
Wires
Posts
Expandable rib cages
Spinal fusion cages
Finger and toe replacements
Maxio-facial prosthetics
57. It is used to create a number titanium surgical devices:
Surgical forceps
Retractors
Surgical tweezers
Suture instruments
Scissors
Needle and micro needle holders
Dental scalers
Dental elevators
Dental drills
Lasik eye surgery equipment
Laser electrodes
Vena cava clips
58. Dental Titanium
Titanium has the ability to fuse together with living bone. This
property makes it a huge benefit in the world of dentistry.
Titanium dental implants have become the most widely
accepted and successfully used type of implant due to its
propensity to osseointegrate.
When bone forming cells attach themselves to the titanium
implant, a structural and functional bridge forms between the
body’s bone and the newly implanted, foreign object.
Titanium orthodontic braces are also growing in popularity.
They are stronger, more secure and lighter than their steel
counterparts.
59. Future of Bio-medical Titanium
It is expected that use within the biomedical industry
will only continue to grow for titanium in the coming
years. With the baby-boomer demographic
continuing to age and our health industry pushing
for people to live more active lives, it’s only logical
that the medical industry will continue researching
new and innovative uses for this popular metal alloy.
And with health care reform a current major issue,
titanium’s cost-efficiency adds even more appeal to
those looking to cut health care costs.
61. Ceramic
Bioceramics and bioglasses are ceramic materials
that are biocompatible Bioceramics are an important
subset of biomaterials.
Bioceramics range in biocompatibility from the
ceramicoxides, which are inert in the body, to the
other extreme of resorbable materials, which are
eventually replaced by the materials which they were
used to repair.
62. Bioceramics are used in many types of medical
procedures. A primary medical procedures where
they are used is as surgical implants.
Though some bioceramics are flexible. The ceramic
materials used are not the same as porcelain type
ceramic materials.
Rather bioceramics are closely related to either the
body's own materials, or are extremely durable metal
oxide
63. Available
1)Specialty steels
2) Cobalt base alloys
3) Titanium and titanium alloys
4) NiTiNOL
5) Zirconium alloys
64. Uses
Ceramics are now commonly used in the medical
fields as dental, and bone implants.
Artificial teeth, and bones are relatively
commonplace.
Surgical cermets are used regularly. Joint
replacements are commonly coated with bioceramic
materials to reduce wear and inflammatory
response.
Other examples of medical uses for bioceramics are
in pacemakers, kidney dialysis machines, and
respirators.
65. Advantages
Porous, strong and non-brittle composition
Rapid fibrovascularization
No risk of disease-transmission
Lightweight and easy to insert during surgery
Easy to suture to extra ocular muscles
Effortlessly hand-drilled without crumbling
Non-dissolving
Does not release soluble components
Does not cause excessive tissue inflammation
77. Hot isostatic pressing
Expensive
The potential for contamination
The necessity for removing the inert foil or other
encapsulating materials