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1st Annual Regen Med Investor Day
       Platform to Bedside

         Marc Hedrick, MD
            President
Safe Harbor Statement
This presentation contains certain ‘forward-looking statements’ about Cytori Therapeutics, Inc. All
statements, other than statements of historical fact, that address activities, events or developments that we
intend, expect, project, believe or anticipate will or may occur in the future are forward-looking statements.

Such statements are based upon certain assumptions and assessments made by our management in light of
their experience and their perception of historical trends, current conditions, expected future developments
and other factors they believe to be appropriate.

The forward-looking statements included in this presentation involve known and unknown risks that relate to
Cytori’s future events or future financial performance and the actual results could differ materially from those
discussed in this presentation. Risks and uncertainties that may cause Cytori's actual results to differ
materially from those discussed in the presentation can be found in the "Risk Factors" section of Cytori’s
Form 10-K, Forms 10-Q and other filings with the United States Securities and Exchange Commission. We
would advise reading our most recent annual report on Form 10-K and quarterly report on Form 10-Q filed
with the United States Securities and Exchange Commission for a more detailed description of these risks.

The forward-looking statements contained in this presentation represent Cytori’s estimates and assumptions
only as of the date of this presentation and Cytori undertakes no duty or obligation to update or revise
publicly any forward-looking statements contained in this presentation as a result of new information, future
events or changes in Cytori’s expectations.
Cytori Platform: Technology

            STEP 1
            Harvest patient
            tissue (100cc)




                                               STEP 2
                                               Separate &
                                               Process




            STEP 3                 Technology for cell
            Deliver ADRCs to       isolation, combination
                                   with other factors,
            Same Patient, ~1 hr.
                                   storage and clinical
                                   therapy
Cytori Platform: Model

          Goal: Leadership in Regenerative Medicine

            Research &   Regulatory    Clinical    Commercial
           Development    Approval      Use

                          Device       Safety       Self Pay
              Basic      Approvals
             Science



CAPITAL                                                           PROFIT




                                       Efficacy   Reimbursement
             Product     Therapeutic
           Development    Approvals
Cytori Platform: Case Study


                                          Radiation
                                          Injury, BARDA


                                          Ischemia &
                       Japan      EU
                                          CV Trials
Gen One       EU
                       Breast   Breast
 Device     Approval                      Sales
                        Pilot   Pivotal




                                          Other Approvals
                                          & Applications
Cytori Cell Therapy:
                   US Government Contract


Discussions   Award        3 Proof-of-concept Objectives      3 Objectives Trigger   Option 1 Objective
Begin         Announcement Ongoing                            Option 1 & 3           Triggers Option 2
2010          Fall, 2012                                      Q1, 2014               Q4, 2015
                           Cell viability

                                                              $32.6 M Option 1
 Pre-Award, White Papers,
                             Animal model POC
 Proposal, Negotiation
                                                                                     $45.5M Option 2
                             Next Gen device feasibility

                             $4.7M Phase 1 Proof of Concept
                                                                       $23.4M Option 3



                                                                                 Commercial Acquisition at
                                                                                   BARDA’s Discretion
Cytori Platform: Clinical Trials and Studies

            43 total: 2 Cytori sponsored trials & 41 investigator studies



               USA                         EU                               AP

                   1                      23                                13
Soft Tissue: 18
     Wound: 7
  Ischemia: 2                                         EM
Ortho/Sport: 8
Vital Organ: 8                                         6
       Total: 43

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ARM Regen Med Investor Day: Cytori Presentation

  • 1. 1st Annual Regen Med Investor Day Platform to Bedside Marc Hedrick, MD President
  • 2. Safe Harbor Statement This presentation contains certain ‘forward-looking statements’ about Cytori Therapeutics, Inc. All statements, other than statements of historical fact, that address activities, events or developments that we intend, expect, project, believe or anticipate will or may occur in the future are forward-looking statements. Such statements are based upon certain assumptions and assessments made by our management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. The forward-looking statements included in this presentation involve known and unknown risks that relate to Cytori’s future events or future financial performance and the actual results could differ materially from those discussed in this presentation. Risks and uncertainties that may cause Cytori's actual results to differ materially from those discussed in the presentation can be found in the "Risk Factors" section of Cytori’s Form 10-K, Forms 10-Q and other filings with the United States Securities and Exchange Commission. We would advise reading our most recent annual report on Form 10-K and quarterly report on Form 10-Q filed with the United States Securities and Exchange Commission for a more detailed description of these risks. The forward-looking statements contained in this presentation represent Cytori’s estimates and assumptions only as of the date of this presentation and Cytori undertakes no duty or obligation to update or revise publicly any forward-looking statements contained in this presentation as a result of new information, future events or changes in Cytori’s expectations.
  • 3. Cytori Platform: Technology STEP 1 Harvest patient tissue (100cc) STEP 2 Separate & Process STEP 3 Technology for cell Deliver ADRCs to isolation, combination with other factors, Same Patient, ~1 hr. storage and clinical therapy
  • 4. Cytori Platform: Model Goal: Leadership in Regenerative Medicine Research & Regulatory Clinical Commercial Development Approval Use Device Safety Self Pay Basic Approvals Science CAPITAL PROFIT Efficacy Reimbursement Product Therapeutic Development Approvals
  • 5. Cytori Platform: Case Study Radiation Injury, BARDA Ischemia & Japan EU CV Trials Gen One EU Breast Breast Device Approval Sales Pilot Pivotal Other Approvals & Applications
  • 6. Cytori Cell Therapy: US Government Contract Discussions Award 3 Proof-of-concept Objectives 3 Objectives Trigger Option 1 Objective Begin Announcement Ongoing Option 1 & 3 Triggers Option 2 2010 Fall, 2012 Q1, 2014 Q4, 2015 Cell viability $32.6 M Option 1 Pre-Award, White Papers, Animal model POC Proposal, Negotiation $45.5M Option 2 Next Gen device feasibility $4.7M Phase 1 Proof of Concept $23.4M Option 3 Commercial Acquisition at BARDA’s Discretion
  • 7. Cytori Platform: Clinical Trials and Studies 43 total: 2 Cytori sponsored trials & 41 investigator studies USA EU AP 1 23 13 Soft Tissue: 18 Wound: 7 Ischemia: 2 EM Ortho/Sport: 8 Vital Organ: 8 6 Total: 43